[ { "key": "MM2XUB9M", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/MM2XUB9M", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/MM2XUB9M", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Bennardo et al.", "parsedDate": "2009-10", "numChildren": 1 }, "data": { "key": "MM2XUB9M", "version": 6, "itemType": "journalArticle", "title": "Limiting the persistence of a chromosome break diminishes its mutagenic potential", "creators": [ { "creatorType": "author", "firstName": "Nicole", "lastName": "Bennardo" }, { "creatorType": "author", "firstName": "Amanda", "lastName": "Gunn" }, { "creatorType": "author", "firstName": "Anita", "lastName": "Cheng" }, { "creatorType": "author", "firstName": "Paul", "lastName": "Hasty" }, { "creatorType": "author", "firstName": "Jeremy M", "lastName": "Stark" } ], "abstractNote": "To characterize the repair pathways of chromosome double-strand breaks (DSBs), one approach involves monitoring the repair of site-specific DSBs generated by rare-cutting endonucleases, such as I-SceI. Using this method, we first describe the roles of Ercc1, Msh2, Nbs1, Xrcc4, and Brca1 in a set of distinct repair events. Subsequently, we considered that the outcome of such assays could be influenced by the persistent nature of I-SceI-induced DSBs, in that end-joining (EJ) products that restore the I-SceI site are prone to repeated cutting. To address this aspect of repair, we modified I-SceI-induced DSBs by co-expressing I-SceI with a non-processive 3' exonuclease, Trex2, which we predicted would cause partial degradation of I-SceI 3' overhangs. We find that Trex2 expression facilitates the formation of I-SceI-resistant EJ products, which reduces the potential for repeated cutting by I-SceI and, hence, limits the persistence of I-SceI-induced DSBs. Using this approach, we find that Trex2 expression causes a significant reduction in the frequency of repair pathways that result in substantial deletion mutations: EJ between distal ends of two tandem DSBs, single-strand annealing, and alternative-NHEJ. In contrast, Trex2 expression does not inhibit homology-directed repair. These results indicate that limiting the persistence of a DSB causes a reduction in the frequency of repair pathways that lead to significant genetic loss. Furthermore, we find that individual genetic factors play distinct roles during repair of non-cohesive DSB ends that are generated via co-expression of I-SceI with Trex2.", "publicationTitle": "PLoS genetics", "publisher": "", "place": "", "date": "Oct 2009", "volume": "5", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "e1000683", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS Genet.", "DOI": "10.1371/journal.pgen.1000683", "citationKey": "", "url": "", "accessDate": "", "PMID": "19834534", "PMCID": "", "ISSN": "1553-7404", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Cells, Cultured", "type": 1 }, { "tag": "Chromosome Breakage", "type": 1 }, { "tag": "DNA Breaks, Double-Stranded", "type": 1 }, { "tag": "DNA Repair", "type": 1 }, { "tag": "Deoxyribonucleases, Type II Site-Specific", "type": 1 }, { "tag": "Exodeoxyribonucleases", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mutagenesis", "type": 1 }, { "tag": "Saccharomyces cerevisiae Proteins", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-01-06T06:33:23Z", "dateModified": "2014-01-06T06:33:23Z" } }, { "key": "RFPPHBG2", "version": 5, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/RFPPHBG2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/RFPPHBG2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/240207/items/MM2XUB9M", "type": "application/json" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } } }, "data": { "key": "RFPPHBG2", "version": 5, "parentItem": "MM2XUB9M", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-06T06:33:23Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19834534", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-06T06:33:23Z", "dateModified": "2014-01-06T06:33:23Z" } }, { "key": "8DDJM3CT", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/8DDJM3CT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/8DDJM3CT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Gunn and Stark", "parsedDate": "2012", "numChildren": 1 }, "data": { "key": "8DDJM3CT", "version": 6, "itemType": "journalArticle", "title": "I-SceI-based assays to examine distinct repair outcomes of mammalian chromosomal double strand breaks", "creators": [ { "creatorType": "author", "firstName": "Amanda", "lastName": "Gunn" }, { "creatorType": "author", "firstName": "Jeremy M", "lastName": "Stark" } ], "abstractNote": "Chromosomal double strand breaks (DSBs) can be repaired by a number of mechanisms that result in diverse genetic outcomes. To examine distinct outcomes of chromosomal DSB repair, a panel of human cell lines has been developed that contain GFP-based reporters with recognition sites for the rare-cutting endonuclease I-SceI. One set of reporters is used to measure DSB repair events that require access to homology: homology-directed repair, homology-directed repair that requires the removal of a nonhomologous insertion, single strand