[
    {
        "key": "5Y9HUGLM",
        "version": 21,
        "library": {
            "type": "group",
            "id": 267322,
            "name": "EMSC",
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        "meta": {
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                }
            },
            "creatorSummary": "Rittenberger et al.",
            "parsedDate": "2011-08",
            "numChildren": 1
        },
        "data": {
            "key": "5Y9HUGLM",
            "version": 21,
            "itemType": "journalArticle",
            "title": "Association between Cerebral Performance Category, Modified Rankin Scale, and Discharge Disposition after Cardiac Arrest",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Jon C.",
                    "lastName": "Rittenberger"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ketki",
                    "lastName": "Raina"
                },
                {
                    "creatorType": "author",
                    "firstName": "Margo B.",
                    "lastName": "Holm"
                },
                {
                    "creatorType": "author",
                    "firstName": "Young Joo",
                    "lastName": "Kim"
                },
                {
                    "creatorType": "author",
                    "firstName": "Clifton W.",
                    "lastName": "Callaway"
                }
            ],
            "abstractNote": "Background\nCerebral Performance Category (CPC), Modified Rankin Scale (mRS) and discharge disposition are commonly used to determine outcomes following cardiac arrest. This study tested the association between these outcome measures.\n\nMethods\nRetrospective chart review of subjects who survived to hospital discharge between 1/1/2006 and 12/31/2009 was conducted. Charts were reviewed for outcomes (CPC, mRS, and discharge disposition). Discharge disposition was classified in 6 categories: home with no services, home with home healthcare, acute rehabilitation facility, skilled nursing facility, long term acute care facility, and hospice. Intra-and inter-rater reliabilities were calculated for outcome measures. Rates of “good outcome” (defined as a CPC of 1–2, mRS of 0–3, or discharge disposition to home or acute rehabilitation facility) were also determined. Kendall’s tau correlation coefficients explored relationships among measures.\n\nResults\nA total of 211 charts were reviewed. Mean age was 60 years (SD 16), the majority (75%) were white males, in- and out-of hospital cardiac arrests were equally prevalent, and ventricular dysrhythmia was most common (N=109, 52%). Half of the subjects were comatose following resuscitation and 75 (35%) received therapeutic hypothermia. Inter-rater percentage agreement for CPC and mRS abstraction was 95.24% (kappa 0.89, p<0.001) and 95.24% (kappa 0.90, p<0.001) respectively., “Good outcomes” were found in 44 subjects (20%) using the CPC definition, 47 subjects (22%) using the mRS definition, and 129 subjects (61%) subjects using discharge disposition definition. There was fair relationship between the CPC and mRS (tau 0.43) and poor relationships between CPC and discharge disposition (tau 0.23) and between mRS and discharge disposition (tau 0.25).\n\nConclusions\nDetermination of the CPC, mRS and discharge disposition at hospital discharge is reliable from chart review. These instruments provide widely differing estimates of “good outcome.” Agreement between these measures ranges from poor to fair. A more nuanced outcome measure designed for the post-cardiac arrest population is needed.",
            "publicationTitle": "Resuscitation",
            "publisher": "",
            "place": "",
            "date": "2011-8",
            "volume": "82",
            "issue": "8",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1036-1040",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Resuscitation",
            "DOI": "10.1016/j.resuscitation.2011.03.034",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3138855/",
            "accessDate": "2016-09-14T20:02:55Z",
            "PMID": "21524837",
            "PMCID": "PMC3138855",
            "ISSN": "0300-9572",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "PubMed Central",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [
                "FSV24BG2"
            ],
            "relations": {},
            "dateAdded": "2023-03-01T16:32:07Z",
            "dateModified": "2023-03-01T16:32:07Z"
        }
    },
    {
        "key": "9AJNJ67P",
        "version": 21,
        "library": {
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            "id": 267322,
            "name": "EMSC",
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            },
            "creatorSummary": "Nitta et al.",
            "parsedDate": "2011-10-01",
            "numChildren": 1
        },
        "data": {
            "key": "9AJNJ67P",
            "version": 21,
            "itemType": "journalArticle",
            "title": "Age-Specific Differences in Outcomes After Out-of-Hospital Cardiac Arrests",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Masahiko",
                    "lastName": "Nitta"
                },
                {
                    "creatorType": "author",
                    "firstName": "Taku",
                    "lastName": "Iwami"
                },
                {
                    "creatorType": "author",
                    "firstName": "Tetsuhisa",
                    "lastName": "Kitamura"
                },
                {
                    "creatorType": "author",
                    "firstName": "Vinay M.",
                    "lastName": "Nadkarni"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert A.",
                    "lastName": "Berg"
                },
                {
                    "creatorType": "author",
                    "firstName": "Naoki",
                    "lastName": "Shimizu"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kunio",
                    "lastName": "Ohta"
                },
                {
                    "creatorType": "author",
                    "firstName": "Tatsuya",
                    "lastName": "Nishiuchi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Yasuyuki",
                    "lastName": "Hayashi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Atsushi",
                    "lastName": "Hiraide"
                },
                {
                    "creatorType": "author",
                    "firstName": "Hiroshi",
                    "lastName": "Tamai"
                },
                {
                    "creatorType": "author",
                    "firstName": "Masanao",
                    "lastName": "Kobayashi"
                },
                {
                    "creatorType": "author",
                    "firstName": "Hiroshi",
                    "lastName": "Morita"
                }
            ],
