[ { "key": "BP5WPSS5", "version": 397, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/BP5WPSS5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/BP5WPSS5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/ZW5IRR2U", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "BP5WPSS5", "version": 397, "parentItem": "ZW5IRR2U", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-11-10T20:10:18Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/15854765", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-11-10T20:10:18Z", "dateModified": "2013-11-10T20:10:18Z" } }, { "key": "ZW5IRR2U", "version": 397, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/ZW5IRR2U", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/ZW5IRR2U", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Bierl et al.", "parsedDate": "2005-05-20", "numChildren": 1 }, "data": { "key": "ZW5IRR2U", "version": 397, "itemType": "journalArticle", "title": "'Mature' nerve growth factor is a minor species in most peripheral tissues", "creators": [ { "creatorType": "author", "firstName": "Michael A", "lastName": "Bierl" }, { "creatorType": "author", "firstName": "Elizabeth E", "lastName": "Jones" }, { "creatorType": "author", "firstName": "Keith A", "lastName": "Crutcher" }, { "creatorType": "author", "firstName": "Lori G", "lastName": "Isaacson" } ], "abstractNote": "The classic neurotrophin hypothesis is based on the idea that innervating neurons derive 'mature' neurotrophin provided by the target for their survival. Yet large precursor forms of the neurotrophin nerve growth factor (NGF) have been reported in both central and peripheral tissues. In the present study, immunoblotting was used to survey peripheral tissues containing NGF-responsive neurons and to characterize various NGF species. These results demonstrate that 'mature' forms of NGF, i.e., the 13 and 16kDa species, are rare in sympathetic and sensory ganglia and in their peripheral targets, and that large molecular weight NGF precursors are abundant. In addition, certain NGF forms predominate in a given tissue, with each tissue exhibiting a characteristic NGF expression pattern. These findings suggest that NGF processing in peripheral tissues and in NGF-responsive ganglia may involve a variety of NGF species.", "publicationTitle": "Neuroscience letters", "publisher": "", "place": "", "date": "2005 May 20-27", "volume": "380", "issue": "1-2", "section": "", "partNumber": "", "partTitle": "", "pages": "133-137", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Neurosci. Lett.", "DOI": "10.1016/j.neulet.2005.01.029", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0304-3940", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 15854765", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Blotting, Western", "type": 1 }, { "tag": "Cerebral Cortex", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Gene Expression Regulation", "type": 1 }, { "tag": "Nerve growth factor", "type": 1 }, { "tag": "Protein Precursors", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Rats, Inbred F344", "type": 1 }, { "tag": "Superior Cervical Ganglion", "type": 1 }, { "tag": "Trigeminal Ganglion", "type": 1 } ], "collections": [ "NT2FTUDZ" ], "relations": {}, "dateAdded": "2013-11-10T20:10:18Z", "dateModified": "2013-11-10T20:10:18Z" } }, { "key": "8BZE8S3X", "version": 394, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/8BZE8S3X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/8BZE8S3X", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/NJ77KF2D", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "8BZE8S3X", "version": 394, "parentItem": "NJ77KF2D", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-03T12:44:10Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22345400", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-03T12:44:10Z", "dateModified": "2013-10-03T12:44:10Z" } }, { "key": "NJ77KF2D", "version": 394, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/NJ77KF2D", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/NJ77KF2D", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Wende et al.", "parsedDate": "2012-03-16", "numChildren": 1 }, "data": { "key": "NJ77KF2D", "version": 394, "itemType": "journalArticle", "title": "The transcription factor c-Maf controls touch receptor development and function", "creators": [ { "creatorType": "author", "firstName": "Hagen", "lastName": "Wende" }, { "creatorType": "author", "firstName": "Stefan G", "lastName": "Lechner" }, { "creatorType": "author", "firstName": "Cyril", "lastName": "Cheret" }, { "creatorType": "author", "firstName": "Steeve", "lastName": "Bourane" }, { "creatorType": "author", "firstName": "Maria E", "lastName": "Kolanczyk" }, { "creatorType": "author", "firstName": "Alexandre", "lastName": "Pattyn" }, { "creatorType": "author", "firstName": "Katja", "lastName": "Reuter" }, { "creatorType": "author", "firstName": "Francis L", "lastName": "Munier" }, { "creatorType": "author", "firstName": "Patrick", "lastName": "Carroll" }, { "creatorType": "author", "firstName": "Gary R", "lastName": "Lewin" }, { "creatorType": "author", "firstName": "Carmen", "lastName": "Birchmeier" } ], "abstractNote": "The sense of touch relies on detection of mechanical stimuli by specialized mechanosensory neurons. The scarcity of molecular data has made it difficult to analyze development of mechanoreceptors and to define the basis of their diversity and function. We show that the transcription factor c-Maf/c-MAF is crucial for mechanosensory function in mice and humans. The development and function of several rapidly adapting mechanoreceptor types are disrupted in c-Maf mutant mice. In particular, Pacinian