[ { "key": "GV79ACIG", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/GV79ACIG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/GV79ACIG", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/149606/items/CJFSCF5F", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } } }, "data": { "key": "GV79ACIG", "version": 23, "parentItem": "CJFSCF5F", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-02-25T17:12:00Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/18448486", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-25T17:12:00Z", "dateModified": "2013-02-25T17:12:00Z" } }, { "key": "CJFSCF5F", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/CJFSCF5F", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/CJFSCF5F", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } }, "creatorSummary": "Wu et al.", "parsedDate": "2008-06", "numChildren": 1 }, "data": { "key": "CJFSCF5F", "version": 23, "itemType": "journalArticle", "title": "Sleep duration, melatonin and breast cancer among Chinese women in Singapore", "creators": [ { "creatorType": "author", "firstName": "Anna H", "lastName": "Wu" }, { "creatorType": "author", "firstName": "Renwei", "lastName": "Wang" }, { "creatorType": "author", "firstName": "Woon-Puay", "lastName": "Koh" }, { "creatorType": "author", "firstName": "Frank Z", "lastName": "Stanczyk" }, { "creatorType": "author", "firstName": "Hin-Peng", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Mimi C", "lastName": "Yu" } ], "abstractNote": "BACKGROUND\n\nSleep duration has been hypothesized to be inversely associated with breast cancer risk, possibly due to greater overall melatonin production in longer sleepers. However, data are inconclusive from the three studies conducted in Western populations on sleep duration and breast cancer risk.\n\n\nMETHODS\n\nWe investigated the relationship between self-reported usual sleep duration determined at baseline and subsequent risk of breast cancer in the prospective, population-based cohort of the Singapore Chinese Health Study. We excluded from the study women with <2 years of follow-up due to possible change in sleep pattern among breast cancer cases close to the time of diagnosis. Five hundred and twenty-five incident cases of breast cancer were identified among the remaining 33 528 women after up to 11 years of follow-up.\n\n\nRESULTS\n\nAmong women postmenopausal at baseline, breast cancer risk decreased with increasing sleep duration (P trend = 0.047); those who reported 9+ h of sleep showed a relative risk of 0.67 (95% confidence interval = 0.4-1.1) compared with women who reported < or =6 h of sleep. This inverse association was observed primarily in lean women [i.e. body mass index below the median value (23.2 kg/m(2))] (P = 0.024). In this study population, irrespective of gender, urinary 6-sulfatoxymelatonin levels increased with increasing self-reported hours of sleep (P trend = 0.035) after adjustment for age and time of day of urine collection. Melatonin levels were 42% higher in those with 9+ versus those with < or =6 h of sleep.\n\n\nCONCLUSION\n\nSleep duration may influence breast cancer risk, possibly via its effect on melatonin levels.", "publicationTitle": "Carcinogenesis", "publisher": "", "place": "", "date": "Jun 2008", "volume": "29", "issue": "6", "section": "", "partNumber": "", "partTitle": "", "pages": "1244-1248", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Carcinogenesis", "DOI": "10.1093/carcin/bgn100", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1460-2180", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 18448486", "tags": [ { "tag": "Aged", "type": 1 }, { "tag": "Asian Continental Ancestry Group", "type": 1 }, { "tag": "Breast Neoplasms", "type": 1 }, { "tag": "Enzyme-Linked Immunosorbent Assay", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Incidence", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Melatonin", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Postmenopause", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Singapore", "type": 1 }, { "tag": "Sleep", "type": 1 }, { "tag": "Time", "type": 1 } ], "collections": [ "Z9FTKJQJ" ], "relations": {}, "dateAdded": "2013-02-25T17:12:00Z", "dateModified": "2013-02-25T17:12:00Z" } }, { "key": "NVIV596V", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/NVIV596V", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/NVIV596V", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } }, "creatorSummary": "Kakizaki et al.", "parsedDate": "2008-11-04", "numChildren": 1 }, "data": { "key": "NVIV596V", "version": 23, "itemType": "journalArticle", "title": "Sleep duration and the risk of breast cancer: the Ohsaki Cohort Study", "creators": [ { "creatorType": "author", "firstName": "M", "lastName": "Kakizaki" }, { "creatorType": "author", "firstName": "S", "lastName": "Kuriyama" }, { "creatorType": "author", "firstName": "T", "lastName": "Sone" }, { "creatorType": "author", "firstName": "K", "lastName": "Ohmori-Matsuda" }, { "creatorType": "author", "firstName": "A", "lastName": "Hozawa" }, { "creatorType": "author", "firstName": "N", "lastName": "Nakaya" }, { "creatorType": "author", "firstName": "S", "lastName": "Fukudo" }, { "creatorType": "author", "firstName": "I", "lastName": "Tsuji" } ], "abstractNote": "In a prospective study of 23 995 Japanese