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"http://stm.sciencemag.org/content/3/82/82ra37.full.pdf", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "PJHWRR9S", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/PJHWRR9S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/PJHWRR9S", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/245045/items/ACPA3RQE", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } } }, "data": { "key": "PJHWRR9S", "version": 3, "parentItem": "ACPA3RQE", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2014-01-28T17:23:41Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462200/", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "NPN86MG8", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/NPN86MG8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/NPN86MG8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Burks et al.", "parsedDate": "2011-05-11", "numChildren": 2 }, "data": { "key": "NPN86MG8", "version": 3, "itemType": "journalArticle", "title": "Losartan Restores Skeletal Muscle Remodeling and Protects Against Disuse Atrophy in Sarcopenia", "creators": [ { "creatorType": "author", "firstName": "Tyesha N.", "lastName": "Burks" }, { "creatorType": "author", "firstName": "Eva", "lastName": "Andres-Mateos" }, { "creatorType": "author", "firstName": "Ruth", "lastName": "Marx" }, { "creatorType": "author", "firstName": "Rebeca", "lastName": "Mejias" }, { "creatorType": "author", "firstName": "Christel Van", "lastName": "Erp" }, { "creatorType": "author", "firstName": "Jessica L.", "lastName": "Simmers" }, { "creatorType": "author", "firstName": "Jeremy D.", "lastName": "Walston" }, { "creatorType": "author", "firstName": "Christopher W.", "lastName": "Ward" }, { "creatorType": "author", "firstName": "Ronald D.", "lastName": "Cohn" } ], "abstractNote": "AbstractBack to Top\nSarcopenia, a critical loss of muscle mass and function because of the physiological process of aging, contributes to disability and mortality in older adults. It increases the incidence of pathologic fractures, causing prolonged periods of hospitalization and rehabilitation. The molecular mechanisms underlying sarcopenia are poorly understood, but recent evidence suggests that increased transforming growth factor–β (TGF-β) signaling contributes to impaired satellite cell function and muscle repair in aged skeletal muscle. We therefore evaluated whether antagonism of TGF-β signaling via losartan, an angiotensin II receptor antagonist commonly used to treat high blood pressure, had a beneficial impact on the muscle remodeling process of sarcopenic mice. We demonstrated that mice treated with losartan developed significantly less fibrosis and exhibited improved in vivo muscle function after cardiotoxin-induced injury. We found that losartan not only blunted the canonical TGF-β signaling cascade but also modulated the noncanonical TGF-β mitogen-activated protein kinase pathway. We next assessed whether losartan was able to combat disuse atrophy in aged mice that were subjected to hindlimb immobilization. We showed that immobilized mice treated with losartan were protected against loss of muscle mass. Unexpectedly, this protective mechanism was not mediated by TGF-β signaling but was due to an increased activation of the insulin-like growth factor 1 (IGF-1)/Akt/mammalian target of rapamycin (mTOR) pathway. Thus, blockade of the AT1 (angiotensin II type I) receptor improved muscle remodeling and protected against disuse atrophy by differentially regulating the TGF-β and IGF-1/Akt/mTOR signaling cascades, two pathways critical for skeletal muscle homeostasis. Thus, losartan, a Food and Drug Administration–approved drug, may prove to have clinical benefits to combat injury-related muscle remodeling and provide protection against disuse atrophy in humans with sarcopenia.", "publicationTitle": "Science Translational Medicine", "publisher": "", "place": "", "date": "05/11/2011", "volume": "3", "issue": "82", "section": "", "partNumber": "", "partTitle": "", "pages": "82ra37-82ra37", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci Transl Med", "DOI": "10.1126/scitranslmed.3002227", "citationKey": "", "url": "http://stm.sciencemag.org/content/3/82/82ra37", "accessDate": "2014-01-27T05:25:09Z", "PMID": "", "PMCID": "", "ISSN": "1946-6234, 