[ { "key": "FEBV8S6J", "version": 895, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/FEBV8S6J", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/FEBV8S6J", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/U8XDFGF9", "type": "application/json" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } } }, "data": { "key": "FEBV8S6J", "version": 895, "parentItem": "U8XDFGF9", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-09-14T01:49:09Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/26159465", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-09-14T01:49:09Z", "dateModified": "2015-09-14T01:49:09Z" } }, { "key": "U8XDFGF9", "version": 895, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/U8XDFGF9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/U8XDFGF9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } }, "creatorSummary": "Lu et al.", "parsedDate": "2015-07-09", "numChildren": 1 }, "data": { "key": "U8XDFGF9", "version": 895, "itemType": "journalArticle", "title": "WebDISCO: A web service for distributed cox model learning without patient-level data sharing", "creators": [ { "creatorType": "author", "firstName": "Chia-Lun", "lastName": "Lu" }, { "creatorType": "author", "firstName": "Shuang", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Zhanglong", "lastName": "Ji" }, { "creatorType": "author", "firstName": "Yuan", "lastName": "Wu" }, { "creatorType": "author", "firstName": "Li", "lastName": "Xiong" }, { "creatorType": "author", "firstName": "Xiaoqian", "lastName": "Jiang" }, { "creatorType": "author", "firstName": "Lucila", "lastName": "Ohno-Machado" } ], "abstractNote": "OBJECTIVE: The Cox proportional hazards model is a widely used method for analyzing survival data. To achieve sufficient statistical power in a survival analysis, it usually requires a large amount of data. Data sharing across institutions could be a potential workaround for providing this added power.\nMETHODS AND MATERIALS: The authors develop a web service for distributed Cox model learning (WebDISCO), which focuses on the proof-of-concept and algorithm development for federated survival analysis. The sensitive patient-level data can be processed locally and only the less-sensitive intermediate statistics are exchanged to build a global Cox model. Mathematical derivation shows that the proposed distributed algorithm is identical to the centralized Cox model.\nRESULTS: The authors evaluated the proposed framework at the University of California, San Diego (UCSD), Emory, and Duke. The experimental results show that both distributed and centralized models result in near-identical model coefficients with differences in the range [Formula: see text] to [Formula: see text]. The results confirm the mathematical derivation and show that the implementation of the distributed model can achieve the same results as the centralized implementation.\nLIMITATION: The proposed method serves as a proof of concept, in which a publicly available dataset was used to evaluate the performance. The authors do not intend to suggest that this method can resolve policy and engineering issues related to the federated use of institutional data, but they should serve as evidence of the technical feasibility of the proposed approach.Conclusions WebDISCO (Web-based Distributed Cox Regression Model; https://webdisco.ucsd-dbmi.org:8443/cox/) provides a proof-of-concept web service that implements a distributed algorithm to conduct distributed survival analysis without sharing patient level data.", "publicationTitle": "Journal of the American Medical Informatics Association: JAMIA", "publisher": "", "place": "", "date": "Jul 9, 2015", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Med Inform Assoc", "DOI": "10.1093/jamia/ocv083", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1527-974X", "archive": "", "archiveLocation": "", "shortTitle": "WebDISCO", "language": "ENG", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 26159465", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-09-14T01:49:09Z", "dateModified": "2015-09-14T01:49:09Z" } }, { "key": "UFKHDAQR", "version": 894, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/UFKHDAQR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/UFKHDAQR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/7S7J2544", "type": "application/json" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "UFKHDAQR", "version": 894, "parentItem": "7S7J2544", "itemType": "attachment", "linkMode": "imported_url", "title": "PubMed Central Full Text PDF", "accessDate": "2015-09-14T01:47:32Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540539/pdf/amia_2012_symp_1450.