[ { "key": "MJ4AHAU7", "version": 21, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/MJ4AHAU7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/MJ4AHAU7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1520253, "username": "Alex_59", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alex_59", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "MJ4AHAU7", "version": 21, "itemType": "webpage", "title": "Revista chilena de infectología - Tuberculosis en el paciente con infección por virus de inmunodeficiencia humana", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.scielo.cl/scielo.php?pid=S0716-10182009000200003&script=sci_arttext", "accessDate": "2013-08-08T16:45:35Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:45:35Z", "dateModified": "2013-08-08T17:47:52Z" } }, { "key": "S7BV7DS4", "version": 20, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/S7BV7DS4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/S7BV7DS4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/VIMZW26R", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } } }, "data": { "key": "S7BV7DS4", "version": 20, "parentItem": "VIMZW26R", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-08-08T17:24:01Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22789747", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T17:24:01Z", "dateModified": "2013-08-08T17:24:01Z" } }, { "key": "VIMZW26R", "version": 20, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/VIMZW26R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/VIMZW26R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } }, "creatorSummary": "Ouladlahsen et al.", "parsedDate": "2012-08", "numChildren": 1 }, "data": { "key": "VIMZW26R", "version": 20, "itemType": "journalArticle", "title": "[Benefit of the rapid test determine HIV1/2 in the clinical diagnosis of HIV infection in Ibn Rochd hospital of Casablanca, Morocco]", "creators": [ { "creatorType": "author", "firstName": "A", "lastName": "Ouladlahsen" }, { "creatorType": "author", "firstName": "R", "lastName": "Bensghir" }, { "creatorType": "author", "firstName": "M", "lastName": "Karkouri" }, { "creatorType": "author", "firstName": "E", "lastName": "Elharti" }, { "creatorType": "author", "firstName": "H", "lastName": "Oumzil" }, { "creatorType": "author", "firstName": "H", "lastName": "Himmich" }, { "creatorType": "author", "firstName": "K M", "lastName": "Elfilali" }, { "creatorType": "author", "firstName": "A", "lastName": "Chakib" } ], "abstractNote": "BACKGROUND: In Morocco, diagnosis of HIV infection remains late, which seriously compromises the timely management of HIV infection in the era of HAART therapies. Rapid test represents a good opportunity to improve the access to early screening of HIV. The objective of this study is to report the experience of the infectious diseases unit of the Ibn Rochd University hospital center of Casablanca, in the use of the rapid test in clinical screening of HIV.\nPATIENTS AND METHODS: This retrospective study reports data relevant to the use of the rapid test Determine VIH-1/2, Abbott Diagnostics, since its introduction in the infectious diseases unit in April 2006 up to December 2009. The test was performed for patients from the infectious diseases unit and patients hospitalized in different units of the Ibn Rochd University hospital center, after their consent. Test was ordered systematically by clinicians in case of any suspected symptom related to HIV and immunodepression. Positive samples were confirmed by Western Blot test, at the National Reference Laboratory for HIV, within the Institut National d'Hygiène in Rabat.\nRESULTS: Between 2006 and 2009, 1105 rapid tests were performed, among which 16.3% were positive. All results were provided to patients and none were lost to follow-up. The main reasons for the prescription of an HIV test were tuberculosis (26.3%) and chronic diarrhea (9.9%) for inpatients. For outpatients, the main symptoms were sexually transmissible infections (16.7%) and weight loss (15.7%). Results of the tests allowed us to adapt the treatment in case of suspicion of pneumocystosis (12 cases) and toxoplasmosis (seven cases).