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P04 Paula y Lourdes", "links": { "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/229649/items/TVEWVBFI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes/items/TVEWVBFI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1668439, "username": "al262429", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/al262429", "type": "text/html" } } }, "creatorSummary": "Rutkove et al.", "parsedDate": "2012-09", "numChildren": 2 }, "data": { "key": "TVEWVBFI", "version": 3, "itemType": "journalArticle", "title": "Electrical impedance myography as a biomarker to assess ALS progression", "creators": [ { "creatorType": "author", "firstName": "Seward B", "lastName": "Rutkove" }, { "creatorType": "author", "firstName": "James B", "lastName": "Caress" }, { "creatorType": "author", "firstName": "Michael S", "lastName": "Cartwright" }, { "creatorType": "author", "firstName": "Ted M", "lastName": "Burns" }, { "creatorType": "author", "firstName": "Judy", "lastName": "Warder" }, { "creatorType": "author", "firstName": "William S", "lastName": "David" }, { "creatorType": "author", "firstName": "Namita", "lastName": "Goyal" }, { "creatorType": "author", "firstName": "Nicholas J", "lastName": "Maragakis" }, { "creatorType": "author", "firstName": "Lora", "lastName": "Clawson" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Benatar" }, { "creatorType": "author", "firstName": "Sharon", "lastName": "Usher" }, { "creatorType": "author", "firstName": "Khema R", "lastName": "Sharma" }, { "creatorType": "author", "firstName": "Shiva", "lastName": "Gautam" }, { "creatorType": "author", "firstName": "Pushpa", "lastName": "Narayanaswami" }, { "creatorType": "author", "firstName": "Elizabeth M", "lastName": "Raynor" }, { "creatorType": "author", "firstName": "Mary Lou", "lastName": "Watson" }, { "creatorType": "author", "firstName": "Jeremy M", "lastName": "Shefner" } ], "abstractNote": "Electrical impedance myography (EIM), a non-invasive, electrophysiological technique, has preliminarily shown value as an ALS biomarker. Here we perform a multicenter study to further assess EIM's potential for tracking ALS. ALS patients were enrolled across eight sites. Each subject underwent EIM, handheld dynamometry (HHD), and the ALS Functional Rating Scale-revised (ALSFRS-R) regularly. Techniques were compared by assessing the coefficient of variation (CoV) in the rate of decline and each technique's correlation to survival. Results showed that in the 60 patients followed for one year, EIM phase measured from the most rapidly progressing muscle in each patient had a CoV in the rate of decline of 0.62, compared to HHD (0.82) and the ALSFRS-R (0.74). Restricting the measurements to the first six months gave a CoV of 0.55 for EIM, 0.93 for HHD, and 0.84 for ALSFRS-R. For both time-periods, all three measures correlated with survival. Based on these data, a six-month clinical trial designed to detect a 20% treatment effect with 80% power using EIM would require only 95 patients/arm compared to the ALSFRS-R, which would require 220 subjects/arm. In conclusion, EIM can serve as a useful ALS biomarker that offers the prospect of greatly accelerating phase 2 clinical trials.", "publicationTitle": "Amyotrophic lateral sclerosis: official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases", "publisher": "", "place": "", "date": "Sep 2012", "volume": "13", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "439-445", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Amyotroph Lateral Scler", "DOI": "10.3109/17482968.2012.688837", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1471-180X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22670883", "tags": [ { "tag": "Adolescent", "type": 1 }, { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Amyotrophic Lateral Sclerosis", "type": 1 }, { "tag": "Clinical Trials as Topic", "type": 1 }, { "tag": "Disease Progression", "type": 1 }, { "tag": "Electric Impedance", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Muscle, Skeletal", "type": 1 }, { "tag": "Myography", "type": 1 }, { "tag": "Survival Rate", "type": 1 }, { "tag": "Time Factors", "type": 1 }, { "tag": "Young Adult", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-05T08:33:19Z", "dateModified": "2013-11-05T08:33:19Z" } }, { "key": "ZKPF4Q3T", "version": 2, "library": { "type": "group", "id": 229649, "name": "MD1112 - P04 Paula y Lourdes", "links": { "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/229649/items/ZKPF4Q3T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes/items/ZKPF4Q3T", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1668439, "username": "al262429", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/al262429", "type": "text/html" } } }, "creatorSummary": "Georgoulopoulou et al.", "parsedDate": "2013-09", "numChildren": 2 }, "data": { "key": "ZKPF4Q3T", "version": 