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L.", "lastName": "Beck" }, { "creatorType": "author", "firstName": "B.", "lastName": "Freihaut" }, { "creatorType": "author", "firstName": "R.", "lastName": "Henry" }, { "creatorType": "author", "firstName": "S.", "lastName": "Pierce" }, { "creatorType": "author", "firstName": "W. L.", "lastName": "Bayer" } ], "abstractNote": "A serum agglutinin reactive with red cells in the presence of polycarboxyl groups is reported. It is likely that this represents an additional example of the type of agglutinin previously described as agglutinating red cells in the absence of ionized calcium. Experimental evidence is presented indicating that it is free polycarboxyl groups that potentiate agglutination and that any metal ion, such as calcium, capable of chelating with these groups will prove to be inhibitory.", "publicationTitle": "British Journal of Haematology", "publisher": "", "place": "", "date": "Jan 1975", "volume": "29", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "149-156", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Br. J. Haematol.", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0007-1048", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "PubMed", "callNumber": "", "rights": "", "extra": "PMID: 32", "tags": [ { "tag": "ABO Blood-Group System", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Agglutinins", "type": 1 }, { "tag": "Antibody Specificity", "type": 1 }, { "tag": "Carboxylic Acids", "type": 1 }, { "tag": "Cations, Divalent", "type": 1 }, { "tag": "Citrates", "type": 1 }, { "tag": "Edetic Acid", "type": 1 }, { "tag": "Ficain", "type": 1 }, { "tag": "Hemagglutination", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Hydrogen-Ion Concentration", "type": 1 }, { "tag": "Neuraminidase", "type": 1 }, { "tag": "Papain", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-10-04T00:57:52Z", "dateModified": "2015-10-04T00:57:52Z" } }, { "key": "EQNT9IJU", "version": 96, "library": { "type": "group", "id": 174522, "name": "CPWF - AN3", "links": { "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/174522/items/EQNT9IJU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3/items/EQNT9IJU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 318766, "username": "marisa.escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marisa.escobar", "type": "text/html" } } }, "creatorSummary": "Koch et al.", "parsedDate": "2011-09-30", "numChildren": 0 }, "data": { "key": "EQNT9IJU", "version": 96, "itemType": "journalArticle", "title": "How Will Hydroelectric Power Generation Develop under Climate Change Scenarios? 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AN3", "links": { "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/174522/items/BSK4FT9C", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3/items/BSK4FT9C", "type": "text/html" } }, "meta": { "createdByUser": { "id": 318766, "username": "marisa.escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marisa.escobar", "type": "text/html" } } }, "creatorSummary": "Jønch-Clausen and Fugl", "parsedDate": "2001", "numChildren": 0 }, "data": { "key": "BSK4FT9C", "version": 81, "itemType": "journalArticle", "title": "Firming up the Conceptual Basis of Integrated Water Resources Management", "creators": [ { "creatorType": "author", "firstName": "Torkil", "lastName": "Jønch-Clausen" }, { "creatorType": "author", "firstName": "Jens", "lastName": "Fugl" } ], "abstractNote": "", "publicationTitle": "International Journal of Water Resources Development", "publisher": "", "place": "", "date": "12/2001", "volume": "17", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "501-510", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1080/07900620120094055", "citationKey": "", "url": "http://www.tandfonline.com/doi/abs/10.1080/07900620120094055", "accessDate": "2015-09-21T18:32:01Z", "PMID": "", "PMCID": "", "ISSN": "0790-0627, 1360-0648", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [], "relations": {}, "dateAdded": "2015-09-21T18:32:01Z", "dateModified": "2015-09-21T18:32:01Z" } }, { "key": "VZPSRCI4", "version": 80, "library": { "type": "group", "id": 174522, "name": "CPWF - 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AN3", "links": { "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/174522/items/33WZHQHZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3/items/33WZHQHZ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/174522/items/NMH9QSC3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 318766, "username": "marisa.escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marisa.escobar", "type": "text/html" } } } }, "data": { "key": "33WZHQHZ", "version": 