\nCONCLUSION: The introduction of the rapid test for HIV clinical screening in the hospital facilities improved considerably the access to diagnosis and consequently allowed a timely management of HIV infection.", "publicationTitle": "Revue d'épidémiologie et de santé publique", "publisher": "", "place": "", "date": "Aug 2012", "volume": "60", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "333-338", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Rev Epidemiol Sante Publique", "DOI": "10.1016/j.respe.2012.01.009", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0398-7620", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "fre", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22789747", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Antiretroviral Therapy, Highly Active", "type": 1 }, { "tag": "Blotting, Western", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Follow-Up Studies", "type": 1 }, { "tag": "HIV Infections", "type": 1 }, { "tag": "HIV Seropositivity", "type": 1 }, { "tag": "HIV-1", "type": 1 }, { "tag": "HIV-2", "type": 1 }, { "tag": "Hospitals, University", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Immunochromatography", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mass Screening", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Morocco", "type": 1 }, { "tag": "Predictive Value of Tests", "type": 1 }, { "tag": "Retrospective Studies", "type": 1 }, { "tag": "Sensitivity and Specificity", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-08T17:24:01Z", "dateModified": "2013-08-08T17:24:01Z" } }, { "key": "4QB9VP4X", "version": 19, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/4QB9VP4X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/4QB9VP4X", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/CVFFM7DK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1526314, "username": "alejopinhur", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alejopinhur", "type": "text/html" } } } }, "data": { "key": "4QB9VP4X", "version": 19, "parentItem": "CVFFM7DK", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2013-08-08T17:19:26Z", "url": "http://www.amjmed.com/article/S0002-9343(08)00959-5/abstract", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T17:19:26Z", "dateModified": "2013-08-08T17:19:26Z" } }, { "key": "JT7AA3DV", "version": 19, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/JT7AA3DV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/JT7AA3DV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/CVFFM7DK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1526314, "username": "alejopinhur", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alejopinhur", "type": "text/html" } } } }, "data": { "key": "JT7AA3DV", "version": 19, "parentItem": "CVFFM7DK", "itemType": "attachment", "linkMode": "linked_url", "title": "Full Text PDF", "accessDate": "2013-08-08T17:19:26Z", "url": "http://www.amjmed.com/article/S0002-9343(08)00959-5/pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T17:19:26Z", "dateModified": "2013-08-08T17:19:26Z" } }, { "key": "CVFFM7DK", "version": 19, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/CVFFM7DK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/CVFFM7DK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1526314, "username": "alejopinhur", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alejopinhur", "type": "text/html" } } }, "creatorSummary": "Kim et al.", "parsedDate": "2009-02", "numChildren": 2 }, "data": { "key": "CVFFM7DK", "version": 19, "itemType": "journalArticle", "title": "Diagnostic Usefulness of a T-cell-based Assay for Extrapulmonary Tuberculosis in Immunocompromised Patients", "creators": [ { "creatorType": "author", "firstName": "Sung-Han", "lastName": "Kim" }, { "creatorType": "author", "firstName": "Kyoung-Ho", "lastName": "Song" }, { "creatorType": "author", "firstName": "Su-Jin", "lastName": "Choi" }, { "creatorType": "author", "firstName": "Hong-Bin", "lastName": "Kim" }, { "creatorType": "author", "firstName": "Nam-Joong", "lastName": "Kim" }, { "creatorType": "author", "firstName": "Myoung-don", "lastName": "Oh" }, { "creatorType": "author", "firstName": "Kang-Won", "lastName": "Choe" } ], "abstractNote": "Background\nThe low reactivity of the tuberculin skin test limits its clinical use in immunocompromised patients with extrapulmonary tuberculosis. A recently developed T-cell-based assay for diagnosing tuberculosis infection gave promising results. However, there were few data on the usefulness of this assay for diagnosing extrapulmonary tuberculosis in immunocompromised patients.\nMethods\nAll adult patients with suspected extrapulmonary tuberculosis were prospectively enrolled at 2 university-affiliated hospitals over an 18-month period. In addition to the conventional tests for diagnosing extrapulmonary tuberculosis, enzyme-linked immunospot (ELISPOT) assay for the interferon-γ-producing T-cell response to early secretory antigenic target-6 and culture filtrate protein-10 was performed. The final diagnoses in patients with suspected extrapulmonary tuberculosis were classified by clinical category.