[ { "key": "QEIDJHES", "version": 28, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/QEIDJHES", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/QEIDJHES", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/KMKBXH2S", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QEIDJHES", "version": 28, "parentItem": "KMKBXH2S", "itemType": "attachment", "linkMode": "imported_url", "title": "PubMed Central Full Text PDF", "accessDate": "2014-02-19T02:52:50Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840668/pdf/1471-2318-13-121.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Fiss et al. - 2013 - Medication management for people with dementia in .pdf", "md5": "e51d3b9e8e06e64c16924877a90c0c7d", "mtime": 1392778371974, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:52:50Z", "dateModified": "2014-02-19T02:52:51Z" } }, { "key": "QQJ3TI4Z", "version": 27, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/QQJ3TI4Z", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/QQJ3TI4Z", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/KMKBXH2S", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "QQJ3TI4Z", "version": 27, "parentItem": "KMKBXH2S", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-02-19T02:52:50Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840668/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:52:50Z", "dateModified": "2014-02-19T02:52:50Z" } }, { "key": "KMKBXH2S", "version": 27, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/KMKBXH2S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/KMKBXH2S", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "creatorSummary": "Fiss et al.", "parsedDate": "2013-11-13", "numChildren": 2 }, "data": { "key": "KMKBXH2S", "version": 27, "itemType": "journalArticle", "title": "Medication management for people with dementia in primary care: description of implementation in the DelpHi study", "creators": [ { "creatorType": "author", "firstName": "Thomas", "lastName": "Fiss" }, { "creatorType": "author", "firstName": "Jochen Rene", "lastName": "Thyrian" }, { "creatorType": "author", "firstName": "Diana", "lastName": "Wucherer" }, { "creatorType": "author", "firstName": "Grit", "lastName": "Assmann" }, { "creatorType": "author", "firstName": "Ingo", "lastName": "Kilimann" }, { "creatorType": "author", "firstName": "Stefan J", "lastName": "Teipel" }, { "creatorType": "author", "firstName": "Wolfgang", "lastName": "Hoffmann" } ], "abstractNote": "Background\nAs the population ages, the relative and absolute number of age-associated diseases such as dementia will increase. Evaluation of the suitability and intake of medication and pharmacological treatment is an important aspect of care for people with dementia, especially if they live at home. Regular medication reviews and systematic cooperation between physicians and pharmacists are not common in routine care. Medication management (MM), based on such a comprehensive home medication review could help to reduce drug-related problems and costs. The present article presents a medication management specifically for the application in the ambulatory setting and describes its implementation as part of a larger trial.\n\nMethods/design\nA home medication review (HMR) and MM is implemented as part of the DelpHi study, a population based prospective, cluster-randomized controlled intervention study to test the efficacy and efficiency of the implementation of a collaborative care model in primary care., Participants: people with dementia (PWD) and their caregivers are recruited by the patient’s general practitioner. Inclusion criteria are a positive screening result for dementia, living at home and regular intake of drugs. PWD are asked to specify their regular pharmacy which is asked to participate in the study, too., Intervention: a comprehensive HMR is conducted as computer-assisted personal interview by specifically qualified Dementia Care Manager (DCM) at the people’s home. It includes detailed information about drugs taken, their storage, administration, adherence and adverse events. The MM is conducted in cooperation between DCM, pharmacist and general practitioner and consists of a pharmaceutical evaluation, pharmaceutical recommendations and their application. Pharmacists are trained and provided with regularly updated information. The MM is designed to give information and recommendations concerning antidementia drugs, occurrence of drug related problems, intake of anticholinergic drugs, potentially clinically relevant drug-drug-interactions, adverse drug events and medication adherence.\n\nDiscussion\nThe DelpHi-approach for medication management employs comprehensive instruments and procedures in the primary care setting under routine care conditions, and this approach should be useful in improving pharmacotherapy as part of the comprehensive treatment and care for people with dementia.