80, "parentItem": "NMH9QSC3", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-09-21T18:30:21Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/627", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-09-21T18:30:21Z", "dateModified": "2015-09-21T18:30:21Z" } }, { "key": "NMH9QSC3", "version": 80, "library": { "type": "group", "id": 174522, "name": "CPWF - AN3", "links": { "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/174522/items/NMH9QSC3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/cpwf_-_an3/items/NMH9QSC3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 318766, "username": "marisa.escobar", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/marisa.escobar", "type": "text/html" } } }, "creatorSummary": "Starke et al.", "parsedDate": "1975", "numChildren": 1 }, "data": { "key": "NMH9QSC3", "version": 80, "itemType": "journalArticle", "title": "Relative pre- and postsynaptic potencies of alpha-adrenoceptor agonists in the rabbit pulmonary artery", "creators": [ { "creatorType": "author", "firstName": "K.", "lastName": "Starke" }, { "creatorType": "author", "firstName": "T.", "lastName": "Endo" }, { "creatorType": "author", "firstName": "H. D.", "lastName": "Taube" } ], "abstractNote": "The rabbit pulmonary artery contains postsynaptic alpha-adrenoceptors which meidate smooth muscle contraction; its noradrenergic nerves contain presynaptic alpha-adrenoceptors which mediate inhibition of the release of the transmitter evoked by nerve impulses. Dose-response curves for the pre- and postsynaptic effects of eight alpha-receptor agonists were determined on superfused strips of the artery in the presence of cocaine, corticosterone and propranolo. 1. According to the concentrations which caused 20% of the maximal contraction (EC20 post), the postsynaptic rank order of potency was: adrenaline greater than noradrenaline greater than oxymetazoline greater than naphazoline greater than phenylephrine greater than tramazoline greater than alpha-methylnoradrenaline greater than methoxamine. The pA2 values of phentolamine againstoxymethazoline, phenylephrine, alpha-methylnoradrenaline and methoxamine were 7.43, 7.48, 7.59 and 7.69, respectively. 2. For the investigation of presynaptic effects, the arteries were preincubated with 3H-noradrenaline. All agonists inhibited the overflow of tritium evoked by transmural sympathetic nerve stimulation. According to the concentrations which reduced the stimulation-induced overflow by 20% (EC20 pre), the rank order of potency was: adrenaline greater than oxymetazoline greater than tramazoline greater than alpha-methylnoradrenaline greater than noradrenaline greater than naphazoline greater than phenylephrine greater than methoxamine. 10(-5) M phentolamine shifted the presynaptic dose-response curves for moradrenaline and oxymethazoline to the right. 3. The ratio EC20 pre/EC20 post was calculated for each agonist as an index of its relative post- and presynaptic potency. According to the ratios, the agonists were arbitrarily classified into three groups. Group 1 (ratio about 30: preferentially postsynaptic agonists) comprised methoxamine and phenylephrine; group 2 (ratio near 1; similar pre- and postsynaptic potencies) comprised noradrenaline, adrenaline and naphazoline; group 3 (ratio below 0.2; preferentially presynaptic agonists) comprised oxymetazoline, alpha-methylnoradrenaline and tramazoline (as well as clonidine). 4. Preferentially presynaptic and preferentially postsynaptic agonists had opposite effects on the basoconstrictor response to nerve stimulation. Methoxamine and phenylephrine either did not change or enhanced, but never reduced, the response. In contrast, oxymetazoline, alpha-methylnoradrenaline and tramazoline at low concentrations selectively inhibited the response to stimulation at low frequency (0.25-2Hz). 5. It is concluded that alpha-adrenoceptor agonists vary widely in their relative pre- and postsynaptic potencies, possibly because of structural differences between pre- and postsynaptic alpha-receptors. Pre- and postsynaptic components contribute to their overll postsynaptic effec in actively transmitting synapses. The preferential activation of presynaptic alpha-receptors results in alpha-adrenergic inhibition of synaptic transmission.", "publicationTitle": "Naunyn-Schmiedeberg's Archives of Pharmacology", "publisher": "", "place": "", "date": "1975", "volume": "291", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "55-78", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Naunyn Schmiedebergs Arch. 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