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For example, τSD increases with demyelination as the exposed membrane is enlarged by inclusion of paranodal and internodal membrane, it decreases with hyperpolarization and it increases with depolarization. The present study was undertaken in 20 normal volunteers to compare strength—duration curves for compound sensory and muscle action potentials, to determine the most appropriate curve fitting equation for the data, and to examine the reproducibility of the calculated time constant on different days, for potentials of different amplitude and at different sites along the nerve. Using a computerized threshold-tracking system, stimulus intensity was adjusted to produce\nan antidromic compound sensory action potential (CSAP) or an orthodromic muscle action potential of 30% of maximum. Stimulus duration was increased every minute in 20 μs steps from 20 μs to 1 ms. The time constant for compound sensory potentials (665±182 μs) was longer than that for compound EMG potentials (459±126 μs). Weiss's formula, which relates threshold charge to stimulus duration, provided an accurate fit for the experimental data, and the study validated that, using it, relatively few experimental measurements were required to calculate the time constant. In repeated studies on the same subject, time constants usually differed by <400 μs for sensory axons and <250 μs for motor axons. They were identical at different sites along the nerve and did not alter with the size of the compound action potential. These characteristics suggest that the determinations of strength-duration time constant could be suitable for clinical usage.", "publicationTitle": "Brain", "publisher": "", "place": "", "date": "04/01/1996", "volume": "119", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "439-447", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Brain", "DOI": "10.1093/brain/119.2.439", "citationKey": "", "url": "http://brain.oxfordjournals.org/content/119/2/439", "accessDate": "2013-11-05T22:16:16Z", "PMID": "", "PMCID": "", "ISSN": "0006-8950, 1460-2156", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "brain.oxfordjournals.org", "callNumber": "", "rights": "", "extra": "PMID: 8800939", "tags": [ { "tag": "motor fibre", "type": 1 }, { "tag": "nodal membrane", "type": 1 }, { "tag": "sensory fibre", "type": 1 }, { "tag": "time constant", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-05T22:16:16Z", "dateModified": "2013-11-05T22:16:16Z" } }, { "key": "J42DMDV2", "version": 63, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/J42DMDV2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/J42DMDV2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } }, "creatorSummary": "Boinagrov et al.", "parsedDate": "2010-10", "numChildren": 1 }, "data": { "key": "J42DMDV2", "version": 63, "itemType": "journalArticle", "title": "Strength-duration relationship for extracellular neural stimulation: numerical and analytical models", "creators": [ { "creatorType": "author", "firstName": "David", "lastName": "Boinagrov" }, { "creatorType": "author", "firstName": "Jim", "lastName": "Loudin" }, { "creatorType": "author", "firstName": "Daniel", "lastName": "Palanker" } ], "abstractNote": "The strength-duration relationship for extracellular stimulation is often assumed to be similar to the classical intracellular stimulation model, with a slope asymptotically approaching 1/τ at pulse durations shorter than chronaxy. We modeled extracellular neural stimulation numerically and analytically for several cell shapes and types of active membrane properties. The strength-duration relationship was found to differ significantly from classical intracellular models. At pulse durations between 4 μs and 5 ms stimulation is dominated by sodium channels, with a slope of -0.72 in log-log coordinates for the Hodgkin-Huxley ion channel model. At shorter durations potassium channels dominate and slope decreases to -0.13. Therefore the charge per phase is decreasing with decreasing stimulus duration. With pulses shorter than cell polarization time (∼0.1-1 μs), stimulation is dominated by polarization dynamics with a classical -1 slope and the charge per phase becomes constant. It is demonstrated that extracellular stimulation can have not only lower but also upper thresholds and may be impossible below certain pulse durations. In some regimes the extracellular current can hyperpolarize cells, suppressing rather than stimulating spiking behavior. Thresholds for burst stimuli can be either higher or lower than that of a single pulse, depending on pulse duration. The modeled thresholds were found to be