relacionado confuente de factores de riesgo
", "tags": [], "relations": { "owl:sameAs": "http://zotero.org/groups/259763/items/82PG722Z" }, "dateAdded": "2014-07-12T16:20:07Z", "dateModified": "2014-07-12T16:20:07Z" } }, { "key": "3Z8PBIC7", "version": 113, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/3Z8PBIC7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/3Z8PBIC7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1868226, "username": "Catalina Escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/catalina_escobar", "type": "text/html" } } }, "creatorSummary": "Stewart et al.", "parsedDate": "2005-01", "numChildren": 2 }, "data": { "key": "3Z8PBIC7", "version": 113, "itemType": "journalArticle", "title": "A 32-year prospective study of change in body weight and incident dementia: the Honolulu-Asia Aging Study", "creators": [ { "creatorType": "author", "firstName": "Robert", "lastName": "Stewart" }, { "creatorType": "author", "firstName": "Kamal", "lastName": "Masaki" }, { "creatorType": "author", "firstName": "Qian-Li", "lastName": "Xue" }, { "creatorType": "author", "firstName": "Rita", "lastName": "Peila" }, { "creatorType": "author", "firstName": "Helen", "lastName": "Petrovitch" }, { "creatorType": "author", "firstName": "Lon R", "lastName": "White" }, { "creatorType": "author", "firstName": "Lenore J", "lastName": "Launer" } ], "abstractNote": "BACKGROUND: The course of weight loss associated with dementia is unclear, particularly prior to and around the onset of the clinical syndrome.\nOBJECTIVE: To compare the natural history of weight change from mid to late life in men with and without dementia in late life.\nDESIGN AND SETTING: The Honolulu-Asia Aging Study, a 32-year, prospective, population-based study of Japanese American men who had been weighed on 6 occasions between 1965 and 1999 and who had been screened for dementia 3 times between 1991 and 1999.\nPARTICIPANTS: Of 1890 men (aged 77-98 years), 112 with incident dementia were compared with 1778 without dementia at the sixth examination (1997-1999).\nMAIN OUTCOME MEASURE: Weight change up to and including the sixth examination was treated as the dependent variable and estimated using a repeated measures analysis.\nRESULTS: Groups with and without dementia did not differ with respect to baseline weight or change in weight from mid to late life (first 26 years' follow-up). In the late-life examinations (final 6 years), mean age- and education-adjusted weight loss was -0.22 kg/y (95% confidence intervals, -0.26 to -0.18) in participants without dementia. Men with incident dementia at the same examination had an additional yearly weight loss of -0.36 kg (95% confidence interval, -0.53 to -0.19). This was not changed substantially with adjustment for risk factors for vascular disease or functional impairment and was significant for both Alzheimer disease and vascular dementia subtypes.\nCONCLUSIONS: Dementia-associated weight loss begins before the onset of the clinical syndrome and accelerates by the time of diagnosis. The potential impact on prognosis should be considered in the case of elderly persons at risk for dementia.", "publicationTitle": "Archives of neurology", "publisher": "", "place": "", "date": "Jan 2005", "volume": "62", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "55-60", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Arch. Neurol.", "DOI": "10.1001/archneur.62.1.55", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0003-9942", "archive": "", "archiveLocation": "", "shortTitle": "A 32-year prospective study of change in body weight and incident dementia", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 15642850", "tags": [ { "tag": "Age Factors", "type": 1 }, { "tag": "Age of Onset", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Asian Americans", "type": 1 }, { "tag": "Body Mass Index", "type": 1 }, { "tag": "Cognition Disorders", "type": 1 }, { "tag": "Cohort Studies", "type": 1 }, { "tag": "Dementia", "type": 1 }, { "tag": "Educational Status", "type": 1 }, { "tag": "Geriatric Assessment", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mental Status Schedule", "type": 1 }, { "tag": "Neuropsychological Tests", "type": 1 }, { "tag": "Physical Examination", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Weight Loss", "type": 1 } ], "collections": [], "relations": { "owl:sameAs": "http://zotero.org/groups/259763/items/IBXDI5VH" }, "dateAdded": "2014-07-12T16:20:07Z", "dateModified": "2014-07-12T16:20:07Z" } }, { "key": "QDAR344J", "version": 111, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/QDAR344J", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/QDAR344J", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/WPXQWTRP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } } }, "data": { "key": "QDAR344J", "version": 111, "parentItem": "WPXQWTRP", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-04-16T01:32:18Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372091/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-16T01:32:18Z", "dateModified": "2014-04-16T01:32:18Z" } }, { "key": "WPXQWTRP", "version": 111, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/WPXQWTRP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/WPXQWTRP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "creatorSummary": "Vauzour", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "WPXQWTRP", "version": 111, "itemType": "journalArticle", "title": "Dietary Polyphenols as Modulators of Brain Functions: Biological Actions and Molecular Mechanisms Underpinning Their Beneficial Effects", "creators": [ { "creatorType": "author", "firstName": "David", "lastName": "Vauzour" } ], "abstractNote": "Accumulating evidence suggests that diet and lifestyle can play an important role in delaying the onset or halting the progression of age-related health disorders and to improve cognitive function. In particular, polyphenols have been reported to exert their neuroprotective actions through the potential to protect neurons against injury induced by neurotoxins, an ability to suppress neuroinflammation, and the potential to promote memory, learning, and cognitive function. Despite significant advances in our understanding of the biology of polyphenols, they are still mistakenly regarded as simply acting as antioxidants. However, recent evidence suggests that their beneficial effects involve decreases in oxidative/inflammatory stress signaling, increases in protective signaling and neurohormetic effects leading to the expression of genes that encode antioxidant enzymes, phase-2 enzymes, neurotrophic factors, and cytoprotective proteins. Specific examples of such pathways include the sirtuin-FoxO pathway, the NF-κB pathway, and the Nrf-2/ARE pathway. Together, these processes act to maintain brain homeostasis and play important roles in neuronal stress adaptation and thus polyphenols have the potential to prevent the progression of neurodegenerative pathologies.", "publicationTitle": "Oxidative Medicine and Cellular Longevity", "publisher": "", "place": "", "date": "2012", "volume": "2012", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Oxid Med Cell Longev", "DOI": "10.1155/2012/914273", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3372091/", "accessDate": "2014-04-16T01:32:18Z", "PMID": "", "PMCID": "", "ISSN": "1942-0900", "archive": "", "archiveLocation": "", "shortTitle": "Dietary Polyphenols as Modulators of Brain Functions", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 22701758\nPMCID: PMC3372091", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-04-16T01:32:18Z", "dateModified": "2014-04-16T01:32:18Z" } }, { "key": "449QEQF4", "version": 109, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/449QEQF4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/449QEQF4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/5WUW6VAW", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868226, "username": "Catalina Escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/catalina_escobar", "type": "text/html" } } } }, "data": { "key": "449QEQF4", "version": 109, "parentItem": "5WUW6VAW", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-04-10T17:22:20Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23930978", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-04-10T17:22:20Z", "dateModified": "2014-04-10T17:22:20Z" } }, { "key": "5WUW6VAW", "version": 109, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/5WUW6VAW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/5WUW6VAW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1868226, "username": "Catalina Escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/catalina_escobar", "type": "text/html" } } }, "creatorSummary": "Cai et al.", "parsedDate": "2014-05", "numChildren": 1 }, "data": { "key": "5WUW6VAW", "version": 109, "itemType": "journalArticle", "title": "Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease", "creators": [ { "creatorType": "author", "firstName": "Zhiyou", "lastName": "Cai" }, { "creatorType": "author", "firstName": "M Delwar", "lastName": "Hussain" }, { "creatorType": "author", "firstName": "Liang-Jun", "lastName": "Yan" } ], "abstractNote": "Compelling