[ { "key": "EG2C3XNW", "version": 10, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/EG2C3XNW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/EG2C3XNW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/GDR7HR8R", "type": "application/json" } }, "meta": { "createdByUser": { "id": 900798, "username": "Mahum inam", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mahum_inam", "type": "text/html" } } } }, "data": { "key": "EG2C3XNW", "version": 10, "parentItem": "GDR7HR8R", "itemType": "attachment", "linkMode": "linked_url", "title": "18420", "accessDate": "2013-04-07T19:42:28Z", "url": "http://www.jci.org/articles/view/18420", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-07T19:42:28Z", "dateModified": "2013-04-07T19:42:28Z" } }, { "key": "GDR7HR8R", "version": 10, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/GDR7HR8R", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/GDR7HR8R", "type": "text/html" } }, "meta": { "createdByUser": { "id": 900798, "username": "Mahum inam", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mahum_inam", "type": "text/html" } } }, "creatorSummary": "Ozawa et al.", "parsedDate": "2004-02-15", "numChildren": 1 }, "data": { "key": "GDR7HR8R", "version": 10, "itemType": "journalArticle", "title": "Microenvironmental VEGF concentration, not total dose, determines a threshold between normal and aberrant angiogenesis", "creators": [ { "creatorType": "author", "firstName": "Clare R.", "lastName": "Ozawa" }, { "creatorType": "author", "firstName": "Andrea", "lastName": "Banfi" }, { "creatorType": "author", "firstName": "Nicole L.", "lastName": "Glazer" }, { "creatorType": "author", "firstName": "Gavin", "lastName": "Thurston" }, { "creatorType": "author", "firstName": "Matthew L.", "lastName": "Springer" }, { "creatorType": "author", "firstName": "Peggy E.", "lastName": "Kraft" }, { "creatorType": "author", "firstName": "Donald M.", "lastName": "McDonald" }, { "creatorType": "author", "firstName": "Helen M.", "lastName": "Blau" } ], "abstractNote": "", "publicationTitle": "Journal of Clinical Investigation", "publisher": "", "place": "", "date": "2004-2-15", "volume": "113", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "516-527", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1172/JCI18420", "citationKey": "", "url": "http://www.jci.org/articles/view/18420", "accessDate": "2013-04-07T19:42:28Z", "PMID": "", "PMCID": "", "ISSN": "0021-9738", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CrossRef", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "R6325GPN" ], "relations": {}, "dateAdded": "2013-04-07T19:42:28Z", "dateModified": "2013-04-07T19:42:28Z" } }, { "key": "RJKTUJWX", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/RJKTUJWX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/RJKTUJWX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/SZEWVJ2Z", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "RJKTUJWX", "version": 9, "parentItem": "SZEWVJ2Z", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-04-02T05:13:04Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527462/pdf/nihms62261.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-02T05:13:04Z", "dateModified": "2013-04-02T05:13:04Z" } }, { "key": "6S2ZPSSW", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/6S2ZPSSW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/6S2ZPSSW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/SZEWVJ2Z", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "6S2ZPSSW", "version": 9, "parentItem": "SZEWVJ2Z", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-04-02T05:13:04Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527462/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-02T05:13:04Z", "dateModified": "2013-04-02T05:13:04Z" } }, { "key": "SZEWVJ2Z", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/SZEWVJ2Z", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/SZEWVJ2Z", "type": "text/html" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } }, "creatorSummary": "DeChancie and Houk", "parsedDate": "2007-05-02", "numChildren": 2 }, "data": { "key": "SZEWVJ2Z", "version": 9, "itemType": "journalArticle", "title": "The Origins of Femtomolar Protein-Ligand Binding: Hydrogen Bond Cooperativity and Desolvation Energetics in the Biotin-(Strept)Avidin Binding Site", "creators": [ { "creatorType": "author", "firstName": "Jason", "lastName": "DeChancie" }, { "creatorType": "author", "firstName": "K.N.", "lastName": "Houk" } ], "abstractNote": "The unusually strong reversible binding of biotin by avidin and streptavidin has been investigated by density functional and MP2 ab initio quantum mechanical methods. The solvation of biotin by water has also been studied through QM/MM/MC calculations. The ureido moiety of biotin in the bound state hydrogen bonds to five residues, three to the carbonyl oxygen and one for each –NH group. These five hydrogen bonds act cooperatively, leading to stabilization that