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2009 - Benefit of Facilitated Percutaneous Coronary Inter.pdf", "md5": "d71511ad81012a7c5ff191d7b42b0e40", "mtime": 1396601262632, "tags": [], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/ACQ7REWD" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } }, { "key": "PZI2WFNG", "version": 2, "library": { "type": "group", "id": 258411, "name": "Clanek NGAL", "links": { "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258411/items/PZI2WFNG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal/items/PZI2WFNG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258411/items/55TCU9TU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1710581, "username": "SL85", "name": "Simona Littnerova", "links": { "alternate": { "href": "https://www.zotero.org/sl85", "type": "text/html" } } } }, "data": { "key": "PZI2WFNG", "version": 2, "parentItem": "55TCU9TU", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-04-04T08:47:18Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17694460", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/WVKIBRTK" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } }, { "key": "BFWD8Q5D", "version": 2, "library": { "type": "group", "id": 258411, "name": "Clanek NGAL", "links": { "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258411/items/BFWD8Q5D", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal/items/BFWD8Q5D", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1710581, "username": "SL85", "name": "Simona Littnerova", "links": { "alternate": { "href": "https://www.zotero.org/sl85", "type": "text/html" } } }, "creatorSummary": "Thune et al.", "parsedDate": "2005-09-27", "numChildren": 3 }, "data": { "key": "BFWD8Q5D", "version": 2, "itemType": "journalArticle", "title": "Simple Risk Stratification at Admission to Identify Patients With Reduced Mortality From Primary Angioplasty", "creators": [ { "creatorType": "author", "firstName": "Jens Jakob", "lastName": "Thune" }, { "creatorType": "author", "firstName": "Dan Eik", "lastName": "Hoefsten" }, { "creatorType": "author", "firstName": "Matias Greve", "lastName": "Lindholm" }, { "creatorType": "author", "firstName": "Leif Spange", "lastName": "Mortensen" }, { "creatorType": "author", "firstName": "Henning Rud", "lastName": "Andersen" }, { "creatorType": "author", "firstName": "Torsten Toftegaard", "lastName": "Nielsen" }, { "creatorType": "author", "firstName": "Lars", "lastName": "Kober" }, { "creatorType": "author", "firstName": "Henning", "lastName": "Kelbaek" } ], "abstractNote": "Background— Randomized trials comparing fibrinolysis with primary angioplasty for acute ST-elevation myocardial infarction have demonstrated a beneficial effect of primary angioplasty on the combined end point of death, reinfarction, and disabling stroke but not on all-cause death. Identifying a patient group with reduced mortality from an invasive strategy would be important for early triage. The Thrombolysis in Myocardial Infarction (TIMI) risk score is a simple validated integer score that makes it possible to identify high-risk patients on admission to hospital. We hypothesized that a high-risk group might have a reduced mortality with an invasive strategy.\nMethods and Results— We classified 1527 patients from the Danish Multicenter Randomized Study on Fibrinolytic Therapy Versus Acute Coronary Angioplasty in Acute Myocardial Infarction (DANAMI-2) trial with information for all variables necessary for calculating the TIMI risk score as low risk (TIMI risk score, 0 to 4) or high risk (TIMI risk score ≥5) and investigated the effect of primary angioplasty versus fibrinolysis on mortality and morbidity in the 2 groups. Follow-up was 3 years. We classified 1134 patients as low risk and 393 as high risk. There was a significant interaction between risk status and effect of primary angioplasty (P=0.008). In the low-risk group, there was no difference in mortality (primary angioplasty, 8.0%; fibrinolysis, 5.6%; P=0.11); in the high-risk group, there was a significant reduction in mortality with primary angioplasty (25.3% versus 36.2%; P=0.02).\nConclusions— Risk stratification at admission based on the TIMI risk score identifies a group of high-risk patients who have a significantly reduced mortality with an invasive strategy of primary angioplasty.", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "09/27/2005", "volume": "112", "issue": "13", "section": "", "partNumber": "", "partTitle": "", "pages": "2017-2021", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/CIRCULATIONAHA.105.558676", "citationKey": "", "url": "http://circ.ahajournals.org/content/112/13/2017", "accessDate": "2014-04-04T08:49:40Z", "PMID": "", "PMCID": "", "ISSN": "0009-7322, 1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "circ.ahajournals.org", "callNumber": "", "rights": "", "extra": "PMID: 16186438", "tags": [ { "tag": "Mortality", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "angioplasty", "type": 1 }, { "tag": "fibrinolysis", "type": 1 } ], "collections": [ "R75SW66X" ], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/2DZE6AXN" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } }, { "key": "G2W5QCMX", "version": 2, "library": { "type": "group", "id": 258411, "name": "Clanek NGAL", "links": { "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258411/items/G2W5QCMX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal/items/G2W5QCMX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1710581, "username": "SL85", "name": "Simona Littnerova", "links": { "alternate": { "href": "https://www.zotero.org/sl85", "type": "text/html" } } }, "creatorSummary": "Herrmann et al.", "parsedDate": "2009", "numChildren": 1 }, "data": { "key": "G2W5QCMX", "version": 2, "itemType": "journalArticle", "title": "Benefit of Facilitated Percutaneous Coronary Intervention in High-Risk ST-Segment Elevation Myocardial Infarction Patients Presenting to Nonpercutaneous Coronary Intervention Hospitals", "creators": [ { "creatorType": "author", "firstName": "Howard C.", "lastName": "Herrmann" }, { "creatorType": "author", "firstName": "Jiandong", "lastName": "Lu" }, { "creatorType": "author", "firstName": "Bruce R.", "lastName": "Brodie" }, { "creatorType": "author", "firstName": "Paul W.", "lastName": "Armstrong" }, { "creatorType": "author", "firstName": "Gilles", "lastName": "Montalescot" }, { "creatorType": "author", "firstName": "Amadeo", "lastName": "Betriu" }, { "creatorType": "author", "firstName": "Franz-Joseph", "lastName": "Neuman" }, { "creatorType": "author", "firstName": "Mark B.", "lastName": "Effron" }, { "creatorType": "author", "firstName": "Elliot S.", "lastName": "Barnathan" }, { "creatorType": "author", "firstName": "Eric J.", "lastName": "Topol" }, { "creatorType": "author", "firstName": "Stephen G.", "lastName": "Ellis" } ], "abstractNote": "Objectives \nWe hypothesized that patients most likely to benefit would be those at high risk with a shorter duration of acute ischemia and who required transfer for percutaneous coronary intervention (PCI).Background\nThe FINESSE (Facilitated Intervention with Enhanced Reperfusion Speed to Stop Events) study failed to demonstrate an improvement in the 90-day composite clinical end point of early treatment with abciximab plus half-dose reteplase (combination-facilitated PCI) or abciximab alone.Methods\nWe performed a retrospective analysis of 2,452 patients in this double-blind, placebo-controlled study. Patients were stratified by Thrombolysis In Myocardial Infarction (TIMI) risk score for ST-segment elevation myocardial infarction (STEMI), presentation to a spoke (no PCI available) or hub site, and symptom-to-randomization time. Outcomes included the primary composite end point of death, ventricular fibrillation after 48 h, cardiogenic shock, and congestive heart failure through day 90 as well as 1-year mortality.Results\nMortality for all patients at 1 year was directly related to TIMI risk score (23 of 1,223 = 1.9% in patients with score <3 and 145 of 1,229 = 11.8% with score ≥3, p < 0.001). Patients with TIMI risk score ≥3 and presentation to a spoke site with a symptom-to-randomization time ≤4 h had significantly better 1-year survival if treated with combination-facilitated PCI (hazard ratio [HR]: 0.351, p = 0.01) as well as 90-day composite outcome (HR: 0.45, p = 0.009). A trend for improved survival was also observed in patients with TIMI score ≥3 and spoke site alone (HR: 0.549, p = 0.06).Conclusions\nFacilitation of PCI with a combination of abciximab and half-dose reteplase improved survival at 1 year in high-risk patients presenting to a spoke hospital with symptom-to-randomization time ≤4 h. Further prospective study of facilitated PCI in this subgroup of patients is warranted.", "publicationTitle": "JACC: Cardiovascular Interventions", "publisher": "", "place": "", "date": "Říjen 1, 2009", "volume": "2", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "917-924", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Coll Cardiol Intv", "DOI": "10.1016/j.jcin.2009.06.018", "citationKey": "", "url": "http://dx.doi.org/10.1016/j.jcin.2009.06.018", "accessDate": "2014-04-04T08:47:40Z", "PMID": "", "PMCID": "", "ISSN": "1936-8798", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Silverchair", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "percutaneous coronary intervention", "type": 1 }, { "tag": "st-segment elevation mi", "type": 1 }, { "tag": "timi grading system", "type": 1 } ], "collections": [ "R75SW66X" ], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/EKDNWUMQ" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } }, { "key": "55TCU9TU", "version": 2, "library": { "type": "group", "id": 258411, "name": "Clanek NGAL", "links": { "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258411/items/55TCU9TU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal/items/55TCU9TU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1710581, "username": "SL85", "name": "Simona Littnerova", "links": { "alternate": { "href": "https://www.zotero.org/sl85", "type": "text/html" } } }, "creatorSummary": "Kozieradzka et al.", "parsedDate": "2007-07", "numChildren": 