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"creatorType": "author", "firstName": "Chansuda", "lastName": "Wongsrichanalai" }, { "creatorType": "author", "firstName": "Ralf", "lastName": "Linke" }, { "creatorType": "author", "firstName": "Rick", "lastName": "O'Brien" }, { "creatorType": "author", "firstName": "Mark", "lastName": "Perkins" }, { "creatorType": "author", "firstName": "Jane", "lastName": "Cunningham" }, { "creatorType": "author", "firstName": "Precious", "lastName": "Matsoso" }, { "creatorType": "author", "firstName": "Carl Michael", "lastName": "Nathanson" }, { "creatorType": "author", "firstName": "Piero", "lastName": "Olliaro" }, { "creatorType": "author", "firstName": "Rosanna W.", "lastName": "Peeling" }, { "creatorType": "author", "firstName": "Andy", "lastName": "Ramsay" } ], "abstractNote": "The TDR Diagnostics Evaluation Expert Panel", "publicationTitle": "Nature Reviews Microbiology", "publisher": "", "place": "", "date": "11/01/2007", "volume": "5", "issue": "", "section": "", "partNumber": "", 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"firstName": "Mickey", "lastName": "Urdea" }, { "creatorType": "author", "firstName": "Laura A.", "lastName": "Penny" }, { "creatorType": "author", "firstName": "Stuart S.", "lastName": "Olmsted" }, { "creatorType": "author", "firstName": "Maria Y.", "lastName": "Giovanni" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Kaspar" }, { "creatorType": "author", "firstName": "Andrew", "lastName": "Shepherd" }, { "creatorType": "author", "firstName": "Penny", "lastName": "Wilson" }, { "creatorType": "author", "firstName": "Carol A.", "lastName": "Dahl" }, { "creatorType": "author", "firstName": "Steven", "lastName": "Buchsbaum" }, { "creatorType": "author", "firstName": "Gerry", "lastName": "Moeller" }, { "creatorType": "author", "firstName": "Deborah C.", "lastName": "Hay Burgess" } ], "abstractNote": "This paper focuses on the technologies required to meet the global health diagnostics needs presented in the previous papers, highlighting how new diagnostic technologies might have the potential to change medical and public-health scenarios in the developing world.", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "November 22, 2006", "volume": "444", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "73-79", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature05448", "citationKey": "", "url": "http://www.nature.com/nature/journal/v444/n1s/full/nature05448.html", "accessDate": "2013-08-21T00:08:48Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2006 Nature Publishing Group", "extra": "", "tags": [ { "tag": "DNA", "type": 1 }, { "tag": "Genomics", "type": 1 }, { "tag": "Nanotechnology", "type": 1 }, { "tag": "Nature", "type": 1 }, { "tag": "RNA", "type": 1 }, { "tag": "astronomy", "type": 1 }, { "tag": "astrophysics", "type": 1 }, { "tag": "biochemistry", "type": 1 }, { "tag": "bioinformatics", "type": 1 }, { "tag": "biology", "type": 1 }, { "tag": "biotechnology", "type": 1 }, { "tag": "cancer", "type": 1 }, { "tag": "cell cycle", "type": 1 }, { "tag": "cell signalling", "type": 1 }, { "tag": "climate change", "type": 1 }, { "tag": "computational biology", "type": 1 }, { "tag": "development", "type": 1 }, { "tag": "developmental biology", "type": 1 }, { "tag": "drug discovery", "type": 1 }, { "tag": "earth science", "type": 1 }, { "tag": "ecology", "type": 1 }, { "tag": "environmental science", "type": 1 }, { "tag": "evolution", "type": 1 }, { "tag": "evolutionary biology", "type": 1 }, { "tag": "functional genomics", "type": 1 }, { "tag": "genetics", "type": 1 }, { "tag": "geophysics", "type": 1 }, { "tag": "immunology", "type": 1 }, { "tag": "interdisciplinary science", "type": 1 }, { "tag": "life", "type": 1 }, { "tag": "marine biology", "type": 1 }, { "tag": "materials science", "type": 1 }, { "tag": "medical research", "type": 1 }, { "tag": "medicine", "type": 1 }, { "tag": "metabolomics", "type": 1 }, { "tag": "molecular biology", "type": 1 }, { "tag": "molecular interactions", "type": 1 }, { "tag": "neurobiology", "type": 1 }, { "tag": "neuroscience", "type": 1 }, { "tag": "palaeobiology", "type": 1 }, { "tag": "pharmacology", "type": 1 }, { "tag": "physics", "type": 1 }, { "tag": "proteomics", "type": 