women, short sleep duration was associated with higher risk of breast cancer (143 cases), compared with women who slept 7 h per day, the multivariate hazard ratio of those who slept or =9 hours were 0.93 (0.79-1.09), 0.98 (0.91-1.06), 1.05 (0.97-1.13), and 0.95 (0.82-1.11), respectively. A moderate trend in risk increase towards longer sleep duration was observed when analyses were restricted to participants who reported same sleep duration in 1986 and 2000 (P(trend) = 0.05). In this prospective study, we found no convincing evidence for an association between sleep duration and the incidence of breast cancer.", "publicationTitle": "Cancer research", "publisher": "", "place": "", "date": "May 15, 2006", "volume": "66", "issue": "10", "section": "", "partNumber": "", "partTitle": "", "pages": "5521-5525", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cancer Res.", "DOI": "10.1158/0008-5472.CAN-05-4652", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0008-5472", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 16707482", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Breast Neoplasms", "type": 1 }, { "tag": "Cohort Studies", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Incidence", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Prospective Studies", "type": 1 }, { "tag": "Sleep", "type": 1 } ], "collections": [ "Z9FTKJQJ" ], "relations": {}, "dateAdded": "2013-02-21T16:56:27Z", "dateModified": "2013-02-21T16:56:27Z" } }, { "key": "US7DDKWR", "version": 12, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/US7DDKWR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/US7DDKWR", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/149606/items/I2AABR64", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } } }, "data": { "key": "US7DDKWR", "version": 12, "parentItem": "I2AABR64", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-02-21T16:56:27Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16707482", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-21T16:56:27Z", "dateModified": "2013-02-21T16:56:27Z" } }, { "key": "QPMQHFNM", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/QPMQHFNM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/QPMQHFNM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } }, "creatorSummary": "McElroy et al.", "parsedDate": "2006-09", "numChildren": 1 }, "data": { "key": "QPMQHFNM", "version": 23, "itemType": "journalArticle", "title": "Duration of sleep and breast cancer risk in a large population-based case-control study", "creators": [ { "creatorType": "author", "firstName": "Jane A", "lastName": "McElroy" }, { "creatorType": "author", "firstName": "Polly A", "lastName": "Newcomb" }, { "creatorType": "author", "firstName": "Linda", "lastName": "Titus-Ernstoff" }, { "creatorType": "author", "firstName": "Amy", "lastName": "Trentham-Dietz" }, { "creatorType": "author", "firstName": "John M", "lastName": "Hampton" }, { "creatorType": "author", "firstName": "Kathleen M", "lastName": "Egan" } ], "abstractNote": "One important function of sleep may be its contribution to the maintenance of the immune system and regulation of the circadian rhythms by melatonin. Researchers have speculated that disruption of immune functions involving cortisol levels and natural killer cell activity may increase breast cancer risk whereas increased melatonin exposure may protect against breast cancer. We conducted a multistate population-based case-control study of 4,033 women with invasive breast cancer and 5,314 community women without breast cancer in which we inquired about women's sleep habits in the recent past and during adult lifetime. Relative to women who slept 7.0-7.9 h/night, the multivariate odds ratio for developing breast cancer among women who slept an average of 9 h or more per night approximately 2 years prior to interview was 1.13 (95% CI 0.93-1.37). The multivariate-adjusted odds ratio for the continuous term was 1.06 (95% CI 1.01-1.11), suggesting a 6% increase in risk for every additional hour of sleep. Similar patterns were observed for average lifetime adult sleep duration. We found little evidence that sleeping few hours per night was associated with breast cancer risk. The results of this study suggest that increasing sleep duration is modestly associated with an increased breast cancer risk. In contrast, short duration of sleep (<7 h/night) is not substantially associated with increased risk. Further research in this area is warranted.", "publicationTitle": "Journal of sleep research", "publisher": "", "place": "", "date": "Sep 2006", "volume": "15", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "241-249", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Sleep Res", "DOI": "10.1111/j.1365-2869.2006.00523.