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"note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-24T19:41:21Z", "dateModified": "2013-08-24T19:41:21Z" } }, { "key": "9WHVBMP9", "version": 31, "library": { "type": "group", "id": 198071, "name": "Citología", "links": { "alternate": { "href": "https://www.zotero.org/groups/citologa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/198071/items/9WHVBMP9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/citologa/items/9WHVBMP9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531172, "username": "liss01", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/liss01", "type": "text/html" } } }, "lastModifiedByUser": { "id": 660806, "username": "cecybelle", "name": "Cecilia Rodriguez Bellegarrigue", "links": { "alternate": { "href": "https://www.zotero.org/cecybelle", "type": "text/html" } } }, "creatorSummary": "Shaikh et al.", "parsedDate": "2012-07-06", "numChildren": 1 }, "data": { "key": "9WHVBMP9", "version": 31, "itemType": "journalArticle", "title": "Molecular screening of compounds to the predicted Protein-Protein Interaction site of Rb1-E7 with p53- E6 in HPV", "creators": [ { "creatorType": "author", "firstName": "Faraz", "lastName": "Shaikh" }, { "creatorType": "author", "firstName": "Parvish", "lastName": "Sanehi" }, { "creatorType": "author", "firstName": "Rakesh", "lastName": "Rawal" } ], "abstractNote": "Cervical cancer is malignant neoplasm of the cervix uteri or cervical area. Human Papillomaviruses (HPVs) which are\nheterogeneous groups of small double stranded DNA viruses are considered as the primary cause of cervical cancer, involved in\n90% of all Cervical Cancers. Two early HPV genes, E6 and E7, are known to play crucial role in tumor formation. E6 binds with p53\nand prevents its translocation and thereby inhibit the ability of p53 to activate or repress target genes. E7 binds to\nhypophosphorylated Rb and thereby induces cells to enter into premature S-phase by disrupting Rb-E2F complexes. The strategy\nof the research work was to target the site of interaction of Rb1 -E7 & p53-E6. A total of 88 compounds were selected for molecular\nscreening, based on comprehensive literature survey for natural compounds with anti-cancer activity. Molecular docking analysis\nwas carried out with Molegro Virtual Docker, to screen the 88 chosen compounds and rank them according to their binding affinity\ntowards the site of interaction of the viral oncoproteins and human tumor suppressor proteins. The docking result revealed that\nNicandrenone a member of Withanolides family of chemical compounds as the most likely molecule that can be used as a\ncandidate drug against HPV induced cervical cancer.", "publicationTitle": "Bioinformation", "publisher": "", "place": "", "date": "2012-7-06", "volume": "8", "issue": "13", "section": "", "partNumber": "", "partTitle": "", "pages": "607-612", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Bioinformation", "DOI": "10.6026/97320630008607", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3400986/", "accessDate": "2013-08-20T07:04:30Z", "PMID": "", "PMCID": "", "ISSN": "0973-8894", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "Cited by 0000", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-20T07:04:43Z", "dateModified": "2013-08-23T20:10:26Z" } }, { "key": "8FR2BAS2", "version": 31, "library": { "type": "group", "id": 198071, "name": "Citología", "links": { "alternate": { "href": "https://www.zotero.org/groups/citologa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/198071/items/8FR2BAS2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/citologa/items/8FR2BAS2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531172, "username": "liss01", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/liss01", "type": "text/html" } } }, "lastModifiedByUser": { "id": 660806, "username": "cecybelle", "name": "Cecilia Rodriguez Bellegarrigue", "links": { "alternate": { "href": "https://www.zotero.org/cecybelle", "type": "text/html" } } }, "creatorSummary": "Lewis-Bell et al.", "parsedDate": "2013-03", "numChildren": 0 }, "data": { "key": "8FR2BAS2", "version": 31, "itemType": "journalArticle", "title": "Genital human papillomaviruses among women of reproductive age in Jamaica", "creators": [ { "creatorType": "author", "firstName": "Karen", "lastName": "Lewis-Bell" }, { "creatorType": "author", "firstName": "Silvana", "lastName": "Luciani" }, { "creatorType": "author", "firstName": "Elizabeth