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"extra": "", "tags": [], "collections": [ "8WPUDCQS" ], "relations": {}, "dateAdded": "2013-11-18T13:21:31Z", "dateModified": "2013-11-18T13:21:31Z" } }, { "key": "FUGZ4J69", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/FUGZ4J69", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/FUGZ4J69", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } }, "creatorSummary": "Schmoldt et al.", "parsedDate": "1975-09-01", "numChildren": 1 }, "data": { "key": "FUGZ4J69", "version": 37, "itemType": "journalArticle", "title": "Digitoxin metabolism by rat liver microsomes", "creators": [ { "creatorType": "author", "firstName": "A", "lastName": "Schmoldt" }, { "creatorType": "author", "firstName": "H F", "lastName": "Benthe" }, { "creatorType": "author", "firstName": "G", "lastName": "Haberland" } ], "abstractNote": "", "publicationTitle": "Biochemical pharmacology", "publisher": "", "place": "", "date": "Sep 1, 1975", "volume": "24", "issue": "17", "section": "", "partNumber": "", "partTitle": "", "pages": "1639-1641", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Biochem. Pharmacol.", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0006-2952", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 10", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Chromatography, Thin Layer", "type": 1 }, { "tag": "Digitoxigenin", "type": 1 }, { "tag": "Digitoxin", "type": 1 }, { "tag": "Hydroxylation", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Microsomes, Liver", "type": 1 }, { "tag": "NADP", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Time Factors", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-18T11:00:53Z", "dateModified": "2013-11-18T11:00:53Z" } }, { "key": "HGIKINF7", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/HGIKINF7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/HGIKINF7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/221901/items/FUGZ4J69", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } } }, "data": { "key": "HGIKINF7", "version": 37, "parentItem": "FUGZ4J69", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-18T11:00:53Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-18T11:00:53Z", "dateModified": "2013-11-18T11:00:53Z" } }, { "key": "7PW5RE3N", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/7PW5RE3N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/7PW5RE3N", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/221901/items/BB9HPJ6V", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } } }, "data": { "key": "7PW5RE3N", "version": 37, "parentItem": "BB9HPJ6V", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-18T11:00:51Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/481", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-18T11:00:51Z", "dateModified": "2013-11-18T11:00:51Z" } }, { "key": "BB9HPJ6V", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/BB9HPJ6V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/BB9HPJ6V", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } }, "creatorSummary": "Cho et al.", "parsedDate": "1975-11", "numChildren": 1 }, "data": { "key": "BB9HPJ6V", "version": 37, "itemType": "journalArticle", "title": "Solubilization and stabilization of the cytotoxic agent coralyne", "creators": [ { "creatorType": "author", "firstName": "M J", "lastName": "Cho" }, { "creatorType": "author", "firstName": "A J", "lastName": "Repta" }, { "creatorType": "author", "firstName": "C C", "lastName": "Cheng" }, { "creatorType": "author", "firstName": "K Y", "lastName": "Zee-Cheng" }, { "creatorType": "author", "firstName": "T", "lastName": "Higuchi" }, { "creatorType": "author", "firstName": "I H", "lastName": "Pitman" } ], "abstractNote": "Kinetic studies were carried out on the ring opening of the quaternary nitrogen cation, coralynium ion (I), to yield 6'-acetylpapaverine (III), on the cyclization of III to yield I, and on a photochemical reaction undergone by I in aqueous solutions exposed to visible light. From the results, it was concluded that: (a) I and III are in facile equilibrium in aqueous solution but appreciable amounts of III do not exist in dilute solutions with pH values below 10: (b) the photochemical reaction of I in water (presumably a photohydration) can be reversed by lyophilization, by heatiing, and by increasing the pH of solutions to values greater than 12; (c) the photochemical reaction of I can be inhibited by protecting the aqueous solutions from visible light, and the rate in the presence of light can be reduced by increasing the concentration of I in the solution; and (d) although the chloride and sulfoacetate salts of I react identically and have similar solubilities in water, it is possible to prepare more concentrated and, hence, more stable solutions of the sulfoacetate salt by including sodium hydroxide in the solvent. The solubility of coralyne chloride remains about the same in dilute sodium hydroxide as in water.", "publicationTitle": "Journal of pharmaceutical sciences", "publisher": "", "place": "", "date": "Nov 1975", "volume": "64", "issue": "11", "section": "", "partNumber": "", "partTitle": "", "pages": "1825-1830", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Pharm Sci", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-3549", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 481", "tags": [ { "tag": "Antineoplastic Agents", "type": 1 }, { "tag": "Berberine Alkaloids", "type": 1 }, { "tag": "Chemistry, Pharmaceutical", "type": 1 }, { "tag": "Drug Stability", "type": 1 }, { "tag": "Hydrogen-Ion Concentration", "type": 1 }, { "tag": "Kinetics", "type": 1 }, { "tag": "Light", "type": 1 }, { "tag": "Photochemistry", "type": 1 }, { "tag": "Solubility", "type": 1 }, { "tag": "Spectrophotometry, Ultraviolet", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-18T11:00:51Z", "dateModified": "2013-11-18T11:00:51Z" } }, { "key": "ABXZWKGZ", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/ABXZWKGZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/ABXZWKGZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/221901/items/FDIK88KI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } } }, "data": { "key": "ABXZWKGZ", "version": 37, "parentItem": "FDIK88KI", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-18T11:00:49Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/54", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-18T11:00:49Z", "dateModified": "2013-11-18T11:00:49Z" } }, { "key": "FDIK88KI", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/FDIK88KI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/FDIK88KI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } }, "creatorSummary": "Martin et al.", "parsedDate": "1975-12-16", "numChildren": 1 }, "data": { "key": "FDIK88KI", "version": 37, "itemType": "journalArticle", "title": "Phospholipase A2 as a probe of phospholipid distribution in erythrocyte membranes. Factors influencing the apparent specificity of the reaction", "creators": [ { "creatorType": "author", "firstName": "J K", "lastName": "Martin" }, { "creatorType": "author", "firstName": "M G", "lastName": "Luthra" }, { "creatorType": "author", "firstName": "M A", "lastName": "Wells" }, { "creatorType": "author", "firstName": "R P", "lastName": "Watts" }, { "creatorType": "author", "firstName": "D J", "lastName": "Hanahan" } ], "abstractNote": "The action of snake venom phospholipases A2 in intact human erythrocytes was investigated in detail. The basis phospholipase from Agkistrodon halys blomhifii was found to induce both hydrolysis of membrane phospholipids and total cell hemolysis under certain experimental conditions. The hydrolytic action of the basic enzyme was found to consist of two sequential events: (a) hydrolysis of 70% of the total cell ph osphatidylcholine without any evident hemolysis; and (b) complete hydrolysis of the remaining phosphatidylcholine, followed closely by extensive phosphatidylethanolamine hydrolysis and finally with onset of hemolysis, attack on the phosphatidylserine. At pH 7.4 and 10 mM Ca2+ only stage (a) occurred. However, a slight elevation of the pH of incubation to pH 8.0 and/or inclusion of 40 mM Ca2+ in the reaction mixture caused both events (a) and (b) to occur. The addition of glucose limited the action of the enzyme to stage (a) under any reaction conditions. An investigation showed that enzymically induced hemolysis occurred under conditions where the intracellular ATP levels were lowered. Data are presented which suggest that stage (b) is mediated by in influx of Ca2+ into the cell when the levels of ATP are low. Interestingly the phosphllipase from Naja naja venom (Pakistan) yielded results similar to those observed with the basic enzyme from Agkistrodon venom. However, the enzyme from Crotalus adamanteus and the acidic enzyme also present in the Agkistrodon venom produced only slight hydrolysis or hemolysis under any of the conditions studied. Other species of erythrocytes, e.g., guinea pig, monkey, pig, and rat, were tested but only those from guinea pig behaved similarly to the human cells. Pig, monkey, and rat erythrocytes underwent very limited hydrolysis and hemolysis. It is evident that the use of these phospholipases to probe the localization of phospholipds in erythrocyte membranes must be approached with caution. Certain facets of this problem are discussed.", "publicationTitle": "Biochemistry", "publisher": "", "place": "", "date": "Dec 16, 1975", "volume": "14", "issue": "25", "section": "", "partNumber": "", "partTitle": "", "pages": "5400-5408", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Biochemistry", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0006-2960", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 54", "tags": [ { "tag": "Adenosine Triphosphate", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Calcium", "type": 1 }, { "tag": "Cell Membrane", "type": 1 }, { "tag": "Citrates", "type": 1 }, { "tag": "Erythrocyte Aging", "type": 1 }, { "tag": "Erythrocytes", "type": 1 }, { "tag": "Glucose", "type": 1 }, { "tag": "Guinea Pigs", "type": 1 }, { "tag": "Haplorhini", "type": 1 }, { "tag": "Hemolysis", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Hydrogen-Ion Concentration", "type": 1 }, { "tag": "Magnesium", "type": 1 }, { "tag": "Phosphatidylcholines", "type": 1 }, { "tag": "Phospholipases", "type": 1 }, { "tag": "Phospholipids", "type": 1 }, { "tag": "Potassium", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Snake Venoms", "type": 1 }, { "tag": "Swine", "type": 1 }, { "tag": "Time Factors", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-18T11:00:49Z", "dateModified": "2013-11-18T11:00:49Z" } }, { "key": "SMWEXRUH", "version": 37, "library": { "type": "group", "id": 221901, "name": "geographie economique regionale", "links": { "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/221901/items/SMWEXRUH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/geographie_economique_regionale/items/SMWEXRUH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/221901/items/CN588PP7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1237647, "username": "npucino", "name": "Nicolas Pucino", "links": { "alternate": { "href": "https://www.zotero.org/npucino", "type": "text/html" } } } }, "data": { "key": "SMWEXRUH", "version": 37, "parentItem": "CN588PP7", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-18T11:00:47Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/391", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-18T11:00:47Z", "dateModified": "2013-11-18T11:00:47Z" } } ]