\n\nTrial registration\nThe trial is registered at ClinicalTrials.gov, number NCT01401582.", "publicationTitle": "BMC Geriatrics", "publisher": "", "place": "", "date": "2013-11-13", "volume": "13", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "121", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "BMC Geriatr", "DOI": "10.1186/1471-2318-13-121", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3840668/", "accessDate": "2014-02-19T02:52:50Z", "PMID": "", "PMCID": "", "ISSN": "1471-2318", "archive": "", "archiveLocation": "", "shortTitle": "Medication management for people with dementia in primary care", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 24225205\nPMCID: PMC3840668", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-19T02:52:50Z", "dateModified": "2014-02-19T02:52:50Z" } }, { "key": "WMASB3WG", "version": 25, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/WMASB3WG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/WMASB3WG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/82Q6UKJ7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "WMASB3WG", "version": 25, "parentItem": "82Q6UKJ7", "itemType": "attachment", "linkMode": "imported_url", "title": "APA PsycNET Snapshot", "accessDate": "2014-02-19T02:43:29Z", "url": "http://psycnet.apa.org/psycinfo/1995-38158-001", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "1995-38158-001.html", "md5": "42589bbac87792e418351ba716f8992b", "mtime": 1392777809986, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:43:29Z", "dateModified": "2014-02-19T02:43:29Z" } }, { "key": "F8MC5KWN", "version": 25, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/F8MC5KWN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/F8MC5KWN", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/3KMCDKMS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "F8MC5KWN", "version": 25, "parentItem": "3KMCDKMS", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2014-02-19T02:41:16Z", "url": "http://stroke.ahajournals.org/content/16/4/562.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Kassell et al. - 1985 - Cerebral vasospasm following aneurysmal subarachno.pdf", "md5": "134bcb531607fa1fdeec61eb963f69d0", "mtime": 1392777681808, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:41:16Z", "dateModified": "2014-02-19T02:41:21Z" } }, { "key": "USM3AUST", "version": 25, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/USM3AUST", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/USM3AUST", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/3KMCDKMS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "USM3AUST", "version": 25, "parentItem": "3KMCDKMS", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-02-19T02:41:19Z", "url": "http://stroke.ahajournals.org/content/16/4/562.short", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "562.html", "md5": "9feb40ad28f86987401feed48f0e3262", "mtime": 1392777680318, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:41:19Z", "dateModified": "2014-02-19T02:41:19Z" } }, { "key": "37D7VK3P", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/37D7VK3P", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/37D7VK3P", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/3KMCDKMS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "37D7VK3P", "version": 23, "parentItem": "3KMCDKMS", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-02-19T02:41:16Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/3895589", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:41:16Z", "dateModified": "2014-02-19T02:41:16Z" } }, { "key": "3KMCDKMS", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/3KMCDKMS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/3KMCDKMS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "creatorSummary": "Kassell et al.", "parsedDate": "1985-07-01", "numChildren": 3 }, "data": { "key": "3KMCDKMS", "version": 23, "itemType": "journalArticle", "title": "Cerebral vasospasm following aneurysmal subarachnoid hemorrhage.", "creators": [ { "creatorType": "author", "firstName": "N. F.", "lastName": "Kassell" }, { "creatorType": "author", "firstName": "T.", "lastName": "Sasaki" }, { "creatorType": "author", "firstName": "A. R.", "lastName": "Colohan" }, { "creatorType": "author", "firstName": "G.", "lastName": "Nazar" } ], "abstractNote": "Cerebral vasospasm following aneurysmal subarachnoid hemorrhage is one of the most important causes of cerebral ischemia, and is the leading cause of death and disability after aneurysm rupture. There are two definitions of cerebral vasospasm: angiographic and clinical. Care must be exercised to be certain that it is clear which entity is being addressed. The diagnosis of the clinical syndrome is one of exclusion and can rarely be made with