[ { "key": "AK5EUWFN", "version": 45, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/AK5EUWFN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/AK5EUWFN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "AK5EUWFN", "version": 45, "itemType": "webpage", "title": "What are the applications of opamp 741?", "creators": [], "abstractNote": "Hi I hear a lot about op amp 741, wat is exactly SO GOOD about this op amp and why is it always being used, is it that special? Also, can this op amp", "websiteTitle": "Forum for Electronics", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.edaboard.com/thread14814.html", "accessDate": "2014-04-25T16:58:19Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "741", "type": 1 }, { "tag": "What", "type": 1 }, { "tag": "applications", "type": 1 }, { "tag": "automatic", "type": 1 }, { "tag": "circuits", "type": 1 }, { "tag": "control", "type": 1 }, { "tag": "gain", "type": 1 }, { "tag": "good", "type": 1 }, { "tag": "hear", "type": 1 }, { "tag": "opamp", "type": 1 }, { "tag": "receiver", "type": 1 }, { "tag": "special", "type": 1 }, { "tag": "ultrasonic", "type": 1 } ], "collections": [ "NGQRJURZ" ], "relations": {}, "dateAdded": "2014-04-25T16:58:19Z", "dateModified": "2014-04-25T16:58:19Z" } }, { "key": "4WIBG9EA", "version": 45, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/4WIBG9EA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/4WIBG9EA", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/AK5EUWFN", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } } }, "data": { "key": "4WIBG9EA", "version": 45, "parentItem": "AK5EUWFN", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2014-04-25T16:58:19Z", "url": "http://www.edaboard.com/thread14814.html", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-25T16:58:19Z", "dateModified": "2014-04-25T16:58:19Z" } }, { "key": "AW9A49QE", "version": 44, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/AW9A49QE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/AW9A49QE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/XFF4EMZ9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } } }, "data": { "key": "AW9A49QE", "version": 44, "parentItem": "XFF4EMZ9", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-04-24T07:33:48Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10990193", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-24T07:33:48Z", "dateModified": "2014-04-24T07:33:48Z" } }, { "key": "XFF4EMZ9", "version": 44, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/XFF4EMZ9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/XFF4EMZ9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } }, "creatorSummary": "Emerich et al.", "parsedDate": "2000-07", "numChildren": 1 }, "data": { "key": "XFF4EMZ9", "version": 44, "itemType": "journalArticle", "title": "Injectable chemotherapeutic microspheres and glioma I: enhanced survival following implantation into the cavity wall of debulked tumors", "creators": [ { "creatorType": "author", "firstName": "D F", "lastName": "Emerich" }, { "creatorType": "author", "firstName": "S R", "lastName": "Winn" }, { "creatorType": "author", "firstName": "Y", "lastName": "Hu" }, { "creatorType": "author", "firstName": "J", "lastName": "Marsh" }, { "creatorType": "author", "firstName": "P", "lastName": "Snodgrass" }, { "creatorType": "author", "firstName": "D", "lastName": "LaFreniere" }, { "creatorType": "author", "firstName": "T", "lastName": "Wiens" }, { "creatorType": "author", "firstName": "B P", "lastName": "Hasler" }, { "creatorType": "author", "firstName": "R T", "lastName": "Bartus" } ], "abstractNote": "PURPOSE: Implantation of biodegradable polymers provides a powerful method to deliver high, sustained concentrations of chemotherapeutics to brain tumors. The present studies examined the ability of injectable polymeric microspheres, formulated to release carboplatin or BCNU for 2-3 weeks, to enhance survival in a rodent model of surgically-resected glioma.\nMETHODS: Rat glioma (RG2) cells were implanted into the cortex of rats and allowed to grow for 10 days prior to surgical resection. Rats were given either surgical resection only, bolus injection (100 microg) or microspheres containing 10, 50, or 100 microg of carboplatin or BCNU. The microspheres were implanted, via hypodermic injection, either directly into the surgical cavity or into the tissue along the perimeter of the cavity.