[
    {
        "key": "TXRH8XSX",
        "version": 6,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/TXRH8XSX",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/TXRH8XSX",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Yadav and Mittal",
            "parsedDate": "2013-11-06",
            "numChildren": 0
        },
        "data": {
            "key": "TXRH8XSX",
            "version": 6,
            "itemType": "journalArticle",
            "title": "Effect of Vitamin D Supplementation on Moderate to Severe Bronchial Asthma",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Madhu",
                    "lastName": "Yadav"
                },
                {
                    "creatorType": "author",
                    "firstName": "Kundan",
                    "lastName": "Mittal"
                }
            ],
            "abstractNote": "",
            "publicationTitle": "The Indian Journal of Pediatrics",
            "publisher": "",
            "place": "",
            "date": "2013-11-6",
            "volume": "",
            "issue": "",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "",
            "DOI": "10.1007/s12098-013-1268-4",
            "citationKey": "",
            "url": "http://link.springer.com/10.1007/s12098-013-1268-4",
            "accessDate": "2013-12-03T15:02:43Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0019-5456, 0973-7693",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "CrossRef",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-12-03T15:02:43Z",
            "dateModified": "2013-12-03T15:02:43Z"
        }
    },
    {
        "key": "33VP7697",
        "version": 5,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/33VP7697",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/33VP7697",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/FVWWAEK5",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "33VP7697",
            "version": 5,
            "parentItem": "FVWWAEK5",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed entry",
            "accessDate": "2013-11-12T05:41:30Z",
            "url": "http://www.ncbi.nlm.nih.gov/pubmed/11450665",
            "note": "",
            "contentType": "text/html",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-11-12T05:41:30Z",
            "dateModified": "2013-11-12T05:41:30Z"
        }
    },
    {
        "key": "FVWWAEK5",
        "version": 5,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/FVWWAEK5",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/FVWWAEK5",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Shapiro and Meslin",
            "parsedDate": "2001-07-12",
            "numChildren": 1
        },
        "data": {
            "key": "FVWWAEK5",
            "version": 5,
            "itemType": "journalArticle",
            "title": "Ethical issues in the design and conduct of clinical trials in developing countries",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "H T",
                    "lastName": "Shapiro"
                },
                {
                    "creatorType": "author",
                    "firstName": "E M",
                    "lastName": "Meslin"
                }
            ],
            "abstractNote": "",
            "publicationTitle": "The New England journal of medicine",
            "publisher": "",
            "place": "",
            "date": "Jul 12, 2001",
            "volume": "345",
            "issue": "2",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "139-142",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "N. Engl. J. Med.",
            "DOI": "10.1056/NEJM200107123450212",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0028-4793",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11450665",
            "tags": [
                {
                    "tag": "Clinical Trials as Topic",
                    "type": 1
                },
                {
                    "tag": "Developing Countries",
                    "type": 1
                },
                {
                    "tag": "Ethical Review",
                    "type": 1
                },
                {
                    "tag": "Ethics, Medical",
                    "type": 1
                },
                {
                    "tag": "Helsinki Declaration",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Internationality",
                    "type": 1
                },
                {
                    "tag": "Research Design",
                    "type": 1
                },
                {
                    "tag": "United States",
                    "type": 1
                },
                {
                    "tag": "Vulnerable Populations",
                    "type": 1
                }
            ],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-11-12T05:41:30Z",
            "dateModified": "2013-11-12T05:41:30Z"
        }
    },
    {
        "key": "8BRN3TDQ",
        "version": 4,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/8BRN3TDQ",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/8BRN3TDQ",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/R4IEFTU4",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "8BRN3TDQ",
