[ { "key": "7585CQ82", "version": 15, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/7585CQ82", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/7585CQ82", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/T8NB2CBC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } } }, "data": { "key": "7585CQ82", "version": 15, "parentItem": "T8NB2CBC", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-11-08T06:45:39Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350603/pdf/nihms370550.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-08T06:45:39Z", "dateModified": "2013-11-08T06:45:39Z" } }, { "key": "CAMZWBTB", "version": 15, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/CAMZWBTB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/CAMZWBTB", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/T8NB2CBC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } } }, "data": { "key": "CAMZWBTB", "version": 15, "parentItem": "T8NB2CBC", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-11-08T06:45:39Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350603/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-08T06:45:39Z", "dateModified": "2013-11-08T06:45:39Z" } }, { "key": "T8NB2CBC", "version": 15, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/T8NB2CBC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/T8NB2CBC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } }, "creatorSummary": "White et al.", "parsedDate": "2012-04", "numChildren": 2 }, "data": { "key": "T8NB2CBC", "version": 15, "itemType": "journalArticle", "title": "Isoniazid vs. Rifampin for Latent Tuberculosis Infection in Jail Inmates: Toxicity and Adherence", "creators": [ { "creatorType": "author", "firstName": "Mary C.", "lastName": "White" }, { "creatorType": "author", "firstName": "Jacqueline P.", "lastName": "Tulsky" }, { "creatorType": "author", "firstName": "Ju Ruey-Jiuan", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Lisa", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Joe", "lastName": "Goldenson" }, { "creatorType": "author", "firstName": "Joanne", "lastName": "Spetz" }, { "creatorType": "author", "firstName": "L. Masae", "lastName": "Kawamura" } ], "abstractNote": "This open-label randomized trial compared isoniazid (9 months) to rifampin (4 months) on toxicity and completion in a jailed population with latent tuberculosis infection. Rifampin resulted in fewer elevated liver function tests (risk ratio [RR] 0.39, 95% confidence interval [CI] [0.18, 0.86]) and less toxicity requiring medication withdrawal (RR 0.51, 95% CI [0.13, 2.01]), although one participant receiving rifampin experienced an allergic reaction. Completion was achieved for 33% receiving rifampin compared to 26% receiving isoniazid (p = .10). With careful monitoring rifampin is a safe and less toxic regimen and appears to be a reasonable alternative because of its shorter duration, allowing more people to complete treatment behind bars. Therapy completion in released inmates is unacceptably low and ensuring follow-up after discharge must be part of a decision to treat.", "publicationTitle": "Journal of Correctional Health Care", "publisher": "", "place": "", "date": "2012-4", "volume": "18", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "131-142", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Correct Health Care", "DOI": "10.1177/1078345811435973", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3350603/", "accessDate": "2013-11-08T06:45:39Z", "PMID": "", "PMCID": "", "ISSN": "1078-3458", "archive": "", "archiveLocation": "", "shortTitle": "Isoniazid vs. Rifampin for Latent Tuberculosis Infection in Jail Inmates", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 22419641\nPMCID: PMC3350603", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-11-08T06:45:39Z", "dateModified": "2013-11-08T06:45:39Z" } }, { "key": "D7UENGVH", "version": 14, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/D7UENGVH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/D7UENGVH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/J7WE6TIX", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } } }, "data": { "key": "D7UENGVH", "version": 14, "parentItem": "J7WE6TIX", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-05T04:21:08Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23967274", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-05T04:21:08Z", "dateModified": "2013-11-05T04:21:08Z" } }, { "key": "J7WE6TIX", "version": 14, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/J7WE6TIX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/J7WE6TIX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } }, "creatorSummary": "Lian