\nRESULTS: The order of survival among treatment groups was: no resection < resection only < bolus chemotherapy < sustained release chemotherapy. Carboplatin and BCNU did not differ in this respect and in each case, the enhanced survival achieved with sustained release was dose-related. However, the enhanced survival achieved with carboplatin was substantially greater when the microspheres were implanted into the perimeter wall of the resection cavity, compared to implantation into the cavity itself. The enhanced survival produced by carboplatin implants along the resection perimeter was associated with a significant attenuation of regrowth of the tumor. Finally, in a separate study in non-tumor brain, atomic absorption spectrophotometry revealed that while the microspheres produced significantly prolonged tissue levels of carboplatin relative to a bolus injection, carboplatin diffusion was limited to brain tissue extending primarily 0.5 mm from the injection site.\nCONCLUSIONS: These data demonstrate: (1) that sustained delivery of chemotherapy is superior to equipotent bolus doses following tumor resection, and (2) that direct injection of sustained release microspheres into the tissue surrounding a growing tumor mass may provide superior effects over injections into the surgical cavity. They also suggest that successful implementation of this approach in humans may require measures or circumstances that improve upon the limited spatial drug diffusion from the implantation site.", "publicationTitle": "Pharmaceutical research", "publisher": "", "place": "", "date": "Jul 2000", "volume": "17", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "767-775", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pharm. Res.", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0724-8741", "archive": "", "archiveLocation": "", "shortTitle": "Injectable chemotherapeutic microspheres and glioma I", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 10990193", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Antineoplastic Agents", "type": 1 }, { "tag": "Brain Neoplasms", "type": 1 }, { "tag": "Carboplatin", "type": 1 }, { "tag": "Carmustine", "type": 1 }, { "tag": "Delayed-Action Preparations", "type": 1 }, { "tag": "Glioma", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Microspheres", "type": 1 }, { "tag": "Polymers", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Rats, Inbred F344", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-04-24T07:33:48Z", "dateModified": "2014-04-24T07:33:48Z" } }, { "key": "WFIEAH7V", "version": 43, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/WFIEAH7V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/WFIEAH7V", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/F4IPPN4H", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } } }, "data": { "key": "WFIEAH7V", "version": 43, "parentItem": "F4IPPN4H", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Snapshot", "accessDate": "2014-04-24T07:27:36Z", "url": "http://www.sciencedirect.com/science/article/pii/S0168365909006634", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-24T07:27:36Z", "dateModified": "2014-04-24T07:27:36Z" } }, { "key": "F4IPPN4H", "version": 43, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/F4IPPN4H", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/F4IPPN4H", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } }, "creatorSummary": "Chen et al.", "parsedDate": "2010-02-25", "numChildren": 1 }, "data": { "key": "F4IPPN4H", "version": 43, "itemType": "journalArticle", "title": "pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles", "creators": [ { "creatorType": "author", "firstName": "Wei", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Fenghua", "lastName": "Meng" }, { "creatorType": "author", "firstName": "Ru", "lastName": "Cheng" }, { "creatorType": "author", "firstName": "Zhiyuan", "lastName": "Zhong" } ], "abstractNote": "pH-Sensitive degradable polymersomes and micelles were prepared based on diblock copolymer of poly(ethylene glycol) (PEG) and an acid-labile polycarbonate, poly(2,4,6-trimethoxybenzylidenepentaerythritol carbonate) (PTMBPEC). Polymersomes of PEG(1.9k)–PTMBPEC(6k) revealed average sizes of 100–200 nm. The acetals of polymersomes, similar to those of PEG(5k)–PTMBPEC(5.8k) micelles, though stable at pH 7.4 were prone to fast hydrolysis at mildly acidic pH of 4.0 and 5.0, with half lives of 0.5 and 3 d, respectively. The acetal hydrolysis resulted in significant size increase of polymersomes, to over 1000 nm in 24 h at pH 4.0. Drug encapsulation studies revealed that polymersomes were able to simultaneously load paclitaxel (PTX, hydrophobic) and doxorubicin hydrochloride (DOX·HCl, hydrophilic), whereas micelles loaded PTX only. Notably, polymersomes showed lower drug loading efficiencies for PTX than micelles (30.0–37.7% versus 61.4–65.2%). The in vitro release studies demonstrated that release of PTX and DOX·HCl from polymersomes was highly pH-dependent, i.e. significantly faster drug