is larger than the sum of individual hydrogen-bonding energies. The charged aspartate is the key residue that provides the driving force for cooperativity in the hydrogen-bonding network for both avidin and streptavidin by greatly polarizing the urea of biotin. If the residue is removed, the network is disrupted, and the attenuation of the energetic contributions from the neighboring residues results in significant reduction of cooperative interactions. Aspartate is directly hydrogen-bonded with biotin in streptavidin and is one residue removed in avidin. The hydrogen-bonding groups in streptavidin are computed to give larger cooperative hydrogen-bonding effects than avidin. However, the net gain in electrostatic binding energy is predicted to favor the avidin-bicyclic urea complex due to the relatively large penalty for desolvation of the streptavidin binding site (specifically expulsion of bound water molecules). QM/MM/MC calculations involving biotin and the ureido moiety in aqueous solution, featuring PDDG/PM3, show that water interactions with the bicyclic urea are much weaker than (strept)avidin interactions due to relatively low polarization of the urea group in water.", "publicationTitle": "Journal of the American Chemical Society", "publisher": "", "place": "", "date": "2007-5-2", "volume": "129", "issue": "17", "section": "", "partNumber": "", "partTitle": "", "pages": "5419-5429", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Am Chem Soc", "DOI": "10.1021/ja066950n", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2527462/", "accessDate": "2013-04-02T05:13:04Z", "PMID": "", "PMCID": "", "ISSN": "0002-7863", "archive": "", "archiveLocation": "", "shortTitle": "The Origins of Femtomolar Protein-Ligand Binding", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 17417839\nPMCID: PMC2527462", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-04-02T05:13:04Z", "dateModified": "2013-04-02T05:13:04Z" } }, { "key": "XIPSDT8T", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/XIPSDT8T", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/XIPSDT8T", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/IEIXS5NS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "XIPSDT8T", "version": 9, "parentItem": "IEIXS5NS", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Full Text PDF", "accessDate": "2013-04-02T05:12:58Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576293/pdf/nihms8686.pdf", "note": "", "contentType": "application/pdf", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-02T05:12:58Z", "dateModified": "2013-04-02T05:12:58Z" } }, { "key": "RJQQRBQH", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/RJQQRBQH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/RJQQRBQH", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/IEIXS5NS", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "RJQQRBQH", "version": 9, "parentItem": "IEIXS5NS", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Central Link", "accessDate": "2013-04-02T05:12:58Z", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576293/", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-04-02T05:12:58Z", "dateModified": "2013-04-02T05:12:58Z" } }, { "key": "IEIXS5NS", "version": 9, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/IEIXS5NS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/IEIXS5NS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } }, "creatorSummary": "Howarth et al.", "parsedDate": "2006-04", "numChildren": 2 }, "data": { "key": "IEIXS5NS", "version": 9, "itemType": "journalArticle", "title": "A monovalent streptavidin with a single femtomolar biotin binding site", "creators": [ { "creatorType": "author", "firstName": "Mark", "lastName": "Howarth" }, { "creatorType": "author", "firstName": "Daniel J-F", "lastName": "Chinnapen" }, { "creatorType": "author", "firstName": "Kimberly", "lastName": "Gerrow" }, { "creatorType": "author", "firstName": "Pieter C", "lastName": "Dorrestein" }, { "creatorType": "author", "firstName": "Melanie R", "lastName": "Grandy" }, { "creatorType": "author", "firstName": "Neil L", "lastName": "Kelleher" }, { "creatorType": "author", "firstName": "Alaa", "lastName": "El-Husseini" }, { "creatorType": "author", "firstName": "Alice Y", "lastName": "Ting" } ], "abstractNote": "Streptavidin and avidin are used ubiquitously because of the remarkable affinity of their biotin binding, but they are tetramers, which disrupts many of their applications. Making either protein monomeric reduces affinity by at least 104-fold because part of the binding site comes from a neighboring subunit. Here we engineered a streptavidin tetramer with only one functional biotin binding subunit that retained the affinity, off rate and thermostability of wild-type streptavidin. In denaturant, we mixed a streptavidin variant containing three mutations that block biotin binding with wild-type streptavidin in a 3:1 ratio. Then we generated monovalent streptavidin by