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Wu et al. - 2012 - Preserving Institutional Privacy in Distributed Bi.pdf", "md5": "663009ccaf7ee99db5c230e856942c87", "mtime": 1442195254000, "tags": [], "relations": {}, "dateAdded": "2015-09-14T01:47:32Z", "dateModified": "2015-09-14T01:47:34Z" } }, { "key": "M3Z8C4E7", "version": 893, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/M3Z8C4E7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/M3Z8C4E7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/7S7J2544", "type": "application/json" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } } }, "data": { "key": "M3Z8C4E7", "version": 893, "parentItem": "7S7J2544", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2015-09-14T01:47:32Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540539/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-09-14T01:47:32Z", "dateModified": "2015-09-14T01:47:32Z" } }, { "key": "7S7J2544", "version": 893, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/7S7J2544", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/7S7J2544", "type": "text/html" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } }, "creatorSummary": "Wu et al.", "parsedDate": "2012-11-03", "numChildren": 2 }, "data": { "key": "7S7J2544", "version": 893, "itemType": "journalArticle", "title": "Preserving Institutional Privacy in Distributed Binary Logistic Regression", "creators": [ { "creatorType": "author", "firstName": "Yuan", "lastName": "Wu" }, { "creatorType": "author", "firstName": "Xiaoqian", "lastName": "Jiang" }, { "creatorType": "author", "firstName": "Lucila", "lastName": "Ohno-Machado" } ], "abstractNote": "Privacy is becoming a major concern when sharing biomedical data across institutions. Although methods for protecting privacy of individual patients have been proposed, it is not clear how to protect the institutional privacy, which is many times a critical concern of data custodians. Built upon our previous work, Grid Binary LOgistic REgression (GLORE)\n \n \n \n , we developed an Institutional Privacy-preserving Distributed binary Logistic Regression model (IPDLR) that considers both individual and institutional privacy for building a logistic regression model in a distributed manner. We tested our method using both simulated and clinical data, showing how it is possible to protect the privacy of individuals and of institutions using a distributed strategy.", "publicationTitle": "AMIA Annual Symposium Proceedings", "publisher": "", "place": "", "date": "2012-11-3", "volume": "2012", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1450-1458", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "AMIA Annu Symp Proc", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3540539/", "accessDate": "2015-09-14T01:47:32Z", "PMID": "", "PMCID": "", "ISSN": "1942-597X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 23304425\nPMCID: PMC3540539", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-09-14T01:47:32Z", "dateModified": "2015-09-14T01:47:32Z" } }, { "key": "8T7XM3N6", "version": 892, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/8T7XM3N6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/8T7XM3N6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/PHWJX7QX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } } }, "data": { "key": "8T7XM3N6", "version": 892, "parentItem": "PHWJX7QX", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-09-14T01:45:23Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22511014", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-09-14T01:45:23Z", "dateModified": "2015-09-14T01:45:23Z" } }, { "key": "PHWJX7QX", "version": 892, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/PHWJX7QX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/PHWJX7QX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 951273, "username": "jimeng", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/jimeng", "type": "text/html" } } }, "creatorSummary": "Wu et al.", "parsedDate": "2012-10", "numChildren": 1 }, "data": { "key": "PHWJX7QX", "version": 892, "itemType": "journalArticle", "title": "Grid Binary LOgistic REgression (GLORE): building shared models without sharing data", "creators": [ { "creatorType": "author", "firstName": "Yuan", "lastName": "Wu" }, { "creatorType": "author", "firstName": "Xiaoqian", "lastName": "Jiang" }, { "creatorType": "author", "firstName": "Jihoon", "lastName": "Kim" }, { "creatorType": "author", "firstName": "Lucila", "lastName": "Ohno-Machado" } ], "abstractNote": "OBJECTIVE: The classification of complex or rare patterns in clinical and genomic data requires the availability of a large, labeled patient set. While methods that operate on large, centralized data sources have been extensively used, little attention has been paid to understanding whether models such as binary logistic regression (LR) can be developed in a distributed manner, allowing researchers to share models without necessarily sharing patient data.