evidence from basic molecular biology has demonstrated the dual roles of microglia in the pathogenesis of Alzheimer's disease (AD). On one hand, microglia are involved in AD pathogenesis by releasing inflammatory mediators such as inflammatory cytokines, complement components, chemokines, and free radicals that are all known to contribute to beta-amyloid (Aβ) production and accumulation. On the other hand, microglia are also known to play a beneficial role in generating anti-Aβ antibodies and stimulating clearance of amyloid plaques. Aβ itself, an inducer of microglia activation and neuroinflammation, has been considered as an underlying and unifying factor in the development of AD. A vicious cycle of inflammation has been formed between Aβ accumulation, activated microglia, and microglial inflammatory mediators, which enhance Aβ deposition and neuroinflammation. Thus, inhibiting the vicious cycle seems to be a promising treatment to restrain further development of AD. With increasing research efforts on microglia in AD, intervention of microglia activation and neuroinflammation in AD may provide a potential target for AD therapy in spite of the provisional failure of nonsteroidal antiinflammatory drugs in clinical trials.", "publicationTitle": "The International journal of neuroscience", "publisher": "", "place": "", "date": "May 2014", "volume": "124", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "307-321", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Int. J. Neurosci.", "DOI": "10.3109/00207454.2013.833510", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1563-5279", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23930978", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-04-10T17:22:20Z", "dateModified": "2014-04-10T17:22:20Z" } }, { "key": "UFJEXU6B", "version": 105, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/UFJEXU6B", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/UFJEXU6B", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/IUDDDIHA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868226, "username": "Catalina Escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/catalina_escobar", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "UFJEXU6B", "version": 105, "parentItem": "IUDDDIHA", "itemType": "note", "note": "", "tags": [], "relations": {}, "dateAdded": "2014-04-10T00:02:35Z", "dateModified": "2014-04-10T00:02:35Z" } }, { "key": "SFK2ZPFZ", "version": 104, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/SFK2ZPFZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/SFK2ZPFZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/NPXUTKUG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1606102, "username": "p.escudero", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/p.escudero", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "SFK2ZPFZ", "version": 104, "parentItem": "NPXUTKUG", "itemType": "note", "note": "Articulo que dice que a traves de la reduccion de la homocisteina y un tratamiento con vitamina b es posible prevenir la atrofia de las regiones que estan relacionadas con el deterioro cognitivo y la enfermedad de alzheimer
Efecto protector del vino en la enfermedad de parkinson y alzheimer por los compuestos fenolicos que este contiene el cual evita la muerte celular y las enfermedades neurodegenerativas
", "tags": [], "relations": {}, "dateAdded": "2014-04-09T22:17:16Z", "dateModified": "2014-04-09T22:26:50Z" } }, { "key": "AEXTN3UQ", "version": 92, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/AEXTN3UQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/AEXTN3UQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/KMP74EIG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1606102, "username": "p.escudero", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/p.escudero", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "AEXTN3UQ", "version": 92, "parentItem": "KMP74EIG", "itemType": "note", "note": "Un déficit de acetilcolina se ha asociado con un mayor riesgo de la enfermedad de Alzheimer , los niveles de acetilcolina disminuyen con el paso de la edad en parte debido a la disminucion de la capacidad del cuerpo para sintetizar colina acetil tranferasa, (enzima necesaria para la produccion de acetilcolina)
Este articulo habla de examinar la evidencia epidemiológica y longitudinal actual entre la ingesta dietética habitual de antioxidantes y la cognición , teniendo en consideración tanto el funcionamiento cognitivo y el riesgo de demencia y sus subtipos , incluyendo la enfermedad de Alzheimer y la demencia vascular.