et al.", "parsedDate": "2013", "numChildren": 1 }, "data": { "key": "J7WE6TIX", "version": 14, "itemType": "journalArticle", "title": "Protective effects of metallothionein on isoniazid and rifampicin-induced hepatotoxicity in mice", "creators": [ { "creatorType": "author", "firstName": "Yong", "lastName": "Lian" }, { "creatorType": "author", "firstName": "Jing", "lastName": "Zhao" }, { "creatorType": "author", "firstName": "Peiyu", "lastName": "Xu" }, { "creatorType": "author", "firstName": "Yimei", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Jun", "lastName": "Zhao" }, { "creatorType": "author", "firstName": "Li", "lastName": "Jia" }, { "creatorType": "author", "firstName": "Ze", "lastName": "Fu" }, { "creatorType": "author", "firstName": "Li", "lastName": "Jing" }, { "creatorType": "author", "firstName": "Gang", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Shuangqing", "lastName": "Peng" } ], "abstractNote": "Isoniazid (INH) and Rifampicin (RFP) are widely used in the world for the treatment of tuberculosis, but the hepatotoxicity is a major concern during clinical therapy. Previous studies showed that these drugs induced oxidative stress in liver, and several antioxidants abated this effect. Metallothionein (MT), a member of cysteine-rich protein, has been proposed as a potent antioxidant. This study attempts to determine whether endogenous expression of MT protects against INH and RFP-induced hepatic oxidative stress in mice. Wild type (MT+/+) and MT-null (MT-/-) mice were treated intragastrically with INH (150 mg/kg), RFP (300 mg/kg), or the combination (150 mg/kg INH +300 mg/kg RFP) for 21 days. The results showed that MT-/- mice were more sensitive than MT+/+ mice to INH and RFP-induced hepatic injuries as evidenced by hepatic histopathological alterations, increased serum AST levels and liver index, and hepatic oxidative stress as evidenced by the increase of MDA production and the change of liver antioxidant status. Furthermore, INH increased the protein expression of hepatic CYP2E1 and INH/RFP (alone or in combination) decreased the expression of hepatic CYP1A2. These findings clearly demonstrate that basal MT provides protection against INH and RFP-induced toxicity in hepatocytes. The CYP2E1 and CYP1A2 were involved in the pathogenesis of INH and RFP-induced hepatotoxicity.", "publicationTitle": "PloS one", "publisher": "", "place": "", "date": "2013", "volume": "8", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "e72058", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS ONE", "DOI": "10.1371/journal.pone.0072058", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1932-6203", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23967274", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-11-05T04:21:08Z", "dateModified": "2013-11-05T04:21:08Z" } }, { "key": "I7RNFMUV", "version": 16, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/I7RNFMUV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/I7RNFMUV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/C58PAGXU", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": "I7RNFMUV", "version": 16, "parentItem": "C58PAGXU", "itemType": "attachment", "linkMode": "linked_url", "title": "SCIELO Journal Snapshot", "accessDate": "2013-11-05T04:10:34Z", "url": "http://www.scielo.cl/scielo.php?script=sci_pdf&pid=S0717-73482011000100010&lng=es&nrm=iso&tlng=es", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-05T04:10:34Z", "dateModified": "2013-11-05T04:10:34Z" } }, { "key": "C58PAGXU", "version": 16, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/C58PAGXU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/C58PAGXU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "AGUAYO C and RODRÍGUEZ D", "parsedDate": "2011", "numChildren": 1 }, "data": { "key": "C58PAGXU", "version": 16, "itemType": "journalArticle", "title": "Hígado y terapia antituberculosa", "creators": [ { "creatorType": "author", "firstName": "MIGUEL", "lastName": "AGUAYO C" }, { "creatorType": "author", "firstName": "JUAN CARLOS", "lastName": "RODRÍGUEZ D" } ], "abstractNote": "", "publicationTitle": "Revista chilena de enfermedades respiratorias", "publisher": "", "place": "", "date": "03/2011", "volume": "27", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "53-57", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.4067/S0717-73482011000100010", "citationKey": "", "url": "http://www.scielo.cl/scielo.php?pid=S0717-73482011000100010&script=sci_arttext", "accessDate": "2013-11-05T04:10:34Z", "PMID": "", "PMCID": "", "ISSN": "0717-7348", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-11-05T04:10:34Z", "dateModified": "2013-11-05T04:10:34Z" } }, { "key": "DRNX7FDD", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/DRNX7FDD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/DRNX7FDD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "Murillo