\nMATERIAL AND METHODS: Instead of bringing data to a central repository for computation, we bring computation to the data. The Grid Binary LOgistic REgression (GLORE) model integrates decomposable partial elements or non-privacy sensitive prediction values to obtain model coefficients, the variance-covariance matrix, the goodness-of-fit test statistic, and the area under the receiver operating characteristic (ROC) curve.\nRESULTS: We conducted experiments on both simulated and clinically relevant data, and compared the computational costs of GLORE with those of a traditional LR model estimated using the combined data. We showed that our results are the same as those of LR to a 10(-15) precision. In addition, GLORE is computationally efficient.\nLIMITATION: In GLORE, the calculation of coefficient gradients must be synchronized at different sites, which involves some effort to ensure the integrity of communication. Ensuring that the predictors have the same format and meaning across the data sets is necessary.\nCONCLUSION: The results suggest that GLORE performs as well as LR and allows data to remain protected at their original sites.", "publicationTitle": "Journal of the American Medical Informatics Association: JAMIA", "publisher": "", "place": "", "date": "2012 Sep-Oct", "volume": "19", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "758-764", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Med Inform Assoc", "DOI": "10.1136/amiajnl-2012-000862", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1527-974X", "archive": "", "archiveLocation": "", "shortTitle": "Grid Binary LOgistic REgression (GLORE)", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22511014\nPMCID: PMC3422844", "tags": [ { "tag": "Area Under Curve", "type": 1 }, { "tag": "Biomedical Research", "type": 1 }, { "tag": "Computer Simulation", "type": 1 }, { "tag": "Confidentiality", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Information dissemination", "type": 1 }, { "tag": "Logistic Models", "type": 1 }, { "tag": "Pattern Recognition, Automated", "type": 1 }, { "tag": "ROC Curve", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-09-14T01:45:23Z", "dateModified": "2015-09-14T01:45:23Z" } }, { "key": "KTIEW937", "version": 822, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/KTIEW937", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/KTIEW937", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1892677, "username": "mohammed.khalilia", "name": "Mohammed Khalilia", "links": { "alternate": { "href": "https://www.zotero.org/mohammed.khalilia", "type": "text/html" } } }, "creatorSummary": "Barry", "parsedDate": "2011-03-31", "numChildren": 0 }, "data": { "key": "KTIEW937", "version": 822, "itemType": "webpage", "title": "The Rise and Fall of HL7", "creators": [ { "creatorType": "author", "firstName": "Smith", "lastName": "Barry" } ], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "March 31, 2011", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://hl7-watch.blogspot.com/2011/03/rise-and-fall-of-hl7.html", "accessDate": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-07-06T09:01:20Z", "dateModified": "2015-07-09T21:24:45Z" } }, { "key": "DX4MDA36", "version": 818, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": 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"accessDate": "2015-05-14T16:35:18Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118663/pdf/nihms545435.pdf", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Wilson et al. - 2013 - Two-way communication with neural networks in vivo.pdf", "md5": "77f874bd03712f0a2eb0906ce16db4bd", "mtime": 1431621319000, "tags": [], "relations": {}, "dateAdded": "2015-05-14T16:35:18Z", "dateModified": "2015-05-14T16:35:19Z" } }, { "key": "M8Z6KZ3E", "version": 806, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/M8Z6KZ3E", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/M8Z6KZ3E", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/BKZT7WVJ", "type": 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"author", "firstName": "Mriganka", "lastName": "Sur" } ], "abstractNote": "Neuronal networks process information in a distributed, spatially heterogeneous fashion that transcends the layout of electrodes. In contrast, directed and steerable light offers the potential to engage specific cells on demand. We present a unified framework for adapting microscopes to use light for simultaneous in vivo stimulation and recording of cells at fine spatiotemporal