comparable to published experimental data. Electroporation thresholds, which limit the range of safe stimulation, were found to exceed stimulation thresholds by about two orders of magnitude. These results provide a biophysical basis for understanding stimulation dynamics and guidance for optimizing the neural stimulation efficacy and safety.", "publicationTitle": "Journal of neurophysiology", "publisher": "", "place": "", "date": "Oct 2010", "volume": "104", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "2236-2248", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurophysiol.", "DOI": "10.1152/jn.00343.2010", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1522-1598", "archive": "", "archiveLocation": "", "shortTitle": "Strength-duration relationship for extracellular neural stimulation", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 20702740", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Axons", "type": 1 }, { "tag": "Cell Membrane", "type": 1 }, { "tag": "Decapodiformes", "type": 1 }, { "tag": "Electric Stimulation", "type": 1 }, { "tag": "Extracellular Fluid", "type": 1 }, { "tag": "Models, Neurological", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Retinal Ganglion Cells", "type": 1 }, { "tag": "Urodela", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-05T22:16:07Z", "dateModified": "2013-11-05T22:16:07Z" } }, { "key": "J3TVRJKP", "version": 63, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/J3TVRJKP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/J3TVRJKP", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/212852/items/J42DMDV2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } } }, "data": { "key": "J3TVRJKP", "version": 63, "parentItem": "J42DMDV2", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-05T22:16:07Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20702740", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-05T22:16:07Z", "dateModified": "2013-11-05T22:16:07Z" } }, { "key": "IF7VHHQT", "version": 62, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/IF7VHHQT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/IF7VHHQT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } }, "creatorSummary": "Fontana and Klein", "parsedDate": "2007-03-07", "numChildren": 1 }, "data": { "key": "IF7VHHQT", "version": 62, "itemType": "journalArticle", "title": "AGing, adiposity, and calorie restriction", "creators": [ { "creatorType": "author", "firstName": "L", "lastName": "Fontana" }, { "creatorType": "author", "firstName": "S", "lastName": "Klein" } ], "abstractNote": "Context Excessive calorie intake and subsequent obesity increases the risk of developing chronic disease and decreases life expectancy. In rodent models, calorie restriction with adequate nutrient intake decreases the risk of developing chronic disease and extends maximum life span.Objective To evaluate the physiological and clinical implications of calorie restriction with adequate nutrient intake.Evidence Acquisition Search of PubMed (1966-December 2006) using terms encompassing various aspects of calorie restriction, dietary restriction, aging, longevity, life span, adiposity, and obesity; hand search of journals that focus on obesity, geriatrics, or aging; and search of reference lists of pertinent research and review articles and books. Reviewed reports (both basic science and clinical) included epidemiologic studies, case-control studies, and randomized controlled trials, with quality of data assessed by taking into account publication in a peer-reviewed journal, number of animals or individuals studied, objectivity of measurements, and techniques used to minimize bias.Evidence Synthesis It is not known whether calorie restriction extends maximum life span or life expectancy in lean humans. However, calorie restriction in adult men and women causes many of the same metabolic adaptations that occur in calorie-restricted rodents and monkeys, including decreased metabolic, hormonal, and inflammatory risk factors for diabetes, cardiovascular disease, and possibly cancer. Excessive calorie restriction causes malnutrition and has adverse clinical effects.Conclusions Calorie restriction in adult men and women causes beneficial metabolic, hormonal, and functional changes, but the precise amount of calorie intake or body fat mass associated with optimal health and maximum longevity in humans is not known. In addition, it is possible that even moderate calorie restriction may be harmful in specific patient populations, such as lean persons who have minimal amounts of body fat.", "publicationTitle": "JAMA", "publisher": "", "place": "", "date": "March 7, 