absolute certainty. The pathogenesis of cerebral vasospasm is poorly understood. Most current theories focus on the release of factors from the subarachnoid clot. More attention must be given to the role of endothelial damage and alterations in the blood-arterial wall barrier. The application of modern techniques for studying vascular smooth muscle which have been developed as a result of research in the areas of hypertension and atherosclerosis must be applied to the problem of cerebral vasospasm. A stress test to select patients with angiographic arterial narrowing who have adequate cerebral vascular reserve to undergo surgery should be developed. The optimal treatment of vasospasm awaits development of agents for blocking or inactivating spasmogenic substances or blocking arterial smooth muscle contraction. Rheological or hemodynamic manipulations to prevent or reverse ischemic consequences of vasospasm are relatively effective, but complicated and hazardous, and should be viewed principally as interim measures awaiting development of more specific therapies for the arterial narrowing.", "publicationTitle": "Stroke", "publisher": "", "place": "", "date": "07/01/1985", "volume": "16", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "562-572", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Stroke", "DOI": "10.1161/01.STR.16.4.562", "citationKey": "", "url": "http://stroke.ahajournals.org/content/16/4/562", "accessDate": "2014-02-19T02:41:16Z", "PMID": "", "PMCID": "", "ISSN": "0039-2499, 1524-4628", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stroke.ahajournals.org", "callNumber": "", "rights": "", "extra": "PMID: 3895589", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-19T02:41:16Z", "dateModified": "2014-02-19T02:41:16Z" } }, { "key": "ATV8QVDK", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/ATV8QVDK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/ATV8QVDK", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/5Q3XNR5U", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "ATV8QVDK", "version": 23, "parentItem": "5Q3XNR5U", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2014-02-19T02:40:26Z", "url": "http://stroke.ahajournals.org/content/31/11/2591.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Schroeder et al. - 2000 - Determinants of Use of Emergency Medical Services .pdf", "md5": "770fa6f9fcc36555d1bf673574d46e7c", "mtime": 1392777633157, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:40:26Z", "dateModified": "2014-02-19T02:40:33Z" } }, { "key": "JHEVZ95X", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/JHEVZ95X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/JHEVZ95X", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/5Q3XNR5U", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "JHEVZ95X", "version": 23, "parentItem": "5Q3XNR5U", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-02-19T02:40:31Z", "url": "http://stroke.ahajournals.org/content/31/11/2591.short", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "2591.html", "md5": "4cc048301bb884da3ed5249d3d7886ef", "mtime": 1392777632111, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:40:31Z", "dateModified": "2014-02-19T02:40:31Z" } }, { "key": "5Q3XNR5U", "version": 22, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/5Q3XNR5U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/5Q3XNR5U", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "creatorSummary": "Schroeder et al.", "parsedDate": "2000-11-01", "numChildren": 3 }, "data": { "key": "5Q3XNR5U", "version": 22, "itemType": "journalArticle", "title": "Determinants of Use of Emergency Medical Services in a Population With Stroke Symptoms The Second Delay in Accessing Stroke Healthcare (DASH II) Study", "creators": [ { "creatorType": "author", "firstName": "Emily B.", "lastName": "Schroeder" }, { "creatorType": "author", "firstName": "Wayne D.", "lastName": "Rosamond" }, { "creatorType": "author", "firstName": "Dexter L.", "lastName": "Morris" }, { "creatorType": "author", "firstName": "Kelly R.", "lastName": "Evenson" }, { "creatorType": "author", "firstName": "Albert R.", "lastName": "Hinn" } ], "abstractNote": "Background and Purpose—With the advent of time-dependent thrombolytic therapy for ischemic stroke, it has become increasingly important for stroke patients to arrive at the hospital quickly. This study investigates the association between the use of emergency medical services (EMS) and delay time among individuals with stroke symptoms and examines the predictors of EMS use.\nMethods—The Second Delay in Accessing Stroke Healthcare Study (DASH II) was a prospective study of 617 individuals arriving at emergency departments in Denver, Colo, Chapel Hill, NC, and Greenville, SC, with stroke symptoms.