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                    "creatorType": "author",
                    "firstName": "Dieter",
                    "lastName": "Mesotten"
                },
                {
                    "creatorType": "author",
                    "firstName": "Greet",
                    "lastName": "Van den Berghe"
                }
            ],
            "abstractNote": "Hyperglycemia during critical illness is associated with adverse outcome. The proof-of-concept Leuven studies assessed causality, and revealed that targeting strict normoglycemia (80-110 mg/dL) with insulin improved outcome compared with tolerating hyperglycemia to the renal threshold (215 mg/dL). A large multicenter trial (NICE-SUGAR [Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation]) found an intermediate blood glucose target (140-180 mg/dL) safer than targeting normoglycemia. Differences in design and in execution of glycemic control at the bedside may have contributed to these results. In NICE-SUGAR (Normoglycaemia in Intensive Care Evaluation and Survival Using Glucose Algorithm Regulation), the blood-glucose target range in the control group was lower, there were problems to reach and maintain normoglycemia in the intervention group, and inaccurate handheld blood glucose meters and variable blood sampling sites were allowed. Inaccurate tools led to insulin-dosing errors with consequently (undetected) hypoglycemia and unacceptable blood glucose variability. Also, the studies were done superimposed upon different nutritional strategies. Thus, such differences do not allow simple, evidence-based recommendations for daily practice, but an intermediate blood glucose target may be preferable while awaiting better tools to facilitate safely reaching normoglycemia.",
            "publicationTitle": "Current Diabetes Reports",
            "publisher": "",
            "place": "",
            "date": "Feb 2012",
            "volume": "12",
            "issue": "1",
            "section": "",
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            "partTitle": "",
            "pages": "101-107",
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                },
                {
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                },
                {
                    "tag": "Hyperglycemia",
                    "type": 1
                },
                {
                    "tag": "Hypoglycemic Agents",
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                },
                {
                    "tag": "Insulin",
                    "type": 1
                },
                {
                    "tag": "Intensive Care",
                    "type": 1
                },
                {
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                    "type": 1
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            "key": "Q3H88BWX",
            "version": 220,
            "itemType": "journalArticle",
            "title": "Intensive Insulin Therapy in Critically Ill Patients",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Greet",
                    "lastName": "Van den Berghe"
                },
                {
                    "creatorType": "author",
                    "firstName": "Pieter",
                    "lastName": "Wouters"
                },
                {
                    "creatorType": "author",
                    "firstName": "Frank",
                    "lastName": "Weekers"
                },
                {
                    "creatorType": "author",
                    "firstName": "Charles",
                    "lastName": "Verwaest"
                },
                {
                    "creatorType": "author",
                    "firstName": "Frans",
                    "lastName": "Bruyninckx"
                },
                {
                    "creatorType": "author",
                    "firstName": "Miet",
                    "lastName": "Schetz"
                },
                {
                    "creatorType": "author",
                    "firstName": "Dirk",
                    "lastName": "Vlasselaers"
                },
                {
                    "creatorType": "author",
                    "firstName": "Patrick",
                    "lastName": "Ferdinande"
                },
                {
                    "creatorType": "author",
                    "firstName": "Peter",
                    "lastName": "Lauwers"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roger",
                    "lastName": "Bouillon"
                }
            ],
            "abstractNote": "Critically ill patients who require intensive care for more than five days have a 20 percent risk of death and substantial morbidity.1 Critical-illness polyneuropathy and skeletal-muscle wasting prolong the need for mechanical ventilation.2–5 Moreover, increased susceptibility to severe infections and failure of vital organs amplify the risk of an adverse outcome. Hyperglycemia associated with insulin resistance6–8 is common in critically ill patients, even those who have not previously had diabetes. It has been reported that pronounced hyperglycemia may lead to complications in such patients,9–13 although data from controlled trials are lacking. In diabetic patients with acute myocardial . . .",
            "publicationTitle": "New England Journal of Medicine",
            "publisher": "",
            "place": "",
            "date": "November 8, 2001",
            "volume": "345",
            "issue": "19",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1359-1367",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "",
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            "citationKey": "",
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            "PMCID": "",