1946-6242", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stm.sciencemag.org.mutex.gmu.edu", "callNumber": "", "rights": "", "extra": "PMID: 21562229", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "Q7QQTBQP", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/Q7QQTBQP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/Q7QQTBQP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Minetti et al.", "parsedDate": "2011-11-29", "numChildren": 0 }, "data": { "key": "Q7QQTBQP", "version": 3, "itemType": "journalArticle", "title": "G{alpha}i2 Signaling Promotes Skeletal Muscle Hypertrophy, Myoblast Differentiation, and Muscle Regeneration", "creators": [ { "creatorType": "author", "firstName": "Giulia C.", "lastName": "Minetti" }, { "creatorType": "author", "firstName": "Jerome N.", "lastName": "Feige" }, { "creatorType": "author", "firstName": "Antonia", "lastName": "Rosenstiel" }, { "creatorType": "author", "firstName": "Florian", "lastName": "Bombard" }, { "creatorType": "author", "firstName": "Viktor", "lastName": "Meier" }, { "creatorType": "author", "firstName": "Annick", "lastName": "Werner" }, { "creatorType": "author", "firstName": "Frederic", "lastName": "Bassilana" }, { "creatorType": "author", "firstName": "Andreas W.", "lastName": "Sailer" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Kahle" }, { "creatorType": "author", "firstName": "Christian", "lastName": "Lambert" }, { "creatorType": "author", "firstName": "David J.", "lastName": "Glass" }, { "creatorType": "author", "firstName": "Mara", "lastName": "Fornaro" } ], "abstractNote": "", "publicationTitle": "Science Signaling", "publisher": "", "place": "", "date": "November 29, 2011", "volume": "4", "issue": "201", "section": "", "partNumber": "", "partTitle": "", "pages": "ra80", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci. Signal.", "DOI": "10.1126/scisignal.2002038", "citationKey": "", "url": "http://stke.sciencemag.org/cgi/content/abstract/sigtrans;4/201/ra80", "accessDate": "2014-01-27T03:38:04Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "ACPA3RQE", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/ACPA3RQE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/ACPA3RQE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Zollner et al.", "parsedDate": "2012-10-01", "numChildren": 1 }, "data": { "key": "ACPA3RQE", "version": 3, "itemType": "journalArticle", "title": "Stretching Skeletal Muscle: Chronic Muscle Lengthening through Sarcomerogenesis", "creators": [ { "creatorType": "author", "firstName": "Alexander M.", "lastName": "Zollner" }, { "creatorType": "author", "firstName": "Oscar J.", "lastName": "Abilez" }, { "creatorType": "author", "firstName": "Markus", "lastName": "Bol" }, { "creatorType": "author", "firstName": "Ellen", "lastName": "Kuhl" } ], "abstractNote": "Skeletal muscle responds to passive overstretch through sarcomerogenesis, the creation and serial deposition of new sarcomere units. Sarcomerogenesis is critical to muscle function: It gradually re-positions the muscle back into its optimal operating regime. Animal models of immobilization, limb lengthening, and tendon transfer have provided significant insight into muscle adaptation in vivo. Yet, to date, there is no mathematical model that allows us to predict how skeletal muscle adapts to mechanical stretch in silico. Here we propose a novel mechanistic model for chronic longitudinal muscle growth in response to passive mechanical stretch. We characterize growth through a single scalar-valued internal variable, the serial sarcomere number. Sarcomerogenesis, the evolution of this variable, is driven by the elastic mechanical stretch. To analyze realistic three-dimensional muscle geometries, we embed our model into a nonlinear finite element framework. In a chronic limb lengthening study with a muscle stretch of 1.14, the model predicts an acute sarcomere lengthening from 3.09m to 3.51m, and a chronic gradual return to the initial sarcomere length within two weeks. Compared to the experiment, the acute model error was 0.00% by design of the model; the chronic model error was 2.13%, which lies within the rage of the experimental standard deviation. Our model explains, from a mechanistic point of view, why gradual multi-step muscle