\nResults\nThere were 179 patients with suspected extrapulmonary tuberculosis enrolled: 59 (33%) were classified as immunocompromised. Of the 179 patients, 75 (42%) were classified as extrapulmonary tuberculosis, including 56 confirmed tuberculosis plus 19 probable tuberculosis, and 97 (54%) were classified as not tuberculosis. The remaining 7 (4%) had possible tuberculosis and were excluded from the final analysis. The tuberculin skin test (induration size ≥10 mm) was less sensitive in immunocompromised patients (38%; 95% confidence interval [CI], 19%-59%) than in immunocompetent patients (69%; 95% CI, 54%-81%, P=.01). In contrast, the ELISPOT assay retained a high sensitivity: (88%; 95% CI, 68%-97%) in immunocompromised patients compared with 96% (95% CI, 87%-100%) in immunocompetent patients (P=.32).\nConclusion\nThe immunosuppressive condition does not affect the diagnostic sensitivity of the ELISPOT assay for extrapulmonary tuberculosis.", "publicationTitle": "The American Journal of Medicine", "publisher": "", "place": "", "date": "February 2009", "volume": "122", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "189-195", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.amjmed.2008.07.028", "citationKey": "", "url": "http://www.amjmed.com/article/S0002-9343(08)00959-5/abstract", "accessDate": "2013-08-08T17:19:26Z", "PMID": "", "PMCID": "", "ISSN": "0002-9343", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "www.amjmed.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "ELISPOT", "type": 1 }, { "tag": "Immunocompromised", "type": 1 }, { "tag": "Tuberculosis", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-08T17:19:26Z", "dateModified": "2013-08-08T17:19:26Z" } }, { "key": "Z95CQF9G", "version": 16, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/Z95CQF9G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/Z95CQF9G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1520253, "username": "Alex_59", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alex_59", "type": "text/html" } } }, "creatorSummary": "NoticieroPanorama", "parsedDate": "2013-06-22", "numChildren": 0 }, "data": { "key": "Z95CQF9G", "version": 16, "itemType": "videoRecording", "title": "Otorgan a El Salvador $27 millones para prevención del VIH y tuberculosis", "creators": [ { "creatorType": "contributor", "name": "NoticieroPanorama" } ], "abstractNote": "El Fondo Mundial contra la lucha del sida otorgó a El Salvador cerca de $27 millones para la prevención del VIH y la coinfección de la tuberculosis.", "videoRecordingFormat": "", "seriesTitle": "", "volume": "", "numberOfVolumes": "", "studio": "", "place": "", "date": "2013-06-22", "runningTime": "135 seconds", "ISBN": "", "DOI": "", "citationKey": "", "url": "http://www.youtube.com/watch?v=eBNKkz-bc3w&feature=youtube_gdata_player", "accessDate": "2013-08-08T17:04:24Z", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "YouTube", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T17:05:30Z", "dateModified": "2013-08-08T17:05:30Z" } }, { "key": "GJKPQ3GM", "version": 15, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/GJKPQ3GM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/GJKPQ3GM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531157, "username": "NelsyAQM", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/nelsyaqm", "type": "text/html" } } }, "creatorSummary": "Pawlowski et al.", "parsedDate": "2012-02-16", "numChildren": 0 }, "data": { "key": "GJKPQ3GM", "version": 15, "itemType": "journalArticle", "title": "Tuberculosis and HIV Co-Infection", "creators": [ { "creatorType": "author", "firstName": "Andrzej", "lastName": "Pawlowski" }, { "creatorType": "author", "firstName": "Marianne", "lastName": "Jansson" }, { "creatorType": "author", "firstName": "Markus", "lastName": "Sköld" }, { "creatorType": "author", "firstName": "Martin E.", "lastName": "Rottenberg" }, { "creatorType": "author", "firstName": "Gunilla", "lastName": "Källenius" } ], "abstractNote": "Tuberculosis (TB) and HIV co-infections place an immense burden on health care systems and pose particular diagnostic and therapeutic challenges. Infection with HIV is the most powerful known risk factor predisposing for Mycobacterium tuberculosis infection and progression to active disease, which increases the risk of latent TB reactivation 20-fold. TB is also the most common cause of AIDS-related death. Thus, M. tuberculosis and HIV act in synergy, accelerating the decline of immunological functions and leading to subsequent death if untreated. The mechanisms behind the breakdown of the immune defense of the co-infected individual are not well known. The aim of this review is to highlight immunological events that may accelerate the development of one of the two diseases in the presence of the co-infecting organism. We also review possible animal models for studies of the interaction of the two pathogens, and describe gaps in knowledge and needs for