resolutions. We utilize straightforward optics to lock onto networks in vivo, steer light to activate circuit elements, and simultaneously record from other cells. We then actualize this “free” augmentation on both an “open” two-photon microscope, and a leading commercial one. Following this protocol, setup of the system takes a few days and the result is a non-invasive interface to brain dynamics based on directed light, at a network resolution that was not previously possible and which will further improve with the rapid advance in development of optical reporters and effectors. This protocol is for physiologists who are competent with computers and wish to extend hardware and software to interface more fluidly with neuronal networks.", "publicationTitle": "Nature protocols", "publisher": "", "place": "", "date": "2013-6", "volume": "8", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1184-1203", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Protoc", "DOI": "10.1038/nprot.2013.063", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4118663/", "accessDate": "2015-05-14T16:35:18Z", "PMID": "", "PMCID": "", "ISSN": "1754-2189", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 23702834\nPMCID: PMC4118663", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-05-14T16:35:18Z", "dateModified": "2015-05-14T16:35:18Z" } }, { "key": "A468U45I", "version": 805, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/A468U45I", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/A468U45I", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/239512/items/ZGJB8W2B", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1744666, "username": "robchen401", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/robchen401", "type": "text/html" } } } }, "data": { "key": "A468U45I", "version": 805, "parentItem": "ZGJB8W2B", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-05-14T16:34:44Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25923145", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-05-14T16:34:44Z", "dateModified": "2015-05-14T16:34:44Z" } }, { "key": "ZGJB8W2B", "version": 805, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/ZGJB8W2B", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/ZGJB8W2B", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1744666, "username": "robchen401", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/robchen401", "type": "text/html" } } }, "creatorSummary": "Brancheau et al.", "parsedDate": "2015", "numChildren": 1 }, "data": { "key": "ZGJB8W2B", "version": 805, "itemType": "journalArticle", "title": "Do cinnamon supplements cause acute hepatitis?", "creators": [ { "creatorType": "author", "firstName": "Daniel", "lastName": "Brancheau" }, { "creatorType": "author", "firstName": "Brijesh", "lastName": "Patel" }, { "creatorType": "author", "firstName": "Marcel", "lastName": "Zughaib" } ], "abstractNote": "Background The use of herbal medications to treat various diseases is on the rise. Cinnamon has been reported to improve glycolated hemoglobin and serum glucose levels. When patients consider the benefit of such substances, they are often not aware of potential adverse effects and drug interactions. Cinnamon, via coumarin, can cause liver toxicity. Therefore, its concomitant use with hepatotoxic drugs should be avoided. Case Report A 73-year-old woman was seen in the Emergency Department complaining of abdominal pain associated with vomiting and diarrhea after she started taking cinnamon supplements for about 1 week. The patient had been taking statin for coronary artery disease for many months. The laboratory workup and imaging studies confirmed the diagnosis of hepatitis. The detail workup did not reveal any specific cause. Cinnamon and statin were held. A few weeks after discharge, the statin was resumed without any further complications. This led to a diagnosis of cinnamon-statin combination-induced hepatitis. Conclusions A combination of cinnamon supplement and statin can cause hepatitis, and it should be discouraged.", "publicationTitle": "The American Journal of Case Reports", "publisher": "", "place": "", "date": "2015", "volume": "16", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "250-254", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am J Case Rep", "DOI": "10.12659/AJCR.892804", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1941-5923", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25923145", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-05-14T16:34:44Z", "dateModified": "2015-05-14T16:34:44Z" } }, { "key": "4SAP6GMZ", "version": 804, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/4SAP6GMZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare/items/4SAP6GMZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 