1 }, { "tag": "quantum physics", "type": 1 }, { "tag": "science", "type": 1 }, { "tag": "science news", "type": 1 }, { "tag": "science policy", "type": 1 }, { "tag": "signal transduction", "type": 1 }, { "tag": "structural biology", "type": 1 }, { "tag": "systems biology", "type": 1 }, { "tag": "transcriptomics", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-21T00:08:48Z", "dateModified": "2013-08-21T00:08:48Z" } }, { "key": "U22FAJV2", "version": 40, "library": { "type": "group", "id": 197331, "name": "POCT", "links": { "alternate": { "href": 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"creatorType": "author", "firstName": "Kjell", "lastName": "Nelson" }, { "creatorType": "author", "firstName": "Milton R.", "lastName": "Tam" }, { "creatorType": "author", "firstName": "Bernhard H.", "lastName": "Weigl" } ], "abstractNote": "The developing world does not have access to many of the best medical diagnostic technologies; they were designed for air-conditioned laboratories, refrigerated storage of chemicals, a constant supply of calibrators and reagents, stable electrical power, highly trained personnel and rapid transportation of samples. Microfluidic systems allow miniaturization and integration of complex functions, which could move sophisticated diagnostic tools out of the developed-world laboratory. These systems must be inexpensive, but also accurate, reliable, rugged and well suited to the medical and social contexts of the developing world.", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "July 27, 2006", "volume": "442", "issue": "7101", "section": "", "partNumber": "", "partTitle": "", "pages": "412-418", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature05064", "citationKey": "", "url": "http://www.nature.com/nature/journal/v442/n7101/full/nature05064.html", "accessDate": "2013-08-21T00:01:54Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2006 Nature Publishing Group", "extra": "", "tags": [ { "tag": "DNA", "type": 1 }, { "tag": "Genomics", "type": 1 }, { "tag": "Nanotechnology", "type": 1 }, { "tag": "Nature", "type": 1 }, { "tag": "RNA", "type": 1 }, { "tag": "astronomy", "type": 1 }, { "tag": "astrophysics", "type": 1 }, { "tag": "biochemistry", "type": 1 }, { "tag": "bioinformatics", "type": 1 }, { "tag": "biology", "type": 1 }, { "tag": "biotechnology", "type": 1 }, { "tag": "cancer", "type": 1 }, { "tag": "cell cycle", "type": 1 }, { "tag": "cell signalling", "type": 1 }, { "tag": "climate change", "type": 1 }, { "tag": "computational biology", "type": 1 }, { "tag": "development", "type": 1 }, { "tag": "developmental biology", "type": 1 }, { "tag": "drug discovery", "type": 1 }, { "tag": "earth science", "type": 1 }, { "tag": "ecology", "type": 1 }, { "tag": "environmental science", "type": 1 }, { "tag": "evolution", "type": 1 }, { "tag": "evolutionary biology", "type": 1 }, { "tag": "functional genomics", "type": 1 }, { "tag": "genetics", "type": 1 }, { "tag": "geophysics", "type": 1 }, { "tag": "immunology", "type": 1 }, { "tag": "interdisciplinary science", "type": 1 }, { "tag": "life", "type": 1 }, { "tag": "marine biology", "type": 1 }, { "tag": "materials science", "type": 1 }, { "tag": "medical research", "type": 1 }, { "tag": "medicine", "type": 1 }, { "tag": "metabolomics", "type": 1 }, { "tag": "molecular biology", "type": 1 }, { "tag": "molecular interactions", "type": 1 }, { "tag": "neurobiology", "type": 1 }, { "tag": "neuroscience", "type": 1 }, { "tag": "palaeobiology", "type": 1 }, { "tag": "pharmacology", "type": 1 }, { "tag": "physics", "type": 1 }, { "tag": "proteomics", "type": 1 }, { "tag": "quantum physics", "type": 1 }, { "tag": "science", "type": 1 }, { "tag": "science news", "type": 1 }, { "tag": "science policy", "type": 1 }, { "tag": "signal transduction", "type": 1 }, { "tag": "structural biology", "type": 1 }, { "tag": "systems biology", "type": 1 }, { "tag": "transcriptomics", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-21T00:01:54Z", "dateModified": "2013-08-21T00:01:54Z" } }, { "key": "J338TRST", "version": 40, "library": { "type": "group", "id": 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"https://www.zotero.org/cindy.romaine", "type": "text/html" } } } }, "data": { "key": "2VE6TDBA", "version": 39, "parentItem": "5B3HGPJ7", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2013-08-20T23:49:49Z", "url": "http://www.nature.com/nrmicro/journal/v11/n8/pdf/nrmicro3068.