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            "abstractNote": "For an increasing number of biologists, cancer is viewed as a dynamic system governed by evolutionary and ecological principles. Throughout most of human history, cancer was an uncommon cause of death and it is generally accepted that common components of modern culture, including increased physiological stresses and caloric intake, favor cancer development. However, the precise mechanisms for this linkage are not well understood. Here, we examine the roles of ecological and physiological disturbances and resource availability on the emergence of cancer in multicellular organisms. We argue that proliferation of ‘profiteering phenotypes’ is often an emergent property of disturbed, resource-rich environments at all scales of biological organization. We review the evidence for this phenomenon, explore it within the context of malignancy, and discuss how this ecological framework may offer a theoretical background for novel strategies of cancer prevention. This work provides a compelling argument that the traditional separation between medicine and evolutionary ecology remains a fundamental limitation that needs to be overcome if complex processes, such as oncogenesis, are to be completely understood.",
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            "abstractNote": "mRNA degradation represents a critical regulated step in gene expression. Although the major pathways in turnover have been identified, accounting for disparate half-lives has been elusive. We show that codon optimality is one feature that contributes greatly to mRNA stability. Genome-wide RNA decay analysis revealed that stable mRNAs are enriched in codons designated optimal, whereas unstable mRNAs contain predominately non-optimal codons. Substitution of optimal codons with synonymous, non-optimal codons results in dramatic mRNA destabilization, whereas the converse substitution significantly increases stability. Further, we demonstrate that codon optimality impacts ribosome translocation, connecting the processes of translation elongation and decay through codon optimality. Finally, we show that optimal codon content accounts for the similar stabilities observed in mRNAs encoding proteins with coordinated physiological function. This work demonstrates that codon optimization exists as a mechanism to finely tune levels of mRNAs and, ultimately, proteins.",
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            "abstractNote": "It is proposed that processes characteristic of biology today, autocatalysis, selection of molecules for linkage by their electrical shape, and evolution by survival selection were also the processes that initiated biology. A reconnaissance is made of both paradoxes and potential questions. It is argued that the minimal requirement for initiating Darwinian evolution is not a molecule copying process, but a linkage copying process. Survival selection evolution does not require a heterocatalytic polymer and a separate replicase process until there is uncertainty where molecular additions will occur. It is argued that a linkage directing process will be found for a lipid membrane (though this needs to be verified) and may in the right environment result in initial evolution, including initiation of α-helices, the development of a single chirality and NTPs. The system has at this point become sufficiently complex that higher precision copying is needed. However it seems likely that this state is able to generate the first miniature ribozymes and their replicases, and so satisfies the prior requirement. With the proposed requirements, it is likely that the development of polymers was within membranes.",
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            "title": "Questioning the cultural evolution of altruism",
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            "abstractNote": "The evolutionary foundations of helping among nonkin in humans have been the object of intense debates in the past decades. One thesis has had a prominent influence in this debate: the suggestion that genuine altruism, strictly defined as a form of help that comes at a net fitness cost for the benefactor, might have evolved owing to cultural transmission. The gene–culture coevolution literature is wont to claim that cultural evolution changes the selective pressures that normally act to limit the emergence of altruistic behaviours. This paper aims to recall, however, that cultural transmission yields altruism only to the extent that it relies on maladaptive mechanisms, such as conformist imitation and (in some cases) payoff-biased transmission. This point is sometimes obscured in the literature by a confusion between genuine altruism, maladaptive by definition, and mutualistic forms of cooperation, that benefit all parties in the long run. Theories of cultural altruism do not lift the selective pressures weighing on strictly altruistic actions; they merely shift the burden of maladaptation from social cognition to cultural transmission.",
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            "abstractNote": "The mind is a biological phenomenon. Thus, biological principles of organization should also be the principles underlying mental operations. Practopoiesis states that the key for achieving intelligence through adaptation is an arrangement in which mechanisms laying at a lower level of organization, by their operations and interaction with the environment, enable creation of mechanisms laying at a higher level of organization. When such an organizational advance of a system occurs, it is called a traverse. A case of traverse is when plasticity mechanisms (at a lower level of organization), by their operations, create a neural network anatomy (at a higher level of organization). Another case is the actual production of behavior by that network, whereby the mechanisms of neuronal activity operate to create motor actions. Practopoietic theory explains why the adaptability of a system increases with each increase in the number of traverses. With a larger number of traverses, a system can be relatively small and yet, produce a higher degree of adaptive/intelligent behavior than a system with a lower number of traverses. The present analyses indicate that the two well-known traverses – neural plasticity and neural activity – are not sufficient to explain human mental capabilities. At least one additional traverse is needed, which is named anapoiesis for its contribution in reconstructing knowledge e.g., from long-term memory into working memory. The conclusions bear implications for brain theory, the mind–body explanatory gap, and developments of artificial intelligence technologies.",