refolding and nickel-affinity purification. Similarly, we purified defined tetramers with two or three biotin binding subunits. Labeling of site-specifically biotinylated neuroligin-1 with monovalent streptavidin allowed stable neuroligin-1 tracking without cross-linking, whereas wild-type streptavidin aggregated neuroligin-1 and disrupted presynaptic contacts. Monovalent streptavidin should find general application in biomolecule labeling, single-particle tracking and nanotechnology.", "publicationTitle": "Nature methods", "publisher": "", "place": "", "date": "2006-4", "volume": "3", "issue": "4", "section": "", "partNumber": "", "partTitle": "", "pages": "267-273", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Methods", "DOI": "10.1038/NMETHXXX", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2576293/", "accessDate": "2013-04-02T05:12:58Z", "PMID": "", "PMCID": "", "ISSN": "1548-7091", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "PubMed Central", "callNumber": "", "rights": "", "extra": "PMID: 16554831\nPMCID: PMC2576293", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-04-02T05:12:58Z", "dateModified": "2013-04-02T05:12:58Z" } }, { "key": "MW7GGHPX", "version": 8, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/MW7GGHPX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/MW7GGHPX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/4NTBZZZV", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "MW7GGHPX", "version": 8, "parentItem": "4NTBZZZV", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-03-22T20:48:21Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23492964", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-03-22T20:48:21Z", "dateModified": "2013-03-22T20:48:21Z" } }, { "key": "4NTBZZZV", "version": 8, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/4NTBZZZV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/4NTBZZZV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } }, "creatorSummary": "Uemura et al.", "parsedDate": "2013-03-14", "numChildren": 1 }, "data": { "key": "4NTBZZZV", "version": 8, "itemType": "journalArticle", "title": "A Minimally Invasive Monitoring System of Cardiac Output Using Aortic Flow Velocity and Peripheral Arterial Pressure Profile", "creators": [ { "creatorType": "author", "firstName": "Kazunori", "lastName": "Uemura" }, { "creatorType": "author", "firstName": "Toru", "lastName": "Kawada" }, { "creatorType": "author", "firstName": "Masashi", "lastName": "Inagaki" }, { "creatorType": "author", "firstName": "Masaru", "lastName": "Sugimachi" } ], "abstractNote": "BACKGROUND:In managing patients with unstable hemodynamics, monitoring cardiac output (CO) can provide critical diagnostic data. However, conventional CO measurements are invasive, intermittent, and/or inaccurate. The purpose of this study was to validate our newly developed CO monitoring system.METHODS:This system automatically determines peak velocity of the ascending aortic flow using continuous-wave Doppler transthoracic echocardiography and estimates cardiac ejection time and aortic cross-sectional area using the pulse contour of the radial arterial pressure. These parameters are continuously processed to estimate CO (COest). In 10 anesthetized closed-chest dogs instrumented with an aortic flowprobe to measure reference CO (COref), hemodynamic conditions were varied over wide ranges by infusing cardiovascular drugs or by random atrial pacing. Under each condition, COref and COest were determined. Absolute changes of COref (ΔCOref) and COest (ΔCOest), and relative changes of COref (%ΔCOref) and COest (%ΔCOest) from the corresponding baseline values were determined in each animal. We calibrated COest against COref to obtain proportionally scaled COest (COest(N)).RESULTS:A total of 1335 datasets of COref and COest were obtained, in which COref ranged from 0.17 to 5.34 L/min. Bland-Altman analysis between COref and COest indicated that the limits of agreement (the bias ± 1.96 × SD of the difference) and the percentage error (1.96 × [SD of the difference]/[mean CO] × 100) were from -1.01 to 1.13 L/min (95% confidence interval, -1.76 to 1.88 L/min) and 43%, respectively. The agreement between COref and COest(N) was improved, with limits of agreement from -0.53 to 0.49 L/min (95% confidence interval, -0.62 to 0.59 L/min) and the percentage error of 20%. Polar plot analysis between ΔCOref and ΔCOest indicated that mean ± 1.96 × SD of polar angle was -2° ± 22°. Four quadrant plot analysis indicated that %ΔCOest correlated tightly with %ΔCOref (R(2) = 0.93). The %ΔCOest and %ΔCOref changed in the same direction in 95% of the datasets. Reliability of this system was well preserved under conditions of random atrial pacing and also in a continuous manner.CONCLUSION:Over a wide range of hemodynamic conditions, irrespective of cardiac beat irregularity, this system may allow minimally invasive monitoring of CO with a good trending ability. The present results warrant