future studies to develop preventive measures against the two diseases.", "publicationTitle": "PLoS Pathog", "publisher": "", "place": "", "date": "February 16, 2012", "volume": "8", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "e1002464", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS Pathog", "DOI": "10.1371/journal.ppat.1002464", "citationKey": "", "url": "http://dx.doi.org/10.1371/journal.ppat.1002464", "accessDate": "2013-08-08T17:04:02Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PLoS Journals", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T17:04:58Z", "dateModified": "2013-08-08T17:04:58Z" } }, { "key": "IMFRDHVP", "version": 14, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/IMFRDHVP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/IMFRDHVP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1520253, "username": "Alex_59", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alex_59", "type": "text/html" } } }, "creatorSummary": "Diario Paciente", "parsedDate": "2012-04-22", "numChildren": 0 }, "data": { "key": "IMFRDHVP", "version": 14, "itemType": "videoRecording", "title": "Coinfección Tuberculosis-VIH. Jornada Alto a la Tuberculosis", "creators": [ { "creatorType": "contributor", "name": "Diario Paciente" } ], "abstractNote": "Jornada Alto a la Tuberculosis en el Hospital General Universitario de Valencia. Intervención de Dra. Nuria Gago.", "videoRecordingFormat": "", "seriesTitle": "", "volume": "", "numberOfVolumes": "", "studio": "", "place": "", "date": "2012-04-22", "runningTime": "758 seconds", "ISBN": "", "DOI": "", "citationKey": "", "url": "http://www.youtube.com/watch?v=l-soIvK4b6k&feature=youtube_gdata_player", "accessDate": "2013-08-08T17:03:46Z", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "YouTube", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T17:04:52Z", "dateModified": "2013-08-08T17:04:52Z" } }, { "key": "AW35ZK27", "version": 13, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/AW35ZK27", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/AW35ZK27", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531157, "username": "NelsyAQM", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/nelsyaqm", "type": "text/html" } } }, "creatorSummary": "Reniero et al.", "parsedDate": "2010", "numChildren": 1 }, "data": { "key": "AW35ZK27", "version": 13, "itemType": "journalArticle", "title": "Larga batalla de un paciente con sida y tuberculosis recurrente: ¿reinfección o reactivación?", "creators": [ { "creatorType": "author", "firstName": "A.", "lastName": "Reniero" }, { "creatorType": "author", "firstName": "M.", "lastName": "Beltrán" }, { "creatorType": "author", "firstName": "I. N.", "lastName": "de Kantor" }, { "creatorType": "author", "firstName": "V.", "lastName": "Ritacco" } ], "abstractNote": "", "publicationTitle": "Revista argentina de microbiología", "publisher": "", "place": "", "date": "12/2010", "volume": "42", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "271-273", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.scielo.org.ar/scielo.php?script=sci_arttext&pid=S0325-75412010000400006&lang=pt", "accessDate": "2013-08-08T16:57:21Z", "PMID": "", "PMCID": "", "ISSN": "0325-7541", "archive": "", "archiveLocation": "", "shortTitle": "Larga batalla de un paciente con sida y tuberculosis recurrente", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:57:21Z", "dateModified": "2013-08-08T16:57:21Z" } }, { "key": "HD4UQ4XT", "version": 13, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/HD4UQ4XT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/HD4UQ4XT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/AW35ZK27", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531157, "username": "NelsyAQM", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/nelsyaqm", "type": "text/html" } } } }, "data": { "key": "HD4UQ4XT", "version": 13, "parentItem": "AW35ZK27", "itemType": "attachment", "linkMode": "linked_url", "title": "SCIELO Journal Snapshot", "accessDate": "2013-08-08T16:57:21Z", "url": "http://www.scielo.org.ar/scielo.php?script=sci_pdf&pid=S0325-75412010000400006&lng=es&nrm=iso&tlng=en", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T16:57:21Z", "dateModified": "2013-08-08T16:57:21Z" } }, { "key": "GXJG7IZM", "version": 12, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/GXJG7IZM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/GXJG7IZM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1526314, "username": "alejopinhur", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alejopinhur", "type": "text/html" } } }, "creatorSummary": "Richeldi et al.", "parsedDate": "2009-07", "numChildren": 1 }, "data": { "key": "GXJG7IZM", "version": 