corpuscles, a type of mechanoreceptor specialized to detect high-frequency vibrations, are severely atrophied. In line with this, sensitivity to high-frequency vibration is reduced in humans carrying a dominant mutation in the c-MAF gene. Thus, our work identifies a key transcription factor specifying development and function of mechanoreceptors and their end organs.", "publicationTitle": "Science (New York, N.Y.)", "publisher": "", "place": "", "date": "Mar 16, 2012", "volume": "335", "issue": "6074", "section": "", "partNumber": "", "partTitle": "", "pages": "1373-1376", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Science", "DOI": "10.1126/science.1214314", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1095-9203", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 22345400", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Gene Expression Regulation, Developmental", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Maf Transcription Factors, Large", "type": 1 }, { "tag": "Mechanoreceptors", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mutation", "type": 1 }, { "tag": "Pacinian Corpuscles", "type": 1 }, { "tag": "Proto-Oncogene Proteins c-maf", "type": 1 }, { "tag": "Proto-Oncogene Proteins c-ret", "type": 1 }, { "tag": "Skin", "type": 1 }, { "tag": "Touch", "type": 1 }, { "tag": "Vibration", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-03T12:44:10Z", "dateModified": "2013-10-03T12:44:10Z" } }, { "key": "4JGAZNFI", "version": 393, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/4JGAZNFI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/4JGAZNFI", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Hjerling-Leffler et al.", "parsedDate": "2007-03-07", "numChildren": 1 }, "data": { "key": "4JGAZNFI", "version": 393, "itemType": "journalArticle", "title": "Emergence of functional sensory subtypes as defined by transient receptor potential channel expression", "creators": [ { "creatorType": "author", "firstName": "Jens", "lastName": "Hjerling-Leffler" }, { "creatorType": "author", "firstName": "Mona", "lastName": "Alqatari" }, { "creatorType": "author", "firstName": "Patrik", "lastName": "Ernfors" }, { "creatorType": "author", "firstName": "Martin", "lastName": "Koltzenburg" } ], "abstractNote": "The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP) cation channels contributes to this functional heterogeneity. However, little is known about the development of functionally diverse neuronal subpopulations. Here, we use calcium imaging of acutely dissociated mouse sensory neurons and quantitative reverse transcription PCR to show that TRP cation channels emerge in waves, with the diversification of functional groups starting at embryonic day 12.5 (E12.5) and extending well into the postnatal life. Functional responses of voltage-gated calcium channels were present in DRG neurons at E11.5 and reached adult levels by E14.5. Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected. Cold-sensitive neurons were present before the expression or functional responses of TRPM8 or TRPA1. Our data support a lineage relationship in which TRPM8- and TRPA1-expressing sensory neurons derive from the population of TRPV1-expressing neurons. The TRPA1 subpopulation of neurons emerges independently in two distinct classes of nociceptors: around birth in the peptidergic population and after P14 in the nonpeptidergic class. This indicates that neurons with similar receptive properties can be generated in different sublineages at different developmental stages. This study describes for the first time the emergence of functional subtypes of sensory neurons, providing new insight into the development of nociception and thermoreception.", "publicationTitle": "The Journal of neuroscience: the official journal of the Society for Neuroscience", "publisher": "", "place": "", "date": "Mar 7, 2007", "volume": "27", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "2435-2443", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurosci.", "DOI": "10.1523/JNEUROSCI.5614-06.2007", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1529-2401", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 17344381", "tags": [ { "tag": "Acrolein", "type": 1 }, { "tag": "Aging", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Animals, Newborn", "type": 1 }, { "tag": "Calcium Channels", "type": 1 }, { "tag": "Capsaicin", "type": 1 }, { "tag": "Cell Differentiation", "type": 1 }, { "tag": "Cell Lineage", "type": 1 }, { "tag": "Cells, Cultured", "type": 1 }, { "tag": "Cold Temperature", "type": 1 }, { "tag": "Embryo, Mammalian", "type": 1 }, { "tag": "Embryonic Development", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Menthol", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mice, Inbred C57BL", "type": 1 }, { "tag": "Neurons, Afferent", "type": 1 }, { "tag": "Nociceptors", "type": 1 }, { "tag": "Plant Lectins", "type": 1 }, { "tag": "RNA, Messenger", "type": 1 }, { "tag": "TRPM Cation Channels", "type": 1 }, { "tag": "TRPV Cation Channels", "type": 1 }, { "tag": "Thermoreceptors", "type": 1 }, { "tag": "Transient Receptor Potential Channels", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-03T12:31:27Z", "dateModified": "2013-10-03T12:31:27Z" } }, { "key": "UPBS4E2F", "version": 393, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/UPBS4E2F", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/UPBS4E2F", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/4JGAZNFI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "UPBS4E2F", "version": 