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                    "firstName": "C.",
                    "lastName": "El Mouden"
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            "abstractNote": "Transmitted culture can be viewed as an inheritance system somewhat independent of genes that is subject to processes of descent with modification in its own right. Although many authors have conceptualized cultural change as a Darwinian process, there is no generally agreed formal framework for defining key concepts such as natural selection, fitness, relatedness and altruism for the cultural case. Here, we present and explore such a framework using the Price equation. Assuming an isolated, independently measurable culturally transmitted trait, we show that cultural natural selection maximizes cultural fitness, a distinct quantity from genetic fitness, and also that cultural relatedness and cultural altruism are not reducible to or necessarily related to their genetic counterparts. We show that antagonistic coevolution will occur between genes and culture whenever cultural fitness is not perfectly aligned with genetic fitness, as genetic selection will shape psychological mechanisms to avoid susceptibility to cultural traits that bear a genetic fitness cost. We discuss the difficulties with conceptualizing cultural change using the framework of evolutionary theory, the degree to which cultural evolution is autonomous from genetic evolution, and the extent to which cultural change should be seen as a Darwinian process. We argue that the nonselection components of evolutionary change are much more important for culture than for genes, and that this and other important differences from the genetic case mean that different approaches and emphases are needed for cultural than genetic processes.",
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            "title": "The evolution of parental care in insects: A test of current hypotheses",
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            "abstractNote": "Which sex should care for offspring is a fundamental question in evolution. Invertebrates, and insects in particular, show some of the most diverse kinds of parental care of all animals, but to date there has been no broad comparative study of the evolution of parental care in this group. Here, we test existing hypotheses of insect parental care evolution using a literature-compiled phylogeny of over 2000 species. To address substantial uncertainty in the insect phylogeny, we use a brute force approach based on multiple random resolutions of uncertain nodes. The main transitions were between no care (the probable ancestral state) and female care. Male care evolved exclusively from no care, supporting models where mating opportunity costs for caring males are reduced—for example, by caring for multiple broods—but rejecting the “enhanced fecundity” hypothesis that male care is favored because it allows females to avoid care costs. Biparental care largely arose by males joining caring females, and was more labile in Holometabola than in Hemimetabola. Insect care evolution most closely resembled amphibian care in general trajectory. Integrating these findings with the wealth of life history and ecological data in insects will allow testing of a rich vein of existing hypotheses.",
            "publicationTitle": "Evolution",
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            "creatorSummary": "Wolf et al.",
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            "version": 142,
            "itemType": "journalArticle",
            "title": "Fitness Trade-offs Result in the Illusion of Social Success",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Jason B.",
                    "lastName": "Wolf"
                },
                {
                    "creatorType": "author",
                    "firstName": "Jennifer A.",
                    "lastName": "Howie"
                },
                {
                    "creatorType": "author",
                    "firstName": "Katie",
                    "lastName": "Parkinson"
                },
                {
                    "creatorType": "author",
                    "firstName": "Nicole",
                    "lastName": "Gruenheit"
                },
                {
                    "creatorType": "author",
                    "firstName": "Diogo",
                    "lastName": "Melo"
                },
                {
                    "creatorType": "author",
                    "firstName": "Daniel",
                    "lastName": "Rozen"
                },
                {
                    "creatorType": "author",
                    "firstName": "Christopher R. L.",
                    "lastName": "Thompson"
                }
            ],