et al.", "parsedDate": "2011", "numChildren": 1 }, "data": { "key": "DRNX7FDD", "version": 13, "itemType": "journalArticle", "title": "Comprehensive evaluation of cervical cancer screening programs: the case of Colombia", "creators": [ { "creatorType": "author", "firstName": "Raúl", "lastName": "Murillo" }, { "creatorType": "author", "firstName": "Carolina", "lastName": "Wiesner" }, { "creatorType": "author", "firstName": "Ricardo", "lastName": "Cendales" }, { "creatorType": "author", "firstName": "Marion", "lastName": "Piñeros" }, { "creatorType": "author", "firstName": "Sandra", "lastName": "Tovar" } ], "abstractNote": "", "publicationTitle": "Salud Pública de México", "publisher": "", "place": "", "date": "12/2011", "volume": "53", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "469-477", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1590/S0036-36342011000600002", "citationKey": "", "url": "http://www.scielosp.org/scielo.php?script=sci_arttext&pid=S0036-36342011000600002&lng=en&nrm=iso&tlng=en", "accessDate": "2013-10-12T22:49:38Z", "PMID": "", "PMCID": "", "ISSN": "0036-3634", "archive": "", "archiveLocation": "", "shortTitle": "Comprehensive evaluation of cervical cancer screening programs", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-12T22:49:38Z", "dateModified": "2013-10-12T22:49:38Z" } }, { "key": "R4HF3GC2", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/R4HF3GC2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/R4HF3GC2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/DRNX7FDD", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": "R4HF3GC2", "version": 13, "parentItem": "DRNX7FDD", "itemType": "attachment", "linkMode": "linked_url", "title": "SCIELO Journal Snapshot", "accessDate": "2013-10-12T22:49:38Z", "url": "http://www.scielosp.org/scielo.php?script=sci_pdf&pid=S0036-36342011000600002&lng=en&nrm=iso&tlng=en", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-12T22:49:38Z", "dateModified": "2013-10-12T22:49:38Z" } }, { "key": "NXEJZHXX", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/NXEJZHXX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/NXEJZHXX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/ZI4TAZJG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": "NXEJZHXX", "version": 13, "parentItem": "ZI4TAZJG", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-10-12T18:35:08Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500953/pdf/13224_2012_Article_298.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-12T18:35:08Z", "dateModified": "2013-10-12T18:35:08Z" } }, { "key": "MUHEZN69", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/MUHEZN69", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/MUHEZN69", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/ZI4TAZJG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": "MUHEZN69", "version": 13, "parentItem": "ZI4TAZJG", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-10-12T18:35:08Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500953/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-12T18:35:08Z", "dateModified": "2013-10-12T18:35:08Z" } }, { "key": "ZI4TAZJG", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/ZI4TAZJG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/ZI4TAZJG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "Pandey et al.", "parsedDate": "2012-08", "numChildren": 2 }, "data": { "key": "ZI4TAZJG", "version": 13, "itemType": "journalArticle", "title": "Fluorescence Spectroscopy: A New Approach in Cervical Cancer", "creators": [ { "creatorType": "author", "firstName": "Kiran", "lastName": "Pandey" }, { "creatorType": "author", "firstName": "Asima", "lastName": "Pradhan" }, { "creatorType": "author", "firstName": "Asha", "lastName": "Agarwal" }, { "creatorType": "author", "firstName": "Ajay", "lastName": "Bhagoliwal" }, { "creatorType": "author", "firstName": "Nidhi", "lastName": "Agarwal" } ], "abstractNote": "Objective\nTo study the diagnostic potential of fluorescence spectroscopy and its comparison with different screening methods, including Pap smear and colposcopy, in detecting early cervical neoplasia.\n\nMethod\nThe study was conducted on patients with gynecological complaints. A full gynecological workup of the patients was done along with Pap smear and colposcopy. Cervical biopsy was done in suspected cases and fresh tissue was sent to IIT for spectroscopy.