", "tags": [], "relations": {}, "dateAdded": "2014-04-08T18:06:07Z", "dateModified": "2014-04-09T21:49:16Z" } }, { "key": "7SHMCUU2", "version": 84, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/7SHMCUU2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/7SHMCUU2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/HQGP4GJC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1606102, "username": "p.escudero", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/p.escudero", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "7SHMCUU2", "version": 84, "parentItem": "HQGP4GJC", "itemType": "note", "note": "", "tags": [], "relations": {}, "dateAdded": "2014-04-09T21:37:42Z", "dateModified": "2014-04-09T21:37:42Z" } }, { "key": "FM6E8HVM", "version": 82, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/FM6E8HVM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/FM6E8HVM", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/IUDDDIHA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1606102, "username": "p.escudero", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/p.escudero", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "FM6E8HVM", "version": 82, "parentItem": "IUDDDIHA", "itemType": "note", "note": "Este articulo habla de la relacion de las vitaminas b1,b2,b6,b12 y los berries con el alzheimer y la enfermedad de parkinson en el cual se experimento con animales , humanos y estudios in vitro, el cual en estudios con animales las deficiencias de vitamina b1 o folato causan disfuncion neurologica, y en estudios en humanos fue de mala calidad y poco convincente.
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", "tags": [], "relations": {}, "dateAdded": "2014-04-08T23:40:38Z", "dateModified": "2014-04-08T23:41:02Z" } }, { "key": "FN8GAV5T", "version": 71, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/FN8GAV5T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/FN8GAV5T", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/CNZKEUMP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "FN8GAV5T", "version": 71, "parentItem": "CNZKEUMP", "itemType": "note", "note": "Interaccion farmacologica
", "tags": [], "relations": {}, "dateAdded": "2014-04-08T23:33:54Z", "dateModified": "2014-04-08T23:34:01Z" } }, { "key": "8UHWP6PD", "version": 70, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/8UHWP6PD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/8UHWP6PD", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/EAZCCRCM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "8UHWP6PD", "version": 70, "parentItem": "EAZCCRCM", "itemType": "note", "note": "Con el pasar de los años (2050) la poblacion ira envejeciendo.
\nEl uso de acidos de bayas, acidos grasos de nueces y aceites de pescado ayuda al envejecimiento del cerebro, mejora la cognicion y habilidades motoras.
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Por estudio los polifenoles de la uva han demostrado ser protectores contra la formacion de la proteina beta amiloide, disminuye la agregacion de la proteina tau.
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\nMenciona estudios en roedores pero no así en humanos por la baja biodisponibilidad de los productos.
\n\n
Este estudio nos ayudaría como introducción al tema a tratar.
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ESTUDIO QUE DEMUESTRA QUE LA CURCUMINA Y SUSTANCIAS TALES COMO epigalocatequina- 3 -galato , el principal catequina del té verde, induce HO- 1 por vía ARE/Nrf2 en las neuronas del hipocampo , y por esta inducción , es capaz de proteger a las neuronas contra diferentes modelos de daños oxidativos
", "tags": [], "relations": {}, "dateAdded": "2014-04-06T22:18:53Z", "dateModified": "2014-04-06T22:20:18Z" } }, { "key": "3KDIW4ZP", "version": 52, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/3KDIW4ZP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/3KDIW4ZP", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/257130/items/EZIW6DJ2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "3KDIW4ZP", "version": 52, "parentItem": "EZIW6DJ2", "itemType": "note", "note": "Efecto protector de la dieta mediterranea por el alto contenido de PUFAS.....