            "abstractNote": "OBJECTIVE: We assessed out-of-hospital cardiac arrests (OHCAs) for various pediatric age groups.\nMETHODS: This prospective, population-based, observational study included all emergency medical service-treated OHCAs in Osaka, Japan, between 1999 and 2006 (excluding 2004). Patients were grouped as adults (>17 years), infants (<1 year), younger children (1–4 years), older children (5–12 years), and adolescents (13–17 years). The primary outcome measure was 1-month survival with favorable neurologic outcome.\nRESULTS: Of 950 pediatric OHCAs, resuscitations were attempted for 875 patients (92%; 347 infants, 203 younger children, 135 older children, and 190 adolescents). The overall incidence of nontraumatic pediatric OHCAs was 7.3 cases per 100 000 person-years, compared with 64.7 cases per 100 000 person-years for adults and 65.5 cases per 100 000 person-years for infants. Most infant OHCAs occurred in homes (93%) and were not witnessed (90%). Adolescent OHCAs often occurred outside the home (45%), were witnessed by bystanders (37%), and had shockable rhythms (18%). One-month survival was more common after nontraumatic pediatric OHCAs than adult OHCAs (8% [56 of 740 patients] vs 5% [1677 of 33 091 patients]; adjusted odds ratio: 2.26 [95% confidence interval: 1.63–3.13]). One-month survival with favorable neurologic outcome was more common among children than adults (3% [21 of 740 patients] vs 2% [648 of 33 091 patients]; adjusted odds ratio: 2.46 [95% confidence interval: 1.45–4.18]). Rates of 1-month survival with favorable neurologic outcome were 1% for infants, 2% for younger children, 2% for older children, and 11% for adolescents.\nCONCLUSION: Survival and favorable neurologic outcome at 1 month were more common after pediatric OHCAs than adult OHCAs.",
            "publicationTitle": "Pediatrics",
            "publisher": "",
            "place": "",
            "date": "10/01/2011",
            "volume": "128",
            "issue": "4",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "e812-e820",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Pediatrics",
            "DOI": "10.1542/peds.2010-3886",
            "citationKey": "",
            "url": "http://pediatrics.aappublications.org/content/128/4/e812",
            "accessDate": "2015-04-29T14:57:45Z",
            "PMID": "21890823",
            "PMCID": "",
            "ISSN": "0031-4005, 1098-4275",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "pediatrics.aappublications.org",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "Cardiac arrest",
                    "type": 1
                },
                {
                    "tag": "Cardiopulmonary resuscitation",
                    "type": 1
                },
                {
                    "tag": "Epidemiology",
                    "type": 1
                },
                {
                    "tag": "outcomes analysis",
                    "type": 1
                }
            ],
            "collections": [
                "FSV24BG2"
            ],
            "relations": {},
            "dateAdded": "2023-03-01T16:32:07Z",
            "dateModified": "2023-03-01T16:32:07Z"
        }
    },
    {
        "key": "IC322TTX",
        "version": 21,
        "library": {
            "type": "group",
            "id": 267322,
            "name": "EMSC",
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                    "href": "https://www.zotero.org/groups/emsc",
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            },
            "creatorSummary": "Young et al.",
            "parsedDate": "2004-07",
            "numChildren": 1
        },
        "data": {
            "key": "IC322TTX",
            "version": 21,
            "itemType": "journalArticle",
            "title": "A prospective, population-based study of the epidemiology and outcome of out-of-hospital pediatric cardiopulmonary arrest",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Kelly D.",
                    "lastName": "Young"
                },
                {
                    "creatorType": "author",
                    "firstName": "Marianne",
                    "lastName": "Gausche-Hill"
                },
                {
                    "creatorType": "author",
                    "firstName": "Christian D.",
                    "lastName": "McClung"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roger J.",
                    "lastName": "Lewis"
                }
            ],
            "abstractNote": "BACKGROUND: This study reports the epidemiologic features, survival rates, and neurologic outcomes of the largest population-based series of pediatric out-of-hospital cardiopulmonary arrest patients with prospectively collected data.\nMETHODS: Secondary analysis of data from a prospective, interventional trial of out-of-hospital pediatric airway management conducted from 1994 to 1997 (Gausche M, Lewis RJ, Stratton SJ, et al. JAMA. 2000;283:783-790). Consecutive out-of-hospital patients from 2 large urban counties in California <12 years old or 40 kg in bodyweight who were determined by paramedics to be pulseless and apneic were included. Main outcome measures included survival to hospital discharge, patient demographics, arrest etiology, arrest rhythm, event intervals, and neurologic outcomes.\nRESULTS: In 599 patients, 601 events were studied (54% were <1 year old, 58% were male). Return of spontaneous circulation was achieved in 29%; 25% were admitted to the hospital, and 8.6% (51) survived to hospital discharge. The most prevalent etiologies were sudden infant death syndrome and trauma; these resulted in relatively higher mortality. Respiratory etiologies and submersions followed; these resulted in relatively lower mortality. Twenty-six percent of the arrests were witnessed by citizens, and an additional 8% were witnessed by rescue personnel. Witnessed arrests had a higher survival rate (16%). Thirty-one percent of patients received bystander cardiopulmonary resuscitation, which was not demonstrated to result in improved survival rates. Arrest rhythms were asystole (67%), pulseless electrical activity (24%), and ventricular fibrillation (9%); children with the latter 2 rhythms had better survival rates. One third of the survivors (16 of 51) had good neurologic outcome, none of whom received >3 doses of epinephrine or were resuscitated for >31 minutes in the emergency department.\nCONCLUSIONS: The 8.6% survival rate after out-of-hospital pediatric cardiopulmonary arrest is poor. Administration of >3 doses of epinephrine or prolonged resuscitation is futile.",
            "publicationTitle": "Pediatrics",
            "publisher": "",
            "place": "",
            "date": "Jul 2004",
            "volume": "114",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "157-164",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Pediatrics",
            "DOI": "",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "15231922",
            "PMCID": "",
            "ISSN": "1098-4275",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "eng",
            "libraryCatalog": "PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "California",
                    "type": 1
                },
                {
                    "tag": "Cardiopulmonary resuscitation",
                    "type": 1
                },
                {
                    "tag": "Child",
                    "type": 1
                },
                {
                    "tag": "Child, Preschool",
                    "type": 1
                },
                {
                    "tag": "Emergency medical services",
                    "type": 1
                },
                {
                    "tag": "Epinephrine",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Heart Arrest",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Infant",
                    "type": 1
                },
                {
                    "tag": "Infant, Newborn",
                    "type": 1
                },
                {