            "version": 4,
            "parentItem": "R4IEFTU4",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "Full Text PDF",
            "accessDate": "2013-11-12T05:28:26Z",
            "url": "http://www.nejm.org/doi/pdf/10.1056/NEJM199709183371212",
            "note": "",
            "contentType": "application/pdf",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-11-12T05:28:26Z",
            "dateModified": "2013-11-12T05:28:26Z"
        }
    },
    {
        "key": "IX4KPNM3",
        "version": 4,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/IX4KPNM3",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/IX4KPNM3",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/R4IEFTU4",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "IX4KPNM3",
            "version": 4,
            "parentItem": "R4IEFTU4",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "Snapshot",
            "accessDate": "2013-11-12T05:28:26Z",
            "url": "http://www.nejm.org/doi/full/10.1056/NEJM199709183371212?keytype2=tfipsecsha&ijkey=6f1497f4f76ccef1833d840b41a12a7358e22a54&&",
            "note": "",
            "contentType": "text/html",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-11-12T05:28:26Z",
            "dateModified": "2013-11-12T05:28:26Z"
        }
    },
    {
        "key": "R4IEFTU4",
        "version": 4,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/R4IEFTU4",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/R4IEFTU4",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Lurie and Wolfe",
            "parsedDate": "1997",
            "numChildren": 2
        },
        "data": {
            "key": "R4IEFTU4",
            "version": 4,
            "itemType": "journalArticle",
            "title": "Unethical Trials of Interventions to Reduce Perinatal Transmission of the Human Immunodeficiency Virus in Developing Countries",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Peter",
                    "lastName": "Lurie"
                },
                {
                    "creatorType": "author",
                    "firstName": "Sidney M.",
                    "lastName": "Wolfe"
                }
            ],
            "abstractNote": "It has been almost three years since the Journal 1 published the results of AIDS Clinical Trials Group (ACTG) Study 076, the first randomized, controlled trial in which an intervention was proved to reduce the incidence of human immunodeficiency virus (HIV) infection. The antiretroviral drug zidovudine, administered orally to HIV-positive pregnant women in the United States and France, administered intravenously during labor, and subsequently administered to the newborn infants, reduced the incidence of HIV infection by two thirds.2 The regimen can save the life of one of every seven infants born to HIV-infected women. Because of these findings, the study was . . .",
            "publicationTitle": "New England Journal of Medicine",
            "publisher": "",
            "place": "",
            "date": "1997",
            "volume": "337",
            "issue": "12",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "853-856",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "",
            "DOI": "10.1056/NEJM199709183371212",
            "citationKey": "",
            "url": "http://www.nejm.org/doi/full/10.1056/NEJM199709183371212",
            "accessDate": "2013-11-12T05:28:26Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0028-4793",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "Taylor and Francis+NEJM",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 9295246",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-11-12T05:28:26Z",
            "dateModified": "2013-11-12T05:28:26Z"
        }
    },
    {
        "key": "P44G3PCB",
        "version": 3,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/P44G3PCB",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/P44G3PCB",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/FU8IA9JI",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "P44G3PCB",
            "version": 3,
            "parentItem": "FU8IA9JI",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed Central Full Text PDF",
            "accessDate": "2013-10-31T22:28:49Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/pdf/0943.pdf",
            "note": "",
            "contentType": "application/pdf",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-10-31T22:28:49Z",
            "dateModified": "2013-10-31T22:28:49Z"
        }
    },
    {
        "key": "6GSGMQS6",
        "version": 3,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/6GSGMQS6",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/6GSGMQS6",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/FU8IA9JI",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "6GSGMQS6",
            "version": 3,
            "parentItem": "FU8IA9JI",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed Central Link",
            "accessDate": "2013-10-31T22:28:49Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/",
            "note": "",