release at mildly acidic pH of 4.0 and 5.0 compared to physiological pH. Furthermore, much higher release rates were observed for PTX release from the polymersomes compared to that from the micelles under otherwise the same conditions. These pH-sensitive nano-sized degradable polymersomes hold great promise for combination therapy for cancers.", "publicationTitle": "Journal of Controlled Release", "publisher": "", "place": "", "date": "February 25, 2010", "volume": "142", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "40-46", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Controlled Release", "DOI": "10.1016/j.jconrel.2009.09.023", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0168365909006634", "accessDate": "2014-04-24T07:27:36Z", "PMID": "", "PMCID": "", "ISSN": "0168-3659", "archive": "", "archiveLocation": "", "shortTitle": "pH-Sensitive degradable polymersomes for triggered release of anticancer drugs", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Anticancer drugs", "type": 1 }, { "tag": "Degradation", "type": 1 }, { "tag": "Drug delivery", "type": 1 }, { "tag": "Micelle", "type": 1 }, { "tag": "Polymersome", "type": 1 }, { "tag": "pH-sensitive", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-04-24T07:27:36Z", "dateModified": "2014-04-24T07:27:36Z" } }, { "key": "6RXXZQD2", "version": 42, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/6RXXZQD2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/6RXXZQD2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/8BKTS476", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } } }, "data": { "key": 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"https://api.zotero.org/groups/258757/items/8BKTS476", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/8BKTS476", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } }, "creatorSummary": "Chen et al.", "parsedDate": "2010-02-25", "numChildren": 2 }, "data": { "key": "8BKTS476", "version": 42, "itemType": "journalArticle", "title": "pH-Sensitive degradable polymersomes for triggered release of anticancer drugs: A comparative study with micelles", "creators": [ { "creatorType": "author", "firstName": "Wei", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Fenghua", "lastName": "Meng" }, { "creatorType": "author", "firstName": "Ru", "lastName": "Cheng" }, { "creatorType": "author", "firstName": "Zhiyuan", "lastName": "Zhong" } ], "abstractNote": "pH-Sensitive degradable polymersomes and micelles were prepared based on diblock copolymer of poly(ethylene glycol) (PEG) and an acid-labile polycarbonate, poly(2,4,6-trimethoxybenzylidenepentaerythritol carbonate) (PTMBPEC). Polymersomes of PEG(1.9k)–PTMBPEC(6k) revealed average sizes of 100–200 nm. The acetals of polymersomes, similar to those of PEG(5k)–PTMBPEC(5.8k) micelles, though stable at pH 7.4 were prone to fast hydrolysis at mildly acidic pH of 4.0 and 5.0, with half lives of 0.5 and 3 d, respectively. The acetal hydrolysis resulted in significant size increase of polymersomes, to over 1000 nm in 24 h at pH 4.0. Drug encapsulation studies revealed that polymersomes were able to simultaneously load paclitaxel (PTX, hydrophobic) and doxorubicin hydrochloride (DOX·HCl, hydrophilic), whereas micelles loaded PTX only. Notably, polymersomes showed lower drug loading efficiencies for PTX than micelles (30.0–37.7% versus 61.4–65.2%). The in vitro release studies demonstrated that release of PTX and DOX·HCl from polymersomes was highly pH-dependent, i.e. significantly faster drug release at mildly acidic pH of 4.0 and 5.0 compared to physiological pH. Furthermore, much higher release rates were observed for PTX release from the polymersomes compared to that from the micelles under otherwise the same conditions. These pH-sensitive nano-sized degradable polymersomes hold great promise for combination therapy for cancers.", "publicationTitle": "Journal of Controlled Release", "publisher": "", "place": "", "date": "February 25, 2010", "volume": "142", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "40-46", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Controlled Release", "DOI": "10.1016/j.jconrel.2009.09.023", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0168365909006634", "accessDate": "2014-04-24T03:15:19Z", "PMID": "", "PMCID": "", "ISSN": "0168-3659", "archive": "", "archiveLocation": "", "shortTitle": "pH-Sensitive degradable polymersomes for triggered release of anticancer drugs", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Anticancer drugs", "type": 1 }, { "tag": "Degradation", "type": 1 }, { "tag": "Drug delivery", "type": 1 }, { "tag": "Micelle", "type": 1 }, { "tag": "Polymersome", "type": 1 }, { "tag": "pH-sensitive", "type": 1 } ], "collections": [ "NGQRJURZ" ], "relations": {}, "dateAdded": "2014-04-24T03:15:19Z", "dateModified": "2014-04-24T03:15:19Z" } }, { "key": "AUZMXETH", "version": 41, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/AUZMXETH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/AUZMXETH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } }, "creatorSummary": "Weinberg et al.", "parsedDate": "2008-05-01", "numChildren": 2 }, "data": { "key": "AUZMXETH", "version": 41, "itemType": "journalArticle", "title": "Polymer implants for intratumoral drug delivery and cancer therapy", "creators": [ { "creatorType": "author", "firstName": "Brent D.", "lastName": "Weinberg" }, { "creatorType": "author", "firstName": "Elvin", "lastName": "Blanco" }, { "creatorType": "author", "firstName": "Jinming", "lastName": "Gao" } ], "abstractNote": "To address the need for minimally invasive treatment of unresectable tumors, intratumoral polymer implants have been developed to release a variety of chemotherapeutic agents for the locoregional therapy of cancer. These implants, also termed “polymer millirods,” were designed to provide optimal drug release kinetics to improve drug delivery efficiency and antitumor efficacy when treating unresectable tumors. Modeling of drug transport properties in different tissue environments has provided theoretical insights on rational implant design, and several imaging techniques have been established to monitor the local drug concentrations surrounding these implants both ex vivo and in vivo. Preliminary antitumor efficacy and drug distribution studies in a rabbit liver tumor model have shown that these implants can restrict tumor growth in small animal tumors (diameter <1 cm). In the future, new approaches, such as three-dimensional (3-D) drug distribution modeling and the use of multiple drug-releasing implants, will be used to extend the efficacy of these implants in treating larger tumors more similar to intractable human tumors. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 97: 1681–1702, 2008", "publicationTitle": "Journal of Pharmaceutical Sciences", "publisher": "", "place": "", "date": "May 1, 2008", "volume": "97", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "1681-1702", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Pharm. Sci.", "DOI": "10.1002/jps.21038", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/jps.21038/abstract", "accessDate": "2014-04-23T23:49:11Z", "PMID": "", "PMCID": "", "ISSN": "1520-6017", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "Copyright © 2007 Wiley-Liss, Inc.", "extra": "", "tags": [ { "tag": "Biodegradable polymers", "type": 1 }, { "tag": "cancer chemotherapy", "type": 1 }, { "tag": "controlled release", "type": 1 }, { "tag": "drug targeting", "type": 1 }, { "tag": "drug transport", "type": 1 }, { "tag": "imaging methods", "type": 1 }, { "tag": "mathematical model", "type": 1 } ], "collections": [ "2B3EDRQZ", "ENDGK3WD" ], "relations": {}, "dateAdded": "2014-04-23T23:49:11Z", "dateModified": "2014-04-23T23:49:11Z" } }, { "key": "HCNU7M66", "version": 40, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/HCNU7M66", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/HCNU7M66", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/AUZMXETH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } } }, "data": { "key": "HCNU7M66", "version": 40, "parentItem": "AUZMXETH", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2014-04-23T23:49:11Z", "url": "http://onlinelibrary.wiley.com/doi/10.1002/jps.21038/abstract", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-23T23:49:11Z", "dateModified": "2014-04-23T23:49:11Z" } }, { "key": "ZEE9287U", "version": 40, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/ZEE9287U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/ZEE9287U", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/AUZMXETH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } } }, "data": { "key": "ZEE9287U", "version": 40, "parentItem": "AUZMXETH", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2014-04-23T23:49:11Z", "url": "http://onlinelibrary.wiley.com/store/10.1002/jps.21038/asset/21038_ftp.pdf?v=1&t=hud9wgqi&s=26f0720e19d71ecff38cc0f07bdb8ee5916e39bd", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-23T23:49:11Z", "dateModified": "2014-04-23T23:49:11Z" } }, { "key": "ME4K8MIV", "version": 41, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/ME4K8MIV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/ME4K8MIV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } }, "creatorSummary": "Saltzman", "parsedDate": "2001-02-19", "numChildren": 1 }, "data": { "key": "ME4K8MIV", "version": 41, "itemType": "book", "title": "Drug Delivery: Engineering Principles for Drug Therapy", "creators": [ { "creatorType": "author", "firstName": "W. Mark", "lastName": "Saltzman" } ], "abstractNote": "Synthetic materials are a tremendous potential resource for treating human disease. For the rational design of many of these biomaterials it is necessary to have an understanding of polymer chemistry and polymer physics. Equally important to those two fields is a quantitative understanding of the principles that govern rates of drug transport, reaction, and disappearance in physiological and pathological situations. This book is a synthesis of these principles, providing a working foundation for those in the field of drug delivery. It covers advanced drug delivery and contemporary biomaterials.", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2001-02-19", "publisher": "Oxford University Press", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "numPages": "463", "ISBN": "9780199879755", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "Drug Delivery", "language": "en", "libraryCatalog": "Google Books", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Science / Life Sciences / Biochemistry", "type": 1 } ], "collections": [ "2B3EDRQZ", "ENDGK3WD" ], "relations": {}, "dateAdded": "2014-04-23T22:49:41Z", "dateModified": "2014-04-23T22:49:41Z" } }, { "key": "HNKI4QWM", "version": 39, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/HNKI4QWM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/HNKI4QWM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/ME4K8MIV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1284228, "username": "JohnMc93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/johnmc93", "type": "text/html" } } } }, "data": { "key": "HNKI4QWM", "version": 39, "parentItem": "ME4K8MIV", "itemType": "attachment", "linkMode": "linked_url", "title": "Google Books Link", "accessDate": "2014-04-23T22:49:41Z", "url": "http://books.google.com/books?id=gK1EMGNSlVAC", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-23T22:49:41Z", "dateModified": "2014-04-23T22:49:41Z" } }, { "key": "U8JB3PHX", "version": 38, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/U8JB3PHX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/U8JB3PHX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/W99M57GA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } } }, "data": { "key": "U8JB3PHX", "version": 38, "parentItem": "W99M57GA", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2014-04-23T02:59:28Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/pdf/nihms169295.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-23T02:59:28Z", "dateModified": "2014-04-23T02:59:28Z" } }, { "key": "W99M57GA", "version": 38, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/W99M57GA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/W99M57GA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } }, "creatorSummary": "Fu and Kao", "parsedDate": "2010-04", "numChildren": 2 }, "data": { "key": "W99M57GA", "version": 38, "itemType": "journalArticle", "title": "Drug Release Kinetics and Transport Mechanisms of Non-degradable and Degradable Polymeric Delivery Systems", "creators": [ { "creatorType": "author", "firstName": "Yao", "lastName": "Fu" }, { "creatorType": "author", "firstName": "Weiyuan John", "lastName": "Kao" } ], "abstractNote": "Importance of the field\nThe advancement in material design and engineering has led to the rapid development of novel materials with increasing complexity and functions. Both non-degradable and degradable polymers have found wide applications in the controlled delivery field. Studies on drug release kinetics provide important information into the function of material systems. To elucidate the detailed transport mechanism and the structure-function relationship of a material system, it is critical to bridge the gap between the macroscopic data and the transport behavior at the molecular level.\n\nAreas covered in this review\nThe structure and function information of selected non-degradable and degradable polymers have been collected and summarized from literatures published after 1990s. The release kinetics of selected drug compounds from various material systems will be discussed in case studies. Recent progresses in the mathematical models based on different transport mechanisms will be highlighted.\n\nWhat the reader will gain\nThis article aims to provide an overview of structure-function relationships of selected non-degradable and degradable polymers as drug delivery matrices.