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-20T23:49:49Z", "dateModified": "2013-08-20T23:49:49Z" } }, { "key": "5B3HGPJ7", "version": 39, "library": { "type": "group", "id": 197331, "name": "POCT", "links": { "alternate": { "href": "https://www.zotero.org/groups/poct", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/197331/items/5B3HGPJ7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/poct/items/5B3HGPJ7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 590810, "username": "cindy.romaine", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cindy.romaine", "type": "text/html" } } }, "creatorSummary": "Fournier et al.", "parsedDate": "2013-08", "numChildren": 2 }, "data": { "key": "5B3HGPJ7", "version": 39, "itemType": "journalArticle", "title": "Modern clinical microbiology: new challenges and solutions", "creators": [ { "creatorType": "author", "firstName": "Pierre-Edouard", "lastName": "Fournier" }, { "creatorType": "author", "firstName": "Michel", "lastName": "Drancourt" }, { "creatorType": "author", "firstName": "Philippe", "lastName": "Colson" }, { "creatorType": "author", "firstName": "Jean-Marc", "lastName": "Rolain" }, { "creatorType": "author", "firstName": "Bernard La", "lastName": "Scola" }, { "creatorType": "author", "firstName": "Didier", "lastName": "Raoult" } ], "abstractNote": "In the twenty-first century, the clinical microbiology laboratory plays a central part in optimizing the management of infectious diseases and surveying local and global epidemiology. This pivotal role is made possible by the adoption of rational sampling, point-of-care tests, extended automation and new technologies, including mass spectrometry for colony identification, real-time genomics for isolate characterization, and versatile and permissive culture systems. When balanced with cost, these developments can improve the workflow and output of clinical microbiology laboratories and, by identifying and characterizing microbial pathogens, provide significant input to scientific discovery.", "publicationTitle": "Nature Reviews Microbiology", "publisher": "", "place": "", "date": "August 2013", "volume": "11", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "574-585", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Rev Micro", "DOI": "10.1038/nrmicro3068", "citationKey": "", "url": "http://www.nature.com/nrmicro/journal/v11/n8/full/nrmicro3068.html#access", "accessDate": "2013-08-20T23:49:49Z", "PMID": "", "PMCID": "", "ISSN": "1740-1526", "archive": "", "archiveLocation": "", "shortTitle": "Modern clinical microbiology", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.", "extra": "", "tags": [ { "tag": "Clinical microbiology", "type": 1 }, { "tag": "Diagnostics", "type": 1 }, { "tag": "Genomics", "type": 1 }, { "tag": "Infectious diseases", "type": 1 }, { "tag": "Nature Reviews Microbiology", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-20T23:49:49Z", "dateModified": "2013-08-20T23:49:49Z" } }, { "key": "RHX68UDF", "version": 38, "library": { "type": "group", "id": 197331, "name": "POCT", "links": { "alternate": { "href": "https://www.zotero.org/groups/poct", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/197331/items/RHX68UDF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/poct/items/RHX68UDF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/197331/items/PMIQ6CWV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 590810, "username": "cindy.romaine", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cindy.romaine", "type": "text/html" } } } }, "data": { "key": "RHX68UDF", "version": 38, "parentItem": "PMIQ6CWV", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2013-08-20T23:44:23Z", "url": "http://link.springer.com/article/10.1007%2Fs10544-011-9552-4", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-20T23:44:23Z", "dateModified": "2013-08-20T23:44:23Z" } }, { "key": "R4QUGUFZ", "version": 38, "library": { "type": "group", "id": 197331, "name": "POCT", "links": { "alternate": { "href": "https://www.zotero.org/groups/poct", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/197331/items/R4QUGUFZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/poct/items/R4QUGUFZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/197331/items/PMIQ6CWV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 590810, "username": "cindy.romaine", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cindy.romaine", "type": "text/html" } } } }, "data": { "key": "R4QUGUFZ", "version": 38, "parentItem": "PMIQ6CWV", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2013-08-20T23:44:23Z", "url": "http://link.springer.com/content/pdf/10.1007%2Fs10544-011-9552-4.