\n\nResult\nThere is a definite increase in NADH fluorescence (67.4 %) and a decrease in collagen fluorescence (74 %) in dysplastic tissues. When epithelial fluorescence and stromal fluorescence are considered together, diagnostic accuracy is increased to 96.5 %.\n\nConclusion\nThe clinical diagnosis of cervical neoplasia by spectroscopic methods is potentially a reliable, fast, and cost-effective alternative to the conventional smear test which needs trained personnel for its interpretation. Research is still continuing to obtain a statistically significant cutoff value from in vitro studies and then use them for in vivo study.", "publicationTitle": "Journal of Obstetrics and Gynaecology of India", "publisher": "", "place": "", "date": "2012-8", "volume": "62", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "432-436", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Obstet Gynaecol India", "DOI": "10.1007/s13224-012-0298-6", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3500953/", "accessDate": "2013-10-12T18:35:08Z", "PMID": "", "PMCID": "", "ISSN": "0971-9202", "archive": "", "archiveLocation": "", "shortTitle": "Fluorescence Spectroscopy", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 23904705\nPMCID: PMC3500953", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-12T18:35:08Z", "dateModified": "2013-10-12T18:35:08Z" } }, { "key": "2AHNETMB", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/2AHNETMB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/2AHNETMB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "Gong et al.", "parsedDate": "2010-04-24", "numChildren": 2 }, "data": { "key": "2AHNETMB", "version": 13, "itemType": "journalArticle", "title": "Clonal status and clinicopathological observation of cervical minimal deviation adenocarcinoma", "creators": [ { "creatorType": "author", "firstName": "Li", "lastName": "Gong" }, { "creatorType": "author", "firstName": "Wen-Dong", "lastName": "Zhang" }, { "creatorType": "author", "firstName": "Xiao-Yan", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Xiu-Juan", "lastName": "Han" }, { "creatorType": "author", "firstName": "Li", "lastName": "Yao" }, { "creatorType": "author", "firstName": "Shao-Jun", "lastName": "Zhu" }, { "creatorType": "author", "firstName": "Miao", "lastName": "Lan" }, { "creatorType": "author", "firstName": "Yan-Hong", "lastName": "Li" }, { "creatorType": "author", "firstName": "Wei", "lastName": "Zhang" } ], "abstractNote": "Background\nMinimal deviation adenocarcinoma (MDA) of the uterine cervix is defined as an extremely well differentiated variant of cervical adenocarcinoma, with well-formed glands that resemble benign glands but show distinct nuclear anaplasia or evidence of stromal invasion. Thus, MDA is difficult to differentiate from other cervical hyperplastic lesions. Monoclonality is a major characteristic of most tumors, whereas normal tissue and reactive hyperplasia are polyclonal.\n\nMethods\nThe clinicopathological features and clonality of MDA were investigated using laser microdissection and a clonality assay based on the polymorphism of androgen receptor (AR) and X-chromosomal inactivation mosaicism in female somatic tissues. \n\nResults\nThe results demonstrated that the glands were positive for CEA, Ki-67, and p53 and negative for estrogen receptor (ER), progesterone receptor (PR), and high-risk human papilloma virus (HPV) DNA. The index of proliferation for Ki-67 was more than 50%. However, the stromal cells were positive for ER, PR, vimentin, and SM-actin. The clonal assay showed that MDA was monoclonal. Thus, our findings indicate that MDA is a true neoplasm but is not associated with high-risk HPV.\n\nConclusions\nDiagnosis of MDA depends mainly on its clinical manifestations, the pathological feature that MDA glands are located deeper than the lower level of normal endocervical glands, and immunostaining.", "publicationTitle": "Diagnostic Pathology", "publisher": "", "place": "", "date": "2010-4-24", "volume": "5", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "25", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Diagn Pathol", "DOI": "10.1186/1746-1596-5-25", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877003/", "accessDate": "2013-10-12T18:30:52Z", "PMID": "", "PMCID": "", "ISSN": "1746-1596", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 20416098\nPMCID: PMC2877003", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-12T18:30:52Z", "dateModified": "2013-10-12T18:30:52Z" } }, { "key": "6B76H9Z2", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/6B76H9Z2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/6B76H9Z2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/2AHNETMB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": "6B76H9Z2", "version": 13, "parentItem": "2AHNETMB", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-10-12T18:30:52Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2877003/pdf/1746-1596-5-25.