[ { "key": "CMDFMTZ9", "version": 1, "library": { "type": "group", "id": 16421, "name": "frosk1980", "links": { "alternate": { "href": "https://www.zotero.org/groups/frosk1980", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/16421/items/CMDFMTZ9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/frosk1980/items/CMDFMTZ9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 224424, "username": "frosk1980", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/frosk1980", "type": "text/html" } } }, "creatorSummary": "Ficheux et al.", "parsedDate": "2010-03", "numChildren": 0 }, "data": { "key": "CMDFMTZ9", "version": 1, "itemType": "journalArticle", "title": "Use of spent dialysate analysis to estimate blood levels of uraemic solutes without blood sampling: urea", "creators": [ { "creatorType": "author", "firstName": "Alain", "lastName": "Ficheux" }, { "creatorType": "author", "firstName": "Nathalie", "lastName": "Gayrard" }, { "creatorType": "author", "firstName": "Ilan", "lastName": "Szwarc" }, { "creatorType": "author", "firstName": "Stéphan", "lastName": "Soullier" }, { "creatorType": "author", "firstName": "Johanna", "lastName": "Bismuth-Mondolfo" }, { "creatorType": "author", "firstName": "Philippe", "lastName": "Brunet" }, { "creatorType": "author", "firstName": "Marie-Françoise", "lastName": "Servel" }, { "creatorType": "author", "firstName": "Angel", "lastName": "Argilés" } ], "abstractNote": "BACKGROUND: Urea kinetic modelling-based methods are widely used to assess dialysis efficacy. However, they require blood sampling and are susceptible to a number of errors, mainly from the calculated parameters (particularly V). Spent dialysate determinations have been used and have been shown to be reliable and simple to use. In this study, we associated dialysate-based and clearance determinations along with Kt/V to estimate blood urea levels. METHODS: Urea kinetic modelling, continuous sampling of spent dialysate and ionic dialysance were determined in 18 stable dialysis patients during 126 dialysis sessions. Mean blood urea levels were estimated as follows: mean urea level = spent dialysate - urea mass/(dialysance T). Blood urea levels before and after dialysis were calculated based on the same determinations and extended formulae. RESULTS: Estimated mean urea level was significantly correlated with measured mean blood urea level (R(2) = 0.957; P < 0.0001), and Bland and Altman analysis showed significant agreement between estimated and measured levels. Estimated and measured blood urea levels were also correlated before and after dialysis (R(2) = 0.972 , P < 0.0001 and R(2) = 0.903 , P < 0.0001, respectively), with good agreement for both blood urea before and after dialysis and their respective estimates. CONCLUSIONS: Blood urea levels may be reliably estimated from the total mass of urea removed in the dialysate and the dialysance measured during dialysis. Coupling both measurements allows a precise monitoring of dialysis efficacy and a specific evaluation of the patient's urea metabolism status. Technical dysfunctions and patient variations may be easily identified using this approach without blood sampling.", "publicationTitle": "Nephrology, Dialysis, Transplantation: Official Publication of the European Dialysis and Transplant Association - European Renal Association", "publisher": "", "place": "", "date": "Mar 2010", "volume": "25", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "873-879", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nephrol. Dial. Transplant", "DOI": "10.1093/ndt/gfp539", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19854847", "accessDate": "2010-04-22T09:27:30Z", "PMID": "", "PMCID": "", "ISSN": "1460-2385", "archive": "", "archiveLocation": "", "shortTitle": "Use of spent dialysate analysis to estimate blood levels of uraemic solutes without blood sampling", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19854847", "tags": [], "collections": [], "relations": {}, "dateAdded": "2010-04-22T09:27:30Z", "dateModified": "2010-04-22T09:27:30Z" } }, { "key": "6T26CA3P", "version": 1, "library": { "type": "group", "id": 16421, "name": "frosk1980", "links": { "alternate": { "href": "https://www.zotero.org/groups/frosk1980", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/16421/items/6T26CA3P", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/frosk1980/items/6T26CA3P", "type": "text/html" } }, "meta": { "createdByUser": { "id": 224424, "username": "frosk1980", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/frosk1980", "type": "text/html" } } }, "creatorSummary": "Faber et al.", "parsedDate": "2009-12", "numChildren": 