2007", "volume": "297", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "986-994", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "JAMA", "DOI": "10.1001/jama.297.9.986", "citationKey": "", "url": "http://dx.doi.org/10.1001/jama.297.9.986", "accessDate": "2013-10-21T03:18:06Z", "PMID": "", "PMCID": "", "ISSN": "0098-7484", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Silverchair", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-11-05T20:58:16Z", "dateModified": "2013-11-05T22:12:54Z" } }, { "key": "KV6H7EVC", "version": 61, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/KV6H7EVC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/KV6H7EVC", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/212852/items/BF2ZEBAF", "type": "application/json" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } } }, "data": { "key": "KV6H7EVC", "version": 61, "parentItem": "BF2ZEBAF", "itemType": "attachment", "linkMode": "imported_url", "title": "Snapshot", "accessDate": "2013-11-05T22:06:52Z", "url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1594.2005.29037.x/abstract;jsessionid=2DB492A13DE753B2522FF5842A6A3CBB.f01t02", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "abstract;jsessionid=2DB492A13DE753B2522FF5842A6A3CBB.html", "md5": "a658909c9d8a0624f8494856dfb9ba95", "mtime": 1383689212732, "tags": [], "relations": {}, "dateAdded": "2013-11-05T22:06:52Z", "dateModified": "2013-11-05T22:06:52Z" } }, { "key": "NDJNTCM3", "version": 61, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/NDJNTCM3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/NDJNTCM3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/212852/items/BF2ZEBAF", "type": "application/json" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "NDJNTCM3", "version": 61, "parentItem": "BF2ZEBAF", "itemType": "attachment", "linkMode": "imported_url", "title": "Full Text PDF", "accessDate": "2013-11-05T22:06:46Z", "url": "http://onlinelibrary.wiley.com/store/10.1111/j.1525-1594.2005.29037.x/asset/j.1525-1594.2005.29037.x.pdf?v=1&t=hnnotrrg&s=157f6b1b78ed9009b8de63540951ebb83eaff366", "note": "", "contentType": "application/pdf", "charset": "", "filename": "Ashley et al. - 2005 - Determination of the Chronaxie and Rheobase of Den.pdf", "md5": "1a9a7013a3f61164f5325f73cb6d9859", "mtime": 1383689210019, "tags": [], "relations": {}, "dateAdded": "2013-11-05T22:06:46Z", "dateModified": "2013-11-05T22:06:50Z" } }, { "key": "BF2ZEBAF", "version": 60, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/BF2ZEBAF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/BF2ZEBAF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } }, "creatorSummary": "Ashley et al.", "parsedDate": "2005", "numChildren": 2 }, "data": { "key": "BF2ZEBAF", "version": 60, "itemType": "journalArticle", "title": "Determination of the Chronaxie and Rheobase of Denervated Limb Muscles in Conscious Rabbits", "creators": [ { "creatorType": "author", "firstName": "Zoe", "lastName": "Ashley" }, { "creatorType": "author", "firstName": "Hazel", "lastName": "Sutherland" }, { "creatorType": "author", "firstName": "Hermann", "lastName": "Lanmuller" }, { "creatorType": "author", "firstName": "Ewald", "lastName": "Unger" }, { "creatorType": "author", "firstName": "Feng", "lastName": "Li" }, { "creatorType": "author", "firstName": "Winfried", "lastName": "Mayr" }, { "creatorType": "author", "firstName": "Helmut", "lastName": "Kern" }, { "creatorType": "author", "firstName": "Jonathan C.", "lastName": "Jarvis" }, { "creatorType": "author", "firstName": "Stanley", "lastName": "Salmons" } ], "abstractNote": "Abstract: Measurements of the rheobase and chronaxie can be used to define the excitability of nerves and muscles. The aim of this study was to obtain a record over many weeks of changes in the rheobase and chronaxie of denervated rabbit tibialis anterior muscle (TA). A custom-built electronic stimulator was implanted into the peritoneal cavity of New Zealand White rabbits. Large stainless steel electrodes were placed on the denervated TA muscle. Rheobase and chronaxie were measured noninvasively at weekly intervals by means of a laptop PC, which communicated with the stimulator via a radio-frequency link. At each setting the denervated TA was palpated manually to detect the response of the muscle. During the first few days after denervation the rheobase increased transiently to 0.8 ± 0.13 mA, approximately twice the value for normal innervated muscle, then decreased to normal for the remainder of the experimental period. Chronaxie underwent a significant 3-fold increase from 4.5 ± 1.1 ms to 14.1 ± 1.1 ms during the first two weeks of denervation and remained elevated