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                    "firstName": "Søren P.",
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            "abstractNote": "We examined the predictive value of the discharge diagnoses of stroke and transient ischemic attack (TIA) in The National Registry of Patients (NRP) for participants in the Danish cohort study \"Diet, Cancer, and Health.\" We retrieved all probable incident registered cases of stroke and TIA, i.e., ICD-10: I60-69.8, or G45 (n = 581) within the cohort from the NRP. Medical records and hospital discharge summaries were retrieved and reviewed using a standardized form. Overall, 299 of 377 cases (79.3%, 95% CI: 74.9-83.3%) of stroke recorded were confirmed. Subarachnoidal hemorrhage and intracerebral hemorrhage were confirmed in 14 of 29 cases (48.3%, 95% CI: 29.4-67.5%), and 23 of 35 cases (65.7%, 95% CI: 47.8-80.9%), respectively. By contrast, ischemic stroke and unspecified stroke were confirmed in 99 of 113 cases (87.6%, 95% CI: 80.1-93.1%) and 152 of 200 cases (76.0%, 95% CI: 69.5-81.7%), respectively. Among 134 patients with a TIA discharge diagnosis, 60.4% (95% CI: 51.6-68.8%) were confirmed. Discharge diagnoses from emergency rooms had lower overall predictive value (48.8%, 95% CI: 39.9-57.8%) than discharge diagnoses from departments of internal medicine (68.8%, 95% CI: 61.3-75.5%) and departments of neurology or neurosurgery (77.9%, 95% CI: 72.3-82.7%). We conclude that stroke and TIA diagnoses in NRP should be used with caution in epidemiological research because the low predictive value for some diagnostic subgroups may lead to serious misclassification and biased results.",
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            "key": "78VW2MJW",
            "version": 309,
            "itemType": "journalArticle",
            "title": "Predictive values of acute coronary syndrome discharge diagnoses differed in the Danish National Patient Registry",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Albert Marni",
                    "lastName": "Joensen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Majken K.",
                    "lastName": "Jensen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kim",
                    "lastName": "Overvad"
                },
                {
                    "creatorType": "author",
                    "firstName": "Claus",
                    "lastName": "Dethlefsen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Erik",
                    "lastName": "Schmidt"
                },
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                    "creatorType": "author",
                    "firstName": "Lars",
                    "lastName": "Rasmussen"
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            "abstractNote": "OBJECTIVE: To investigate the predictive value of acute coronary syndrome (ACS) diagnoses, including unstable angina pectoris, myocardial infarction, and cardiac arrest, in the Danish National Patient Registry.\nSTUDY DESIGN AND SETTING: We identified all first-time ACS diagnoses in the Danish National Patient Registry among participants in the Danish cohort study \"Diet, Cancer and Health\" through the end of 2003. We retrieved and reviewed medical records based on current European Society of Cardiology criteria for ACS.\nRESULTS: We reviewed hospital medical records of 1,577 out of 1,654 patients (95.3%) who had been hospitalized with a first-time ACS diagnosis. The overall positive predictive value for ACS was 65.5% (95% confidence interval [CI]=63.1-67.9%). Stratification by sub-diagnosis and hospital department produced significantly higher positive predictive values for myocardial infarction diagnoses (81.9%; 95% CI=79.5-84.2%) and among patients who received an ACS diagnosis in a ward (80.1%; 95% CI=77.7-82.3%).\nCONCLUSION: The ACS diagnoses contained in hospital discharge registries should be used with caution. If validation is not possible, restricting analyses to patients with myocardial infarction and/or patients discharged from wards might be a useful alternative.",
            "publicationTitle": "Journal of Clinical Epidemiology",
            "publisher": "",
            "place": "",
            "date": "Feb 2009",
            "volume": "62",
            "issue": "2",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "188-194",
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            "journalAbbreviation": "J Clin Epidemiol",
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            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
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                    "tag": "Acute Coronary Syndrome",
                    "type": 1
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                    "tag": "Angina, Unstable",
                    "type": 1
                },
                {
                    "tag": "Cohort Studies",
                    "type": 1
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                    "tag": "Denmark",
                    "type": 1
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                    "tag": "Female",
                    "type": 1
                },
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                    "tag": "Heart Arrest",
                    "type": 1
                },
                {
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                    "type": 1
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                    "type": 1
