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    {
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            "itemType": "journalArticle",
            "title": "(18)F-FDG PET/CT surveillance at 3-6 and 12 months for detection of recurrence and second primary cancer in patients with head and neck squamous cell carcinoma",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "J W",
                    "lastName": "Kim"
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                {
                    "creatorType": "author",
                    "firstName": "J-L",
                    "lastName": "Roh"
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                {
                    "creatorType": "author",
                    "firstName": "J S",
                    "lastName": "Kim"
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                    "firstName": "J H",
                    "lastName": "Lee"
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                {
                    "creatorType": "author",
                    "firstName": "K-J",
                    "lastName": "Cho"
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                    "creatorType": "author",
                    "firstName": "S-H",
                    "lastName": "Choi"
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                    "firstName": "S Y",
                    "lastName": "Nam"
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                    "creatorType": "author",
                    "firstName": "S Y",
                    "lastName": "Kim"
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            ],
            "abstractNote": "Background:Early detection of recurrence of head and neck squamous cell carcinoma (HNSCC), which is often obscured by surgical or radiotherapy-induced tissue distortion, is essential for proper patient management.Methods:A total of 143 consecutive patients with previously untreated HNSCC were evaluated by whole-body fluorine 18-fluorodeoxyglucose positron emission tomography/computed tomography ((18)F-FDG PET/CT) and regular clinical follow-up after curative treatment. The (18)F-FDG PET/CT was performed ∼3-6 and 12 months after treatment and findings suspicious for recurrence or SPC were confirmed using histopathology.Results:The sensitivities of 3-6- and 12-month PET/CT scans at patient level were 96% and 93%, respectively, and those of regular clinical follow-up were 11% and 19%, respectively (McNemar test, P<0.001). In patients with no clinical suspicion, PET/CT detected 95% and 91% of recurrent patients at 3-6 and 12 months, respectively. The sensitivity of PET/CT for the identification of SPC was 29% and 80% at 3-6 and 12 months, respectively. A positive interpretation of PET/CT was significantly associated with poor overall survival (log-rank test, P<0.001).Conclusion:The (18)F-FDG PET/CT surveillance is beneficial for the detection of recurrence that may be missed by regular follow-up physical and endoscopic examinations of the head and neck area after curative treatment for HNSCC.",
            "publicationTitle": "British journal of cancer",
            "publisher": "",
            "place": "",
            "date": "Dec 10, 2013",
            "volume": "109",
            "issue": "12",
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            "pages": "2973-2979",
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            "DOI": "10.1038/bjc.2013.668",
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            "title": "Prediction of nodal metastasis in head and neck cancer using a 3T MRI ADC map",
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                {
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                    "firstName": "M-C",
                    "lastName": "Lee"
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                {
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                    "lastName": "Tsai"
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                {
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                    "firstName": "K-S",
                    "lastName": "Chuang"
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                {
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                    "firstName": "C-K",
                    "lastName": "Liu"
                },
                {
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                    "firstName": "M-K",
                    "lastName": "Chen"
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            ],
            "abstractNote": "BACKGROUND AND PURPOSE: The detection of cervical nodal metastases is important for the prognosis and treatment of head and neck tumors. The purpose of this study was to assess the ability of ADC values at 3T to distinguish malignant from benign lymph nodes.\nMATERIALS AND METHODS: From July 2009 to June 2010, twenty-two patients (21 men and 1 woman; mean age, 49.8±9.5 years; age range, 28-66 years) scheduled for surgical treatment of biopsy-proved head and neck cancer were prospectively and consecutively enrolled in this study. All patients were scanned on a 3T imaging unit (Verio) by using a 12-channel head coil combined with a 4-channel neck coil. Histologic findings were the reference standard for the diagnosis of lymph node metastasis.\nRESULTS: The ADC values derived from the signal intensity averaged across images obtained with b-values of 0 and 800 s/mm2 were 1.086±0.222×10(-3) mm2/s for benign lymph nodes and 0.705±0.118×10(-3) mm2/s for malignant lymph nodes (P<.0001). When an ADC value of 0.851×10(-3) mm2/s was used as a threshold value for differentiating benign from malignant lymph nodes, the best results were obtained with an accuracy of 91.0%, sensitivity of 91.3%, and specificity of 91.1%.\nCONCLUSIONS: The ADC value is a sensitive and specific parameter that can help to differentiate malignant from benign lymph nodes.",
            "publicationTitle": "AJNR. American journal of neuroradiology",
            "publisher": "",
            "place": "",
            "date": "Apr 2013",
            "volume": "34",
            "issue": "4",
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            "partNumber": "",
            "partTitle": "",
            "pages": "864-869",
            "series": "",
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            "DOI": "10.3174/ajnr.A3281",
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                    "type": 1
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            "creatorSummary": "Makeieff et al.",
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            "itemType": "journalArticle",
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            "creators": [
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                    "creatorType": "author",
                    "firstName": "M",
                    "lastName": "Makeieff"
                },
                {
                    "creatorType": "author",
                    "firstName": "V",
                    "lastName": "Burcia"
                },
                {
                    "creatorType": "author",
                    "firstName": "I",
                    "lastName": "Raingeard"
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                {
                    "creatorType": "author",
                    "firstName": "M C",
                    "lastName": "Eberlé"
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                    "firstName": "C",
                    "lastName": "Cartier"