lengthening is less invasive than single-step lengthening. It also explains regional variations in sarcomere length, shorter close to and longer away from the muscle-tendon interface. Once calibrated with a richer data set, our model may help surgeons to prevent muscle overstretch and make informed decisions about optimal stretch increments, stretch timing, and stretch amplitudes. We anticipate our study to open new avenues in orthopedic and reconstructive surgery and enhance treatment for patients with ill proportioned limbs, tendon lengthening, tendon transfer, tendon tear, and chronically retracted muscles.", "publicationTitle": "PLoS ONE", "publisher": "", "place": "", "date": "2012-10-1", "volume": "7", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS One", "DOI": "10.1371/journal.pone.0045661", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3462200/", "accessDate": "2014-01-28T17:23:40Z", "PMID": "", "PMCID": "", "ISSN": "1932-6203", "archive": "", "archiveLocation": "", "shortTitle": "Stretching Skeletal Muscle", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 23049683\nPMCID: PMC3462200", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "68K2IBT7", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/68K2IBT7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/68K2IBT7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Sartorelli and Fulco", "parsedDate": "2004-08-03", "numChildren": 0 }, "data": { "key": "68K2IBT7", "version": 3, "itemType": "journalArticle", "title": "Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy", "creators": [ { "creatorType": "author", "firstName": "Vittorio", "lastName": "Sartorelli" }, { "creatorType": "author", "firstName": "Marcella", "lastName": "Fulco" } ], "abstractNote": "The maintenance of adult skeletal muscle mass is ensured by physical exercise. Accordingly, physiological and pathological situations characterized by either impaired motor neuron activity, reduced gravity (microgravity during space flights), or reduced physical activity result in loss of muscle mass. Furthermore, a plethora of clinical conditions, including cancer, sepsis, diabetes, and AIDS, are associated with varying degrees of muscle atrophy. The cellular and molecular pathways responsible for maintaining the skeletal muscle mass are not well defined. Nonetheless, studies aimed at the understanding of the mechanisms underlying either muscular atrophy or hypertrophy have begun to identify the physiological determinants and clarify the molecular pathways responsible for the maintenance of muscle mass.", "publicationTitle": "Science Signaling", "publisher": "", "place": "", "date": "August 3, 2004", "volume": "2004", "issue": "244", "section": "", "partNumber": "", "partTitle": "", "pages": "re11", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci. STKE", "DOI": "10.1126/stke.2442004re11", "citationKey": "", "url": "http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2004/244/re11", "accessDate": "2014-01-27T05:26:26Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "92AVBBE9", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/92AVBBE9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/92AVBBE9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/245045/items/ZCK8KW4W", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } } }, "data": { "key": "92AVBBE9", "version": 3, "parentItem": "ZCK8KW4W", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-27T02:47:45Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23596205", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "I2PZ5PCB", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/I2PZ5PCB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/I2PZ5PCB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/245045/items/5Z5BDKC9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } } }, "data": { "key": "I2PZ5PCB", "version": 3, "parentItem": "5Z5BDKC9", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-27T05:27:03Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20368179", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "JB8CCWTX", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/JB8CCWTX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/JB8CCWTX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/245045/items/5Z5BDKC9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } } }, "data": { "key": "JB8CCWTX", "version": 