            "contentType": "text/html",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-10-31T22:28:49Z",
            "dateModified": "2013-10-31T22:28:49Z"
        }
    },
    {
        "key": "FU8IA9JI",
        "version": 3,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/FU8IA9JI",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/FU8IA9JI",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Du et al.",
            "parsedDate": "2002-03",
            "numChildren": 2
        },
        "data": {
            "key": "FU8IA9JI",
            "version": 3,
            "itemType": "journalArticle",
            "title": "Role of Fraction 1 Antigen of Yersinia pestis in Inhibition of Phagocytosis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Yidong",
                    "lastName": "Du"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roland",
                    "lastName": "Rosqvist"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ake",
                    "lastName": "Forsberg"
                }
            ],
            "abstractNote": "Yersinia pestis, the causative agent of plague, expresses a capsule-like antigen, fraction 1 (F1), at 37°C. F1 is encoded by the caf1 gene located on the large 100-kb pFra plasmid, which is unique to Y. pestis. F1 is a surface polymer composed of a protein subunit, Caf1, with a molecular mass of 15.5 kDa. The secretion and assembly of F1 require the caf1M and caf1A genes, which are homologous to the chaperone and usher protein families required for biogenesis of pili. F1 has been implicated to be involved in the ability of Y. pestis to prevent uptake by macrophages. In this study we addressed the role of F1 antigen in inhibition of phagocytosis by the macrophage-like cell line J774. The Y. pestis strain EV76 was found to be highly resistant to uptake by J774 cells. An in-frame deletion of the caf1M gene of the Y. pestis strain EV76 was constructed and found to be unable to express F1 polymer on the bacterial surface. This strain had a somewhat lowered ability to prevent uptake by J774 cells. Strain EV76C, which is cured for the virulence plasmid common to the pathogenic Yersinia species, was, as expected, much reduced in its ability to resist uptake. A strain lacking both the virulence plasmid and caf1M was even further hampered in the ability to prevent uptake and, in this case, essentially all bacteria (95%) were phagocytosed. Thus, F1 and the virulence plasmid-encoded type III system act in concert to make Y. pestis highly resistant to uptake by phagocytes. In contrast to the type III effector proteins YopE and YopH, F1 did not have any influence on the general phagocytic ability of J774 cells. Expression of F1 also reduced the number of bacteria that interacted with the macrophages. This suggests that F1 prevents uptake by interfering at the level of receptor interaction in the phagocytosis process.",
            "publicationTitle": "Infection and Immunity",
            "publisher": "",
            "place": "",
            "date": "2002-3",
            "volume": "70",
            "issue": "3",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1453-1460",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Infect Immun",
            "DOI": "10.1128/IAI.70.3.1453-1460.2002",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/",
            "accessDate": "2013-10-31T22:28:49Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0019-9567",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "PubMed Central",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11854232\nPMCID: PMC127752",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-10-31T22:28:49Z",
            "dateModified": "2013-10-31T22:28:49Z"
        }
    },
    {
        "key": "3GC95QZ9",
        "version": 2,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/3GC95QZ9",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/3GC95QZ9",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/65FQPBVQ",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "3GC95QZ9",
            "version": 2,
            "parentItem": "65FQPBVQ",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed Central Full Text PDF",
            "accessDate": "2013-10-11T04:09:35Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/pdf/0943.pdf",
            "note": "",
            "contentType": "application/pdf",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-10-11T04:09:35Z",
            "dateModified": "2013-10-11T04:09:35Z"
        }
    },
    {
        "key": "VGK9RK62",
        "version": 2,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/VGK9RK62",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/VGK9RK62",
                "type": "text/html"
            },
            "up": {
                "href": "https://api.zotero.org/groups/222700/items/65FQPBVQ",
                "type": "application/json"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            }
        },
        "data": {
            "key": "VGK9RK62",
            "version": 2,
            "parentItem": "65FQPBVQ",
            "itemType": "attachment",
            "linkMode": "linked_url",
            "title": "PubMed Central Link",