393, "parentItem": "4JGAZNFI", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-03T12:31:27Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17344381", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-03T12:31:27Z", "dateModified": "2013-10-03T12:31:27Z" } }, { "key": "EXT97RQP", "version": 392, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/EXT97RQP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/EXT97RQP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Luo et al.", "parsedDate": "2007-06-07", "numChildren": 1 }, "data": { "key": "EXT97RQP", "version": 392, "itemType": "journalArticle", "title": "A hierarchical NGF signaling cascade controls Ret-dependent and Ret-independent events during development of nonpeptidergic DRG neurons", "creators": [ { "creatorType": "author", "firstName": "Wenqin", "lastName": "Luo" }, { "creatorType": "author", "firstName": "S Rasika", "lastName": "Wickramasinghe" }, { "creatorType": "author", "firstName": "Joseph M", "lastName": "Savitt" }, { "creatorType": "author", "firstName": "John W", "lastName": "Griffin" }, { "creatorType": "author", "firstName": "Ted M", "lastName": "Dawson" }, { "creatorType": "author", "firstName": "David D", "lastName": "Ginty" } ], "abstractNote": "NGF controls survival, differentiation, and target innervation of both peptidergic and nonpeptidergic DRG sensory neurons. The common receptor for GDNF family ligands, Ret, is highly expressed in nonpeptidergic neurons, but its function during development of these neurons is unclear. Here, we show that expression of Ret and its coreceptors GFRalpha1 and GFRalpha2 is dependent on NGF. GFR/Ret signaling, in turn, autoregulates expression of both GFRalpha1 and GFRalpha2 and promotes expression of TrpA1, MrgA1, MrgA3, and MrgB4, acquisition of normal neuronal size, axonal innervation of the epidermis, and postnatal extinction of the NGF receptor TrkA. Moreover, NGF controls expression of several other genes characteristic of nonpeptidergic neurons, such as TrpC3, TrpM8, MrgD, and the transcription factor Runx1, via a Ret-independent signaling pathway. These findings support a model in which NGF controls maturation of nonpeptidergic DRG neurons through a combination of GFR/Ret-dependent and -independent signaling pathways.", "publicationTitle": "Neuron", "publisher": "", "place": "", "date": "Jun 7, 2007", "volume": "54", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "739-754", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Neuron", "DOI": "10.1016/j.neuron.2007.04.027", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0896-6273", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 17553423", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Cell Differentiation", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Gene Expression Regulation, Developmental", "type": 1 }, { "tag": "Glial Cell Line-Derived Neurotrophic Factor Receptors", "type": 1 }, { "tag": "Ion Channels", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mice, Inbred C57BL", "type": 1 }, { "tag": "Mice, Knockout", "type": 1 }, { "tag": "Mice, Transgenic", "type": 1 }, { "tag": "Nerve growth factor", "type": 1 }, { "tag": "Neurons, Afferent", "type": 1 }, { "tag": "Nociceptors", "type": 1 }, { "tag": "Organ Culture Techniques", "type": 1 }, { "tag": "Proto-Oncogene Proteins c-ret", "type": 1 }, { "tag": "Receptors, G-Protein-Coupled", "type": 1 }, { "tag": "Signal Transduction", "type": 1 }, { "tag": "Transcription Factors", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-03T12:13:41Z", "dateModified": "2013-10-03T12:13:41Z" } }, { "key": "3XAWDJ3T", "version": 392, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/3XAWDJ3T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/3XAWDJ3T", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/EXT97RQP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "3XAWDJ3T", "version": 392, "parentItem": "EXT97RQP", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-03T12:13:41Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17553423", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-03T12:13:41Z", "dateModified": "2013-10-03T12:13:41Z" } }, { "key": "6DVC5DAV", "version": 391, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/6DVC5DAV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/6DVC5DAV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Patel et al.", "parsedDate": "2000-02", "numChildren": 1 }, "data": { "key": "6DVC5DAV", "version": 391, "itemType": "journalArticle", "title": "Development of sensory neurons in the absence of NGF/TrkA signaling in vivo", "creators": [ { "creatorType": "author", "firstName": "T D", "lastName": "Patel" }, { "creatorType": "author", "firstName": "A", "lastName": "Jackman" }, { "creatorType": "author", "firstName": "F L", "lastName": "Rice" }, { "creatorType": "author", "firstName": "J", "lastName": "Kucera" }, { "creatorType": "author", "firstName": "W D", "lastName": "Snider" } ], "abstractNote": "The neurotrophin survival dependence of peripheral neurons in vitro is regulated by the proapoptotic BCL-2 homolog BAX. To study peripheral neuron development in the absence of neurotrophin signaling, we have generated mice that are double null for BAX and nerve growth factor (NGF), and BAX and the NGF receptor TrkA. All dorsal root ganglion (DRG) neurons that normally die in the absence of NGF/TrkA signaling survive if BAX is also eliminated. These neurons extend axons through the dorsal roots and collateral branches into the dorsal horn. In contrast, superficial cutaneous innervation is absent. Furthermore, rescued sensory neurons fail to express biochemical markers characteristic of the nociceptive phenotype. These findings establish that NGF/TrkA signaling regulates peripheral target field innervation and is required for the full