                    "tag": "Male",
                    "type": 1
                },
                {
                    "tag": "Outcome Assessment (Health Care)",
                    "type": 1
                },
                {
                    "tag": "Prospective Studies",
                    "type": 1
                },
                {
                    "tag": "Sudden Infant Death",
                    "type": 1
                },
                {
                    "tag": "Survival Rate",
                    "type": 1
                },
                {
                    "tag": "Sympathomimetics",
                    "type": 1
                }
            ],
            "collections": [
                "FSV24BG2"
            ],
            "relations": {},
            "dateAdded": "2023-03-01T16:32:07Z",
            "dateModified": "2023-03-01T16:32:07Z"
        }
    },
    {
        "key": "G6VTTXF8",
        "version": 20,
        "library": {
            "type": "group",
            "id": 267322,
            "name": "EMSC",
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                    "href": "https://www.zotero.org/groups/emsc",
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                "href": "https://api.zotero.org/groups/267322/items/G6VTTXF8",
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        "meta": {
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                    }
                }
            },
            "creatorSummary": "Girotra et al.",
            "parsedDate": "2013-01-01",
            "numChildren": 1
        },
        "data": {
            "key": "G6VTTXF8",
            "version": 20,
            "itemType": "journalArticle",
            "title": "Survival Trends in Pediatric In-Hospital Cardiac Arrests An Analysis From Get With The Guidelines–Resuscitation",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Saket",
                    "lastName": "Girotra"
                },
                {
                    "creatorType": "author",
                    "firstName": "John A.",
                    "lastName": "Spertus"
                },
                {
                    "creatorType": "author",
                    "firstName": "Yan",
                    "lastName": "Li"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert A.",
                    "lastName": "Berg"
                },
                {
                    "creatorType": "author",
                    "firstName": "Vinay M.",
                    "lastName": "Nadkarni"
                },
                {
                    "creatorType": "author",
                    "firstName": "Paul S.",
                    "lastName": "Chan"
                }
            ],
            "abstractNote": "Background—Despite ongoing efforts to improve the quality of pediatric resuscitation, it remains unknown whether survival in children with in-hospital cardiac arrest has improved.\nMethods and Results—Between 2000 and 2009, we identified children (<18 years of age) with an in-hospital cardiac arrest at hospitals with >3 years of participation and >5 cases annually within the national Get With The Guidelines–Resuscitation registry. Multivariable logistic regression was used to examine temporal trends in survival to discharge. We also explored whether trends in survival were attributable to improvement in acute resuscitation or postresuscitation care and examined trends in neurological disability among survivors. Among 1031 children at 12 hospitals, the initial cardiac arrest rhythm was asystole and pulseless electrical activity in 874 children (84.8%) and ventricular fibrillation and pulseless ventricular tachycardia in 157 children (15.2%), with an increase in cardiac arrests due to pulseless electrical activity over time (P for trend <0.001). Risk-adjusted rates of survival to discharge increased from 14.3% in 2000 to 43.4% in 2009 (adjusted rate ratio per year, 1.08; 95% confidence interval, 1.01–1.16; P for trend=0.02). Improvement in survival was driven largely by an improvement in acute resuscitation survival (risk-adjusted rates: 42.9% in 2000, 81.2% in 2009; adjusted rate ratio per year: 1.04; 95% confidence interval, 1.01–1.08; P for trend=0.006). Moreover, survival trends were not accompanied by higher rates of neurological disability among survivors over time (unadjusted P for trend=0.32), suggesting an overall increase in the number of survivors without neurological disability over time.\nConclusions—Rates of survival to hospital discharge in children with in-hospital cardiac arrests have improved over the past decade without higher rates of neurological disability among survivors.",
            "publicationTitle": "Circulation: Cardiovascular Quality and Outcomes",
            "publisher": "",
            "place": "",
            "date": "01/01/2013",
            "volume": "6",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "42-49",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Circ Cardiovasc Qual Outcomes",
            "DOI": "10.1161/CIRCOUTCOMES.112.967968",
            "citationKey": "",
            "url": "http://circoutcomes.ahajournals.org/content/6/1/42",
            "accessDate": "2015-04-29T15:01:26Z",
            "PMID": "23250980",
            "PMCID": "",
            "ISSN": "1941-7705, 1941-7705",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "circoutcomes.ahajournals.org",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "Cardiopulmonary resuscitation",
                    "type": 1
                },
                {
                    "tag": "Survival",
                    "type": 1
                },
                {
                    "tag": "pediatrics",
                    "type": 1
                }
            ],
            "collections": [
                "FSV24BG2"
            ],
            "relations": {},
            "dateAdded": "2023-03-01T16:32:07Z",
            "dateModified": "2023-03-01T16:32:07Z"
        }
    },
    {
        "key": "NUFPDICV",
        "version": 20,
        "library": {
            "type": "group",
            "id": 267322,
            "name": "EMSC",
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                    "href": "https://www.zotero.org/groups/emsc",
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            "self": {
                "href": "https://api.zotero.org/groups/267322/items/NUFPDICV",
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            },
            "creatorSummary": "Kleinman et al.",
            "parsedDate": "2010-11-02",
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        },
        "data": {
            "key": "NUFPDICV",
            "version": 20,
            "itemType": "journalArticle",
            "title": "Part 14: pediatric advanced life support: 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Monica E.",
                    "lastName": "Kleinman"
                },
                {
                    "creatorType": "author",
                    "firstName": "Leon",
                    "lastName": "Chameides"
                },
                {
                    "creatorType": "author",
                    "firstName": "Stephen M.",
                    "lastName": "Schexnayder"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ricardo A.",
                    "lastName": "Samson"
                },
                {
                    "creatorType": "author",
                    "firstName": "Mary Fran",
                    "lastName": "Hazinski"