3, "parentItem": "5Z5BDKC9", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2014-01-27T05:27:03Z", "url": "http://stm.sciencemag.org/content/1/6/6ra15.full.pdf", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "QGDUDPDW", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/QGDUDPDW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/QGDUDPDW", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Hunter and Borg", "parsedDate": "2003-03", "numChildren": 0 }, "data": { "key": "QGDUDPDW", "version": 3, "itemType": "journalArticle", "title": "Integration from proteins to organs: the Physiome Project", "creators": [ { "creatorType": "author", "firstName": "Peter J.", "lastName": "Hunter" }, { "creatorType": "author", "firstName": "Thomas K.", "lastName": "Borg" } ], "abstractNote": "The Physiome Project will provide a framework for modelling the human body, using computational methods that incorporate biochemical, biophysical and anatomical information on cells, tissues and organs. The main project goals are to use computational modelling to analyse integrative biological function and to provide a system for hypothesis testing.", "publicationTitle": "Nature Reviews Molecular Cell Biology", "publisher": "", "place": "", "date": "March 2003", "volume": "4", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "237-243", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Rev Mol Cell Biol", "DOI": "10.1038/nrm1054", "citationKey": "", "url": "http://www.nature.com/nrm/journal/v4/n3/full/nrm1054.html", "accessDate": "2014-01-30T00:22:52Z", "PMID": "", "PMCID": "", "ISSN": "1471-0072", "archive": "", "archiveLocation": "", "shortTitle": "Integration from proteins to organs", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2003 Nature Publishing Group", "extra": "", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "ZCK8KW4W", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/ZCK8KW4W", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/ZCK8KW4W", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Margolin et al.", "parsedDate": "2013-04-17", "numChildren": 1 }, "data": { "key": "ZCK8KW4W", "version": 3, "itemType": "journalArticle", "title": "Systematic Analysis of Challenge-Driven Improvements in Molecular Prognostic Models for Breast Cancer", "creators": [ { "creatorType": "author", "firstName": "Adam A.", "lastName": "Margolin" }, { "creatorType": "author", "firstName": "Erhan", "lastName": "Bilal" }, { "creatorType": "author", "firstName": "Erich", "lastName": "Huang" }, { "creatorType": "author", "firstName": "Thea C.", "lastName": "Norman" }, { "creatorType": "author", "firstName": "Lars", "lastName": "Ottestad" }, { "creatorType": "author", "firstName": "Brigham H.", "lastName": "Mecham" }, { "creatorType": "author", "firstName": "Ben", "lastName": "Sauerwine" }, { "creatorType": "author", "firstName": "Michael R.", "lastName": "Kellen" }, { "creatorType": "author", "firstName": "Lara M.", "lastName": "Mangravite" }, { "creatorType": "author", "firstName": "Matthew D.", "lastName": "Furia" }, { "creatorType": "author", "firstName": "Hans Kristian Moen", "lastName": "Vollan" }, { "creatorType": "author", "firstName": "Oscar M.", "lastName": "Rueda" }, { "creatorType": "author", "firstName": "Justin", "lastName": "Guinney" }, { "creatorType": "author", "firstName": "Nicole A.", "lastName": "Deflaux" }, { "creatorType": "author", "firstName": "Bruce", "lastName": "Hoff" }, { "creatorType": "author", "firstName": "Xavier", "lastName": "Schildwachter" }, { "creatorType": "author", "firstName": "Hege G.", "lastName": "Russnes" }, { "creatorType": "author", "firstName": "Daehoon", "lastName": "Park" }, { "creatorType": "author", "firstName": "Veronica O.", "lastName": "Vang" }, { "creatorType": "author", "firstName": "Tyler", "lastName": "Pirtle" }, { "creatorType": "author", "firstName": "Lamia", "lastName": "Youseff" }, { "creatorType": "author", "firstName": "Craig", "lastName": "Citro" }, { "creatorType": "author", "firstName": "Christina", "lastName": "Curtis" }, { "creatorType": "author", "firstName": "Vessela N.", "lastName": "Kristensen" }, { "creatorType": "author", "firstName": "Joseph", "lastName": "Hellerstein" }, { "creatorType": "author", "firstName": "Stephen