\n\nTake home message\nUnderstanding the structure-function relationship of the material system is key to the successful design of a delivery system for a particular application. Moreover, developing complex polymeric matrices requires more robust mathematical models to elucidate the solute transport mechanisms.", "publicationTitle": "Expert opinion on drug delivery", "publisher": "", "place": "", "date": "2010-4", "volume": "7", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "429-444", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Expert Opin Drug Deliv", "DOI": "10.1517/17425241003602259", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/", "accessDate": "2014-04-23T02:59:28Z", "PMID": "", "PMCID": "", "ISSN": "1742-5247", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 20331353\nPMCID: PMC2846103", "tags": [], "collections": [ "NGQRJURZ" ], "relations": {}, "dateAdded": "2014-04-23T02:59:28Z", "dateModified": "2014-04-23T02:59:28Z" } }, { "key": "WCZPUH9S", "version": 38, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/WCZPUH9S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/WCZPUH9S", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/W99M57GA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } } }, "data": { "key": "WCZPUH9S", "version": 38, "parentItem": "W99M57GA", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-04-23T02:59:28Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2846103/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-23T02:59:28Z", "dateModified": "2014-04-23T02:59:28Z" } }, { "key": "SVEFUGR5", "version": 37, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/SVEFUGR5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/SVEFUGR5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/495UD4UM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } } }, "data": { "key": "SVEFUGR5", "version": 37, "parentItem": "495UD4UM", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2014-04-22T15:25:29Z", "url": "http://onlinelibrary.wiley.com/doi/10.1002/0471221929.ch2/summary", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-22T15:25:29Z", "dateModified": "2014-04-22T15:25:29Z" } }, { "key": "495UD4UM", "version": 37, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/495UD4UM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/495UD4UM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1293669, "username": "vlanka", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/vlanka", "type": "text/html" } } }, "creatorSummary": "Kielty and Grant", "parsedDate": "2002", "numChildren": 1 }, "data": { "key": "495UD4UM", "version": 37, "itemType": "bookSection", "title": "The Collagen Family: Structure, Assembly, and Organization in the Extracellular Matrix", "creators": [ { "creatorType": "author", "firstName": "Cay M.", "lastName": "Kielty" }, { "creatorType": "author", "firstName": "Michael E.", "lastName": "Grant" }, { "creatorType": "editor", "firstName": "Peter M.", "lastName": "Royce" }, { "creatorType": "editor", "firstName": "Beat", "lastName": "Steinmann" } ], "abstractNote": "In this chapter, we discuss the current understanding of the family of matrix macromolecules that are classified as collagens. Reference is made to reviews and recent papers to provide the reader with a way into the relevant literature rather than an exhaustive survey of the bibliography.", "bookTitle": "Connective Tissue and Its Heritable Disorders", "series": "", "seriesNumber": "", "volume": "", "numberOfVolumes": "", "edition": "", "date": "2002", "publisher": "John Wiley & Sons, Inc.", "place": "", "originalDate": "", "originalPublisher": "", "originalPlace": "", "format": "", "pages": "159-221", "ISBN": "9780471221920", "DOI": "", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1002/0471221929.ch2/summary", "accessDate": "2014-04-22T15:25:29Z", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "The Collagen Family", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "Copyright © 2002 by Wiley-Liss, Inc.", "extra": "", "tags": [ { "tag": "FACIT collagens", "type": 1 }, { "tag": "basement membrane collagens", "type": 1 }, { "tag": "classical fibrous collagen", "type": 1 }, { "tag": "collagen characterization", "type": 1 }, { "tag": "collagen family", "type": 1 }, { "tag": "extracellular matrix", "type": 1 }, { "tag": "fibril-forming collagens", "type": 1 }, { "tag": "multiplexin collagens", "type": 1 }, { "tag": "short-chain collagens", "type": 1 }, { "tag": "structure", "type": 1 }, { "tag": "transmembrane collagens", "type": 1 } ], "collections": [ "NGQRJURZ" ], "relations": {}, "dateAdded": "2014-04-22T15:25:29Z", "dateModified": "2014-04-22T15:25:29Z" } }, { "key": "PRXRRWFA", "version": 36, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/PRXRRWFA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/PRXRRWFA", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/43N6JNQB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } } }, "data": { "key": "PRXRRWFA", "version": 36, "parentItem": "43N6JNQB", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Full Text PDF", "accessDate": "2014-04-22T01:34:00Z", "url": "http://www.sciencedirect.com/science/article/pii/S0168365907002787/pdfft?md5=9c5957047343195277ef9762272868c1&pid=1-s2.0-S0168365907002787-main.