                },
                {
                    "creatorType": "author",
                    "firstName": "Dianne L.",
                    "lastName": "Atkins"
                },
                {
                    "creatorType": "author",
                    "firstName": "Marc D.",
                    "lastName": "Berg"
                },
                {
                    "creatorType": "author",
                    "firstName": "Allan R.",
                    "lastName": "de Caen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ericka L.",
                    "lastName": "Fink"
                },
                {
                    "creatorType": "author",
                    "firstName": "Eugene B.",
                    "lastName": "Freid"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert W.",
                    "lastName": "Hickey"
                },
                {
                    "creatorType": "author",
                    "firstName": "Bradley S.",
                    "lastName": "Marino"
                },
                {
                    "creatorType": "author",
                    "firstName": "Vinay M.",
                    "lastName": "Nadkarni"
                },
                {
                    "creatorType": "author",
                    "firstName": "Lester T.",
                    "lastName": "Proctor"
                },
                {
                    "creatorType": "author",
                    "firstName": "Faiqa A.",
                    "lastName": "Qureshi"
                },
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                    "lastName": "Menegazzi"
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                    "lastName": "Rea"
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                    "firstName": "Robert A.",
                    "lastName": "Berg"
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                }
            ],
            "abstractNote": "AIM: High-quality cardiopulmonary resuscitation (CPR) may improve survival. The quality of CPR performed during pediatric out-of-hospital cardiac arrest (p-OHCA) is largely unknown. The main objective of this study was to describe the quality of CPR performed during p-OHCA resuscitation attempts.\nMETHODS: Prospective observational multi-center cohort study of p-OHCA patients ≥ 1 and < 19 years of age registered in the Resuscitation Outcomes Consortium (ROC) Epistry database. The primary outcome was an a priori composite variable of compliance with American Heart Association (AHA) guidelines for both chest compression (CC) rate and CC fraction (CCF). Event compliance was defined as a case with 60% or more of its minute epochs compliant with AHA targets (rate 100-120 min(-1); depth ≥ 38 mm; and CCF ≥ 0.80). In a secondary analysis, multivariable logistic regression was used to evaluate the association between guideline compliance and return of spontaneous circulation (ROSC).\nRESULTS: Between December 2005 and December 2012, 2564 pediatric events were treated by EMS providers, 390 of which were included in the final cohort. Of these events, 22% achieved AHA compliance for both rate and CCF, 36% for rate alone, 53% for CCF alone, and 58% for depth alone. Over time, there was a significant increase in CCF (p < 0.001) and depth (p = 0.03). After controlling for potential confounders, there was no significant association between AHA guideline compliance and ROSC.\nCONCLUSIONS: In this multi-center study, we have established that there are opportunities for professional rescuers to improve prehospital CPR quality. Encouragingly, CCF and depth both increased significantly over time.",
            "publicationTitle": "Resuscitation",
            "publisher": "",
            "place": "",
            "date": "Aug 2015",
            "volume": "93",
            "issue": "",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "150-157",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Resuscitation",
            "DOI": "10.1016/j.resuscitation.2015.04.010",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "25917262",
            "PMCID": "PMC4506865",
            "ISSN": "1873-1570",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "eng",
            "libraryCatalog": "PubMed",
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            "rights": "",
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            "tags": [
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                    "type": 1
                },
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                    "tag": "Cardiopulmonary resuscitation",
                    "type": 1
                },
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                    "tag": "Child",
                    "type": 1
                },
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                    "type": 1
                },
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                    "tag": "Cohort Studies",
                    "type": 1
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                    "type": 1
                },
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                    "tag": "Female",
                    "type": 1
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                    "type": 1
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                    "type": 1
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                    "type": 1
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                    "type": 1
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                    "tag": "Quality improvement",
                    "type": 1
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                {
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                    "type": 1
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                    "type": 1
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                {
                    "tag": "out-of-hospital cardiac arrest",
                    "type": 1
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            "creatorSummary": "Jayaram et al.",
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            "version": 20,
            "itemType": "journalArticle",
            "title": "Survival After Out‐of‐Hospital Cardiac Arrest in Children",
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                {
                    "creatorType": "author",
                    "firstName": "Natalie",
                    "lastName": "Jayaram"
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                    "firstName": "Bryan",
                    "lastName": "McNally"
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                {
                    "creatorType": "author",
                    "firstName": "Fengming",
                    "lastName": "Tang"
                },
                {
                    "creatorType": "author",
                    "firstName": "Paul S.",
                    "lastName": "Chan"
                }
            ],