            "ISSN": "0028-4793",
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            "shortTitle": "",
            "language": "",
            "libraryCatalog": "Taylor and Francis+NEJM",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11794168",
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            ],
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            "dateModified": "2015-03-23T16:49:32Z"
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            },
            "creatorSummary": "Kim and Johnson",
            "parsedDate": "2002-03-01",
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        "data": {
            "key": "EIZ5QKA2",
            "version": 220,
            "itemType": "journalArticle",
            "title": "Personal Health Records Evaluation of Functionality and Utility",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Matthew I.",
                    "lastName": "Kim"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kevin B.",
                    "lastName": "Johnson"
                }
            ],
            "abstractNote": "Objectives Web-based applications have been developed that allow patients to enter their own information into secure personal health records. These applications are being promoted as a means of providing patients and providers with universal access to updated medical information. The authors evaluated the functionality and utility of a selection of personal health records.\nDesign A targeted search strategy was used to identify eleven Web sites promoting different personal health records. Specific criteria related to the entry and display of data elements were developed to evaluate the functionality of each PHR. Information abstracted from an actual case was used to create a series of representative PHRs. Output generated for review was evaluated to assess the accuracy and completeness of clinical information related to the diagnosis and treatment of specific disorders.\nResults The PHRs selected for review employed data entry methods that limited the range and content of patient-entered information related to medical history, medications, laboratory tests, diagnostic studies, and immunizations. Representative PHRs created with information abstracted from an actual case displayed varying amounts of information at basic and comprehensive levels of representation.\nConclusions Currently available PHRs demonstrate limited functionality. The data entry, validation, and information display methods they employ may limit their utility as representations of medical information.",
            "publicationTitle": "Journal of the American Medical Informatics Association",
            "publisher": "",
            "place": "",
            "date": "03/01/2002",
            "volume": "9",
            "issue": "2",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "171-180",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J Am Med Inform Assoc",
            "DOI": "10.1197/jamia.M0978",
            "citationKey": "",
            "url": "http://jamia.bmj.com/content/9/2/171",
            "accessDate": "2014-09-19T23:59:05Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": ", 1527-974X",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "jamia.bmj.com",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11861632",
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            "dateAdded": "2015-03-23T16:49:32Z",
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    {
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            "creatorSummary": "Halamka et al.",
            "parsedDate": "2008-01-01",
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        "data": {
            "key": "7P2ZTIFV",
            "version": 220,
            "itemType": "journalArticle",
            "title": "Early Experiences with Personal Health Records",
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                {
                    "creatorType": "author",
                    "firstName": "John D.",
                    "lastName": "Halamka"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kenneth D.",
                    "lastName": "Mandl"
                },
                {
                    "creatorType": "author",
                    "firstName": "Paul C.",
                    "lastName": "Tang"
                }
            ],
            "abstractNote": "Over the past year, several payers, employers, and commercial vendors have announced personal health record projects. Few of these are widely deployed and few are fully integrated into ambulatory or hospital-based electronic record systems. The earliest adopters of personal health records have many lessons learned that can inform these new initiatives. We present three case studies—MyChart at Palo Alto Medical Foundation, PatientSite at Beth Israel Deaconess Medical Center, and Indivo at Children’s Hospital Boston. We describe our implementation challenges from 1999 to 2007 and postulate the evolving challenges we will face over the next five years.",
            "publicationTitle": "Journal of the American Medical Informatics Association",
            "publisher": "",
            "place": "",
            "date": "01/01/2008",
            "volume": "15",
            "issue": "1",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1-7",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J Am Med Inform Assoc",
            "DOI": "10.1197/jamia.M2562",
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            "url": "http://jamia.bmj.com/content/15/1/1",
            "accessDate": "2014-09-19T23:56:05Z",
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            "PMCID": "",
            "ISSN": ", 1527-974X",