phenotypic differentiation of sensory neurons.", "publicationTitle": "Neuron", "publisher": "", "place": "", "date": "Feb 2000", "volume": "25", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "345-357", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Neuron", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0896-6273", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 10719890", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Calcitonin Gene-Related Peptide", "type": 1 }, { "tag": "Cell Count", "type": 1 }, { "tag": "Cell Differentiation", "type": 1 }, { "tag": "Cell Survival", "type": 1 }, { "tag": "Cells, Cultured", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Gene Expression Regulation, Developmental", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Mice, Inbred C57BL", "type": 1 }, { "tag": "Mice, Mutant Strains", "type": 1 }, { "tag": "Nerve growth factor", "type": 1 }, { "tag": "Neurons, Afferent", "type": 1 }, { "tag": "Phenotype", "type": 1 }, { "tag": "Proto-Oncogene Proteins", "type": 1 }, { "tag": "Proto-Oncogene Proteins c-bcl-2", "type": 1 }, { "tag": "Receptor, trkA", "type": 1 }, { "tag": "Signal Transduction", "type": 1 }, { "tag": "Skin", "type": 1 }, { "tag": "Spinal Cord", "type": 1 }, { "tag": "Substance P", "type": 1 }, { "tag": "bcl-2-Associated X Protein", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-03T12:11:29Z", "dateModified": "2013-10-03T12:11:29Z" } }, { "key": "IMRCZ8X4", "version": 391, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/IMRCZ8X4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/IMRCZ8X4", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/6DVC5DAV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "IMRCZ8X4", "version": 391, "parentItem": "6DVC5DAV", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-03T12:11:29Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10719890", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-03T12:11:29Z", "dateModified": "2013-10-03T12:11:29Z" } }, { "key": "DH6H7Q9G", "version": 390, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/DH6H7Q9G", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/DH6H7Q9G", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Marmigère and Ernfors", "parsedDate": "2007-02", "numChildren": 1 }, "data": { "key": "DH6H7Q9G", "version": 390, "itemType": "journalArticle", "title": "Specification and connectivity of neuronal subtypes in the sensory lineage", "creators": [ { "creatorType": "author", "firstName": "Frédéric", "lastName": "Marmigère" }, { "creatorType": "author", "firstName": "Patrik", "lastName": "Ernfors" } ], "abstractNote": "During the development of the nervous system, many different types of neuron are produced. As well as forming the correct type of neuron, each must also establish precise connections. Recent findings show that, because of shared gene programmes, neuronal identity is intimately linked to and coordinated with axonal behaviour. Peripheral sensory neurons provide an excellent system in which to study these interactions. This review examines how neuronal diversity is created in the PNS and describes proteins that help to direct the diversity of neuronal subtypes, cell survival, axonal growth and the establishment of central patterns of modality-specific connections.", "publicationTitle": "Nature reviews. Neuroscience", "publisher": "", "place": "", "date": "Feb 2007", "volume": "8", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "114-127", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat. Rev. Neurosci.", "DOI": "10.1038/nrn2057", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1471-003X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 17237804", "tags": [ { "tag": "Afferent Pathways", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Cell Differentiation", "type": 1 }, { "tag": "Cell Movement", "type": 1 }, { "tag": "Embryonic Induction", "type": 1 }, { "tag": "Neurons, Afferent", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-03T11:58:10Z", "dateModified": "2013-10-03T11:58:10Z" } }, { "key": "BN4Q3RTF", "version": 390, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/BN4Q3RTF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/BN4Q3RTF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/DH6H7Q9G", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "BN4Q3RTF", "version": 390, "parentItem": "DH6H7Q9G", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-03T11:58:10Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/17237804", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-03T11:58:10Z", "dateModified": "2013-10-03T11:58:10Z" } }, { "key": "4A72VPXV", "version": 389, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/4A72VPXV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/4A72VPXV", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/XK7T8K8N", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "4A72VPXV", "version": 389, "parentItem": "XK7T8K8N", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-02T17:06:30Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/18056406", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-02T17:06:30Z", "dateModified": "2013-10-02T17:06:30Z" } }, { "key": "XK7T8K8N", "version": 389, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/XK7T8K8N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/XK7T8K8N", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Wright et al.", "parsedDate": "2007-12-03", "numChildren": 1 }, "data": { "key": "XK7T8K8N", "version": 389, "itemType": "journalArticle", "title": "Chromatin modification of Apaf-1 restricts the apoptotic pathway in mature neurons", "creators": [ { "creatorType": "author", "firstName": "Kevin M", "lastName": "Wright" }, { "creatorType": "author", "firstName": "Michelle I", "lastName": "Smith" }, { "creatorType": "author", "firstName": "Lila", "lastName": "Farrag" }, { "creatorType": "author", "firstName": "Mohanish", "lastName": "Deshmukh" } ], "abstractNote": "Although apoptosis has been extensively studied in developing neurons, the dynamic changes in this pathway after neuronal maturation remain largely unexplored. We show that as neurons mature, cytochrome c- mediated apoptosis progresses from inhibitor of apoptosis protein-dependent to -independent regulation because of a complete loss of Apaf-1 expression. However, after DNA damage, mature neurons resynthesize Apaf-1 through the cell cycle-related E2F1 pathway and restore their apoptotic potential. Surprisingly, we find that E2F1 is sufficient to induce Apaf-1 expression in developing but not mature neurons. Rather, Apaf-1 up-regulation in mature neurons requires both chromatin derepression and E2F1 transcriptional activity. This differential capacity of E2F1 to induce Apaf-1 transcription is because of the association of the Apaf-1 promoter with active chromatin in developing neurons and repressed chromatin in mature neurons. These data specifically illustrate how the apoptotic pathway in mature neurons becomes increasingly restricted by a novel mechanism involving the regulation of chromatin structure.", "publicationTitle": "The Journal of cell biology", "publisher": "", "place": "", "date": "Dec 3, 2007", "volume": "179", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "825-832", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Cell Biol.", "DOI": "10.1083/jcb.200708086", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1540-8140", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 18056406", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Apoptosis", "type": 1 }, { "tag": "Apoptosomes", "type": 1 }, { "tag": "Apoptotic Protease-Activating Factor 1", "type": 1 }, { "tag": "Cell Cycle Proteins", "type": 1 }, { "tag": "Chromatin", "type": 1 }, { "tag": "Cytochromes c", "type": 1 }, { "tag": "DNA Damage", "type": 1 }, { "tag": "Inhibitor of Apoptosis Proteins", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Transcription, Genetic", "type": 1 }, { "tag": "Transcriptional Activation", "type": 1 }, { "tag": "Up-Regulation", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-02T17:06:30Z", "dateModified": "2013-10-02T17:06:30Z" } }, { "key": "QZ9VA4RQ", "version": 388, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/QZ9VA4RQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/QZ9VA4RQ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/FF9C24SQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "QZ9VA4RQ", "version": 388, "parentItem": "FF9C24SQ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-10-01T20:58:56Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/8887754", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-10-01T20:58:56Z", "dateModified": "2013-10-01T20:58:56Z" } }, { "key": "FF9C24SQ", "version": 388, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/FF9C24SQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/FF9C24SQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "England et al.", "parsedDate": "1996-09-01", "numChildren": 1 }, "data": { "key": "FF9C24SQ", "version": 388, "itemType": "journalArticle", "title": "PGE2 modulates the tetrodotoxin-resistant sodium current in neonatal rat dorsal root ganglion neurones via the cyclic AMP-protein kinase A cascade", "creators": [ { "creatorType": "author", "firstName": "S", "lastName": "England" }, { "creatorType": "author", "firstName": "S", "lastName": "Bevan" }, { "creatorType": "author", "firstName": "R J", "lastName": "Docherty" } ], "abstractNote": "1. In current-clamp recordings, 1 microM prostaglandin E2 (PGE2) increased the excitability of neonatal rat dorsal root ganglion neurones. The current threshold for firing was reduced, and the response to a constant suprathreshold stimulation was modified such that a single evoked action potential was converted to a train of action potentials. The excitatory action of PGE2 was still apparent when action potentials were evoked in the presence of 500 nM tetrodotoxin. 2. In voltage-clamp experiments 1 microM PGE2 frequently increased the magnitude of the peak currents recorded, and caused a hyperpolarizing shift (of approximately 6 mV) in the activation curve for the tetrodotoxin-resistant sodium current (TTX-R INa). In some cells, the hyperpolarizing shift in the activation curve was accompanied by a decrease in peak conductance. PGE2 also caused a hyperpolarizing shift in the steady-state inactivation curve for the sodium current. 3. Extracellular application of the cAMP analogue dibutyryl cAMP (dbcAMP) at a concentration of 1 mM produced effects on both the current-voltage relationship and the steady-state inactivation curve for the TTX-R INa which were indistinguishable from those observed with PGE2. Prior exposure of the neurones to dbcAMP occluded the effect of a subsequent treatment with PGE2. 4. Forskolin (10 microM), a direct activator of adenylate cyclase, mimicked the effects of PGE2 and dbcAMP on TTX-R INa. The inactive congener of forskolin, 1, 9-dideoxyforskolin (10 microM), reduced the amplitude of TTX-R INa, but did not evoke a hyperpolarizing shift in the activation curve. 5. Intracellular perfusion of the neurones with an inhibitor of protein kinase A inhibited the effect of PGE2 on TTX-R INa. 6. PGE2 also reduced the amplitude of voltage-gated potassium currents (IK), which will contribute to the excitatory action. The mechanisms underlying the changes in IK have yet to be elucidated. 