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                    "type": 1
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                {
                    "tag": "Medical Audit",
                    "type": 1
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                {
                    "tag": "Medical Records",
                    "type": 1
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                    "tag": "Middle Aged",
                    "type": 1
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                    "tag": "Myocardial Infarction",
                    "type": 1
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                    "type": 1
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                    "type": 1
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            "creatorSummary": "Haycock et al.",
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            "itemType": "journalArticle",
            "title": "Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Philip C",
                    "lastName": "Haycock"
                },
                {
                    "creatorType": "author",
                    "firstName": "Emma E",
                    "lastName": "Heydon"
                },
                {
                    "creatorType": "author",
                    "firstName": "Stephen",
                    "lastName": "Kaptoge"
                },
                {
                    "creatorType": "author",
                    "firstName": "Adam S",
                    "lastName": "Butterworth"
                },
                {
                    "creatorType": "author",
                    "firstName": "Alex",
                    "lastName": "Thompson"
                },
                {
                    "creatorType": "author",
                    "firstName": "Peter",
                    "lastName": "Willeit"
                }
            ],
            "abstractNote": "Objective To assess the association between leucocyte telomere length and risk of cardiovascular disease., Design Systematic review and meta-analysis., Data sources Studies published up to March 2014 identified through searches of Medline, Web of Science, and Embase., Eligibility criteria Prospective and retrospective studies that reported on associations between leucocyte telomere length and coronary heart disease (defined as non-fatal myocardial infarction, coronary heart disease death, or coronary revascularisation) or cerebrovascular disease (defined as non-fatal stroke or death from cerebrovascular disease) and were broadly representative of general populations—that is, they did not select cohort or control participants on the basis of pre-existing cardiovascular disease or diabetes., Results Twenty four studies involving 43 725 participants and 8400 patients with cardiovascular disease (5566 with coronary heart disease and 2834 with cerebrovascular disease) were found to be eligible. In a comparison of the shortest versus longest third of leucocyte telomere length, the pooled relative risk for coronary heart disease was 1.54 (95% confidence interval 1.30 to 1.83) in all studies, 1.40 (1.15 to 1.70) in prospective studies, and 1.80 (1.32 to 2.44) in retrospective studies. Heterogeneity between studies was moderate (I2=64%, 41% to 77%, Phet<0.001) and was not significantly explained by mean age of participants (P=0.23), the proportion of male participants (P=0.45), or distinction between retrospective versus prospective studies (P=0.32). Findings for coronary heart disease were similar in meta-analyses restricted to studies that adjusted for conventional vascular risk factors (relative risk 1.42, 95% confidence interval 1.17 to 1.73); studies with ≥200 cases (1.44, 1.20 to 1.74); studies with a high quality score (1.53, 1.22 to 1.92); and in analyses that corrected for publication bias (1.34, 1.12 to 1.60). The pooled relative risk for cerebrovascular disease was 1.42 (1.11 to 1.81), with no significant heterogeneity between studies (I2=41%, 0% to 72%, Phet=0.08). Shorter telomeres were not significantly associated with cerebrovascular disease risk in prospective studies (1.14, 0.85 to 1.54) or in studies with a high quality score (1.21, 0.83 to 1.76)., Conclusion Available observational data show an inverse association between leucocyte telomere length and risk of coronary heart disease independent of conventional vascular risk factors. The association with cerebrovascular disease is less certain.",
            "publicationTitle": "BMJ : British Medical Journal",
            "publisher": "",
            "place": "",
            "date": "2014-7-8",
            "volume": "349",
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            "partNumber": "",
            "partTitle": "",
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            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "BMJ",
            "DOI": "10.1136/bmj.g4227",
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            "accessDate": "",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0959-8138",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "Leucocyte telomere length and risk of cardiovascular disease",
            "language": "",
            "libraryCatalog": "PubMed Central",
            "callNumber": "",
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            "extra": "PMID: 25006006\nPMCID: PMC4086028",
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