12, "itemType": "journalArticle", "title": "Performance of tests for latent tuberculosis in different groups of immunocompromised patients", "creators": [ { "creatorType": "author", "firstName": "Luca", "lastName": "Richeldi" }, { "creatorType": "author", "firstName": "Monica", "lastName": "Losi" }, { "creatorType": "author", "firstName": "Roberto", "lastName": "D'Amico" }, { "creatorType": "author", "firstName": "Mario", "lastName": "Luppi" }, { "creatorType": "author", "firstName": "Angela", "lastName": "Ferrari" }, { "creatorType": "author", "firstName": "Cristina", "lastName": "Mussini" }, { "creatorType": "author", "firstName": "Mauro", "lastName": "Codeluppi" }, { "creatorType": "author", "firstName": "Stefania", "lastName": "Cocchi" }, { "creatorType": "author", "firstName": "Francesca", "lastName": "Prati" }, { "creatorType": "author", "firstName": "Valentina", "lastName": "Paci" }, { "creatorType": "author", "firstName": "Marisa", "lastName": "Meacci" }, { "creatorType": "author", "firstName": "Barbara", "lastName": "Meccugni" }, { "creatorType": "author", "firstName": "Fabio", "lastName": "Rumpianesi" }, { "creatorType": "author", "firstName": "Pietro", "lastName": "Roversi" }, { "creatorType": "author", "firstName": "Stefania", "lastName": "Cerri" }, { "creatorType": "author", "firstName": "Fabrizio", "lastName": "Luppi" }, { "creatorType": "author", "firstName": "Giovanni", "lastName": "Ferrara" }, { "creatorType": "author", "firstName": "Irene", "lastName": "Latorre" }, { "creatorType": "author", "firstName": "Giorgio E", "lastName": "Gerunda" }, { "creatorType": "author", "firstName": "Giuseppe", "lastName": "Torelli" }, { "creatorType": "author", "firstName": "Roberto", "lastName": "Esposito" }, { "creatorType": "author", "firstName": "Leonardo M", "lastName": "Fabbri" } ], "abstractNote": "BACKGROUND: Immunocompromised persons infected with Mycobacterium tuberculosis (MTB) have increased risk of tuberculosis (TB) reactivation, but their management is hampered by the occurrence of false-negative results of the tuberculin skin test (TST). The T-cell interferon (IFN)-gamma release blood assays T-SPOT.TB (TS.TB) [Oxford Immunotec; Abingdon, UK] and QuantiFERON-TB Gold In-Tube (QFT-IT) [Cellestis Ltd; Carnegie, VIC, Australia] might improve diagnostic accuracy for latent TB infection (LTBI) in high-risk persons, although their performance in different groups of immunocompromised patients is largely unknown.\nMETHODS AND RESULTS: Over a 1-year period, we prospectively enrolled patients in three different immunosuppressed groups, as follows: 120 liver transplantation candidates (LTCs); 116 chronically HIV-infected persons; and 95 patients with hematologic malignancies (HMs). TST, TS.TB, and QFT-IT were simultaneously performed, their results were compared, and intertest agreement was evaluated. Overall, TST provided fewer positive results (10.9%) than TS.TB (18.4%; p < 0.001) and QFT-IT (15.1%; p = 0.033). Significantly fewer HIV-infected individuals had at least one positive test (9.5%) compared with LTCs (35.8%; p < 0.001) and patients with HMs (29.5%; p < 0.001). Diagnostic agreement between tests was moderate (kappa = 0.40 to 0.65) and decreased in the HIV-infected group when the results of the TS.TB were compared with either TST (kappa = 0.16) or QFT-IT (kappa = 0.19). Indeterminate blood test results due to low positive control values were significantly more frequent with QFT-IT (7.2%) than with TS.TB (0.6%; p < 0.001).\nCONCLUSIONS: Blood tests identified significantly more patients as being infected with MTB than TST, although diagnostic agreement varied across groups. Based on these results, we recommend tailoring application of the new blood IFN-gamma assays for LTBI in different high-risk groups and advise caution in their current use in immunosuppressed patients.", "publicationTitle": "Chest", "publisher": "", "place": "", "date": "Jul 2009", "volume": "136", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "198-204", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Chest", "DOI": "10.1378/chest.08-2575", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1931-3543", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19318676", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Aged, 80 and over", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "HIV Infections", "type": 1 }, { "tag": "Hematologic Neoplasms", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Immunocompromised Host", "type": 1 }, { "tag": "Liver Failure", "type": 1 }, { "tag": "Liver Transplantation", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Mycobacterium tuberculosis", "type": 1 }, { "tag": "Predictive Value of Tests", "type": 1 }, { "tag": "Reproducibility of Results", "type": 1 }, { "tag": "Tuberculin