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Recently we observed the same variant in a second family, and found that the oxy-derivative of Hb-Manitoba is slightly unstable at 65 degrees C, dissociates less readily at alkaline pH than does Hb-A, and forms asymmetric hybrids with other hemoglobins which are readily detectable by electrophoresis.", "publicationTitle": "Biochimica et biophysica acta", "publisher": "", "place": "", "date": "Dec 15, 1975", "volume": "412", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "283-287", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Biochim. Biophys. 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A report from the drug epidemiology unit and the Boston collaborative drug surveillance program", "creators": [ { "creatorType": "author", "firstName": "C, Jr", "lastName": "Swett" } ], "abstractNote": "Phenothiazine-induced bone marrow depression (BMD) was evaluated in three separate but complementary data bases: (1) Among 1,048 patients admitted to psychiatric hospitals, there was no evidence of subclinical depression of the white blood cell (WBC) count attributable to phenothiazines used before admission. (2) Among 18,587 medical inpatients, there were 34 patients admitted for BMD in the absence of neoplasia or prior cytotoxic drug therapy; one of the latter reported using chlorpromazine hydrochloride, but it is doubtful whether this drug was the cause of the BMD. 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