            "accessDate": "2013-10-11T04:09:35Z",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/",
            "note": "",
            "contentType": "text/html",
            "charset": "",
            "tags": [],
            "relations": {},
            "dateAdded": "2013-10-11T04:09:35Z",
            "dateModified": "2013-10-11T04:09:35Z"
        }
    },
    {
        "key": "65FQPBVQ",
        "version": 2,
        "library": {
            "type": "group",
            "id": 222700,
            "name": "Bacterio Yersinia",
            "links": {
                "alternate": {
                    "href": "https://www.zotero.org/groups/bacterio_yersinia",
                    "type": "text/html"
                }
            }
        },
        "links": {
            "self": {
                "href": "https://api.zotero.org/groups/222700/items/65FQPBVQ",
                "type": "application/json"
            },
            "alternate": {
                "href": "https://www.zotero.org/groups/bacterio_yersinia/items/65FQPBVQ",
                "type": "text/html"
            }
        },
        "meta": {
            "createdByUser": {
                "id": 1531158,
                "username": "hans1593",
                "name": "",
                "links": {
                    "alternate": {
                        "href": "https://www.zotero.org/hans1593",
                        "type": "text/html"
                    }
                }
            },
            "creatorSummary": "Du et al.",
            "parsedDate": "2002-03",
            "numChildren": 2
        },
        "data": {
            "key": "65FQPBVQ",
            "version": 2,
            "itemType": "journalArticle",
            "title": "Role of Fraction 1 Antigen of Yersinia pestis in Inhibition of Phagocytosis",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Yidong",
                    "lastName": "Du"
                },
                {
                    "creatorType": "author",
                    "firstName": "Roland",
                    "lastName": "Rosqvist"
                },
                {
                    "creatorType": "author",
                    "firstName": "Ake",
                    "lastName": "Forsberg"
                }
            ],
            "abstractNote": "Yersinia pestis, the causative agent of plague, expresses a capsule-like antigen, fraction 1 (F1), at 37°C. F1 is encoded by the caf1 gene located on the large 100-kb pFra plasmid, which is unique to Y. pestis. F1 is a surface polymer composed of a protein subunit, Caf1, with a molecular mass of 15.5 kDa. The secretion and assembly of F1 require the caf1M and caf1A genes, which are homologous to the chaperone and usher protein families required for biogenesis of pili. F1 has been implicated to be involved in the ability of Y. pestis to prevent uptake by macrophages. In this study we addressed the role of F1 antigen in inhibition of phagocytosis by the macrophage-like cell line J774. The Y. pestis strain EV76 was found to be highly resistant to uptake by J774 cells. An in-frame deletion of the caf1M gene of the Y. pestis strain EV76 was constructed and found to be unable to express F1 polymer on the bacterial surface. This strain had a somewhat lowered ability to prevent uptake by J774 cells. Strain EV76C, which is cured for the virulence plasmid common to the pathogenic Yersinia species, was, as expected, much reduced in its ability to resist uptake. A strain lacking both the virulence plasmid and caf1M was even further hampered in the ability to prevent uptake and, in this case, essentially all bacteria (95%) were phagocytosed. Thus, F1 and the virulence plasmid-encoded type III system act in concert to make Y. pestis highly resistant to uptake by phagocytes. In contrast to the type III effector proteins YopE and YopH, F1 did not have any influence on the general phagocytic ability of J774 cells. Expression of F1 also reduced the number of bacteria that interacted with the macrophages. This suggests that F1 prevents uptake by interfering at the level of receptor interaction in the phagocytosis process.",
            "publicationTitle": "Infection and Immunity",
            "publisher": "",
            "place": "",
            "date": "2002-3",
            "volume": "70",
            "issue": "3",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1453-1460",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Infect Immun",
            "DOI": "10.1128/IAI.70.3.1453-1460.2002",
            "citationKey": "",
            "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC127752/",
            "accessDate": "2013-10-11T04:09:35Z",
            "PMID": "",
            "PMCID": "",
            "ISSN": "0019-9567",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "",
            "libraryCatalog": "PubMed Central",
            "callNumber": "",
            "rights": "",
            "extra": "PMID: 11854232\nPMCID: PMC127752",
            "tags": [],
            "collections": [],
            "relations": {},
            "dateAdded": "2013-10-11T04:09:35Z",
            "dateModified": "2013-10-11T04:09:35Z"
        }
    }
]