H.", "lastName": "Friend" }, { "creatorType": "author", "firstName": "Gustavo", "lastName": "Stolovitzky" }, { "creatorType": "author", "firstName": "Samuel", "lastName": "Aparicio" }, { "creatorType": "author", "firstName": "Carlos", "lastName": "Caldas" }, { "creatorType": "author", "firstName": "Anne-Lise", "lastName": "Børresen-Dale" } ], "abstractNote": "AbstractBack to Top\nAlthough molecular prognostics in breast cancer are among the most successful examples of translating genomic analysis to clinical applications, optimal approaches to breast cancer clinical risk prediction remain controversial. The Sage Bionetworks–DREAM Breast Cancer Prognosis Challenge (BCC) is a crowdsourced research study for breast cancer prognostic modeling using genome-scale data. The BCC provided a community of data analysts with a common platform for data access and blinded evaluation of model accuracy in predicting breast cancer survival on the basis of gene expression data, copy number data, and clinical covariates. This approach offered the opportunity to assess whether a crowdsourced community Challenge would generate models of breast cancer prognosis commensurate with or exceeding current best-in-class approaches. The BCC comprised multiple rounds of blinded evaluations on held-out portions of data on 1981 patients, resulting in more than 1400 models submitted as open source code. Participants then retrained their models on the full data set of 1981 samples and submitted up to five models for validation in a newly generated data set of 184 breast cancer patients. Analysis of the BCC results suggests that the best-performing modeling strategy outperformed previously reported methods in blinded evaluations; model performance was consistent across several independent evaluations; and aggregating community-developed models achieved performance on par with the best-performing individual models.", "publicationTitle": "Science Translational Medicine", "publisher": "", "place": "", "date": "04/17/2013", "volume": "5", "issue": "181", "section": "", "partNumber": "", "partTitle": "", "pages": "181re1-181re1", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci Transl Med", "DOI": "10.1126/scitranslmed.3006112", "citationKey": "", "url": "http://stm.sciencemag.org/content/5/181/181re1", "accessDate": "2014-01-27T02:47:31Z", "PMID": "", "PMCID": "", "ISSN": "1946-6234, 1946-6242", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stm.sciencemag.org", "callNumber": "", "rights": "", "extra": "PMID: 23596205", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "5Z5BDKC9", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/5Z5BDKC9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/5Z5BDKC9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Kota et al.", "parsedDate": "2009-11-11", "numChildren": 2 }, "data": { "key": "5Z5BDKC9", "version": 3, "itemType": "journalArticle", "title": "Follistatin Gene Delivery Enhances Muscle Growth and Strength in Nonhuman Primates", "creators": [ { "creatorType": "author", "firstName": "Janaiah", "lastName": "Kota" }, { "creatorType": "author", "firstName": "Chalonda R.", "lastName": "Handy" }, { "creatorType": "author", "firstName": "Amanda M.", "lastName": "Haidet" }, { "creatorType": "author", "firstName": "Chrystal L.", "lastName": "Montgomery" }, { "creatorType": "author", "firstName": "Amy", "lastName": "Eagle" }, { "creatorType": "author", "firstName": "Louise R.", "lastName": "Rodino-Klapac" }, { "creatorType": "author", "firstName": "Danielle", "lastName": "Tucker" }, { "creatorType": "author", "firstName": "Christopher J.", "lastName": "Shilling" }, { "creatorType": "author", "firstName": "Walter R.", "lastName": "Therlfall" }, { "creatorType": "author", "firstName": "Christopher M.", "lastName": "Walker" }, { "creatorType": "author", "firstName": "Steven E.", "lastName": "Weisbrode" }, { "creatorType": "author", "firstName": "Paul M. L.", "lastName": "Janssen" }, { "creatorType": "author", "firstName": "K. Reed", "lastName": "Clark" }, { "creatorType": "author", "firstName": "Zarife", "lastName": "Sahenk" }, { "creatorType": "author", "firstName": "Jerry R.", "lastName": "Mendell" }, { "creatorType": "author", "firstName": "Brian