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-20T23:44:23Z", "dateModified": "2013-08-20T23:44:23Z" } }, { "key": "PMIQ6CWV", "version": 38, "library": { "type": "group", "id": 197331, "name": "POCT", "links": { "alternate": { "href": "https://www.zotero.org/groups/poct", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/197331/items/PMIQ6CWV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/poct/items/PMIQ6CWV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 590810, "username": "cindy.romaine", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/cindy.romaine", "type": "text/html" } } }, "creatorSummary": "Ritzi-Lehnert et al.", "parsedDate": "2011-10-01", "numChildren": 2 }, "data": { "key": "PMIQ6CWV", "version": 38, "itemType": "journalArticle", "title": "On-chip analysis of respiratory viruses from nasopharyngeal samples", "creators": [ { "creatorType": "author", "firstName": "Marion", "lastName": "Ritzi-Lehnert" }, { "creatorType": "author", "firstName": "Ralf", "lastName": "Himmelreich" }, { "creatorType": "author", "firstName": "Hans", "lastName": "Attig" }, { "creatorType": "author", "firstName": "Jan", "lastName": "Claußen" }, { "creatorType": "author", "firstName": "Rainer", "lastName": "Dahlke" }, { "creatorType": "author", "firstName": "Gerd", "lastName": "Großhauser" }, { "creatorType": "author", "firstName": "Eva", "lastName": "Holzer" }, { "creatorType": "author", "firstName": "Markus", "lastName": "Jeziorski" }, { "creatorType": "author", "firstName": "Eva", "lastName": "Schaeffer" }, { "creatorType": "author", "firstName": "Andy", "lastName": "Wende" }, { "creatorType": "author", "firstName": "Sabine", "lastName": "Werner" }, { "creatorType": "author", "firstName": "Jens Ole", "lastName": "Wiborg" }, { "creatorType": "author", "firstName": "Isabell", "lastName": "Wick" }, { "creatorType": "author", "firstName": "Klaus Stefan", "lastName": "Drese" }, { "creatorType": "author", "firstName": "Thomas", "lastName": "Rothmann" } ], "abstractNote": "Point-of-care (PoC) testing followed by personalized efficient therapy of infectious diseases may result in a considerable reduction of associated health care costs. Lab-on-a-chip (LoC) systems represent a potentially high efficient class of PoC tools. Here, we present a LoC system for automated pathogen analysis of respiratory viruses from nasopharyngeal specimens. The device prepares total nucleic acids from extracted swab samples using magnetic silica beads. After reverse transcription the co-purified viral RNA is amplified in accordance with the QIAplex multiplex PCR technology. Hybridized to corresponding QIAGEN LiquiChip beads and labelled with streptavidin R-phycoerythrin, the amplified target sequences are finally detected using a QIAGEN LiquiChip200 workstation. All chemicals needed are either stored freeze-dried on the disposable chip or are provided in liquid form in a reagent cartridge for up to 24 runs. Magnetic stir bars for mixing as well as turning valves with metering structures are integrated into the injection-moulded disposable chip. The core of the controlling instrument is a rotating heating bar construction providing fixed temperatures for fast cycling. PCR times of about half an hour (for 30 cycles) could be achieved for 120 μl reactions, making this system the fastest currently available high-volume PCR chip. The functionality of the system was shown by comparing automatically processed nasopharyngeal samples to ones processed manually according to the QIAGEN “ResPlex™ II Panel v2.0” respiratory virus detection kit. 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