858668, "username": "zhenyisx", "name": "Yi", "links": { "alternate": { "href": "https://www.zotero.org/zhenyisx", "type": "text/html" } } }, "creatorSummary": "Rousseeuw", "parsedDate": "1987-11", "numChildren": 0 }, "data": { "key": "4SAP6GMZ", "version": 804, "itemType": "journalArticle", "title": "Silhouettes: A graphical aid to the interpretation and validation of cluster analysis", "creators": [ { "creatorType": "author", "firstName": "Peter J.", "lastName": "Rousseeuw" } ], "abstractNote": "A new graphical display is proposed for partitioning techniques. Each cluster is represented by a so-called silhouette, which is based on the comparison of its tightness and separation. This silhouette shows which objects lie well within their cluster, and which ones are merely somewhere in between clusters. The entire clustering is displayed by combining the silhouettes into a single plot, allowing an appreciation of the relative quality of the clusters and an overview of the data configuration. The average silhouette width provides an evaluation of clustering validity, and might be used to select an ‘appropriate’ number of clusters.", "publicationTitle": "Journal of Computational and Applied Mathematics", "publisher": "", "place": "", "date": "November 1987", "volume": "20", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "53-65", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Computational and Applied Mathematics", "DOI": "10.1016/0377-0427(87)90125-7", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/pii/0377042787901257", "accessDate": "2015-05-08T18:13:40Z", "PMID": "", "PMCID": "", "ISSN": "0377-0427", "archive": "", "archiveLocation": "", "shortTitle": "Silhouettes", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Cluster Analysis", "type": 1 }, { "tag": "Graphical display", "type": 1 }, { "tag": "classification", 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"version": 800, "parentItem": "AV7BI7FP", "itemType": "attachment", "linkMode": "imported_url", "title": "IEEE Xplore Full Text PDF", "accessDate": "2015-03-13T03:37:15Z", "url": "http://ieeexplore.ieee.org/ielx7/6607262/6627745/06627810.pdf?tp=&arnumber=6627810&isnumber=6627745", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Bender and Sartipi - 2013 - HL7 FHIR An Agile and RESTful approach to healthc.pdf", "md5": "7e97a329ff59afd255f48c11baa72c6e", "mtime": 1426217837787, "tags": [], "relations": {}, "dateAdded": "2015-03-13T03:37:15Z", "dateModified": "2015-03-13T03:37:17Z" } }, { "key": "AV7BI7FP", "version": 799, "library": { "type": "group", "id": 239512, "name": "big_data_healthcare", "links": { "alternate": { "href": "https://www.zotero.org/groups/big_data_healthcare", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/239512/items/AV7BI7FP", "type": "application/json" }, "alternate": { "href": 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HL7 messaging standards are widely implemented by the healthcare industry and have been deployed internationally for decades. HL7 Version 2 (“v2”) health information exchange standards are a popular choice of local hospital communities for the exchange of healthcare information, including electronic medical record information. In development for 15 years, HL7 Version 3 (“v3”) was designed to be the successor to Version 2, addressing Version 2's shortcomings. HL7 v3 has been heavily criticized by the industry for being internally inconsistent even in it's own documentation, too complex and expensive to implement in real world systems and has been accused of contributing towards many failed and stalled systems implementations. HL7 is now experimenting with a new approach to the development of standards with FHIR. This research provides a chronicle of the evolution of the HL7 messaging standards, an introduction to HL7 FHIR and a comparative analysis between HL7 FHIR and previous HL7 messaging standards.", "proceedingsTitle": "2013 IEEE 26th International Symposium on Computer-Based Medical Systems (CBMS)", "conferenceName": "2013 IEEE 26th International Symposium on Computer-Based Medical Systems (CBMS)", "publisher": "", "place": "", "date": "June 2013", "eventPlace": "", "volume": "", "issue": "", "numberOfVolumes": "", "pages": "326-331", "series": "", "seriesNumber": "", "DOI": "10.1109/CBMS.2013.6627810", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "HL7 FHIR", "language": "", "libraryCatalog": "IEEE Xplore", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Agile", "type": 1 }, { "tag": "Agile approach", "type": 1 }, { "tag": "FHIR", "type": 1 }, { "tag": "HL7 FHIR", "type": 1 }, { "tag": "HL7 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