annealing, and alternative end joining. An additional reporter (EJ5-GFP) is used to measure end joining (EJ) between distal DSB ends of two tandem I-SceI sites. These Distal-EJ events do not require access to homology, and thus are distinct from the repair events described above. Indeed, this assay provides a measure of DSB end protection during EJ, via physical analysis of Distal-EJ products to determine the frequency of I-SceI-restoration. The EJ5-GFP reporter can also be adapted to examine EJ of non-cohesive DSB ends, using co-expression of I-SceI with a non-processive 3' exonuclease (Trex2), which can cause partial degradation of the 4 nucleotide 3' cohesive overhangs generated by I-SceI. Such co-expression of I-SceI and Trex2 leads to measurable I-SceI-resistant EJ products that use proximal DSB ends (Proximal-EJ), as well as distal DSB ends (Distal-EJ). Therefore, this co-expression approach can be used to examine the relative frequency of Proximal-EJ versus Distal-EJ, and hence provide a measure of the fidelity of end utilization during repair of multiple DSBs. In this report, the repair outcomes examined by each reporter are described, along with methods for cell culture, transient expression of I-SceI and Trex2, and repair product analysis.", "publicationTitle": "Methods in molecular biology (Clifton, N.J.)", "publisher": "", "place": "", "date": "2012", "volume": "920", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "379-391", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Methods Mol. Biol.", "DOI": "10.1007/978-1-61779-998-3_27", "citationKey": "", "url": "", "accessDate": "", "PMID": "22941618", "PMCID": "", "ISSN": "1940-6029", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Chromosomes, Mammalian", "type": 1 }, { "tag": "DNA Breaks, Double-Stranded", "type": 1 }, { "tag": "DNA Repair", "type": 1 }, { "tag": "Deoxyribonucleases, Type II Site-Specific", "type": 1 }, { "tag": "Flow Cytometry", "type": 1 }, { "tag": "Genes, Reporter", "type": 1 }, { "tag": "Genetic Techniques", "type": 1 }, { "tag": "HEK293 Cells", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Mutagenesis", "type": 1 }, { "tag": "Polymerase Chain Reaction", "type": 1 }, { "tag": "RNA, Small Interfering", "type": 1 }, { "tag": "Transfection", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2014-01-06T06:32:37Z", "dateModified": "2014-01-06T06:32:37Z" } }, { "key": "9CUKSMCI", "version": 4, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/9CUKSMCI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/9CUKSMCI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/240207/items/8DDJM3CT", "type": "application/json" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } } }, "data": { "key": "9CUKSMCI", "version": 4, "parentItem": "8DDJM3CT", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-01-06T06:32:37Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22941618", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-01-06T06:32:37Z", "dateModified": "2014-01-06T06:32:37Z" } }, { "key": "4XRKVXUD", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/4XRKVXUD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/4XRKVXUD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Weiser et al.", "parsedDate": "2013-12-05", "numChildren": 1 }, "data": { "key": "4XRKVXUD", "version": 6, "itemType": "journalArticle", "title": "Premedication with midazolam for urethral catheterization of febrile infants", "creators": [ { "creatorType": "author", "firstName": "Giora", "lastName": "Weiser" }, { "creatorType": "author", "firstName": "Dana", "lastName": "Cohen" }, { "creatorType": "author", "firstName": "Baruch", "lastName": "Krauss" }, { "creatorType": "author", "firstName": "Roger", "lastName": "Galbraith" }, { "creatorType": "author", "firstName": "Itai", "lastName": "Shavit" } ], "abstractNote": "Febrile infants undergoing urethral catheterization (UC) are often not treated for pain and distress. The aim was to evaluate the effectiveness of midazolam premedication. We compared a convenience sample of infants who underwent UC with midazolam with those who did not receive midazolam. Outcome measures were Visual Analog Scale assessment, duration of cry, and emergency department length of stay. Thirty-two study participants and 18 controls were prospectively enrolled. Midazolam premedication showed a 53% decrease in the mean Visual Analog Scale score when parents assessed distress (33.6 vs. 71.7, P<0.0001) and a 48% decrease when nurses assessed distress (28.7 vs. 55.5, P<0.0002); the median cry duration was significantly shorter (0 vs. 240 s). Serious adverse events were not observed during sedation and at 48 h after discharge. Study participants had longer emergency department length of stay compared with the controls (191.5 vs. 139 min, P<0.017). In this cohort, midazolam significantly reduced the distress associated with UC without causing serious adverse events.", "publicationTitle": "European journal of emergency medicine: official journal of the European Society for Emergency Medicine", "publisher": "", "place": "", "date": "Dec 5, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Eur J Emerg