            "abstractNote": "Summary\nCooperation is ubiquitous across the tree of life, from simple microbes to the complex social systems of animals [1]. Individuals cooperate by engaging in costly behaviors that can be exploited by other individuals who benefit by avoiding these associated costs. Thus, if successful exploitation of social partners during cooperative interactions increases relative fitness, then we expect selection to lead to the emergence of a single optimal winning strategy in which individuals maximize their gain from cooperation while minimizing their associated costs [2]. Such social “cheating” appears to be widespread in nature [3], including in several microbial systems [4–11], but despite the fitness advantages favoring social cheating, populations tend to harbor significant variation in social success rather than a single optimal winning strategy. Using the social amoeba Dictyostelium discoideum, we provide a possible explanation for the coexistence of such variation. We find that genotypes typically designated as “cheaters” [12] because they produce a disproportionate number of spores in chimeric fruiting bodies do not actually gain higher fitness as a result of this apparent advantage because they produce smaller, less viable spores than putative “losers.” As a consequence of this trade-off between spore number and viability, genotypes with different spore production strategies, which give the appearance of differential social success, ultimately have similar realized fitness. These findings highlight the limitations of using single fitness proxies in evolutionary studies and suggest that interpreting social trait variation in terms of strategies like cheating or cooperating may be misleading unless these behaviors are considered in the context of the true multidimensional nature of fitness.",
            "publicationTitle": "Current Biology",
            "publisher": "",
            "place": "",
            "date": "April 20, 2015",
            "volume": "25",
            "issue": "8",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "1086-1090",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Current Biology",
            "DOI": "10.1016/j.cub.2015.02.061",
            "citationKey": "",
            "url": "http://www.sciencedirect.com/science/article/pii/S0960982215002638",
            "accessDate": "2015-05-12T07:15:52Z",
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            "PMCID": "",
            "ISSN": "0960-9822",
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            "language": "",
            "libraryCatalog": "ScienceDirect",
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            "dateModified": "2015-05-12T07:15:52Z"
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    {
        "key": "MCNAADM3",
        "version": 139,
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            },
            "creatorSummary": "Levin et al.",
            "parsedDate": "2015-04-01",
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        },
        "data": {
            "key": "MCNAADM3",
            "version": 139,
            "itemType": "journalArticle",
            "title": "Concurrent coevolution of intra-organismal cheaters and resisters",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "S. R.",
                    "lastName": "Levin"
                },
                {
                    "creatorType": "author",
                    "firstName": "D. A.",
                    "lastName": "Brock"
                },
                {
                    "creatorType": "author",
                    "firstName": "D. C.",
                    "lastName": "Queller"
                },
                {
                    "creatorType": "author",
                    "firstName": "J. E.",
                    "lastName": "Strassmann"
                }
            ],
            "abstractNote": "The evolution of multicellularity is a major transition that is not yet fully understood. Specifically, we do not know whether there are any mechanisms by which multicellularity can be maintained without a single-cell bottleneck or other relatedness-enhancing mechanisms. Under low relatedness, cheaters can evolve that benefit from the altruistic behaviour of others without themselves sacrificing. If these are obligate cheaters, incapable of cooperating, their spread can lead to the demise of multicellularity. One possibility, however, is that cooperators can evolve resistance to cheaters. We tested this idea in a facultatively multicellular social amoeba, Dictyostelium discoideum. This amoeba usually exists as a single cell but, when stressed, thousands of cells aggregate to form a multicellular organism in which some of the cells sacrifice for the good of others. We used lineages that had undergone experimental evolution at very low relatedness, during which time obligate cheaters evolved. Unlike earlier experiments, which found resistance to cheaters that were prevented from evolving, we competed cheaters and noncheaters that evolved together, and cheaters with their ancestors. We found that noncheaters can evolve resistance to cheating before cheating sweeps through the population and multicellularity is lost. Our results provide insight into cheater–resister coevolutionary dynamics, in turn providing experimental evidence for the maintenance of at least a simple form of multicellularity by means other than high relatedness.",
            "publicationTitle": "Journal of Evolutionary Biology",
            "publisher": "",
            "place": "",
            "date": "April 1, 2015",
            "volume": "28",
            "issue": "4",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "756-765",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J. Evol. Biol.",
            "DOI": "10.1111/jeb.12618",
            "citationKey": "",
            "url": "http://onlinelibrary.wiley.com/doi/10.1111/jeb.12618/abstract",
            "accessDate": "2015-05-09T08:44:35Z",
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            "PMCID": "",
            "ISSN": "1420-9101",
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            "shortTitle": "",
            "language": "en",
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            "callNumber": "",