R.", "lastName": "Unger" }, { "creatorType": "author", "firstName": "Susan", "lastName": "Hariri" }, { "creatorType": "author", "firstName": "Shelly", "lastName": "McFarlane" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Steinau" }, { "creatorType": "author", "firstName": "Elisa", "lastName": "Prieto-Lara" }, { "creatorType": "author", "firstName": "Andrea S.", "lastName": "Vicari" }, { "creatorType": "author", "firstName": "Beryl", "lastName": "Irons" }, { "creatorType": "author", "firstName": "Merle J.", "lastName": "Lewis" }, { "creatorType": "author", "firstName": "Jon Kim", "lastName": "Andrus" } ], "abstractNote": "Objective. To characterize the prevalence and distribution of genital human papillomavirus (HPV) types among women in Jamaica, and to explore risk factors associated with HPV infection. Methods. This was a cross-sectional study that took place in April-July 2010 with 852 sexually-active women, 16-49 years of age, who had attended a selected public or private primary health clinic in one of Jamaica's four health authority regions. Sociodemographic data was collected from each participant by trained study staff. Each participant had a gynecological examination that included a clinical Pap test and a cervical sample for HPV detection and typing--performed using the Research Use Only Linear Array (LA) genotyping assay (Roche Diagnostics Corp., Indianapolis, Indiana, United States). Overall and type-specific prevalence of HPV infection was calculated for 37 HPV types included in the LA genotyping assay. Results. HPV DNA was detected in 460 of the 852 women (54.0%). Oncogenic HPV was detected in 297 women (34.9%) and HPV types 16/18 were found in 86 women (10.1%). The most frequently occurring HPV types were: 16 (6.2%); 35 (6.0%); 62 and 83 (5.5%); 61 and 58 (5.4%); 84 (4.7%); 18 (4.3%); and, 66 and 81 (4.2%). HPV prevalence was highest among women who were single, young (16-19 years), and had had more than three sexual partners in their lifetime. Conclusions. These results, coupled with high rates of cervical cancer, support introducing HPV vaccines while maintaining and strengthening cervical cancer screening services. Policy decisionmaking that reflects these results is instrumental to establishing a comprehensive cervical cancer program in Jamaica. (English)", "publicationTitle": "Virus de los papilomas humanos genitales en mujeres en edad reproductiva de Jamaica.", "publisher": "", "place": "", "date": "Marzo 2013", "volume": "33", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "159-165", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Revista Panamericana de Salud Publica", "DOI": "", "citationKey": "", "url": "http://search.ebscohost.com/login.aspx?direct=true&db=aph&AN=88918424&lang=es&site=ehost-live", "accessDate": "2013-08-21T21:59:36Z", "PMID": "", "PMCID": "", "ISSN": "10204989", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "EBSCOhost", "callNumber": "88918424", "rights": "", "extra": "Cited by 0000", "tags": [ { "tag": "AGE distribution (Demography)", "type": 1 }, { "tag": "CERVIX uteri", "type": 1 }, { "tag": "CONFIDENCE intervals", "type": 1 }, { "tag": "CORRELATION (Statistics)", "type": 1 }, { "tag": "CROSS-sectional 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"lastName": "García" }, { "creatorType": "author", "firstName": "Ignacio", "lastName": "Briceño" }, { "creatorType": "author", "firstName": "Marcos", "lastName": "Castillo" }, { "creatorType": "author", "firstName": "Fabio A.", "lastName": "Aristizábal" } ], "abstractNote": "Introduction: Cervical cancer is the second most common cancer among women worldwide and the second cause of cancer mortality in women. It has been demonstrated that the process of cervical carcinogenesis displays genetic and environmental epigenetic components. Currently, research is focused on new prognosis markers like oncogene amplification. Objectives: To perform detection of MYCN, C-MYC, MYCL1, ERBB2, EGFR, and AKT2 amplification. Additionally, to detect human papillomavirus in samples from normal cytology smear, cervical intraepithelial neoplasia (CIN) I, II, and III and cervical cancer patients. Methods: Papillomavirus (HPV) genotyping by reverse line blot (RLB) performed and gene amplification by detection with real-time PCR with Taqman probes. Results: HPV was present in 4% of the patients with normal cytology, 48% in CIN I, 63.6% in CIN II, 64% in CIN III, and 70.8% in cervical cancer. Genes amplified in cervical cancer were MYCN (39.1%), ERBB2 (34.7%), and MYCL1 (30.4%); showed higher amplification in high-grade lesions and cervical cancer in relation to low-grade lesions and normal cytology with statistically significant differences. Besides the genes, C-MYC, EGFR, and AKT2 were amplified in samples from patients with cervical cancer by 12%, 18%, and 13%, respectively; we did not find statistical differences. Conclusion: Higher prevalence of gene amplification and HPV was found in high-grade cervical lesions and cervical cancer. 