Med", "DOI": "10.1097/MEJ.0000000000000080", "citationKey": "", "url": "", "accessDate": "", "PMID": "24323046", "PMCID": "", "ISSN": "1473-5695", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AIKW34T7" ], "relations": {}, "dateAdded": "2014-01-04T22:36:26Z", "dateModified": "2014-01-04T22:36:26Z" } }, { "key": "XFRSTSUE", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/XFRSTSUE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/XFRSTSUE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Merry et al.", "parsedDate": "2013-12", "numChildren": 1 }, "data": { "key": "XFRSTSUE", "version": 6, "itemType": "journalArticle", "title": "Randomized comparison between the combination of acetaminophen and ibuprofen and each constituent alone for analgesia following tonsillectomy in children", "creators": [ { "creatorType": "author", "firstName": "Alan F", "lastName": "Merry" }, { "creatorType": "author", "firstName": "Kylie-Ellen", "lastName": "Edwards" }, { "creatorType": "author", "firstName": "Zahoor", "lastName": "Ahmad" }, { "creatorType": "author", "firstName": "Colin", "lastName": "Barber" }, { "creatorType": "author", "firstName": "Murali", "lastName": "Mahadevan" }, { "creatorType": "author", "firstName": "Chris", "lastName": "Frampton" } ], "abstractNote": "PURPOSE: Combined acetaminophen and ibuprofen may be more effective than either constituent alone for pain in adults. The combination was compared with the individual constituents for analgesia following tonsillectomy in children.\nMETHODS: One hundred and fifty-two children (6-14 yr) undergoing tonsillectomy were randomized to receive either combination acetaminophen (48 mg·kg(-1)·day(-1)) and ibuprofen (24 mg·kg(-1)·day(-1)) or the same doses of acetaminophen alone or ibuprofen alone, every six hours for 48 hr. The primary outcome measure was a time-corrected area under the curve (AUCt) calculated from assessments on a 100-mm visual analogue scale (with Wong Baker FACES(®) as anchors). At each assessment the children rated pain while at rest and on swallowing at multiple time points over the study duration. Secondary outcome measures were a global pain rating, requirement for rescue analgesia, sleep disturbance, and frequency of adverse events.\nRESULTS: The mean [standard error of the mean (SEM)] AUCt values at rest were; combination 29.6 (1.9), acetaminophen 30.4 (2.0), ibuprofen 34 (1.9). The mean (SEM) AUCt values on swallowing were; combination 39.1 (2.0), acetaminophen 39.9 (2.0), ibuprofen 43.7 (1.9). The mean (95% confidence interval) differences in AUCt values between groups on swallowing were: combination vs acetaminophen -0.9 (-6.2 to 4.5); combination vs ibuprofen -4.6 (-9.9 to 0.67) and at rest were: combination vs acetaminophen -0.81 (-6.11 to 4.48); combination vs ibuprofen -4.37 (-9.62 to 0.88). Differences between groups were not clinically important for the pain scores, similarly for the secondary outcomes.\nCONCLUSION: The combination of ibuprofen and acetaminophen was not superior to its individual components in the regimen studied in this pediatric population undergoing tonsillectomy. The study was registered with the Australia New Zealand Clinical Trial Registry (ACTRN12607000005459) on January 4, 2007.", "publicationTitle": "Canadian journal of anaesthesia = Journal canadien d'anesthesie", "publisher": "", "place": "", "date": "Dec 2013", "volume": "60", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "1180-1189", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Can J Anaesth", "DOI": "10.1007/s12630-013-0043-3", "citationKey": "", "url": "", "accessDate": "", "PMID": "24150660", "PMCID": "", "ISSN": "1496-8975", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "ENG", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AIKW34T7" ], "relations": {}, "dateAdded": "2014-01-04T22:36:26Z", "dateModified": "2014-01-04T22:36:26Z" } }, { "key": "5ETZBEP9", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/5ETZBEP9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/5ETZBEP9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Pace et al.", "parsedDate": "2013", "numChildren": 2 }, "data": { "key": "5ETZBEP9", "version": 6, "itemType": "journalArticle", "title": "Pain management in urology training: A national survey of senior residents", "creators": [ { "creatorType": "author", "firstName": "Jonathan", "lastName": "Pace" }, { "creatorType": "author", "firstName": "Melanie", "lastName": "Jaeger" }, { "creatorType": "author", "firstName": "J. Curtis", "lastName": "Nickel" }, { "creatorType": "author", "firstName": "D. Robert", "lastName": "Siemens" } ], "abstractNote": "Introduction:\nWe explore the attitudes and experience of urology residents toward acute and chronic pain management during their training.\n\nMethod:\nA convenience sample of Canadian Urology chief residents were invited to complete an anonymous questionnaire involving both open and closed-ended questions using a 5-point Likert scale. Descriptive and quantitative statistics were used to analyze the attitudes toward pain management, including their experience and training issues.