            "abstractNote": "Background Little is known about survival after out‐of‐hospital cardiac arrest (OHCA) in children. We examined whether OHCA survival in children differs by age, sex, and race, as well as recent survival trends.\nMethods and Results Within the prospective Cardiac Arrest Registry to Enhance Survival (CARES), we identified children (age <18 years) with an OHCA from October 2005 to December 2013. Survival to hospital discharge by age (categorized as infants [0 to 1 year], younger children [2 to 7 years], older children [8 to 12 years], and teenagers [13 to 17 years]), sex, and race was assessed using modified Poisson regression. Additionally, we assessed whether survival has improved over 3 time periods: 2005–2007, 2008–2010, and 2011–2013. Of 1980 children with an OHCA, 429 (21.7%) were infants, 952 (48.1%) younger children, 276 (13.9%) older children, and 323 (16.3%) teenagers. Fifty‐nine percent of the study population was male and 31.8% of black race. Overall, 162 (8.2%) children survived to hospital discharge. After multivariable adjustment, infants (rate ratio: 0.56; 95% CI: 0.35, 0.90) and younger children (rate ratio: 0.42; 95% CI: 0.27, 0.65) were less likely to survive compared with teenagers. In contrast, there were no differences in survival by sex or race. Finally, there were no temporal trends in survival across the study periods (P=0.21).\nConclusions In a large, national registry, we found no evidence for racial or sex differences in survival among children with OHCA, but survival was lower in younger age groups. Unlike in adults with OHCA, survival rates in children have not improved in recent years.",
            "publicationTitle": "Journal of the American Heart Association",
            "publisher": "",
            "place": "",
            "date": "10/27/2015",
            "volume": "4",
            "issue": "10",
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            "partNumber": "",
            "partTitle": "",
            "pages": "e002122",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J Am Heart Assoc",
            "DOI": "10.1161/JAHA.115.002122",
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            "accessDate": "2016-06-20T17:44:13Z",
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            "ISSN": ", 2047-9980",
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            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "jaha.ahajournals.org",
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            "rights": "",
            "extra": "",
            "tags": [
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                    "tag": "Heart Arrest",
                    "type": 1
                },
                {
                    "tag": "Survival",
                    "type": 1
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                {
                    "tag": "pediatrics",
                    "type": 1
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                {
                    "creatorType": "author",
                    "firstName": "Monica E.",
                    "lastName": "Kleinman"
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                {
                    "creatorType": "author",
                    "firstName": "Allan R.",
                    "lastName": "de Caen"
                },
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                    "firstName": "Leon",
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                },
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                    "lastName": "Berg"
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                    "firstName": "Ashraf H.",
                    "lastName": "Coovadia"
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                {
                    "creatorType": "author",
                    "firstName": "Mary Fran",
                    "lastName": "Hazinski"
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                {
                    "creatorType": "author",
                    "firstName": "Robert W.",
                    "lastName": "Hickey"
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                {
                    "creatorType": "author",
                    "firstName": "Vinay M.",
                    "lastName": "Nadkarni"
                },
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                    "firstName": "Amelia G.",
                    "lastName": "Reis"
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                    "firstName": "Antonio",
                    "lastName": "Rodriguez-Nunez"
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                {
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                    "firstName": "James",
                    "lastName": "Tibballs"
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                {
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                    "firstName": "Arno L.",
                    "lastName": "Zaritsky"
                },
                {
                    "creatorType": "author",
                    "firstName": "David",
                    "lastName": "Zideman"
                },
                {
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                    "name": "Pediatric Basic and Advanced Life Support Chapter Collaborators"
                }
            ],
            "abstractNote": "",
            "publicationTitle": "Circulation",
            "publisher": "",
            "place": "",
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            "volume": "122",
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            "partTitle": "",
            "pages": "S466-515",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Circulation",
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            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "20956258",
            "PMCID": "PMC3748977",
            "ISSN": "1524-4539",
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            "shortTitle": "Part 10",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
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                    "type": 1
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                    "type": 1
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                    "tag": "Echocardiography",
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            "creatorSummary": "Moler et al.",
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        "data": {
            "key": "FL4PVH4Q",
            "version": 20,
            "itemType": "journalArticle",
            "title": "Multicenter Cohort Study of Out-of-Hospital Pediatric Cardiac Arrest",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Frank W.",
                    "lastName": "Moler"
                },
                {
                    "creatorType": "author",
                    "firstName": "Amy E.",
                    "lastName": "Donaldson"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kathleen",
                    "lastName": "Meert"
                },
                {
                    "creatorType": "author",
                    "firstName": "Richard J.",
                    "lastName": "Brilli"
                },
                {
                    "creatorType": "author",
                    "firstName": "Vinay",
                    "lastName": "Nadkarni"
                },
                {
                    "creatorType": "author",
                    "firstName": "D. H.",
                    "lastName": "Shaffner"
                },
                {
                    "creatorType": "author",
                    "firstName": "Charles L.",