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-12T18:30:52Z", "dateModified": "2013-10-12T18:30:52Z" } }, { "key": "6FTS9FGC", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/6FTS9FGC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/6FTS9FGC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/2AHNETMB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } } }, "data": { "key": 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"", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } } }, "data": { "key": "TSJZRMVA", "version": 12, "parentItem": "42B8QH5K", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-10-08T22:38:41Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397663/pdf/nihms385447.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-08T22:38:41Z", "dateModified": "2013-10-08T22:38:41Z" } }, { "key": "3VUE7AQ3", "version": 12, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/3VUE7AQ3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/3VUE7AQ3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/219152/items/42B8QH5K", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } } }, "data": { "key": "3VUE7AQ3", "version": 12, "parentItem": "42B8QH5K", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-10-08T22:38:41Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397663/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-08T22:38:41Z", "dateModified": "2013-10-08T22:38:41Z" } }, { "key": "42B8QH5K", "version": 12, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/42B8QH5K", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/42B8QH5K", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } }, "creatorSummary": "Kiser et al.", "parsedDate": "2012-08", "numChildren": 2 }, "data": { "key": "42B8QH5K", "version": 12, "itemType": "journalArticle", "title": "Isoniazid pharmacokinetics, pharmacodynamics and dosing in South African infants", "creators": [ { "creatorType": "author", "firstName": "Jennifer J.", "lastName": "Kiser" }, { "creatorType": "author", "firstName": "Rui", "lastName": "Zhu" }, { "creatorType": "author", "firstName": "David Z.", "lastName": "D'Argenio" }, { "creatorType": "author", "firstName": "Mark F.", "lastName": "Cotton" }, { "creatorType": "author", "firstName": "Raziya", "lastName": "Bobat" }, { "creatorType": "author", "firstName": "George D.", "lastName": "McSherry" }, { "creatorType": "author", "firstName": "Shabir A", "lastName": "Madhi" }, { "creatorType": "author", "firstName": "Vincent J.", "lastName": "Carey" }, { "creatorType": "author", "firstName": "Heiner I.", "lastName": "Seifart" }, { "creatorType": "author", "firstName": "Cedric J.", "lastName": "Werely" }, { "creatorType": "author", "firstName": "Courtney V.", "lastName": "Fletcher" } ], "abstractNote": "Aims\nThere are limited data on isoniazid (INH) pharmacokinetics in infants and young children and, therefore, uncertainty on appropriate dosing.\n\nMethods\nPharmacokinetic data were obtained from perinatally HIV-exposed South African infants ages 3–24 months receiving INH 10–20 mg/kg/day orally for Mycobacterium tuberculosis (TB) prophylaxis. INH pharmacokinetic parameters were characterized with a population pharmacokinetic approach. Dosing simulations were performed to evaluate weight-based INH doses in children based on N-acetyltransferase 2 enzyme (NAT2) genotype, age, maximum concentrations (Cmax) ≥ 3mg/L, and area under the curve (AUC0-24) ≥ 10.52 mg*hr/L.\n\nResults\nIn 151 infants (53% female, 48% HIV positive) receiving a mean INH dose of 14.5 mg/kg/day, mean (±SD) Cmax at 3, 6, and 23 months of age were 10.0 (3.5), 8.6 (2.6), and 9.3 (3.8) mg/L, respectively, mean (±SD) AUC0-24 were 53.6 (26.8), 42 (19.9), and 44 (30.7) mg*hr/L, respectively, and mean (±SD) half-life were 2.1 (0.7), 1.9 (0.6), and 1.8 (0.9) hours, respectively. A trimodal apparent oral clearance of INH as a function of NAT2 genotype was apparent as early as 3 months. INH was well tolerated. At an average INH dose of 14.5 mg/kg/day, 99% of infants ages 3–24 months have an INH Cmax ≥ 3 mg/L and 98% have an INH AUC0-24 ≥ 10.52 mg*hr/L.