0 }, "data": { "key": "6T26CA3P", "version": 1, "itemType": "journalArticle", "title": "Impaired immune function: an early marker for cancer cachexia", "creators": [ { "creatorType": "author", "firstName": "Joyce", "lastName": "Faber" }, { "creatorType": "author", "firstName": "Arjan P", "lastName": "Vos" }, { "creatorType": "author", "firstName": "Diane", "lastName": "Kegler" }, { "creatorType": "author", "firstName": "Josep", "lastName": "Argilés" }, { "creatorType": "author", "firstName": "Alessandro", "lastName": "Laviano" }, { "creatorType": "author", "firstName": "Johan", "lastName": "Garssen" }, { "creatorType": "author", "firstName": "Ardy", "lastName": "Van Helvoort" } ], "abstractNote": "Cachexia and chronic inflammation are major challenges for cancer patients, leading to serious consequences. Accordingly, it is of high clinical relevance to identify early risk factors for optimal treatment, as these are currently not available. The present study demonstrates a strong decline in contact hypersensitivity, a parameter for cell-mediated immunity, in tumor-bearing cachectic mice. Interestingly, a significant reduction was already observed during the pre-cachectic state, reflecting an impaired immune function prior to weight loss. Extrapolating to the human setting, reduced immune competence of cancer patients could serve as an early marker for cancer cachexia, enabling an early supportive care strategy.", "publicationTitle": "Oncology Reports", "publisher": "", "place": "", "date": "Dec 2009", "volume": "22", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1403-1406", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Oncol. Rep", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19885593", "accessDate": "2010-04-22T09:27:20Z", "PMID": "", "PMCID": "", "ISSN": "1791-2431", "archive": "", "archiveLocation": "", "shortTitle": "Impaired immune function", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 19885593", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Biological Markers", "type": 1 }, { "tag": "Cachexia", "type": 1 }, { "tag": "Cell Line, Tumor", "type": 1 }, { "tag": "Cytokines", "type": 1 }, { "tag": "Immune System", "type": 1 }, { "tag": "Inflammation", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mice, Inbred BALB C", "type": 1 }, { "tag": "Mice, Inbred DBA", "type": 1 }, { "tag": "Monocytes", "type": 1 }, { "tag": "Neoplasms", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Time Factors", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2010-04-22T09:27:20Z", "dateModified": "2010-04-22T09:27:20Z" } }, { "key": "PD9DUSFS", "version": 1, "library": { "type": "group", "id": 16421, "name": "frosk1980", "links": { "alternate": { "href": "https://www.zotero.org/groups/frosk1980", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/16421/items/PD9DUSFS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/frosk1980/items/PD9DUSFS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 224424, "username": "frosk1980", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/frosk1980", "type": "text/html" } } }, "creatorSummary": "Muscaritoli et al.", "parsedDate": "2010-04", "numChildren": 0 }, "data": { "key": "PD9DUSFS", "version": 1, "itemType": "journalArticle", "title": "Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) \"cachexia-anorexia in chronic wasting diseases\" and \"nutrition in geriatrics\"", "creators": [ { "creatorType": "author", "firstName": "M", "lastName": "Muscaritoli" }, { "creatorType": "author", "firstName": "S D", "lastName": "Anker" }, { "creatorType": "author", "firstName": "J", "lastName": "Argilés" }, { "creatorType": "author", "firstName": "Z", "lastName": "Aversa" }, { "creatorType": "author", "firstName": "J M", "lastName": "Bauer" }, { "creatorType": "author", "firstName": "G", "lastName": "Biolo" }, { "creatorType": "author", "firstName": "Y", "lastName": "Boirie" }, { "creatorType": "author", "firstName": "I", "lastName": "Bosaeus" }, { "creatorType": "author", "firstName": "T", "lastName": "Cederholm" }, { "creatorType": "author", "firstName": "P", "lastName": "Costelli" }, { "creatorType": "author", "firstName": "K C", "lastName": "Fearon" }, { "creatorType": "author", "firstName": "A", "lastName": "Laviano" }, { "creatorType": "author", "firstName": "M", "lastName": "Maggio" }, { "creatorType": "author", "firstName": "F Rossi", "lastName": "Fanelli" }, { "creatorType": "author", "firstName": "S M", "lastName": "Schneider" }, { "creatorType": "author", "firstName": "A", "lastName": "Schols" }, { "creatorType": "author", "firstName": "C