1 }, "data": { "key": "55TCU9TU", "version": 2, "itemType": "journalArticle", "title": "TIMI Risk Score accurately predicts risk of death in 30-day and one-year follow-up in STEMI patients treated with primary percutaneous coronary interventions", "creators": [ { "creatorType": "author", "firstName": "Anna", "lastName": "Kozieradzka" }, { "creatorType": "author", "firstName": "Karol", "lastName": "Kamiński" }, { "creatorType": "author", "firstName": "Sławomir", "lastName": "Dobrzycki" }, { "creatorType": "author", "firstName": "Konrad", "lastName": "Nowak" }, { "creatorType": "author", "firstName": "Włodzimierz", "lastName": "Musiał" } ], "abstractNote": "BACKGROUND: TIMI Risk Score for ST-elevation myocardial infarction (STEMI) was developed in a cohort of patients treated with fibrinolysis. It was though to predict in-hospital and short-term prognosis. Later studies validated this approach in large cohorts of patients, regardless of the applied treatment and presented its good power to predict 30-day mortality.\nAIM: We applied the TIMI Risk Score to our registry of STEMI patients treated with primary percutaneous intervention (pPCI) to validate the possibility to predict one-year survival.\nMETHODS: Our registry comprised 494 consecutive patients (mean age 58.5+/-11.3 years) with STEMI treated with pPCI who were followed for approximately one year. STEMI was diagnosed based on typical criteria: chest pain, ECG changes and rise in myocardial necrosis markers. In all patients TIMI Risk Score for STEMI was calculated and they were divided into three groups: low risk (0-5 points), medium risk (6-7) and high risk (>7 points). Multivariate logistic regression analysis, Kaplan-Meier survival analysis with Cox and log-rank tests as well as c statistics from receiver-operator curves (ROC) were used for statistical analysis.\nRESULTS: TIMI 3 flow was obtained in 95.5% of patients. Median TIMI risk score was 4 (ranging from 0 to 10). During follow-up there were 47 deaths (9.5%). There was a statistically significant difference in survival between all risk groups both in 30-day and one-year follow-up (p <0.001 log-rank test). TIMI Risk Score had good power to predict 30-day (c statistic 0.834, 95% CI 0.757-0.91, p <0.0001) as well as one-year mortality (c statistic 0.809, 95% CI 0.739-0.878, p <0.0001). Interestingly, when we excluded from the analysis all patients who died during the first 30 days, TIMI Risk score maintained its very good prognostic value. All analysed risk groups significantly differed between each other with respect to mortality (p <0.05, log-rank test) and the c statistic was 0.745 (95% CI 0.612-0.879, p <0.0002). In multivariate logistic regression analysis TIMI Risk Score was one of the independent risk factors of death during one-year follow-up (OR 1.59, p <0.001).\nCONCLUSIONS: TIMI Risk Score accurately defines the population of STEMI patients who are at high risk of death not only during the first 30 days, but also during a long-term follow-up. This simple score should be included in the discharge letters because it contains very useful information for further care.", "publicationTitle": "Kardiologia polska", "publisher": "", "place": "", "date": "Jul 2007", "volume": "65", "issue": "7", "section": "", "partNumber": "", "partTitle": "", "pages": "788-795; discussion 796-797", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Kardiol Pol", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-9032", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 17694460", "tags": [ { "tag": "Aged", "type": 1 }, { "tag": "Angioplasty, Balloon, Coronary", "type": 1 }, { "tag": "Electrocardiography", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Fibrinolytic Agents", "type": 1 }, { "tag": "Follow-Up Studies", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Myocardial Infarction", "type": 1 }, { "tag": "Predictive Value of Tests", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Thrombolytic Therapy", "type": 1 } ], "collections": [ "R75SW66X" ], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/J5DICXFB" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } }, { "key": "WXJG4UZQ", "version": 2, "library": { "type": "group", "id": 258411, "name": "Clanek NGAL", "links": { "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/258411/items/WXJG4UZQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/clanek_ngal/items/WXJG4UZQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/258411/items/BFWD8Q5D", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1710581, "username": "SL85", "name": "Simona Littnerova", "links": { "alternate": { "href": "https://www.zotero.org/sl85", "type": "text/html" } } } }, "data": { "key": "WXJG4UZQ", "version": 2, "parentItem": "BFWD8Q5D", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-04-04T08:49:40Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16186438", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": { "owl:sameAs": "http://zotero.org/groups/246615/items/HTJM4E9M" }, "dateAdded": "2014-04-04T09:57:42Z", "dateModified": "2014-04-04T09:57:42Z" } } ]