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            "itemType": "journalArticle",
            "title": "Pregnancy outcome after exposure to the probiotic Lactobacillus in early pregnancy",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "J E",
                    "lastName": "Lee"
                },
                {
                    "creatorType": "author",
                    "firstName": "J Y",
                    "lastName": "Han"
                },
                {
                    "creatorType": "author",
                    "firstName": "J S",
                    "lastName": "Choi"
                },
                {
                    "creatorType": "author",
                    "firstName": "H K",
                    "lastName": "Ahn"
                },
                {
                    "creatorType": "author",
                    "firstName": "S W",
                    "lastName": "Lee"
                },
                {
                    "creatorType": "author",
                    "firstName": "M H",
                    "lastName": "Kim"
                },
                {
                    "creatorType": "author",
                    "firstName": "H M",
                    "lastName": "Ryu"
                },
                {
                    "creatorType": "author",
                    "firstName": "J H",
                    "lastName": "Yang"
                },
                {
                    "creatorType": "author",
                    "firstName": "A A",
                    "lastName": "Nava-Ocampo"
                },
                {
                    "creatorType": "author",
                    "firstName": "G",
                    "lastName": "Koren"
                }
            ],
            "abstractNote": "The present study prospectively assessed pregnancy outcome of women taking probiotics during the periconceptional period. A group of 104 women who had taken Lactobacillus in early pregnancy and 200 age- and parity-matched control pregnant women exposed to non-teratogenic agents were also recruited into the study and followed-up prospectively. Median gestational age of women exposed to Lactobacillus was 5.2 (range: 1.9-17.6) weeks. Exposure was at a mean dose of 510 mg/day for a median of 4.0 days (range: 1-90 days). In the exposed group, pregnancy outcomes included 96 live births and eight spontaneous abortions versus 187 live births and 21 spontaneous abortions in the non-exposed group. There was no statistical difference in adverse pregnancy outcomes, including the number of spontaneous abortions, pre-term births as well as a low birth weight between the two groups (p > 0.05). In the exposed group, there were two (2.1%) major congenital malformations in comparison with five (2.7%) in the comparison group (p = 0.7). In conclusion, no association was identified between ingestion of Lactobacillus in early pregnancy for a limited period of time and adverse pregnancy outcomes. However, rare pregnancy outcomes may have been missed due to the limited sample size included in the study.",
            "publicationTitle": "Journal of obstetrics and gynaecology: the journal of the Institute of Obstetrics and Gynaecology",
            "publisher": "",
            "place": "",
            "date": "Apr 2012",
            "volume": "32",
            "issue": "3",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "227-229",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J Obstet Gynaecol",
            "DOI": "10.3109/01443615.2011.641621",
            "citationKey": "",
            "url": "",
            "accessDate": "",
            "PMID": "22369393",
            "PMCID": "",
            "ISSN": "1364-6893",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "eng",
            "libraryCatalog": "NCBI PubMed",
            "callNumber": "",
            "rights": "",
            "extra": "",
            "tags": [
                {
                    "tag": "Abortion, Spontaneous",
                    "type": 1
                },
                {
                    "tag": "Adult",
                    "type": 1
                },
                {
                    "tag": "Birth Weight",
                    "type": 1
                },
                {
                    "tag": "Congenital Abnormalities",
                    "type": 1
                },
                {
                    "tag": "Female",
                    "type": 1
                },
                {
                    "tag": "Follow-Up Studies",
                    "type": 1
                },
                {
                    "tag": "Gestational Age",
                    "type": 1
                },
                {
                    "tag": "Humans",
                    "type": 1
                },
                {
                    "tag": "Infant, Low Birth Weight",
                    "type": 1
                },
                {
                    "tag": "Infant, Newborn",
                    "type": 1
                },
                {
                    "tag": "Lactobacillus",
                    "type": 1
                },
                {
                    "tag": "Live Birth",
                    "type": 1
                },
                {
                    "tag": "Maternal Exposure",
                    "type": 1
                },
                {
                    "tag": "Pregnancy",
                    "type": 1
                },
                {
                    "tag": "Pregnancy Trimester, First",
                    "type": 1
                },
                {
                    "tag": "Premature Birth",
                    "type": 1
                },
                {
                    "tag": "Probiotics",
                    "type": 1
                },
                {
                    "tag": "Prospective Studies",
                    "type": 1
                },
                {
                    "tag": "Single-Blind Method",
                    "type": 1
                }
            ],
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