further research and development of this system for future clinical application.", "publicationTitle": "Anesthesia and analgesia", "publisher": "", "place": "", "date": "Mar 14, 2013", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Anesth. Analg.", "DOI": "10.1213/ANE.0b013e31828a75bd", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1526-7598", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23492964", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-03-22T20:48:21Z", "dateModified": "2013-03-22T20:48:21Z" } }, { "key": "PKEBQIR3", "version": 7, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/PKEBQIR3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/PKEBQIR3", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/U58TPUX2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } } }, "data": { "key": "PKEBQIR3", "version": 7, "parentItem": "U58TPUX2", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed Link", "accessDate": "2013-03-22T20:47:17Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23498050", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-03-22T20:47:17Z", "dateModified": "2013-03-22T20:47:17Z" } }, { "key": "U58TPUX2", "version": 7, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/U58TPUX2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/U58TPUX2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 899645, "username": "ningyu", "name": "Max Yang", "links": { "alternate": { "href": "https://www.zotero.org/ningyu", "type": "text/html" } } }, "creatorSummary": "Shih", "parsedDate": "2013-04", "numChildren": 1 }, "data": { "key": "U58TPUX2", "version": 7, "itemType": "journalArticle", "title": "Cardiac output monitoring in horses", "creators": [ { "creatorType": "author", "firstName": "Andre", "lastName": "Shih" } ], "abstractNote": "Cardiac output (CO) is the volume of blood pumped out by the heart in 1 minute. Monitoring of CO can guide therapy and improve clinical outcome in critically ill patients and during anesthesia. Although there is increasing research into clinically useful methods of monitoring CO in equine patients, there are limitations to the available methods. There are 4 basic methods of measuring CO: (1) indicator methods, (2) a derivation of the Fick principle, (3) arterial pulse wave analysis, and (4) imaging diagnostic techniques. This article discusses the importance of CO, available technology, and challenges of monitoring CO in equine medicine.", "publicationTitle": "The Veterinary clinics of North America. Equine practice", "publisher": "", "place": "", "date": "Apr 2013", "volume": "29", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "155-167", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Vet. Clin. North Am. 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Output Monitors", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23511279", "tags": [], "collections": [], "relations": {}, "dateAdded": "2013-03-22T20:46:50Z", "dateModified": "2013-03-22T20:46:50Z" } }, { "key": "KU9Z3X49", "version": 1, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/KU9Z3X49", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/KU9Z3X49", "type": "text/html" } }, "meta": { "createdByUser": { "id": 901024, "username": "mpc2wv", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mpc2wv", "type": "text/html" } } }, "creatorSummary": "Battler et al.", "parsedDate": "1979-11-01", "numChildren": 0 }, "data": { "key": "KU9Z3X49", "version": 1, "itemType": "journalArticle", "title": "Relationship of QRS amplitude changes during exercise to left ventricular function and volumes and the diagnosis of coronary artery disease.", "creators": [ { "creatorType": "author", "firstName": "A.", "lastName": "Battler" }, { "creatorType": "author", "firstName": "V.", "lastName": "Froelicher" }, { "creatorType": "author", "firstName": "R.", "lastName": "Slutsky" }, { "creatorType": "author", "firstName": "W.", "lastName": "Ashburn" } ], "abstractNote": "", "publicationTitle": "Circulation", "publisher": "", "place": "", "date": "11/01/1979", "volume": "60", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "1004-1013", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Circulation", "DOI": "10.1161/01.CIR.60.5.1004", "citationKey": "", "url": "http://circ.ahajournals.org/content/60/5/1004", "accessDate": "2013-02-05T23:43:18Z", "PMID": "", "PMCID": "", "ISSN": "0009-7322, 1524-4539", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "circ.ahajournals.org", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "R6325GPN" ], "relations": {}, "dateAdded": "2013-02-05T23:44:27Z", "dateModified": "2013-02-05T23:44:27Z" } }, { "key": "AXJ3C8R3", "version": 1, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/AXJ3C8R3", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/AXJ3C8R3", "type": "text/html" } }, "meta": { "createdByUser": { "id": 900798, "username": "Mahum