                },
                {
                    "creatorType": "author",
                    "firstName": "R",
                    "lastName": "Garrel"
                },
                {
                    "creatorType": "author",
                    "firstName": "L",
                    "lastName": "Crampette"
                },
                {
                    "creatorType": "author",
                    "firstName": "B",
                    "lastName": "Guerrier"
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            ],
            "abstractNote": "OBJECTIVES: Recurrence is observed in 15-20% of patients under surveillance following treatment of differentiated thyroid cancer (DTC). However, due to cell dedifferentiation, the recurrence may be iodine-negative, thereby compromising detection. For this reason, new methods of exploration are indispensable to enable localization of such recurrences. The purpose of this work is to review the contribution of positron emission tomography-computed tomography (PET-CT) in the exploration of iodine-negative recurrent DTC.\nMETHOD: A comprehensive review and discussion of the medical literature was carried out.\nRESULTS: Depending on the report, the sensitivity of PET-CT ranged from 70% to 85%, with up to 90% specificity. However, the large number of false negatives, which can reach 40%, is the disadvantage of this examination. PET-CT results lead to change in the therapeutic strategy in approximately 50% of patients with isolated raised serum thyroglobulin levels, and surgical exploration of a precise anatomical area in the neck.\nCONCLUSION: As post-treatment recurrence of a DTC can affect patient survival, a thorough diagnostic work-up is required in these cases. Where thyroglobulin levels are elevated with no uptake on 131-iodine scans, PET-CT can be a useful complementary exploration, especially for localizing the site of recurrence.",
            "publicationTitle": "European annals of otorhinolaryngology, head and neck diseases",
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            "place": "",
            "date": "Oct 2012",
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            "pages": "251-256",
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            "extra": "PMID: 22818209",
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                    "type": 1
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                    "tag": "Multimodal Imaging",
                    "type": 1
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                    "tag": "Neoplasm Recurrence, Local",
                    "type": 1
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                {
                    "tag": "Positron-Emission Tomography",
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                    "tag": "Sensitivity and Specificity",
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                    "tag": "Thyroglobulin",
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                {
                    "tag": "Thyroid Neoplasms",
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            "abstractNote": "Contexte : Définir quel a été l’apport de la TEP au 18F-FDG au CHU de Lille en oncologie cervico-faciale, depuis sa mise en service (Avril 2009) jusqu’à mai 2011. Méthode : Soixante-dix patients adressés pour un examen TEP au 18F-FDG au CHU de Lille pour le bilan carcinologique de tumeurs cervico-faciales ont été étudiés rétrospectivement. Il y avait 25 patients adressés pour bilan d’extension initial, 23 patients pour bilan d’une adénopathie cervicale prévalente, 14 patients pour suivi postthérapeutique, 6 patients pour bilan d’extension d’un carcinome indifférencié du nasopharynx et 2 mélanomes de localisation ORL. Les examens ont été réalisés sur une morpho TEP Discovery RX HD 16 (General Electric Medical Systems, FWMH 4 mm). Résultats : Dans le bilan d’extension initial, la TEP au 18F-FDG a été très intéressante dans la détection des adénopathies cervicales et surtout des localisations à distance ; dans le bilan d’une adénopathie cervicale sans primitif connu la TEP a été performante dans la recherche de la tumeur primitive et des localisations à distance. La TEP a aussi montré son intérêt dans le suivi du mélanome pour les deux patients étudiés dans cette indication. Dans le bilan d’un UCNT, la TEP par son excellente valeur prédictive négative et sa forte sensibilité à détecter des lésions à distance représente ici un examen très contributif. Enfin dans le suivi post-thérapeutique la TEP et l’imagerie morphologique apparaissent complémentaires. Conclusion : Dans les 5 indications étudiées, la TEP au 18F-FDG a montré son utilité particulièrement dans la détection des lésions à distance, des adénopathies cervicales et également des tumeurs primitives non connues. L’imagerie quantitative et aussi l’arrivée des nouveaux traceurs pourraient encore en améliorer les performances.",
            "thesisType": "Thèse d'exercice",
            "university": "Université du droit et de la santé",
            "place": "Lille, France",
            "date": "2012",
            "series": "",
            "seriesNumber": "",
            "numPages": "104",
            "DOI": "",
            "ISBN": "",
            "citationKey": "",
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            "accessDate": "",
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            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "français",
            "libraryCatalog": "Library Catalog - www.sudoc.abes.fr",
            "callNumber": "",
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            "tags": [
                {
                    "tag": "Cancer cervicofacial -- Thèses et écrits académiques",
                    "type": 1
                },
                {
                    "tag": "Désoxyglucose -- Dissertations universitaires",
                    "type": 1
                },
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                    "tag": "Fludésoxyglucose (18F) -- Thèses et écrits académiques",
                    "type": 1
                },
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                    "tag": "Tomographie par émission -- Thèses et écrits académiques",
                    "type": 1
                },
                {
                    "tag": "Tomographie par émission de positons -- Dissertations universitaires",
                    "type": 1
                },
                {
                    "tag": "Tumeurs oto-rhino-laryngologiques -- Dissertations universitaires",
                    "type": 1
                }
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            "abstractNote": "Role of PET-CT in the follow-up of treated tumors of the head and neck F-18 FDG PET-CT is a well established medical imaging technique used routinely for the follow-up of treated head and neck tumors. Currently, PET-CT is performed 4 months after the end of therapy to assess its efficacy. More recently it has been suggested that this delay could be reduced to one month with major therapeutic implications.\n\nDuring follow-up, PET-CT could improve sensitivity and specificity compared to other imaging techniques. Moreover, since PET-CT is a “whole body technique”, it allows restaging in a single procedure.",
            "publicationTitle": "Journal de Radiologie",
            "publisher": "",
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            "date": "juillet 2008",
            "volume": "89",
            "issue": "7–8, Part 2",
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