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            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "jamia.bmj.com",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 17947615",
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            "dateModified": "2015-03-23T16:49:32Z"
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            "creatorSummary": "Krist et al.",
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            "version": 220,
            "itemType": "journalArticle",
            "title": "Engaging Primary Care Patients to Use a Patient-Centered Personal Health Record",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Alex H.",
                    "lastName": "Krist"
                },
                {
                    "creatorType": "author",
                    "firstName": "Steven H.",
                    "lastName": "Woolf"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ghalib A.",
                    "lastName": "Bello"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roy T.",
                    "lastName": "Sabo"
                },
                {
                    "creatorType": "author",
                    "firstName": "Daniel R.",
                    "lastName": "Longo"
                },
                {
                    "creatorType": "author",
                    "firstName": "Paulette",
                    "lastName": "Kashiri"
                },
                {
                    "creatorType": "author",
                    "firstName": "Rebecca S.",
                    "lastName": "Etz"
                },
                {
                    "creatorType": "author",
                    "firstName": "John",
                    "lastName": "Loomis"
                },
                {
                    "creatorType": "author",
                    "firstName": "Stephen F.",
                    "lastName": "Rothemich"
                },
                {
                    "creatorType": "author",
                    "firstName": "J. Eric",
                    "lastName": "Peele"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jeffrey",
                    "lastName": "Cohn"
                }
            ],
            "abstractNote": "PURPOSE Health care leaders encourage clinicians to offer portals that enable patients to access personal health records, but implementation has been a challenge. Although large integrated health systems have promoted use through costly advertising campaigns, other implementation methods are needed for small to medium-sized practices where most patients receive their care. METHODS We conducted a mixed methods assessment of a proactive implementation strategy for a patient portal (an interactive preventive health record [IPHR]) offered by 8 primary care practices. The practices implemented a series of learning collaboratives with practice champions and redesigned workflow to integrate portal use into care. Practice implementation strategies, portal use, and factors influencing use were assessed prospectively. RESULTS A proactive and customized implementation strategy designed by practices resulted in 25.6% of patients using the IPHR, with the rate increasing 1.0% per month over 31 months. Fully 23.5% of IPHR users signed up within 1 day of their office visit. Older patients and patients with comorbidities were more likely to use the IPHR, but blacks and Hispanics were less likely. Older age diminished as a factor after adjusting for comorbidities. Implementation by practice varied considerably (from 22.1% to 27.9%, P <.001) based on clinician characteristics and workflow innovations adopted by practices to enhance uptake. CONCLUSIONS By directly engaging patients to use a portal and supporting practices to integrate use into care, primary care practices can match or potentially surpass the usage rates achieved by large health systems.",
            "publicationTitle": "Annals of Family Medicine",
            "publisher": "",
            "place": "",
            "date": "2014/09//Sep/Oct2014",
            "volume": "12",
            "issue": "5",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "418-426",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Annals of Family Medicine",
            "DOI": "10.1370/afm.1691",
            "citationKey": "",
            "url": "http://www.proxy.its.virginia.edu/login?url=https://search.ebscohost.com/login.aspx?direct=true&db=a9h&AN=98039924&site=ehost-live",
            "accessDate": "2014-09-19T23:47:54Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "15441709",
            "archive": "",
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            "shortTitle": "",
            "language": "",
            "libraryCatalog": "EBSCOhost",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "COMORBIDITY",
                    "type": 1
                },
                {
                    "tag": "HISPANIC Americans",
                    "type": 1
                },
                {
                    "tag": "MEDICAL records -- Access control",
                    "type": 1
                },
                {
                    "tag": "OLDER patients",
                    "type": 1
                },
                {
                    "tag": "PATIENT-centered care",
                    "type": 1
                },
                {
                    "tag": "PRIMARY care (Medicine)",
                    "type": 1
                },
                {
                    "tag": "Primary Health Care",
                    "type": 1
                },
                {
                    "tag": "health promotion",
                    "type": 1
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                    "tag": "informatics",
                    "type": 1
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                    "type": 1
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]