K.", "lastName": "Kaspar" } ], "abstractNote": "AbstractBack to Top\nAntagonists of myostatin, a blood-borne negative regulator of muscle growth produced in muscle cells, have shown considerable promise for enhancing muscle mass and strength in rodent studies and could serve as potential therapeutic agents for human muscle diseases. One of the most potent of these agents, follistatin, is both safe and effective in mice, but similar tests have not been performed in nonhuman primates. To assess this important criterion for clinical translation, we tested an alternatively spliced form of human follistatin that affects skeletal muscle but that has only minimal effects on nonmuscle cells. When injected into the quadriceps of cynomolgus macaque monkeys, a follistatin isoform expressed from an adeno-associated virus serotype 1 vector, AAV1-FS344, induced pronounced and durable increases in muscle size and strength. Long-term expression of the transgene did not produce any abnormal changes in the morphology or function of key organs, indicating the safety of gene delivery by intramuscular injection of an AAV1 vector. Our results, together with the findings in mice, suggest that therapy with AAV1-FS344 may improve muscle mass and function in patients with certain degenerative muscle disorders.", "publicationTitle": "Science Translational Medicine", "publisher": "", "place": "", "date": "11/11/2009", "volume": "1", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "6ra15-6ra15", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci Transl Med", "DOI": "10.1126/scitranslmed.3000112", "citationKey": "", "url": "http://stm.sciencemag.org/content/1/6/6ra15", "accessDate": "2014-01-27T05:27:01Z", "PMID": "", "PMCID": "", "ISSN": "1946-6234, 1946-6242", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "stm.sciencemag.org.mutex.gmu.edu", "callNumber": "", "rights": "", "extra": "PMID: 20368179", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } }, { "key": "5ENRWMA9", "version": 3, "library": { "type": "group", "id": 245045, "name": "BENG 495", "links": { "alternate": { "href": "https://www.zotero.org/groups/beng_495", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/245045/items/5ENRWMA9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/beng_495/items/5ENRWMA9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1618755, "username": "cedeno", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cedeno", "type": "text/html" } } }, "creatorSummary": "Sartorelli and Fulco", "parsedDate": "2004-08-03", "numChildren": 0 }, "data": { "key": "5ENRWMA9", "version": 3, "itemType": "journalArticle", "title": "Molecular and Cellular Determinants of Skeletal Muscle Atrophy and Hypertrophy", "creators": [ { "creatorType": "author", "firstName": "Vittorio", "lastName": "Sartorelli" }, { "creatorType": "author", "firstName": "Marcella", "lastName": "Fulco" } ], "abstractNote": "The maintenance of adult skeletal muscle mass is ensured by physical exercise. Accordingly, physiological and pathological situations characterized by either impaired motor neuron activity, reduced gravity (microgravity during space flights), or reduced physical activity result in loss of muscle mass. Furthermore, a plethora of clinical conditions, including cancer, sepsis, diabetes, and AIDS, are associated with varying degrees of muscle atrophy. The cellular and molecular pathways responsible for maintaining the skeletal muscle mass are not well defined. Nonetheless, studies aimed at the understanding of the mechanisms underlying either muscular atrophy or hypertrophy have begun to identify the physiological determinants and clarify the molecular pathways responsible for the maintenance of muscle mass.", "publicationTitle": "Science Signaling", "publisher": "", "place": "", "date": "August 3, 2004", "volume": "2004", "issue": "244", "section": "", "partNumber": "", "partTitle": "", "pages": "re11", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Sci. STKE", "DOI": "10.1126/stke.2442004re11", "citationKey": "", "url": "http://stke.sciencemag.org/cgi/content/abstract/sigtrans;2004/244/re11", "accessDate": "2014-01-27T04:42:33Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AWTFVBUA" ], "relations": {}, "dateAdded": "2014-01-30T02:01:56Z", "dateModified": "2014-01-30T02:01:56Z" } } ]