                    "lastName": "Schleien"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert S. B.",
                    "lastName": "Clark"
                },
                {
                    "creatorType": "author",
                    "firstName": "H.J.",
                    "lastName": "Dalton"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kimberly",
                    "lastName": "Statler"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kelly S.",
                    "lastName": "Tieves"
                },
                {
                    "creatorType": "author",
                    "firstName": "Richard",
                    "lastName": "Hackbarth"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert",
                    "lastName": "Pretzlaff"
                },
                {
                    "creatorType": "author",
                    "firstName": "Elise W.",
                    "lastName": "van der Jagt"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jose",
                    "lastName": "Pineda"
                },
                {
                    "creatorType": "author",
                    "firstName": "Lynn",
                    "lastName": "Hernan"
                },
                {
                    "creatorType": "author",
                    "firstName": "J Michael",
                    "lastName": "Dean"
                }
            ],
            "abstractNote": "Objectives\nTo describe a large cohort of children with out-of-hospital (OH) cardiac arrest with return of circulation (ROC) and to identify factors in the early post-arrest period associated with survival. These objectives were for planning an interventional trial of therapeutic hypothermia after pediatric cardiac arrest.\n\nMethods\nA retrospective cohort study was conducted at 15 Pediatric Emergency Care Applied Research Network (PECARN) clinical sites over an 18 month study period. All children 24 hours to 18 years of age with OH cardiac arrest and a history of at least 1 minute of chest compressions with ROC for at least 20 minutes were eligible.\n\nMeasurements and Main Results\n138 cases met study entry criteria; the overall mortality was 62% (85/138). Event characteristics associated with increased survival were the following: weekend arrests, CPR not ongoing at hospital arrival, arrest rhythm not asystole, no atropine or NaHCO3, fewer epinephrine doses, shorter duration of CPR, and drowning or asphyxial arrest event. For the 0–12 hour post-arrest ROC period, absence of any vasopressor or inotropic agent (dopamine, epinephrine) use, higher lowest temperature recorded, greater lowest pH, lower lactate, lower maximum glucose and normal pupillary responses were all associated with survival. A multivariate logistic model of variables available at the time of arrest, which controlled for gender, age, race, asystole or ventricular fibrillation/ventricular tachycardia (VF/VT) anytime during the arrest, found the administration of atropine and epinephrine to be associated with mortality. A second model using additional information available up to 12 hours post ROC found 1) preexisting lung or airway disease, 2) etiology of arrest drowning or asphyxia, 3) higher pH and 4) bilateral reactive pupils to be associated with lower mortality. More than 3 doses of epinephrine were associated with poor outcome in 96% (44/46) of cases.\n\nConclusions\nMultiple factors were identified to be associated with survival after OH pediatric cardiac arrest with ROC. Additional information available within a few hours after ROC may diminish outcome associations of factors available at earlier times in regression models. These factors should be considered in the design of future interventional trials aimed to improve outcome after pediatric cardiac arrest.",
            "publicationTitle": "Critical Care Medicine",
            "publisher": "",
            "place": "",
            "date": "2011-1",
            "volume": "39",
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            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "141-149",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Crit Care Med",
            "DOI": "10.1097/CCM.0b013e3181fa3c17",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3297020/",
            "accessDate": "2015-04-29T14:57:17Z",
            "PMID": "20935561",
            "PMCID": "PMC3297020",
            "ISSN": "0090-3493",
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            "dateAdded": "2023-03-01T16:32:07Z",
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            "creatorSummary": "Meert et al.",
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        "data": {
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            "version": 20,
            "itemType": "journalArticle",
            "title": "Multicenter Cohort Study of In-Hospital Pediatric Cardiac Arrest",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Kathleen L.",
                    "lastName": "Meert"
                },
                {
                    "creatorType": "author",
                    "firstName": "Amy",
                    "lastName": "Donaldson"
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                {
                    "creatorType": "author",
                    "firstName": "Vinay",
                    "lastName": "Nadkarni"
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                {
                    "creatorType": "author",
                    "firstName": "Kelly S.",
                    "lastName": "Tieves"
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                {
                    "creatorType": "author",
                    "firstName": "Charles L.",
                    "lastName": "Schleien"
                },
                {
                    "creatorType": "author",
                    "firstName": "Richard J.",
                    "lastName": "Brilli"
                },
                {
                    "creatorType": "author",
                    "firstName": "Robert S. B.",
                    "lastName": "Clark"
                },
                {
                    "creatorType": "author",
                    "firstName": "D. H.",
                    "lastName": "Shaffner"
                },
                {
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                    "firstName": "Fiona",
                    "lastName": "Levy"
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                    "firstName": "Kimberly",
                    "lastName": "Statler"
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                {
                    "creatorType": "author",
                    "firstName": "H.J.",
                    "lastName": "Dalton"
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                {
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                    "firstName": "Elise W.",
                    "lastName": "van der Jagt"
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                {
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                    "lastName": "Hackbarth"
                },
                {
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                    "firstName": "Robert",
                    "lastName": "Pretzlaff"
                },
                {
                    "creatorType": "author",
                    "firstName": "Lynn",
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                },
                {