\n\nConclusions\nINH at an average dose of 14.5 mg/kg once daily was well tolerated in infants and achieved INH Cmax values ≥ 3 mg/L and AUC0-24 values ≥ 10.52 mg*hr/L.", "publicationTitle": "Therapeutic Drug Monitoring", "publisher": "", "place": "", "date": "2012-8", "volume": "34", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "446-451", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ther Drug Monit", "DOI": "10.1097/FTD.0b013e31825c4bc3", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3397663/", "accessDate": "2013-10-08T22:38:41Z", "PMID": "", "PMCID": "", "ISSN": "0163-4356", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 22695364\nPMCID: PMC3397663", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-08T22:38:41Z", "dateModified": "2013-10-08T22:38:41Z" } }, { "key": "MFRSUMQC", "version": 11, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/MFRSUMQC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/MFRSUMQC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531158, "username": "hans1593", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/hans1593", "type": "text/html" } } }, "parsedDate": "2010", "numChildren": 0 }, "data": { "key": "MFRSUMQC", "version": 11, "itemType": "document", "title": "Hepatotoxicidad por Farmacos", "creators": [ { "creatorType": "author", "firstName": "Francisco Tejada Cifuentes", "lastName": "" } ], "abstractNote": "l daño hepático causado por medicamentos, drogas de abuso o remedios medicamentosos\n(productos de herboristería, etc.) se está convirtiendo en un importante problema de salud\npública que afecta a los pacientes, médicos, industria farmacéutica y agencias reguladoras.\nEl daño hepático inducido por drogas es la causa más común de muerte por fallo hepático\nagudo y representa alrededor del 10% de casos de fallo hepático agudo a nivel mundial.\nLa hepatotoxicidad por medicamentos es la principal reacción adversa implicada en el\nabandono del desarrollo de futuros medicamentos en la fase preclínica o clínica, denegación\nde registros por parte de las agencias reguladoras, y retirada del mercado o restricciones\nde uso después de ser registrado. La mayor parte de la información se obtiene de los datos\nreferidos a las agencias reguladoras a través del sistema de notificación voluntaria (tarjeta\namarilla) y por la información aparecida en las revistas médicas, pero esto probablemente\nes sólo la “punta del iceberg”. El reconocimiento y diagnóstico de la hepatotoxicidad es a\nmenudo difícil y largo en el tiempo, debido a la necesidad de excluir numerosas causas\nalternativas de daño hepático", "type": "", "date": "2010", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://scielo.isciii.es/pdf/albacete/v3n3/especial1.pdf", "accessDate": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "Espanol", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-08T22:20:09Z", "dateModified": "2013-10-08T22:21:20Z" } }, { "key": "UBC9BRR4", "version": 13, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/UBC9BRR4", "type": "application/json" }, "alternate": { "href": 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"https://www.zotero.org/groups/farmaco", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/219152/items/NX5VXRTU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/farmaco/items/NX5VXRTU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "Gómez Calzada et al.", "parsedDate": "2008", "numChildren": 1 }, "data": { "key": "NX5VXRTU", "version": 13, "itemType": "journalArticle", "title": "Hepatotoxicity induced by antituberculosis drugs", "creators": [ { "creatorType": "author", "firstName": "Ubier Eduardo", "lastName": "Gómez Calzada" }, { "creatorType": "author", "firstName": "Yuli", "lastName": "Agudelo Berruecos" }, { "creatorType": "author", "firstName": "Marie Claire", "lastName": "Berrouet Mejía" }, { "creatorType": "author", "firstName": "Isabel Eugenia", "lastName": "Escobar Toledo" } ], "abstractNote": "", "publicationTitle": "Iatreia", "publisher": "", "place": "", "date": "03/2008", "volume": "21", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "41-48", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.scielo.org.co/scielo.php?pid=S0121-07932008000100005&script=sci_arttext", "accessDate": "2013-10-08T22:10:39Z", "PMID": "", "PMCID": "", "ISSN": "0121-0793", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-10-08T22:10:39Z", "dateModified": "2013-10-08T22:10:39Z" } }, { "key": "87ZIRM6H", "version": 9, "library": { "type": "group", "id": 219152, "name": "FARMACO", "links": { "alternate": { "href": "https://www.zotero.org/groups/farmaco", "type": 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