Test", "type": 1 }, { "tag": "Tuberculosis", "type": 1 }, { "tag": "Virus Latency", "type": 1 }, { "tag": "Young Adult", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:55:13Z", "dateModified": "2013-08-08T16:55:13Z" } }, { "key": "8EUD43FT", "version": 12, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/8EUD43FT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/8EUD43FT", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/GXJG7IZM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1526314, "username": "alejopinhur", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alejopinhur", "type": "text/html" } } } }, "data": { "key": "8EUD43FT", "version": 12, "parentItem": "GXJG7IZM", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-08-08T16:55:13Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19318676", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T16:55:13Z", "dateModified": "2013-08-08T16:55:13Z" } }, { "key": "UD87NRXG", "version": 11, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/UD87NRXG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/UD87NRXG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1520253, "username": "Alex_59", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/alex_59", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "UD87NRXG", "version": 11, "itemType": "webpage", "title": "TUBERCULOSIS E INFECCIÓN POR VIH/SIDA", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://sisbib.unmsm.edu.pe/bvrevistas/rfmh_urp/v04_n1/a07.htm", "accessDate": "2013-08-08T16:55:12Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:55:12Z", "dateModified": "2013-08-08T16:55:12Z" } }, { "key": "QQ6TNEJ8", "version": 10, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/QQ6TNEJ8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/QQ6TNEJ8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531157, "username": "NelsyAQM", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/nelsyaqm", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QQ6TNEJ8", "version": 10, "itemType": "webpage", "title": "Prevalence of Pulmonary Tuberculosis Among HI... [N Am J Med Sci. 2013] - PubMed - NCBI", "creators": [], "abstractNote": "", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23923111", "accessDate": "2013-08-08T16:48:38Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:50:45Z", "dateModified": "2013-08-08T16:50:45Z" } }, { "key": "ZEUBMQ6A", "version": 6, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/ZEUBMQ6A", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/ZEUBMQ6A", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "ZEUBMQ6A", "version": 6, "itemType": "webpage", "title": "Diario El Mundo » El Salvador: modelo en el manejo de VIH y la tuberculosis", "creators": [], "abstractNote": "La séptima reunión de Tuberculosis (TB) y VIH en las Américas, que se realiza en la ciudad de Panamá, ha logrado muchos frutos.   Maybel Hernández Diario El Mundo Cada uno de los 17 países asistentes ha discutido diversas experiencias en el trabajo de estas dos epidemias y se han comprometido a cumplir cinco retos, [...]...", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://elmundo.com.sv/el-salvador-modelo-en-el-manejo-de-vih-y-la-tuberculosis", "accessDate": "2013-08-08T16:44:33Z", "shortTitle": "Diario El Mundo » El Salvador", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:44:33Z", "dateModified": "2013-08-08T16:44:33Z" } }, { "key": "3WUQSTGS", "version": 6, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/3WUQSTGS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/3WUQSTGS", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/ZEUBMQ6A", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } } }, "data": { "key": "3WUQSTGS", "version": 6, "parentItem": "ZEUBMQ6A", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2013-08-08T16:44:33Z", "url": "http://elmundo.com.sv/el-salvador-modelo-en-el-manejo-de-vih-y-la-tuberculosis", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T16:44:33Z", "dateModified": "2013-08-08T16:44:33Z" } }, { "key": "EEAMEQFI", "version": 5, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/EEAMEQFI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/EEAMEQFI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/WEJJ5IC7", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } } }, "data": { "key": "EEAMEQFI", "version": 5, "parentItem": "WEJJ5IC7", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2013-08-08T16:40:00Z", "url": "http://aidsinfo.nih.gov/news/213/tuberculosis-relacionada-con-el-vih", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T16:40:00Z", "dateModified": "2013-08-08T16:40:00Z" } }, { "key": "AUKQVHVS", "version": 3, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/AUKQVHVS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/AUKQVHVS", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/5Q7K8JJC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } } }, "data": { "key": "AUKQVHVS", "version": 3, "parentItem": "5Q7K8JJC", "itemType": "attachment", "linkMode": "linked_url", "title": "Snapshot", "accessDate": "2013-08-08T16:33:05Z", "url": "http://www.who.int/tb/challenges/mdr/es/index.html", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-08-08T16:33:05Z", "dateModified": "2013-08-08T16:33:05Z" } }, { "key": "5Q7K8JJC", "version": 3, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/5Q7K8JJC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/5Q7K8JJC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } }, "numChildren": 1 }, "data": { "key": "5Q7K8JJC", "version": 3, "itemType": "webpage", "title": "OMS | Tuberculosis resistente y multirresistente", "creators": [], "abstractNote": "", "websiteTitle": "WHO", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.who.int/tb/challenges/mdr/es/index.html", "accessDate": "2013-08-08T16:33:05Z", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:33:05Z", "dateModified": "2013-08-08T16:33:05Z" } }, { "key": "ZE5TH9BR", "version": 2, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/ZE5TH9BR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/ZE5TH9BR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1513042, "username": "Rebeca_v", "name": "Rebeca Villegas", "links": { "alternate": { "href": "https://www.zotero.org/rebeca_v", "type": "text/html" } } }, "creatorSummary": "Balcells M", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "ZE5TH9BR", "version": 2, "itemType": "journalArticle", "title": "Tuberculosis en el paciente con infección por virus de inmunodeficiencia humana", "creators": [ { "creatorType": "author", "firstName": "M. Elvira", "lastName": "Balcells M" } ], "abstractNote": "", "publicationTitle": "Revista chilena de infectología", "publisher": "", "place": "", "date": "04/2009", "volume": "26", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "126-134", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.4067/S0716-10182009000200003", "citationKey": "", "url": "http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182009000200003&lang=pt", "accessDate": "2013-08-08T16:21:58Z", "PMID": "", "PMCID": "", "ISSN": "0716-1018", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-08-08T16:23:38Z", "dateModified": "2013-08-08T16:23:38Z" } }, { "key": "PV2CEUH9", "version": 18, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/PV2CEUH9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/PV2CEUH9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531204, "username": "marmaguirre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marmaguirre", "type": "text/html" } } }, "creatorSummary": "Neves et al.", "parsedDate": "2012", "numChildren": 0 }, "data": { "key": "PV2CEUH9", "version": 18, "itemType": "journalArticle", "title": "Aids and tuberculosis: coinfection from the perspective of the quality of life of patients", "creators": [ { "creatorType": "author", "firstName": "Lis Aparecida de Souza", "lastName": "Neves" }, { "creatorType": "author", "firstName": "Sílvia Rita Marin", "lastName": "Canini" }, { "creatorType": "author", "firstName": "Renata Karina", "lastName": "Reis" }, { "creatorType": "author", "firstName": "Cláudia Benedita dos", "lastName": "Santos" }, { "creatorType": "author", "firstName": "Elucir", "lastName": "Gir" } ], "abstractNote": "", "publicationTitle": "Revista da Escola de Enfermagem da USP", "publisher": "", "place": "", "date": "06/2012", "volume": "46", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "704-710", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1590/S0080-62342012000300024", "citationKey": "", "url": "http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0080-62342012000300024&lng=en&nrm=iso&tlng=en", "accessDate": "2013-04-08T05:14:26Z", "PMID": "", "PMCID": "", "ISSN": "0080-6234", "archive": "", "archiveLocation": "", "shortTitle": "Aids and tuberculosis", "language": "", "libraryCatalog": "SciELO", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-04-08T05:19:57Z", "dateModified": "2013-04-08T05:19:57Z" } }, { "key": "4W34CNDJ", "version": 17, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/4W34CNDJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/4W34CNDJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/195696/items/PIVIS3EJ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1531204, "username": "marmaguirre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marmaguirre", "type": "text/html" } } } }, "data": { "key": "4W34CNDJ", "version": 