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0962-1105", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 16911025", "tags": [ { "tag": "Adult", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Breast Neoplasms", "type": 1 }, { "tag": "Case-Control Studies", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Odds Ratio", "type": 1 }, { "tag": "Risk Factors", "type": 1 }, { "tag": "Sleep", "type": 1 }, { "tag": "Time Factors", "type": 1 }, { "tag": "United States", "type": 1 } ], "collections": [ "Z9FTKJQJ" ], "relations": {}, "dateAdded": "2013-02-21T16:55:17Z", "dateModified": "2013-02-21T16:55:17Z" } }, { "key": "HQGGIN5S", "version": 11, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/HQGGIN5S", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/HQGGIN5S", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/149606/items/QPMQHFNM", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } } }, "data": { "key": "HQGGIN5S", "version": 11, "parentItem": "QPMQHFNM", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-02-21T16:55:17Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16911025", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-21T16:55:17Z", "dateModified": "2013-02-21T16:55:17Z" } }, { "key": "WWVE39NG", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/WWVE39NG", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/WWVE39NG", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } }, "creatorSummary": "Pandi-Perumal et al.", "parsedDate": "2006-07", "numChildren": 1 }, "data": { "key": "WWVE39NG", "version": 23, "itemType": "journalArticle", "title": "Melatonin: Nature's most versatile biological signal?", "creators": [ { "creatorType": "author", "firstName": "S R", "lastName": "Pandi-Perumal" }, { "creatorType": "author", "firstName": "V", "lastName": "Srinivasan" }, { "creatorType": "author", "firstName": "G J M", "lastName": "Maestroni" }, { "creatorType": "author", "firstName": "D P", "lastName": "Cardinali" }, { "creatorType": "author", "firstName": "B", "lastName": "Poeggeler" }, { "creatorType": "author", "firstName": "R", "lastName": "Hardeland" } ], "abstractNote": "Melatonin is a ubiquitous molecule and widely distributed in nature, with functional activity occurring in unicellular organisms, plants, fungi and animals. In most vertebrates, including humans, melatonin is synthesized primarily in the pineal gland and is regulated by the environmental light/dark cycle via the suprachiasmatic nucleus. Pinealocytes function as 'neuroendocrine transducers' to secrete melatonin during the dark phase of the light/dark cycle and, consequently, melatonin is often called the 'hormone of darkness'. Melatonin is principally secreted at night and is centrally involved in sleep regulation, as well as in a number of other cyclical bodily activities. Melatonin is exclusively involved in signaling the 'time of day' and 'time of year' (hence considered to help both clock and calendar functions) to all tissues and is thus considered to be the body's chronological pacemaker or 'Zeitgeber'. Synthesis of melatonin also occurs in other areas of the body, including the retina, the gastrointestinal tract, skin, bone marrow and in lymphocytes, from which it may influence other physiological functions through paracrine signaling. Melatonin has also been extracted from the seeds and leaves of a number of plants and its concentration in some of this material is several orders of magnitude higher than its night-time plasma value in humans. Melatonin participates in diverse physiological functions. In addition to its timekeeping functions, melatonin is an effective antioxidant which scavenges free radicals and up-regulates several antioxidant enzymes. It also has a strong antiapoptotic signaling function, an effect which it exerts even during ischemia. Melatonin's cytoprotective properties have practical implications in the treatment of neurodegenerative diseases. Melatonin also has immune-enhancing and oncostatic properties. Its 'chronobiotic' properties have been shown to have value in treating various circadian rhythm sleep disorders, such as jet lag or shift-work sleep disorder. Melatonin acting as an 'internal sleep facilitator' promotes sleep, and melatonin's sleep-facilitating properties have been found to be useful for treating insomnia symptoms in elderly and depressive patients. A recently introduced melatonin analog, agomelatine, is also efficient for the treatment of major depressive disorder and bipolar affective disorder. Melatonin's role as a 'photoperiodic molecule' in seasonal reproduction has been established in photoperiodic species, although its regulatory influence in humans remains under investigation. Taken together, this evidence implicates melatonin in a broad range of effects with a significant regulatory influence over many of the body's physiological functions.", "publicationTitle": "The FEBS journal", "publisher": "", "place": "", "date": "Jul 2006", "volume": "273", "issue": "13", "section": "", "partNumber": "", "partTitle": "", "pages": "2813-2838", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "FEBS J.", "DOI": "10.1111/j.1742-4658.2006.05322.x", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1742-464X", "archive": "", "archiveLocation": "", "shortTitle": "Melatonin", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 16817850", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Antioxidants", "type": 1 }, { "tag": "Apoptosis", "type": 1 }, { "tag": "Chronobiology Phenomena", "type": 1 }, { "tag": "Depression", "type": 1 }, { "tag": "Free Radical Scavengers", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Melatonin", "type": 1 }, { "tag": "Models, Chemical", "type": 1 }, { "tag": "Plant Proteins", "type": 1 }, { "tag": "Receptors, Melatonin", "type": 1 }, { "tag": "Signal Transduction", "type": 1 }, { "tag": "Sleep", "type": 1 } ], "collections": [ "Z9FTKJQJ" ], "relations": {}, "dateAdded": "2013-02-21T16:33:30Z", "dateModified": "2013-02-21T16:33:30Z" } }, { "key": "57NKVE43", "version": 10, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/57NKVE43", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/57NKVE43", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/149606/items/WWVE39NG", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } } }, "data": { "key": "57NKVE43", "version": 10, "parentItem": "WWVE39NG", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-02-21T16:33:30Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16817850", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-21T16:33:30Z", "dateModified": "2013-02-21T16:33:30Z" } }, { "key": "V8ZSCQEQ", "version": 23, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/V8ZSCQEQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/V8ZSCQEQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } }, "creatorSummary": "Cos and Sánchez-Barceló", "parsedDate": "2000-04", "numChildren": 1 }, "data": { "key": "V8ZSCQEQ", "version": 23, "itemType": "journalArticle", "title": "Melatonin and mammary pathological growth", "creators": [ { "creatorType": "author", "firstName": "S", "lastName": "Cos" }, { "creatorType": "author", "firstName": "E J", "lastName": "Sánchez-Barceló" } ], "abstractNote": "In this article we review the state of the art on the role of the pineal gland and melatonin in mammary cancer tumorigenesis in vivo as well as in vitro. The former hypothesis of a possible role of the pineal gland in mammary cancer development was based on the evidence that the pineal, via its main secretory product, melatonin, downregulates some of the pituitary and gonadal hormones which control mammary gland development and are also responsible for the growth of hormone-dependent mammary tumors. Furthermore, melatonin could act directly on tumoral cells, thereby influencing their proliferative rate. Other possible origins of melatonin's antitumoral actions could be found in its antioxidant or immunoenhancing properties. The working hypotheses of most experiments were that the activation of the pineal gland, or the administration of melatonin, should give rise to antitumoral behavior; conversely, suppression of the pineal gland or melatonin deficits should stimulate mammary tumorigenesis. From in vivo studies on animal models of tumorigenesis, the general conclusion is that experimental manipulations activating the pineal gland, or the administration of melatonin, enlarge the latency and reduce the incidence and growth rate of chemically induced mammary tumors, while pinealectomy usually has the opposite effects. The direct actions of melatonin on mammary tumors have been suggested because of its ability to inhibit, at physiological doses (1 nM), the in vitro proliferation and invasiveness of MCF-7 human breast cancer cells. The fact that most studies have been performed on two models, chemically induced mammary adenocarcinoma in rats (in vivo studies) and the cell tumor line MCF-7 (in vitro studies), makes the generalization of the results somewhat difficult. However, the characteristics of these actions, comprising different aspects of tumor biology such as initiation, proliferation, and metastasis, as well as the doses (physiological range) at which the effect is accomplished, give special value to these findings. On the strength of these data, the small number of clinical studies focusing on the possible therapeutic value of melatonin on breast cancer is surprising.", "publicationTitle": "Frontiers in neuroendocrinology", "publisher": "", "place": "", "date": "Apr 2000", "volume": "21", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "133-170", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Front Neuroendocrinol", "DOI": "10.1006/frne.1999.0194", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0091-3022", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 10764528", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Breast Neoplasms", "type": 1 }, { "tag": "Cell Division", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Mammary Neoplasms, Experimental", "type": 1 }, { "tag": "Melatonin", "type": 1 }, { "tag": "Pineal Gland", "type": 1 }, { "tag": "Tumor Cells, Cultured", "type": 1 } ], "collections": [ "Z9FTKJQJ" ], "relations": {}, "dateAdded": "2013-02-21T16:32:29Z", "dateModified": "2013-02-21T16:32:29Z" } }, { "key": "W9CAI8WF", "version": 9, "library": { "type": "group", "id": 149606, "name": "Var DDM", "links": { "alternate": { "href": "https://www.zotero.org/groups/var_ddm", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/149606/items/W9CAI8WF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/var_ddm/items/W9CAI8WF", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/149606/items/V8ZSCQEQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 1147800, "username": "apedfle", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/apedfle", "type": "text/html" } } } }, "data": { "key": "W9CAI8WF", "version": 9, "parentItem": "V8ZSCQEQ", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-02-21T16:32:29Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/10764528", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-21T16:32:29Z", "dateModified": "2013-02-21T16:32:29Z" } } ]