throughout. The custom-built implantable electronic stimulator allowed changes in muscle excitability to be studied over a long period of denervation within individual animals, providing an accurate assessment of the time course of denervation-induced changes in muscle excitability.", "publicationTitle": "Artificial Organs", "publisher": "", "place": "", "date": "2005", "volume": "29", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "212–215", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1111/j.1525-1594.2005.29037.x", "citationKey": "", "url": "http://onlinelibrary.wiley.com/doi/10.1111/j.1525-1594.2005.29037.x/abstract", "accessDate": "2013-11-05T22:06:46Z", "PMID": "", "PMCID": "", "ISSN": "1525-1594", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "Wiley Online Library", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Chronaxie", "type": 1 }, { "tag": "Denervated muscle", "type": 1 }, { "tag": "Functional electrical stimulation", "type": 1 }, { "tag": "Rabbit", "type": 1 }, { "tag": "Rheobase", "type": 1 }, { "tag": "Tibialis anterior", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-11-05T22:06:46Z", "dateModified": "2013-11-05T22:06:46Z" } }, { "key": "MKNNFHCW", "version": 67, "library": { "type": "group", "id": 212852, "name": "Capstone_EstimationOfEI", "links": { "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/212852/items/MKNNFHCW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/capstone_estimationofei/items/MKNNFHCW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/212852/items/U5KTF7Z5", "type": "application/json" } }, "meta": { "createdByUser": { "id": 905579, "username": "lfirey", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/lfirey", "type": "text/html" } } } }, "data": { "key": "MKNNFHCW", "version": 67, "parentItem": "U5KTF7Z5", "itemType": "attachment", "linkMode": "imported_url", "title": "The Economist Snapshot", "accessDate": "2013-09-23T01:12:11Z", "url": "http://www.economist.com/node/21542373", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "2012 - 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Our objective is to compare validity of self-reported energy intake obtained by three dietary assessment methods with total energy expenditure (TEE) obtained by doubly labeled water (DLW) among Brazilian women.\nDESIGN: We used a cross-sectional study.\nSUBJECTS/SETTING: Sixty-five females aged 18 to 57 years (28 normal-weight, 10 overweight, and 27 obese) were recruited from two universities to participate.\nMAIN OUTCOME MEASURES: TEE determined by DLW, energy intake estimated by three 24-hour recalls, 3-day food record, and a food frequency questionnaire (FFQ).\nSTATISTICAL ANALYSES PERFORMED: Regression and analysis of variance with repeated measures compared TEE and energy intake values, and energy intake-to-TEE ratios and energy intake-TEE values between dietary assessment methods. Bland and Altman plots were provided for each method. chi(2) test compared proportion of underreporters between the methods.\nRESULTS: Mean TEE was 2,622 kcal (standard deviation [SD]=490 kcal), while mean energy intake was 2,078 kcal (SD=430 kcal) for the diet recalls; 2,044 kcal (SD=479 kcal) for the food record and 1,984 kcal (SD=832 kcal) for the FFQ (all energy intake values significantly differed from TEE; P<0.0001). Bland and Altman plots indicated great dispersion, negative mean differences between measurements, and wide limits of agreement. Obese subjects underreported more than normal-weight subjects in the diet recalls and in the food records, but not in the FFQ. Years of education, income and ethnicity were associated with reporting accuracy.\nCONCLUSIONS: The FFQ produced greater under- and overestimation of energy intake. Underreporting of energy intake is a serious and prevalent error in dietary self-reports provided by Brazilian women, as has been described in studies conducted in developed countries.", "publicationTitle": "Journal of the American Dietetic Association", "publisher": "", "place": "", "date": "Dec 2008", "volume": "108", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "2031-2040", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Diet Assoc", "DOI": "10.1016/j.jada.2008.09.012", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0002-8223", "archive": "", "archiveLocation": "", "shortTitle": "Underreporting of energy intake in Brazilian women varies according to dietary assessment", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19027406", "tags": [ { "tag": "Adolescent", "type": 1 }, { "tag": "Adult", "type": 1 }, { "tag": "Analysis of Variance", 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