17, "parentItem": "PIVIS3EJ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-04-08T05:15:21Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691799/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-08T05:19:36Z", "dateModified": "2013-04-08T05:19:36Z" } }, { "key": "PIVIS3EJ", "version": 17, "library": { "type": "group", "id": 195696, "name": "Metodos", "links": { "alternate": { "href": "https://www.zotero.org/groups/metodos", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/195696/items/PIVIS3EJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/metodos/items/PIVIS3EJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1531204, "username": "marmaguirre", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marmaguirre", "type": "text/html" } } }, "creatorSummary": "Pitabut et al.", "parsedDate": "2013-06-15", "numChildren": 1 }, "data": { "key": "PIVIS3EJ", "version": 17, "itemType": "journalArticle", "title": "Potential Function of Granulysin, Other Related Effector Molecules and Lymphocyte Subsets in Patients with TB and HIV/TB Coinfection", "creators": [ { "creatorType": "author", "firstName": "Nada", "lastName": "Pitabut" }, { "creatorType": "author", "firstName": "Shinsaku", "lastName": "Sakurada" }, { "creatorType": "author", "firstName": "Takahiro", "lastName": "Tanaka" }, { "creatorType": "author", "firstName": "Chutharut", "lastName": "Ridruechai" }, { "creatorType": "author", "firstName": "Junko", "lastName": "Tanuma" }, { "creatorType": "author", "firstName": "Takahiro", "lastName": "Aoki" }, { "creatorType": "author", "firstName": "Pacharee", "lastName": "Kantipong" }, { "creatorType": "author", "firstName": "Surachai", "lastName": "Piyaworawong" }, { "creatorType": "author", "firstName": "Nobuyuki", "lastName": "Kobayashi" }, { "creatorType": "author", "firstName": "Panadda", "lastName": "Dhepakson" }, { "creatorType": "author", "firstName": "Hideki", "lastName": "Yanai" }, { "creatorType": "author", "firstName": "Norio", "lastName": "Yamada" }, { "creatorType": "author", "firstName": "Shinichi", "lastName": "Oka" }, { "creatorType": "author", "firstName": "Masaji", "lastName": "Okada" }, { "creatorType": "author", "firstName": "Srisin", "lastName": "Khusmith" }, { "creatorType": "author", "firstName": "Naoto", "lastName": "Keicho" } ], "abstractNote": "Background: Host effector mechanism against Mycobacterium tuberculosis (Mtb) infection is dependent on innate immune response by macrophages and neutrophils and the alterations in balanced adaptive immunity. Coordinated release of cytolytic effector molecules from NK cells and effector T cells and the subsequent granule-associated killing of infected cells have been documented; however, their role in clinical tuberculosis (TB) is still controversy., Objective: To investigate whether circulating granulysin and other effector molecules are associated with the number of NK cells, iNKT cells, Vγ9+Vδ2+ T cells, CD4+ T cells and CD8+ T cells, and such association influences the clinical outcome of the disease in patients with pulmonary TB and HIV/TB coinfection., Methods: Circulating granulysin, perforin, granzyme-B and IFN-γ levels were determined by ELISA. The isoforms of granulysin were analyzed by Western blot analysis. The effector cells were analyzed by flow cytometry., Results: Circulating granulysin and perforin levels in TB patients were lower than healthy controls, whereas the granulysin levels in HIV/TB coinfection were much higher than in any other groups, TB and HIV with or without receiving HAART, which corresponded to the number of CD8+ T cells which kept high, but not with NK cells and other possible cellular sources of granulysin. In addition, the 17kDa, 15kDa and 9kDa isoforms of granulysin were recognized in plasma of HIV/TB coinfection. Increased granulysin and decreased IFN-γ levels in HIV/TB coinfection and TB after completion of anti-TB therapy were observed., Conclusion: The results suggested that the alteration of circulating granulysin has potential function in host immune response against TB and HIV/TB coinfection. This is the first demonstration so far of granulysin in HIV/TB coinfection.", "publicationTitle": "International Journal of Medical Sciences", "publisher": "", "place": "", "date": "2013-6-15", "volume": "10", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "1003-1014", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Int J Med Sci", "DOI": "10.7150/ijms.6437", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3691799/", "accessDate": "2013-04-08T05:15:21Z", "PMID": "", "PMCID": "", "ISSN": "1449-1907", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 23801887\nPMCID: PMC3691799", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-04-08T05:19:36Z", "dateModified": "2013-04-08T05:19:36Z" } } ]