inam", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mahum_inam", "type": "text/html" } } }, "creatorSummary": "Webster", "parsedDate": "1977-05", "numChildren": 0 }, "data": { "key": "AXJ3C8R3", "version": 1, "itemType": "conferencePaper", "title": "Interference And Motion Artifact In Biopotentials", "creators": [ { "creatorType": "author", "firstName": "J.C.", "lastName": "Webster" } ], "abstractNote": "Not available", "proceedingsTitle": "Region Six Conference Record, 1977. IEEE 1977", "conferenceName": "Region Six Conference Record, 1977. IEEE 1977", "publisher": "", "place": "", "date": "May 1977", "eventPlace": "", "volume": "", "issue": "", "numberOfVolumes": "", "pages": "53 - 64", "series": "", "seriesNumber": "", "DOI": "10.1109/REG6.1977.721100", "ISBN": "", "citationKey": "", "url": "", "accessDate": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "IEEE Xplore", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Bioelectric phenomena", "type": 1 }, { "tag": "Biomembranes", "type": 1 }, { "tag": "Cells (biology)", "type": 1 }, { "tag": "Displays", "type": 1 }, { "tag": "Electric potential", "type": 1 }, { "tag": "Electrodes", "type": 1 }, { "tag": "Frequency response", "type": 1 }, { "tag": "Interference", "type": 1 }, { "tag": "Muscles", "type": 1 }, { "tag": "Skin", "type": 1 } ], "collections": [ "R6325GPN" ], "relations": {}, "dateAdded": "2013-02-02T20:45:32Z", "dateModified": "2013-02-02T20:45:32Z" } }, { "key": "CHIA6PP4", "version": 1, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/CHIA6PP4", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/CHIA6PP4", "type": "text/html" } }, "meta": { "createdByUser": { "id": 901024, "username": "mpc2wv", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mpc2wv", "type": "text/html" } } }, "creatorSummary": "Adams-Hamoda et al.", "parsedDate": "2003-01-01", "numChildren": 0 }, "data": { "key": "CHIA6PP4", "version": 1, "itemType": "journalArticle", "title": "Factors to Consider When Analyzing 12-Lead Electrocardiograms for Evidence of Acute Myocardial Ischemia", "creators": [ { "creatorType": "author", "firstName": "Mary G.", "lastName": "Adams-Hamoda" }, { "creatorType": "author", "firstName": "Mary A.", "lastName": "Caldwell" }, { "creatorType": "author", "firstName": "Nancy A.", "lastName": "Stotts" }, { "creatorType": "author", "firstName": "Barbara J.", "lastName": "Drew" } ], "abstractNote": "An important factor to consider when using findings on electrocardiograms for clinical decision making is that the waveforms are influenced by normal physiological and technical factors as well as by pathophysiological factors. Traditionally, the focus of bedside monitoring is detection of arrhythmia. However, continuous ST-segment monitoring for the detection of myocardial ischemia is now readily available. Many factors affect electrocardiographic waveforms and may interfere with diagnosis of myocardial ischemia based on electrocardiographic findings. Accordingly, a principal leadership role for clinical nurse specialists and nurse practitioners is to become knowledgeable about interpretation of 12-lead electrocardiograms and to share this knowledge with staff nurses who care for patients with acute coronary syndromes. The factors that alter electrocardiographic findings are reviewed, and the alterations that interfere with electrocardiogram-based diagnosis of myocardial ischemia are discussed.", "publicationTitle": "American Journal of Critical Care", "publisher": "", "place": "", "date": "01/01/2003", "volume": "12", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "9-16", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Am J Crit Care", "DOI": "", "citationKey": "", "url": "http://ajcc.aacnjournals.org/content/12/1/9", "accessDate": "2013-02-02T20:22:30Z", "PMID": "", "PMCID": "", "ISSN": "1062-3264, 1937-710X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "ajcc.aacnjournals.org", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "R6325GPN" ], "relations": {}, "dateAdded": "2013-02-02T20:22:53Z", "dateModified": "2013-02-02T20:22:53Z" } }, { "key": "NVZSGHAU", "version": 1, "library": { "type": "group", "id": 144012, "name": "IDEAS G10", "links": { "alternate": { "href": "https://www.zotero.org/groups/ideas_g10", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/144012/items/NVZSGHAU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/ideas_g10/items/NVZSGHAU", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/144012/items/NCSFRXA3", "type": "application/json" } }, "meta": { "createdByUser": { "id": 901024, "username": "mpc2wv", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mpc2wv", "type": "text/html" } } } }, "data": { "key": "NVZSGHAU", "version": 1, "parentItem": "NCSFRXA3", "itemType": "attachment", "linkMode": "linked_url", "title": "Google Books Link", "accessDate": "2013-02-01T21:49:06Z", "url": "http://books.google.com/books?id=rbSfWTrKwnAC", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2013-02-01T21:57:12Z", "dateModified": "2013-02-01T21:57:12Z" } } ]