C", "lastName": "Sieber" } ], "abstractNote": "Chronic diseases as well as aging are frequently associated with deterioration of nutritional status, loss muscle mass and function (i.e. sarcopenia), impaired quality of life and increased risk for morbidity and mortality. Although simple and effective tools for the accurate screening, diagnosis and treatment of malnutrition have been developed during the recent years, its prevalence still remains disappointingly high and its impact on morbidity, mortality and quality of life clinically significant. Based on these premises, the Special Interest Group (SIG) on cachexia-anorexia in chronic wasting diseases was created within ESPEN with the aim of developing and spreading the knowledge on the basic and clinical aspects of cachexia and anorexia as well as of increasing the awareness of cachexia among health professionals and care givers. The definition, the assessment and the staging of cachexia, were identified as a priority by the SIG. This consensus paper reports the definition of cachexia, pre-cachexia and sarcopenia as well as the criteria for the differentiation between cachexia and other conditions associated with sarcopenia, which have been developed in cooperation with the ESPEN SIG on nutrition in geriatrics.", "publicationTitle": "Clinical Nutrition (Edinburgh, Scotland)", "publisher": "", "place": "", "date": "Apr 2010", "volume": "29", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "154-159", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Clin Nutr", "DOI": "10.1016/j.clnu.2009.12.004", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20060626", "accessDate": "2010-04-22T09:27:12Z", "PMID": "", "PMCID": "", "ISSN": "1532-1983", "archive": "", "archiveLocation": "", "shortTitle": "Consensus definition of sarcopenia, cachexia and pre-cachexia", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 20060626", "tags": [], "collections": [], "relations": {}, "dateAdded": "2010-04-22T09:27:12Z", "dateModified": "2010-04-22T09:27:12Z" } }, { "key": "B9NAJD7G", "version": 1, "library": { "type": "group", "id": 16421, "name": "frosk1980", "links": { "alternate": { "href": "https://www.zotero.org/groups/frosk1980", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/16421/items/B9NAJD7G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/frosk1980/items/B9NAJD7G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 224424, "username": "frosk1980", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/frosk1980", "type": "text/html" } } }, "creatorSummary": "Capdevila et al.", "parsedDate": "2010-02", "numChildren": 0 }, "data": { "key": "B9NAJD7G", "version": 1, "itemType": "journalArticle", "title": "New approaches in the management of radioiodine-refractory thyroid cancer: the molecular targeted therapy era", "creators": [ { "creatorType": "author", "firstName": "Jaume", "lastName": "Capdevila" }, { "creatorType": "author", "firstName": "Guillem", "lastName": "Argiles" }, { "creatorType": "author", "firstName": "Victor", "lastName": "Rodriguez-Frexinos" }, { "creatorType": "author", "firstName": "Isaac", "lastName": "Nuñez" }, { "creatorType": "author", "firstName": "Josep", "lastName": "Tabernero" } ], "abstractNote": "Although thyroid carcinoma usually has an excellent prognosis, the lack of therapeutic options is an issue for patients that develop metastases and are resistant to radioiodine therapy. The development of novel molecular targeted therapies and the characterization of several proteins that have a crucial role in the carcinogenesis process of differentiated thyroid cancer have created an opportunity to design new clinical trials for this setting. Moreover, the encouraging initial results of first clinical trials have accelerated the development of placebo-controlled phase III studies that will assess the role of these new agents in the management of differentiated thyroid cancer.", "publicationTitle": "Discovery Medicine", "publisher": "", "place": "", "date": "Feb 2010", "volume": "9", "issue": "45", "section": "", "partNumber": "", "partTitle": "", "pages": "153-162", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Discov Med", "DOI": "", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20193642", "accessDate": "2010-04-22T09:26:54Z", "PMID": "", "PMCID": "", "ISSN": "1944-7930", "archive": "", "archiveLocation": "", "shortTitle": "New approaches in the management of radioiodine-refractory thyroid cancer", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 20193642", "tags": [], "collections": [], "relations": {}, "dateAdded": "2010-04-22T09:26:54Z", "dateModified": "2010-04-22T09:26:54Z" } } ]