\n\nResults:\nThe response rate was 97%. Most residents agreed or strongly agreed that more formal training in acute pain (77% agreement, mean 4.03 ± 0.98 SD) and chronic pain (68%, 3.97 ± 0.95) management would be valuable in urology residency with only 1 respondent disagreeing that training should be mandatory. There was a significant difference of training experience in chronic versus acute pain management, with only 13% agreement (2.99 ± 0.67) that their training in chronic pain was adequate. Most residents agreed (74%, 3.84 ± 1.00) that most of their training in pain management came from their senior residents or fellows. Many of the residents (65%, 3.61 ± 0.84) felt that they could manage their patients’ acute pain issues independently, even in the absence of an acute pain service, although apparent knowledge of opioids was poor.\n\nConclusions:\nThe results of this survey suggest that urology residents attain their knowledge of pain management experientially with what may be insufficient formal training, particularly in chronic pain. These observations are limited by the relatively small number of respondents and by the nature of a cross-sectional, self-reported survey; however, they would appear to underscore a need to redouble efforts in residency education.", "publicationTitle": "Canadian Urological Association Journal", "publisher": "", "place": "", "date": "2013", "volume": "7", "issue": "11-12", "section": "", "partNumber": "", "partTitle": "", "pages": "456-461", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Can Urol Assoc J", "DOI": "10.5489/cuaj.1562", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3876451/", "accessDate": "2014-01-04T21:50:25Z", "PMID": "24381670", "PMCID": "PMC3876451", "ISSN": "1911-6470", "archive": "", "archiveLocation": "", "shortTitle": "Pain management in urology training", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "AIKW34T7" ], "relations": {}, "dateAdded": "2014-01-04T22:36:26Z", "dateModified": "2014-01-04T22:36:26Z" } }, { "key": "UC9NGC79", "version": 6, "library": { "type": "group", "id": 240207, "name": "Postoperative Pediatric Pain Assessment", "links": { "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/240207/items/UC9NGC79", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/postoperative_pediatric_pain_assessment/items/UC9NGC79", "type": "text/html" } }, "meta": { "createdByUser": { "id": 443349, "username": "tmandt", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/tmandt", "type": "text/html" } } }, "creatorSummary": "Stinson et al.", "parsedDate": "2006-11", "numChildren": 1 }, "data": { "key": "UC9NGC79", "version": 6, "itemType": "journalArticle", "title": "Systematic review of the psychometric properties, interpretability and feasibility of self-report pain intensity measures for use in clinical trials in children and adolescents", "creators": [ { "creatorType": "author", "firstName": "Jennifer N", "lastName": "Stinson" }, { "creatorType": "author", "firstName": "Tricia", "lastName": "Kavanagh" }, { "creatorType": "author", "firstName": "Janet", "lastName": "Yamada" }, { "creatorType": "author", "firstName": "Navreet", "lastName": "Gill" }, { "creatorType": "author", "firstName": "Bonnie", "lastName": "Stevens" } ], "abstractNote": "The aim of this study was to systematically review the psychometric properties, interpretability and feasibility of self-report pain intensity measures for children and adolescents for use in clinical trials evaluating pain treatments. Databases were searched for self-report measures of single-item ratings of pain intensity for children aged 3-18 years. A total of 34 single-item self-report measures were found. The measures' psychometric properties, interpretability and feasibility, were evaluated independently by two investigators according to a set of psychometric criteria. Six single-item measures met the a priori criteria and were included in the final analysis. While these six scales were determined as psychometrically sound and show evidence of responsivity, they had varying degrees of interpretability and feasibility. No single scale was found to be optimal for use with all types of pain or across the developmental age span. Specific recommendations regarding the most psychometrically sound and feasible measures based on age/developmental level and type of pain are discussed. Future research is needed to strengthen the measurement of pain in clinical trials with children.", "publicationTitle": "Pain", "publisher": "", "place": "", "date": "Nov 2006", "volume": "125", "issue": "1-2", "section": "", "partNumber": "", "partTitle": "", "pages": "143-157", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pain", "DOI": "10.1016/j.pain.2006.05.006", "citationKey": "", "url": "", "accessDate": "", "PMID": "16777328", "PMCID": "", "ISSN": "1872-6623", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Adolescent", "type": 1 }, { "tag": "Child", "type": 1 }, { "tag": "Child, Preschool", "type": 1 }, { "tag": "Clinical Trials as Topic", "type": 1 }, { "tag": "Feasibility Studies", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Outcome Assessment (Health 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