7. We propose that the PGE2-mediated increase in excitability in sensory neurones may be due, at least in part, to the cAMP-protein kinase A-dependent modulation of the tetrodotoxin-resistant sodium channel.", "publicationTitle": "The Journal of physiology", "publisher": "", "place": "", "date": "Sep 1, 1996", "volume": "495 ( Pt 2)", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "429-440", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Physiol. (Lond.)", "DOI": "", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-3751", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 8887754", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Animals, Newborn", "type": 1 }, { "tag": "Bucladesine", "type": 1 }, { "tag": "Cyclic AMP", "type": 1 }, { "tag": "Cyclic AMP-Dependent Protein Kinases", "type": 1 }, { "tag": "Dinoprostone", "type": 1 }, { "tag": "Electrophysiology", "type": 1 }, { "tag": "Forskolin", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Membrane Potentials", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Patch-Clamp Techniques", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Rats, Sprague-Dawley", "type": 1 }, { "tag": "Sodium Channels", "type": 1 }, { "tag": "Tetrodotoxin", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2013-10-01T20:58:56Z", "dateModified": "2013-10-01T20:58:56Z" } }, { "key": "22BCW5B2", "version": 386, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/22BCW5B2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/22BCW5B2", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/G648HE77", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "22BCW5B2", "version": 386, "parentItem": "G648HE77", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T23:49:34Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20978020", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T23:49:34Z", "dateModified": "2013-09-25T23:49:34Z" } }, { "key": "WEDDIT3N", "version": 385, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/WEDDIT3N", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/WEDDIT3N", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/ES2GJIFI", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "WEDDIT3N", "version": 385, "parentItem": "ES2GJIFI", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T23:48:38Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/14976160", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T23:48:38Z", "dateModified": "2013-09-25T23:48:38Z" } }, { "key": "4DGSXATH", "version": 384, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/4DGSXATH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/4DGSXATH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/SEQJ3P6E", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "4DGSXATH", "version": 384, "parentItem": "SEQJ3P6E", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T12:41:42Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/8696348", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T12:41:42Z", "dateModified": "2013-09-25T12:41:42Z" } }, { "key": "FC53HZBK", "version": 383, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/FC53HZBK", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/FC53HZBK", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Indo et al.", "parsedDate": "1996-08", "numChildren": 1 }, "data": { "key": "FC53HZBK", "version": 383, "itemType": "journalArticle", "title": "Mutations in the TRKA/NGF receptor gene in patients with congenital insensitivity to pain with anhidrosis", "creators": [ { "creatorType": "author", "firstName": "Y", "lastName": "Indo" }, { "creatorType": "author", "firstName": "M", "lastName": "Tsuruta" }, { "creatorType": "author", "firstName": "Y", "lastName": "Hayashida" }, { "creatorType": "author", "firstName": "M A", "lastName": "Karim" }, { "creatorType": "author", "firstName": "K", "lastName": "Ohta" }, { "creatorType": "author", "firstName": "T", "lastName": "Kawano" }, { "creatorType": "author", "firstName": "H", "lastName": "Mitsubuchi" }, { "creatorType": "author", "firstName": "H", "lastName": "Tonoki" }, { "creatorType": "author", "firstName": "Y", "lastName": "Awaya" }, { "creatorType": "author", "firstName": "I", "lastName": "Matsuda" } ], "abstractNote": "Congenital insensitivity to pain with anhidrosis (CIPA; MIM 256800) is an autosomal-recessive disorder characterized by recurrent episodes of unexplained fever, anhidrosis (absence of sweating) and absence of reaction to noxious stimuli, self-mutilating behaviour and mental retardation. The genetic basis for CIPA is unknown. Nerve growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic sensory and sympathetic neurons. Mice lacking the gene for TrkA, a receptor tyrosine kinase for NGF, share dramatic phenotypic features of CIPA, including loss of responses to painful stimuli, although anhidrosis is not apparent in these animals. We therefore considered the human TRKA homologue as a candidate for the CIPA gene. The mRNA and genomic DNA encoding TRKA were analysed in three unrelated CIPA patients who had consanguineous parents. We detected a deletion-, splice- and missense-mutation in the tyrosine kinase domain in these three patients. Our findings strongly suggest that defects in TRKA cause CIPA and that the NGF-TRKA system has a crucial role in the development and function of the nociceptive reception as well as establishment of thermoregulation via sweating in humans. These results also implicate genes encoding other TRK and neurotrophin family members as candidates for developmental defect(s) of the nervous system.", "publicationTitle": "Nature genetics", "publisher": "", "place": "", "date": "Aug 