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"version": 9, "library": { "type": "group", "id": 198071, "name": "Citología", "links": { "alternate": { "href": "https://www.zotero.org/groups/citologa", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/198071/items/W5364N4C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/citologa/items/W5364N4C", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531160, "username": "abrizuela93", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/abrizuela93", "type": "text/html" } } }, "creatorSummary": "Lazcano-Ponce et al.", "parsedDate": "2008-10-01", "numChildren": 1 }, "data": { "key": "W5364N4C", "version": 9, "itemType": "journalArticle", "title": "Decreasing Cervical Cancer Mortality in Mexico: Effect of Papanicolaou Coverage, Birthrate, and the Importance of Diagnostic Validity of Cytology", "creators": [ { "creatorType": "author", "firstName": "Eduardo", "lastName": "Lazcano-Ponce" }, { "creatorType": "author", "firstName": "Lina Sofía", "lastName": "Palacio-Mejia" }, { "creatorType": "author", "firstName": "Betania", "lastName": "Allen-Leigh" }, { "creatorType": "author", "firstName": "Elsa", "lastName": "Yunes-Diaz" }, { "creatorType": "author", "firstName": "Patricia", "lastName": "Alonso" }, { "creatorType": "author", "firstName": "Raffaela", "lastName": "Schiavon" }, { "creatorType": "author", "firstName": "Mauricio", "lastName": "Hernandez-Avila" } ], "abstractNote": "Background: The reduction in cervical cancer mortality in developed countries has been attributed to well-organized, population-based prevention and control programs that incorporate screening with the Papanicolaou (Pap) smear. In Mexico, there has been a decrease in cervical cancer mortality, but it is unclear what factors have prompted this reduction.\nMethods: Using data from national indicators, we determined the correlation between cervical cancer mortality rates and Pap coverage, birthrate, and gross national product, using a linear regression model. We determined relative risk of dying of cervical cancer according to place of residence (rural/urban, region) using a Poisson model. We also estimated Pap smear coverage using national survey data and evaluated the validity and reproducibility of Pap smear diagnosis.\nResults: An increase in Pap coverage (β = −0.069) and a decrease in birthrate (β = 0.054) correlate with decreasing cervical cancer mortality in Mexico. Self-reported Pap smear rates in the last 12 months vary from 27.4% to 48.1%. Women who live in the central (relative risk, 1.04) and especially the southern (relative risk, 1.47) parts of Mexico have a greater relative risk of dying of cervical cancer than those who live in the north. There is a high incidence of false negatives in cervical cytology laboratories in Mexico; the percentage of false negatives varies from 3.33% to 53.13%.\nConclusions: The decrease in cervical cancer mortality observed in Mexico is proportional to increasing Pap coverage and decreasing birthrate. Accreditation of cervical cytology laboratories is needed to improve diagnostic precision. (Cancer Epidemiol Biomarkers Prev 2008;17(10):2808–17)", "publicationTitle": "Cancer Epidemiology Biomarkers & Prevention", "publisher": "", "place": "", "date": "10/01/2008", "volume": "17", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "2808-2817", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer Epidemiol Biomarkers Prev", "DOI": "10.1158/1055-9965.EPI-07-2659", "citationKey": "", "url": "http://cebp.aacrjournals.org/content/17/10/2808", "accessDate": "2013-08-16T03:05:17Z", "PMID": "", "PMCID": "", "ISSN": "1055-9965, 1538-7755", "archive": "", "archiveLocation": "", "shortTitle": "Decreasing Cervical Cancer Mortality in Mexico", "language": "en", "libraryCatalog": "cebp.aacrjournals.org", "callNumber": "", "rights": "", "extra": "PMID: 18843027", "tags": [ { "tag": "Pap coverage", "type": 1 }, { "tag": "birthrate", "type": 1 }, { "tag": "cervical cancer mortality", "type": 1 }, { "tag": "diagnostic validity", "type": 1 }, { "tag": "reproducibility", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-16T03:05:35Z", "dateModified": "2013-08-16T03:05:35Z" } } ]