            "rights": "© 2015 European Society For Evolutionary Biology. Journal of Evolutionary Biology © 2015 European Society For Evolutionary Biology",
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            "dateAdded": "2015-05-09T08:44:35Z",
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    {
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            "creatorSummary": "Gardner",
            "parsedDate": "2015-02-01",
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            "version": 137,
            "itemType": "journalArticle",
            "title": "The genetical theory of multilevel selection",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "A.",
                    "lastName": "Gardner"
                }
            ],
            "abstractNote": "The theory of multilevel selection (MLS) is beset with conceptual difficulties. Although it is widely agreed that covariance between group trait and group fitness may arise in the natural world and drive a response to ‘group selection’, ambiguity exists over the precise meaning of group trait and group fitness and as to whether group selection should be defined according to changes in frequencies of different types of individual or different types of group. Moreover, the theory of MLS has failed to properly engage with the problem of class structure, which greatly limits its empirical application to, for example, social insects whose colonies are structured into separate age, sex, caste and ploidy classes. Here, I develop a genetical theory of MLS, to address these problems. I show that taking a genetical approach facilitates a decomposition of group-level traits – including reproductive success – into the separate contributions made by each constituent individual, even in the context of so-called emergence. However, I uncover a novel problem with the group-oriented approach: in many scenarios, it may not be possible to express a meaningful covariance between trait and fitness at the level of the social group, because the group's constituents belong to separate, irreconcilable classes.",
            "publicationTitle": "Journal of Evolutionary Biology",
            "publisher": "",
            "place": "",
            "date": "February 1, 2015",
            "volume": "28",
            "issue": "2",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "305-319",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "J. Evol. Biol.",
            "DOI": "10.1111/jeb.12566",
            "citationKey": "",
            "url": "http://onlinelibrary.wiley.com/doi/10.1111/jeb.12566/abstract",
            "accessDate": "2015-04-10T15:09:26Z",
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            "PMCID": "",
            "ISSN": "1420-9101",
            "archive": "",
            "archiveLocation": "",
            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "Wiley Online Library",
            "callNumber": "",
            "rights": "© 2014 The Author. Journal of Evolutionary Biology published by John Wiley & Sons Ltd on behalf of European Society for Evolutionary Biology., This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.",
            "extra": "",
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            "creatorSummary": "Melnyk et al.",
            "parsedDate": "2015",
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            "version": 136,
            "itemType": "journalArticle",
            "title": "The fitness costs of antibiotic resistance mutations",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Anita H.",
                    "lastName": "Melnyk"
                },
                {
                    "creatorType": "author",
                    "firstName": "Alex",
                    "lastName": "Wong"
                },
                {
                    "creatorType": "author",
                    "firstName": "Rees",
                    "lastName": "Kassen"
                }
            ],
            "abstractNote": "Antibiotic resistance is increasing in pathogenic microbial populations and is thus a major threat to public health. The fate of a resistance mutation in pathogen populations is determined in part by its fitness. Mutations that suffer little or no fitness cost are more likely to persist in the absence of antibiotic treatment. In this review, we performed a meta-analysis to investigate the fitness costs associated with single mutational events that confer resistance. Generally, these mutations were costly, although several drug classes and species of bacteria on average did not show a cost. Further investigations into the rate and fitness values of compensatory mutations that alleviate the costs of resistance will help us to better understand both the emergence and management of antibiotic resistance in clinical settings.",
            "publicationTitle": "Evolutionary Applications",
            "publisher": "",
            "place": "",
            "date": "2015",
            "volume": "8",
            "issue": "3",
            "section": "",
            "partNumber": "",
            "partTitle": "",
            "pages": "273-283",
            "series": "",
            "seriesTitle": "",
            "seriesText": "",
            "journalAbbreviation": "Evol Appl",
            "DOI": "10.1111/eva.12196",
            "citationKey": "",
            "url": "http://onlinelibrary.wiley.com/doi/10.1111/eva.12196/abstract",
            "accessDate": "2015-04-01T15:32:39Z",
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            "PMCID": "",
            "ISSN": "1752-4571",
            "archive": "",
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            "shortTitle": "",
            "language": "en",
            "libraryCatalog": "Wiley Online Library",
            "callNumber": "",
            "rights": "© 2014 The Authors. Evolutionary Applications published by John Wiley & Sons Ltd., This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.",
            "extra": "",
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]