1996", "volume": "13", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "485-488", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat. Genet.", "DOI": "10.1038/ng0896-485", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1061-4036", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 8696348", "tags": [ { "tag": "Amino Acid Sequence", "type": 1 }, { "tag": "Base Sequence", "type": 1 }, { "tag": "DNA Primers", "type": 1 }, { "tag": "Frameshift Mutation", "type": 1 }, { "tag": "Gene Expression", "type": 1 }, { "tag": "Genes", "type": 1 }, { "tag": "Genes, Recessive", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Hypohidrosis", "type": 1 }, { "tag": "Molecular Sequence Data", "type": 1 }, { "tag": "Pain Insensitivity, Congenital", "type": 1 }, { "tag": "Point Mutation", "type": 1 }, { "tag": "Proto-Oncogene Proteins", "type": 1 }, { "tag": "RNA, Messenger", "type": 1 }, { "tag": "Receptor Protein-Tyrosine Kinases", "type": 1 }, { "tag": "Receptor, trkA", "type": 1 }, { "tag": "Receptors, Nerve Growth Factor", "type": 1 }, { "tag": "Restriction Mapping", "type": 1 }, { "tag": "Sequence Alignment", "type": 1 }, { "tag": "Sequence Deletion", "type": 1 }, { "tag": "Sequence Homology, Amino Acid", "type": 1 }, { "tag": "Syndrome", "type": 1 } ], "collections": [ "NT2FTUDZ" ], "relations": {}, "dateAdded": "2013-09-25T12:40:17Z", "dateModified": "2013-09-25T12:40:17Z" } }, { "key": "5DTHKPNJ", "version": 383, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/5DTHKPNJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/5DTHKPNJ", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/FC53HZBK", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "5DTHKPNJ", "version": 383, "parentItem": "FC53HZBK", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T12:40:17Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/8696348", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T12:40:17Z", "dateModified": "2013-09-25T12:40:17Z" } }, { "key": "MHVV2E73", "version": 382, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/MHVV2E73", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/MHVV2E73", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/4CHNIE93", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "MHVV2E73", "version": 382, "parentItem": "4CHNIE93", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T12:37:17Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20978020", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T12:37:17Z", "dateModified": "2013-09-25T12:37:17Z" } }, { "key": "4CHNIE93", "version": 382, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/4CHNIE93", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/4CHNIE93", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Carvalho et al.", "parsedDate": "2011-02", "numChildren": 1 }, "data": { "key": "4CHNIE93", "version": 382, "itemType": "journalArticle", "title": "A novel NGF mutation clarifies the molecular mechanism and extends the phenotypic spectrum of the HSAN5 neuropathy", "creators": [ { "creatorType": "author", "firstName": "Ofélia P", "lastName": "Carvalho" }, { "creatorType": "author", "firstName": "Gemma K", "lastName": "Thornton" }, { "creatorType": "author", "firstName": "Joseph", "lastName": "Hertecant" }, { "creatorType": "author", "firstName": "Henry", "lastName": "Houlden" }, { "creatorType": "author", "firstName": "Adeline K", "lastName": "Nicholas" }, { "creatorType": "author", "firstName": "James J", "lastName": "Cox" }, { "creatorType": "author", "firstName": "Mary", "lastName": "Rielly" }, { "creatorType": "author", "firstName": "Lihadh", "lastName": "Al-Gazali" }, { "creatorType": "author", "firstName": "C Geoffrey", "lastName": "Woods" } ], "abstractNote": "BACKGROUND: Nerve growth factor β (NGFβ) and tyrosine kinase receptor type A (TRKA) are a well studied neurotrophin/receptor duo involved in neuronal survival and differentiation. The only previously reported hereditary sensory neuropathy caused by an NGF mutation, c.661C>T (HSAN5), and the pathology caused by biallelic mutations in the TRKA gene (NTRK1) (HSAN4), share only some clinical features. A consanguineous Arab family, where five of the six children were completely unable to perceive pain, were mentally retarded, did not sweat, could not discriminate temperature, and had a chronic immunodeficiency, is reported here. The condition is linked to a new homozygous mutation in the NGF gene, c.[680C>A]+[681_682delGG].\nMETHODS: Genetic linkage and standard sequencing techniques were used to identify the causative gene. Using wild-type or mutant over-expression constructs transfected into PC12 and COS-7 cells, the cellular and molecular consequences of the mutations were investigated.\nRESULTS: The mutant gene produced a precursor protein V232fs that was unable to differentiate PC12 cells. V232fs was not secreted from cells as mature NGFβ.\nCONCLUSIONS: Both the clinical and cellular data suggest that the c.