\nResults—EMS use was associated with decreased prehospital and in-hospital delay. Those who used EMS had a median prehospital delay time of 2.85 hours compared with 4.03 hours for those who did not use EMS (P=0.002). Older individuals were more likely to use EMS (odds ratio [OR] 1.21 for each 5-year increase, 95% CI 1.14 to 1.29), as were individuals who expressed a high sense of urgency about their symptoms (OR 1.69, 95% CI 1.09 to 2.62). Knowledge of stroke symptoms was not associated with increased EMS use (OR 0.63, 95% CI 0.40 to 0.98). Patients were more likely to use EMS if someone other than the patient first identified that there was a problem (OR 2.35, 95% CI 1.61 to 3.44).\nConclusions—Interventions aimed at increasing EMS use among stroke patients need to stress the urgency of stroke symptoms and the importance of calling 911 and need to be broad-based, encompassing not only those at high risk for stroke but also their friends and family.", "publicationTitle": "Stroke", "publisher": "", "place": "", "date": "11/01/2000", "volume": "31", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "2591-2596", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Stroke", "DOI": "10.1161/01.STR.31.11.2591", "citationKey": "", "url": "http://stroke.ahajournals.org/content/31/11/2591", "accessDate": "2014-02-19T02:40:26Z", "PMID": "", "PMCID": "", "ISSN": "0039-2499, 1524-4628", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stroke.ahajournals.org", "callNumber": "", "rights": "", "extra": "PMID: 11062280", "tags": [ { "tag": "cerebrovascular disorders", "type": 1 }, { "tag": "emergency medical services", "type": 1 }, { "tag": "stroke onset", "type": 1 }, { "tag": "stroke, acute", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-02-19T02:40:26Z", "dateModified": "2014-02-19T02:40:26Z" } }, { "key": "CZH94BXC", "version": 22, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/CZH94BXC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/CZH94BXC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/5Q3XNR5U", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "CZH94BXC", "version": 22, "parentItem": "5Q3XNR5U", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-02-19T02:40:26Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/11062280", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:40:26Z", "dateModified": "2014-02-19T02:40:26Z" } }, { "key": "K8H223BV", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/K8H223BV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/K8H223BV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/BBKPK5NH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "K8H223BV", "version": 23, "parentItem": "BBKPK5NH", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2014-02-19T02:38:32Z", "url": "http://stroke.ahajournals.org/content/32/2/438.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Larrue et al. - 2001 - Risk Factors for Severe Hemorrhagic Transformation.pdf", "md5": "bd86b18776628a04ffc08f6c237abb53", "mtime": 1392777517616, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:32Z", "dateModified": "2014-02-19T02:38:37Z" } }, { "key": "CQV3KKCC", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/CQV3KKCC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/CQV3KKCC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/BBKPK5NH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "CQV3KKCC", "version": 23, "parentItem": "BBKPK5NH", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-02-19T02:38:36Z", "url": "http://stroke.ahajournals.org/content/32/2/438.short", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "438.html", "md5": "1a100a2de39895928039faf455d7f654", "mtime": 1392777516977, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:36Z", "dateModified": "2014-02-19T02:38:36Z" } }, { "key": "BBKPK5NH", "version": 21, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/BBKPK5NH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/BBKPK5NH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "creatorSummary": "Larrue et al.", "parsedDate": "2001-02-01", "numChildren": 3 }, "data": { "key": "BBKPK5NH", "version": 21, "itemType": "journalArticle", "title": "Risk Factors for Severe Hemorrhagic Transformation in Ischemic Stroke Patients Treated With Recombinant Tissue Plasminogen Activator A Secondary Analysis of the European-Australasian Acute Stroke Study (ECASS II)", "creators": [ { "creatorType": "author", "firstName": "Vincent", "lastName": "Larrue" }, { "creatorType": "author", "firstName": "Rüdiger von", "lastName": "Kummer" }, { "creatorType": "author", "firstName": "Achim", "lastName": "Müller" }, { "creatorType": "author", "firstName": "Erich", "lastName": "Bluhmki" } ], "abstractNote": "Background and Purpose—Intravenous thrombolysis with recombinant tissue plasminogen activator (rtPA) improves the outcome for ischemic stroke patients who can be treated within 3 hours of symptom onset. The efficacy of thrombolysis has been demonstrated despite an increased risk of severe hemorrhagic transformation (HT) in patients treated with rtPA. We performed an analysis of risk factors for severe HT in the second European-Australasian Acute Stroke Study (ECASS II).