2, "itemType": "journalArticle", "title": "The impact of clinical factors, riluzole and therapeutic interventions on ALS survival: a population based study in Modena, Italy", "creators": [ { "creatorType": "author", "firstName": "Eleni", "lastName": "Georgoulopoulou" }, { "creatorType": "author", "firstName": "Nicola", "lastName": "Fini" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Vinceti" }, { "creatorType": "author", "firstName": "Marco", "lastName": "Monelli" }, { "creatorType": "author", "firstName": "Paolo", "lastName": "Vacondio" }, { "creatorType": "author", "firstName": "Giorgia", "lastName": "Bianconi" }, { "creatorType": "author", "firstName": "Patrizia", "lastName": "Sola" }, { "creatorType": "author", "firstName": "Paolo", "lastName": "Nichelli" }, { "creatorType": "author", "firstName": "Jessica", "lastName": "Mandrioli" } ], "abstractNote": "The prognostic role of riluzole, enteral nutrition (EN), non-invasive ventilation (NIV) and interdisciplinary care in ALS is still debated. A population based study has been performed focusing on ALS survival, with particular attention to prognostic factors and therapeutic intervention. All patients diagnosed with ALS between 2000 and 2009 and residing in Modena, Italy, have been registered. A centre for motor neuron disease (MND) has been active in our province since 2000, in addition to a prospective registry collecting all incident cases. One hundred and ninety-three incident cases have been collected during the 10 years of the study. Results demonstrated that median survival was 41 months (the overall three-year and five-year survival rates being 54.36% and 28.81%, respectively). Based on univariate analysis, factors related to survival were: age at diagnosis, gender, site of onset, phenotype, riluzole treatment and tracheostomy. In the Cox multivariable model, the factors independently related to a longer survival were age (p < 0.01), site of onset (p = 0.02) and riluzole treatment (p < 0.01), with a median gain in survival of 29 months (patients aged < 55 years compared with patients ≥ 55 years), 20 months (spinal versus bulbar onset), and 12 months (riluzole, yes vs. no), respectively. In conclusion, the study has confirmed the prognostic role of clinical features, but has surprisingly demonstrated that riluzole prolonged life significantly longer than NIV and EN. This observational study described the effects of ALS management in a setting that may approximate routine clinical practice more closely than randomized controlled trial (RCT); effects of uncontrolled potential confounders, however, cannot be excluded.", "publicationTitle": "Amyotrophic lateral sclerosis & frontotemporal degeneration", "publisher": "", "place": "", "date": "Sep 2013", "volume": "14", "issue": "5-6", "section": "", "partNumber": "", "partTitle": "", "pages": "338-345", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Amyotroph Lateral Scler Frontotemporal Degener", "DOI": "10.3109/21678421.2013.763281", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "2167-9223", "archive": "", "archiveLocation": "", "shortTitle": "The impact of clinical factors, riluzole and therapeutic interventions on ALS survival", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23373475", "tags": [ { "tag": "Age Factors", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Amyotrophic Lateral Sclerosis", "type": 1 }, { "tag": "Cohort Studies", "type": 1 }, { "tag": "Enteral Nutrition", "type": 1 }, { "tag": "Excitatory Amino Acid Antagonists", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Italy", "type": 1 }, { "tag": "Kaplan-Meier Estimate", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Noninvasive Ventilation", "type": 1 }, { "tag": "Prognosis", "type": 1 }, { "tag": "Proportional Hazards Models", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Riluzole", "type": 1 }, { "tag": "Sex Factors", "type": 1 }, { "tag": "Tracheostomy", "type": 1 }, { "tag": "Treatment Outcome", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-05T08:31:37Z", "dateModified": "2013-11-05T08:31:37Z" } }, { "key": "834S4F44", "version": 2, "library": { "type": "group", "id": 229649, "name": "MD1112 - P04 Paula y Lourdes", "links": { "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/229649/items/834S4F44", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/md1112_-_p04_paula_y_lourdes/items/834S4F44", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/229649/items/ZKPF4Q3T", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1668439, "username": "al262429", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/al262429", "type": "text/html" } } } }, "data": { "key": "834S4F44", "version": 2, "parentItem": "ZKPF4Q3T", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-05T08:31:37Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23373475", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-05T08:31:37Z", "dateModified": "2013-11-05T08:31:37Z" } } ]