                    "creatorType": "author",
                    "firstName": "J. Michael",
                    "lastName": "Dean"
                },
                {
                    "creatorType": "author",
                    "firstName": "Frank W.",
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            ],
            "abstractNote": "Objectives\n(1) Describe the clinical characteristics, hospital courses and outcomes of a cohort of children cared for within the Pediatric Emergency Care Applied Research Network (PECARN) who experienced in-hospital cardiac arrest with sustained return of circulation between July 1, 2003 and December 31, 2004, and (2) identify factors associated with hospital mortality in this population. These data are required to prepare a randomized trial of therapeutic hypothermia on neurobehavioral outcomes in children after in-hospital cardiac arrest.\n\nDesign\nRetrospective cohort study.\n\nSetting\nFifteen children’s hospitals associated with PECARN.\n\nPatients\nPatients between one day and 18 years of age who had cardiopulmonary resuscitation (CPR) and received chest compressions for >1 minute, and had a return of circulation for >20 minutes.\n\nInterventions\nNone.\n\nMeasurements and Main Results\nA total of 353 patients met entry criteria; 172 (48.7%) survived to hospital discharge. Among survivors, 132 (76.7%) had good neurological outcome documented by Pediatric Cerebral Performance Category scores. After adjustment for age, gender and first documented cardiac arrest rhythm, variables available prior to and during the arrest that were independently associated with increased mortality included pre-existing hematologic, oncologic, or immunologic disorders, genetic or metabolic disorders, presence of an endotracheal tube prior to the arrest, and the use of sodium bicarbonate during the arrest. Variables associated with decreased mortality included post-operative CPR. Extending the time frame to include variables available prior to, during, and within 12 hours following arrest, variables independently associated with increased mortality included the use of calcium during the arrest. Variables associated with decreased mortality included higher minimum blood pH and pupillary responsiveness.\n\nConclusions\nMany factors are associated with hospital mortality among children after in-hospital cardiac arrest and return of circulation. Such factors must be considered when designing a trial of therapeutic hypothermia after cardiac arrest in pediatric patients.",
            "publicationTitle": "Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies",
            "publisher": "",
            "place": "",
            "date": "2009-9",
            "volume": "10",
            "issue": "5",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "544-553",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Pediatr Crit Care Med",
            "DOI": "10.1097/PCC.0b013e3181a7045c",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2741542/",
            "accessDate": "2016-11-21T19:34:58Z",
            "PMID": "19451846",
            "PMCID": "PMC2741542",
            "ISSN": "1529-7535",
            "archive": "",
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            "shortTitle": "",
            "language": "",
            "libraryCatalog": "PubMed Central",
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            "dateAdded": "2023-03-01T16:32:07Z",
            "dateModified": "2023-03-01T16:32:07Z"
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    },
    {
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        "version": 20,
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            "creatorSummary": "Goto et al.",
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            "version": 20,
            "itemType": "journalArticle",
            "title": "Decision tree model for predicting long-term outcomes in children with out-of-hospital cardiac arrest: a nationwide, population-based observational study",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Yoshikazu",
                    "lastName": "Goto"
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                {
                    "creatorType": "author",
                    "firstName": "Tetsuo",
                    "lastName": "Maeda"
                },
                {
                    "creatorType": "author",
                    "firstName": "Yumiko",
                    "lastName": "Nakatsu-Goto"
                }
            ],
            "abstractNote": "Introduction\nAt hospital arrival, early prognostication for children after out-of-hospital cardiac arrest (OHCA) might help clinicians formulate strategies, particularly in the emergency department. In this study, we aimed to develop a simple and generally applicable bedside tool for predicting outcomes in children after cardiac arrest.\n\nMethods\nWe analyzed data of 5,379 children who had undergone OHCA. The data were extracted from a prospectively recorded, nationwide, Utstein-style Japanese database. The primary endpoint was survival with favorable neurological outcome (Cerebral Performance Category (CPC) scale categories 1 and 2) at 1 month after OHCA. We developed a decision tree prediction model by using data from a 2-year period (2008 to 2009, n = 3,693), and the data were validated using external data from 2010 (n = 1,686).\n\nResults\nRecursive partitioning analysis for 11 predictors in the development cohort indicated that the best single predictor for CPC 1 and 2 at 1 month was the prehospital return of spontaneous circulation (ROSC). The next predictor for children with prehospital ROSC was an initial shockable rhythm. For children without prehospital ROSC, the next best predictor was a witnessed arrest. Use of a simple decision tree prediction model permitted stratification into four outcome prediction groups: good (prehospital ROSC and initial shockable rhythm), moderately good (prehospital ROSC and initial nonshockable rhythm), poor (prehospital non-ROSC and witnessed arrest) and very poor (prehospital non-ROSC and unwitnessed arrest). By using this model, we identified patient groups ranging from 0.2% to 66.2% for 1-month CPC 1 and 2 probabilities. The validated decision tree prediction model demonstrated a sensitivity of 69.7% (95% confidence interval (CI) = 58.7% to 78.9%), a specificity of 95.2% (95% CI = 94.1% to 96.2%) and an area under the receiver operating characteristic curve of 0.88 (95% CI = 0.87 to 0.90) for predicting 1-month CPC 1 and 2.\n\nConclusions\nWith our decision tree prediction model using three prehospital variables (prehospital ROSC, initial shockable rhythm and witnessed arrest), children can be readily stratified into four groups after OHCA. This simple prediction model for evaluating children after OHCA may provide clinicians with a practical bedside tool for counseling families and making management decisions soon after patient arrival at the hospital.",
            "publicationTitle": "Critical Care",
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            "date": "2014",
            "volume": "18",
            "issue": "3",
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            "partTitle": "",
            "pages": "R133",
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            "seriesTitle": "",
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            "DOI": "10.1186/cc13951",
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            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4227055/",