\nMethods—HTs were classified by using clinical and radiological criteria as follows: hemorrhagic infarction (HI), parenchymal hemorrhage (PH), and symptomatic intracranial hemorrhage (SICH). Potential risk factors for HT were tested by stepwise logistic regression analysis, including rtPA-by-variable interactions. In addition, the distribution of bad outcome (modified Rankin score 5 to 6) at day 90 was stratified according to each category of HT.\nResults—PH and SICH but not HI were associated with rtPA. Also, PH and SICH but not HI were more severe in rtPA-treated patients than in those receiving placebo. Risk factors for PH were rtPA, extent of parenchymal hypoattenuation on baseline CT, congestive heart failure, increasing age, and baseline systolic blood pressure. The risk of PH on rtPA was increased in older patients and in those who were treated with aspirin before thrombolysis. Risk factors for SICH were rtPA, congestive heart failure, extent of parenchymal hypoattenuation, and increasing age. The risk of SICH on rtPA was increased in patients who were treated with aspirin before thrombolysis.\nConclusions—This secondary analysis of ECASS II has confirmed the importance of the extent of hypoattenuation as a risk factor for severe HT. The findings also suggest that older patients and those who have used aspirin before stroke are at higher risk of a severe HT on rtPA.", "publicationTitle": "Stroke", "publisher": "", "place": "", "date": "02/01/2001", "volume": "32", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "438-441", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Stroke", "DOI": "10.1161/01.STR.32.2.438", "citationKey": "", "url": "http://stroke.ahajournals.org/content/32/2/438", "accessDate": "2014-02-19T02:38:32Z", "PMID": "", "PMCID": "", "ISSN": "0039-2499, 1524-4628", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stroke.ahajournals.org", "callNumber": "", "rights": "", "extra": "PMID: 11157179", "tags": [ { "tag": "intracerebral hemorrhage", "type": 1 }, { "tag": "risk factors", "type": 1 }, { "tag": "stroke, acute", "type": 1 }, { "tag": "thrombolytic therapy", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-02-19T02:38:32Z", "dateModified": "2014-02-19T02:38:32Z" } }, { "key": "B3MR48SX", "version": 21, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/B3MR48SX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/B3MR48SX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/BBKPK5NH", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "B3MR48SX", "version": 21, "parentItem": "BBKPK5NH", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-02-19T02:38:32Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/11157179", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:32Z", "dateModified": "2014-02-19T02:38:32Z" } }, { "key": "3KTGV3BX", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/3KTGV3BX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/3KTGV3BX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/SUNBKQHU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "3KTGV3BX", "version": 23, "parentItem": "SUNBKQHU", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2014-02-19T02:38:04Z", "url": "http://jnnp.bmj.com/content/53/1/16.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Bamford et al. - 1990 - A prospective study of acute cerebrovascular disea.pdf", "md5": "28f06a58dfaf080b52e9737e75398ffb", "mtime": 1392777497307, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:04Z", "dateModified": "2014-02-19T02:38:17Z" } }, { "key": "UV6GA38D", "version": 23, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/UV6GA38D", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/UV6GA38D", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/SUNBKQHU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "UV6GA38D", "version": 23, "parentItem": "SUNBKQHU", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2014-02-19T02:38:13Z", "url": "http://jnnp.bmj.com/content/53/1/16.short", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "16.html", "md5": "55730f5d4f77514eeb381a534d2ce664", "mtime": 1392777496252, "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:13Z", "dateModified": "2014-02-19T02:38:13Z" } }, { "key": "JC4N4SSZ", "version": 21, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/JC4N4SSZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/JC4N4SSZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/SUNBKQHU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } } }, "data": { "key": "JC4N4SSZ", "version": 