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-22T01:34:00Z", "dateModified": "2014-04-22T01:34:00Z" } }, { "key": "574MZ7JQ", "version": 36, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/574MZ7JQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/574MZ7JQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258757/items/43N6JNQB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } } }, "data": { "key": "574MZ7JQ", "version": 36, "parentItem": "43N6JNQB", "itemType": "attachment", "linkMode": "linked_url", "title": "ScienceDirect Snapshot", "accessDate": "2014-04-22T01:34:00Z", "url": "http://www.sciencedirect.com/science/article/pii/S0168365907002787", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-22T01:34:00Z", "dateModified": "2014-04-22T01:34:00Z" } }, { "key": "43N6JNQB", "version": 36, "library": { "type": "group", "id": 258757, "name": "Biotransport Group 16", "links": { "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258757/items/43N6JNQB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/biotransport_group_16/items/43N6JNQB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1293665, "username": "jrm4ag", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jrm4ag", "type": "text/html" } } }, "creatorSummary": "Zolnik and Burgess", "parsedDate": "2007-10-08", "numChildren": 2 }, "data": { "key": "43N6JNQB", "version": 36, "itemType": "journalArticle", "title": "Effect of acidic pH on PLGA microsphere degradation and release", "creators": [ { "creatorType": "author", "firstName": "Banu S.", "lastName": "Zolnik" }, { "creatorType": "author", "firstName": "Diane J.", "lastName": "Burgess" } ], "abstractNote": "Polymer degradation and drug release kinetics from PLGA microspheres were investigated under neutral and acidic pH conditions. Two different Mw formulations (Mw: 25,000 and 70,000) were investigated and both exhibited a triphasic release profile at pH 7.4 as well as at pH 2.4. The initial burst and lag phases were similar for both pH values, while the secondary apparent-zero-order phase was substantially accelerated at pH 2.4. The polymer molecular weight change with time for the microspheres followed first order degradation kinetics for both pH values. A linear relationship was established between % drug release (post burst release) and Ln (Mw) for both pH conditions. Most significantly, morphological studies showed that the mechanism of polymer degradation changed from “inside-out” degradation at pH 7.4 to “outside-in” at pH 2.4. At pH 7.4, the microspheres followed the usual morphological changes such as surface pitting and pore formation. Whereas, at pH 2.4 the microspheres maintained smooth surfaces throughout the degradation process and were susceptible to fracturing. The fracturing of the microspheres was attributed to crystallization of oligomeric degradation products as a consequence of their low solubility at this pH. It also appeared that degradation occurred in a more homogeneous pattern at pH 2.4 than is typical of PLGA microspheres at pH 7.4. This may be a result of the entire microspheres experiencing a close-to-uniform pH at 2.4. However, at pH 7.4, the local micro-environmental pH within the microspheres has been reported to vary considerably due to a build up of acid oligomers. This heterogeneous degradation results in the random formation of channels within microspheres degraded at pH 7.4 which was not observed in those degraded at pH 2.4. This is the first time that morphological changes during PLGA microsphere degradation have been compared for low and neutral pH and the data shows a change in the mechanism of degradation at the low pH.", "publicationTitle": "Journal of Controlled Release", "publisher": "", "place": "", "date": "October 8, 2007", "volume": "122", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "338-344", "series": "Proceedings of the Thirteenth International Symposium on Recent Advances in Drug Delivery Systems", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Controlled Release", "DOI": "10.1016/j.jconrel.2007.05.034", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/S0168365907002787", "accessDate": "2014-04-22T01:34:00Z", "PMID": "", "PMCID": "", "ISSN": "0168-3659", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": 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