            "accessDate": "2016-08-04T17:49:10Z",
            "PMID": "24972847",
            "PMCID": "PMC4227055",
            "ISSN": "1364-8535",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Decision tree model for predicting long-term outcomes in children with out-of-hospital cardiac arrest",
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            "title": "CARES: Cardiac Arrest Registry to Enhance Survival",
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                    "creatorType": "author",
                    "firstName": "Bryan",
                    "lastName": "McNally"
                },
                {
                    "creatorType": "author",
                    "firstName": "Allen",
                    "lastName": "Stokes"
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                    "creatorType": "author",
                    "firstName": "Allison",
                    "lastName": "Crouch"
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                    "lastName": "Kellermann"
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            "abstractNote": "Despite 3 decades of scientific progress, rates of survival from out-of-hospital cardiac arrest remain low. The Cardiac Arrest Registry to Enhance Survival (CARES) was created to provide communities with a means to identify cases of out-of-hospital cardiac arrest, measure how well emergency medical services (EMS) perform key elements of emergency cardiac care, and determine outcomes through hospital discharge. CARES collects data from 3 sources-911 dispatch, EMS, and receiving hospitals-and links them to form a single record. Once data entry is completed, individual identifiers are stripped from the record. The anonymity of CARES records allows participating agencies and institutions to compile cases without informed consent. CARES generates standard reports that can be used to characterize the local epidemiology of cardiac arrest and help managers determine how well EMS is delivering out-of-hospital cardiac arrest care. After pilot implementation in Atlanta, GA, and subsequent expansion to 7 surrounding counties, CARES was implemented in 22 US cities with a combined population of 14 million people. Additional cities are interested in joining the registry. CARES currently contains more than 13,000 cases and is growing rapidly.",
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                    "type": 1
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            "title": "Time on the scene and interventions are associated with improved survival in pediatric out-of-hospital cardiac arrest",
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                    "creatorType": "author",
                    "firstName": "Janice A.",
                    "lastName": "Tijssen"
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                {
                    "creatorType": "author",
                    "firstName": "David K.",
                    "lastName": "Prince"
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                {
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                    "firstName": "Laurie J.",
                    "lastName": "Morrison"
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                    "creatorType": "author",
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                    "lastName": "Atkins"
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                    "creatorType": "author",
                    "firstName": "Michael A.",
                    "lastName": "Austin"
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                {
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                    "lastName": "Berg"
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                {
                    "creatorType": "author",
                    "firstName": "Siobhan P.",
                    "lastName": "Brown"
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                {
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                    "firstName": "Jim",
                    "lastName": "Christenson"
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                {
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                    "firstName": "Debra",
                    "lastName": "Egan"
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                    "firstName": "Preston J.",
                    "lastName": "Fedor"
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                    "firstName": "Ericka L.",
                    "lastName": "Fink"
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                    "firstName": "Garth D.",
                    "lastName": "Meckler"
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                    "lastName": "Osmond"
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                    "firstName": "Kathryn A.",
                    "lastName": "Sims"
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                {
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            "abstractNote": "Background\nSurvival is less than 10% for pediatric patients following out-of-hospital cardiac arrest. It is not known if more time on the scene of the cardiac arrest and advanced life support interventions by emergency services personnel are associated with improved survival.\nAim\nThis study was performed to determine which times on the scene and which prehospital interventions were associated with improved survival.\nMethods\nWe studied patients aged 3 days to 19 years old with out-of-hospital cardiac arrest, using the Resuscitation Outcomes Consortium cardiac arrest database from 11 North American regions, from 2005 to 2012. We evaluated survival to hospital discharge according to on-scene times (&lt;10, 10 to 35 and &gt;35 min).\nResults\nData were available for 2244 patients (1017 infants, 594 children and 633 adolescents). Infants had the lowest rate of survival (3.7%) compared to children (9.8%) and adolescents (16.3%). Survival improved over the 7 year study period especially among adolescents. Survival was highest in the 10 to 35 min on-scene time group (10.2%) compared to the &gt; 35 min. group (6.9%) and the &lt;10 min. group (5.3%, p = 0.01). Intravenous or intra-osseous access attempts and fluid administration were associated with improved survival, whereas advanced airway attempts were not associated with survival and resuscitation drugs were associated with worse survival.\nConclusions\nIn this observational study, a scene time of 10 to 35 min was associated with the highest survival, especially among adolescents. Access for fluid resuscitation was associated with increased survival but advanced airway and resuscitation drugs were not.",
            "publicationTitle": "Resuscitation",
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            "date": "September 2015",
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            "partTitle": "",
            "pages": "1-7",
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            "journalAbbreviation": "Resuscitation",
            "DOI": "10.1016/j.resuscitation.2015.06.012",
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            "libraryCatalog": "ScienceDirect",
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                    "type": 1
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