21, "parentItem": "SUNBKQHU", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-02-19T02:38:04Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/2303826", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-02-19T02:38:04Z", "dateModified": "2014-02-19T02:38:04Z" } }, { "key": "SUNBKQHU", "version": 21, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/SUNBKQHU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/SUNBKQHU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "creatorSummary": "Bamford et al.", "parsedDate": "1990-01-01", "numChildren": 3 }, "data": { "key": "SUNBKQHU", "version": 21, "itemType": "journalArticle", "title": "A prospective study of acute cerebrovascular disease in the community: the Oxfordshire Community Stroke Project--1981-86. 2. Incidence, case fatality rates and overall outcome at one year of cerebral infarction, primary intracerebral and subarachnoid haemorrhage.", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "Bamford" }, { "creatorType": "author", "firstName": "P.", "lastName": "Sandercock" }, { "creatorType": "author", "firstName": "M.", "lastName": "Dennis" }, { "creatorType": "author", "firstName": "J.", "lastName": "Burn" }, { "creatorType": "author", "firstName": "C.", "lastName": "Warlow" } ], "abstractNote": "The age and sex specific incidence rates for cerebral infarction, primary intracerebral haemorrhage and subarachnoid haemorrhage in a population of approximately 105,000 are presented. Over four years 675 patients with a first-ever stroke were registered with the Oxfordshire Community Stroke Project. The pathological diagnosis was confirmed by computerised tomography (CT) scan, necropsy or lumbar puncture (cases of subarachnoid haemorrhage only) in 78% of cases and a further 17% were diagnosed according to the Guy's Hospital Stroke Diagnostic Score. The proportion of all first-ever strokes by pathological type was: cerebral infarction 81% (95% confidence interval 78-84), primary intracerebral haemorrhage 10% (8-12), subarachnoid haemorrhage 5% (3-7) and uncertain type 5% (3-7). These proportions are similar to other community-based studies. The overall 30 day case fatality rate was 19% (16-22), that for cerebral infarction being 10% (7-13), primary intracerebral haemorrhage 50% (38-62) and subarachnoid haemorrhage 46% (29-63). One year post stroke 23% (19-27) with cerebral infarction were dead and 65% (60-70) of survivors were functionally independent. The figures for primary intracerebral haemorrhage were 62% (43-81) dead and 68% (50-86) of survivors functionally independent and for subarachnoid haemorrhage were 48% (24-72) dead and 76% (56-96) of survivors functionally independent. There are important differences between these rates and those from other sources possibly due to more complete case ascertainment in our study. Nevertheless, the generally more optimistic early prognosis in our study, particularly for cases of cerebral infarction, has important implications for the planning of clinical trials and for the expected impact that any treatment might have on the general population.", "publicationTitle": "Journal of Neurology, Neurosurgery & Psychiatry", "publisher": "", "place": "", "date": "01/01/1990", "volume": "53", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "16-22", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Neurol Neurosurg Psychiatry", "DOI": "10.1136/jnnp.53.1.16", "citationKey": "", "url": "http://jnnp.bmj.com/content/53/1/16", "accessDate": "2014-02-19T02:38:04Z", "PMID": "", "PMCID": "", "ISSN": ", 1468-330X", "archive": "", "archiveLocation": "", "shortTitle": "A prospective study of acute cerebrovascular disease in the community", "language": "en", "libraryCatalog": "jnnp.bmj.com", "callNumber": "", "rights": "", "extra": "PMID: 2303826", "tags": [], "collections": [], "relations": {}, "dateAdded": "2014-02-19T02:38:04Z", "dateModified": "2014-02-19T02:38:04Z" } }, { "key": "P3X7FB2R", "version": 21, "library": { "type": "group", "id": 247308, "name": "AdvDesign", "links": { "alternate": { "href": "https://www.zotero.org/groups/advdesign", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/247308/items/P3X7FB2R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/advdesign/items/P3X7FB2R", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/247308/items/F7HS4UQU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1294093, "username": "jkkim93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jkkim93", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "P3X7FB2R", "version": 21, "parentItem": "F7HS4UQU", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2014-02-19T02:37:28Z", "url": "http://stroke.ahajournals.org/content/25/11/2315.full.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Mayberg et al. - 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