", "tags": [], "relations": {}, "dateAdded": "2014-04-06T22:11:18Z", "dateModified": "2014-04-06T22:11:56Z" } }, { "key": "KMP74EIG", "version": 49, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/KMP74EIG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/KMP74EIG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "KMP74EIG", "version": 49, "itemType": "webpage", "title": "Los alimentos con alto contenido de acetilcolina", "creators": [], "abstractNote": "La acetilcolina es un neurotransmisor esencial para almacenar y recuperar recuerdos. Un déficit de acetilcolina se ha asociado con un mayor riesgo de la enfermedad de Alzheimer, ...", "websiteTitle": "eHow en Español", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.ehowenespanol.com/alimentos-alto-contenido-acetilcolina-info_142378/", "accessDate": "2014-04-06T22:00:18Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-04-06T22:00:18Z", "dateModified": "2014-04-06T22:00:18Z" } }, { "key": "BFQABRAK", "version": 48, "library": { "type": "group", "id": 257130, "name": "Tesis Alzheimer", "links": { "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/257130/items/BFQABRAK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/tesis_alzheimer/items/BFQABRAK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1868223, "username": "wiwina", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/wiwina", "type": "text/html" } } }, "creatorSummary": "Williams and Spencer", "parsedDate": "2012-01-01", "numChildren": 2 }, "data": { "key": "BFQABRAK", "version": 48, "itemType": "journalArticle", "title": "Flavonoids, cognition, and dementia: actions, mechanisms, and potential therapeutic utility for Alzheimer disease", "creators": [ { "creatorType": "author", "firstName": "Robert J", "lastName": "Williams" }, { "creatorType": "author", "firstName": "Jeremy P E", "lastName": "Spencer" } ], "abstractNote": "There is increasing evidence that the consumption of flavonoid-rich foods can beneficially influence normal cognitive function. In addition, a growing number of flavonoids have been shown to inhibit the development of Alzheimer disease (AD)-like pathology and to reverse deficits in cognition in rodent models, suggestive of potential therapeutic utility in dementia. The actions of flavonoid-rich foods (e.g., green tea, blueberry, and cocoa) seem to be mediated by the direct interactions of absorbed flavonoids and their metabolites with a number of cellular and molecular targets. For example, their specific interactions within the ERK and PI3-kinase/Akt signaling pathways, at the level of receptors or kinases, have been shown to increase the expression of neuroprotective and neuromodulatory proteins and increase the number of, and strength of, connections between neurons. Concurrently, their effects on the vascular system may also lead to enhancements in cognitive performance through increased brain blood flow and an ability to initiate neurogenesis in the hippocampus. Additional mechanisms have been suggested for the ability of flavonoids to delay the initiation of and/or slow the progression of AD-like pathology and related neurodegenerative disorders, including a potential to inhibit neuronal apoptosis triggered by neurotoxic species (e.g., oxidative stress and neuroinflammation) or disrupt amyloid β aggregation and effects on amyloid precursor protein processing through the inhibition of β-secretase (BACE-1) and/or activation of α-secretase (ADAM10). Together, these processes act to maintain the number and quality of synaptic connections in key brain regions and thus flavonoids have the potential to prevent the progression of neurodegenerative pathologies and to promote cognitive performance.", "publicationTitle": "Free radical biology & medicine", "publisher": "", "place": "", "date": "Jan 1, 2012", "volume": "52", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "35-45", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Free Radic. Biol. Med.", "DOI": "10.1016/j.freeradbiomed.2011.09.010", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1873-4596", "archive": "", "archiveLocation": "", "shortTitle": "Flavonoids, cognition, and dementia", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 21982844", "tags": [ { "tag": "Alzheimer Disease", "type": 1 }, { "tag": "Amyloid Precursor Protein Secretases", "type": 1 }, { "tag": "Amyloid beta-Peptides", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Brain", "type": 1 }, { "tag": "Cognition", "type": 1 }, { "tag": "Enzyme Activation", "type": 1 }, { "tag": "Flavonoids", "type": 1 }, { "tag": "Gene Expression", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mitogen-Activated Protein Kinase 1", "type": 1 }, { "tag": "Mitogen-Activated Protein Kinase 3", "type": 1 }, { "tag": "Neurogenesis", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Phosphatidylinositol 3-Kinases", "type": 1 }, { "tag": "Proto-Oncogene Proteins c-akt", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Signal Transduction", "type": 1 } ], "collections": [], "relations": { "dc:relation": [ "http://zotero.org/groups/257130/items/CMIS2XE2", "http://zotero.org/groups/257130/items/J5T48TPG", "http://zotero.org/groups/257130/items/GS9I8HX8" ] }, "dateAdded": "2014-04-03T02:17:04Z", "dateModified": "2014-04-06T21:48:15Z" } } ]