[680C>A]+[681_682delGG] NGF mutation is a functional null. The HSAN5 phenotype is extended to encompass HSAN4-like characteristics. It is concluded that the HSAN4 and HSAN5 phenotypes are parts of a phenotypic spectrum caused by changes in the NGF/TRKA signalling pathway.", "publicationTitle": "Journal of medical genetics", "publisher": "", "place": "", "date": "Feb 2011", "volume": "48", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "131-135", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Med. Genet.", "DOI": "10.1136/jmg.2010.081455", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1468-6244", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 20978020", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Base Sequence", "type": 1 }, { "tag": "Blotting, Western", "type": 1 }, { "tag": "COS Cells", "type": 1 }, { "tag": "Cercopithecus aethiops", "type": 1 }, { "tag": "Chromosome Mapping", "type": 1 }, { "tag": "Enzyme-Linked Immunosorbent Assay", "type": 1 }, { "tag": "Genotype", "type": 1 }, { "tag": "Hereditary Sensory and Autonomic Neuropathies", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Molecular Sequence Data", "type": 1 }, { "tag": "Mutation", "type": 1 }, { "tag": "Nerve growth factor", "type": 1 }, { "tag": "PC12 Cells", "type": 1 }, { "tag": "Pedigree", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Receptor Protein-Tyrosine Kinases", "type": 1 }, { "tag": "Receptor, trkA", "type": 1 }, { "tag": "Sequence Analysis, DNA", "type": 1 } ], "collections": [ "NT2FTUDZ" ], "relations": {}, "dateAdded": "2013-09-25T12:37:17Z", "dateModified": "2013-09-25T12:37:17Z" } }, { "key": "KQZVSFAE", "version": 381, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/KQZVSFAE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/KQZVSFAE", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/159559/items/23QJMABA", "type": "application/json" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } } }, "data": { "key": "KQZVSFAE", "version": 381, "parentItem": "23QJMABA", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2013-09-25T12:36:54Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/14976160", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-09-25T12:36:54Z", "dateModified": "2013-09-25T12:36:54Z" } }, { "key": "23QJMABA", "version": 381, "library": { "type": "group", "id": 159559, "name": "NGF chapter", "links": { "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/159559/items/23QJMABA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ngf_chapter/items/23QJMABA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 283300, "username": "glewin", "name": "Gary Lewin", "links": { "alternate": { "href": "https://www.zotero.org/glewin", "type": "text/html" } } }, "creatorSummary": "Einarsdottir et al.", "parsedDate": "2004-04-15", "numChildren": 1 }, "data": { "key": "23QJMABA", "version": 381, "itemType": "journalArticle", "title": "A mutation in the nerve growth factor beta gene (NGFB) causes loss of pain perception", "creators": [ { "creatorType": "author", "firstName": "Elisabet", "lastName": "Einarsdottir" }, { "creatorType": "author", "firstName": "Anna", "lastName": "Carlsson" }, { "creatorType": "author", "firstName": "Jan", "lastName": "Minde" }, { "creatorType": "author", "firstName": "Göran", "lastName": "Toolanen" }, { "creatorType": "author", "firstName": "Olle", "lastName": "Svensson" }, { "creatorType": "author", "firstName": "Göran", "lastName": "Solders" }, { "creatorType": "author", "firstName": "Gösta", "lastName": "Holmgren" }, { "creatorType": "author", "firstName": "Dan", "lastName": "Holmberg" }, { "creatorType": "author", "firstName": "Monica", "lastName": "Holmberg" } ], "abstractNote": "Identification of genes associated with pain insensitivity syndromes can increase the understanding of the pathways involved in pain and contribute to the understanding of how sensory pathways relate to other neurological functions. In this report we describe the mapping and identification of the gene responsible for loss of deep pain perception in a large family from northern Sweden. The loss of pain perception in this family is characterized by impairment in the sensing of deep pain and temperature but with normal mental abilities and with most other neurological responses intact. A severe reduction of unmyelinated nerve fibers and a moderate loss of thin myelinated nerve fibers are observed in the patients. Thus the cases in this study fall into the class of patients with loss of pain perception with underlying peripheral neuropathy. Clinically they best fit into HSAN V. Using a model of recessive inheritance we identified an 8.3 Mb region on chromosome 1p11.2-p13.2 shared by the affected individuals in the family. Analysis of functional candidate genes in the disease critical region revealed a mutation in the coding region of the nerve growth-factor beta (NGFB) gene specific for the disease haplotype. This NGF mutation seems to separate the effects of NGF involved in development of central nervous system functions such as mental abilities, from those involved in peripheral pain pathways. This mutation could therefore potentially provide an important tool to study different roles of NGF, and of pain control.", "publicationTitle": "Human molecular genetics", "publisher": "", "place": "", "date": "Apr 15, 2004", "volume": "13", "issue": "8", "section": "", "partNumber": "", "partTitle": "", "pages": "799-805", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Hum. Mol. Genet.", "DOI": "10.1093/hmg/ddh096", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0964-6906", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 14976160", "tags": [ { "tag": "Adolescent", "type": 1 }, { "tag": "Adult", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Cattle", "type": 1 }, { "tag": "Child", "type": 1 }, { "tag": "Child, Preschool", "type": 1 }, { "tag": "DNA Mutational Analysis", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Guinea Pigs", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Nerve growth factor", "type": 1 }, { "tag": "Pain Insensitivity, Congenital", "type": 1 }, { "tag": "Pedigree", "type": 1 }, { "tag": "Protein Structure, Secondary", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "pain", "type": 1 } ], "collections": [ "NT2FTUDZ" ], "relations": {}, "dateAdded": "2013-09-25T12:36:54Z", "dateModified": "2013-09-25T12:36:54Z" } } ]