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            "abstractNote": "D. Grahek [1], F. Montravers [1], C. Mayaud [2], J.-F. Regnard [3], K. Kerrou [1], N. Younsi [1], J.-N. Talbot [1]\n[1]  Service de Médecine Nucléaire, Hôpital Tenon (AP-HP), 4 rue de la Chine, 75020 Paris.\n[2]  Service de Pneumologie, Hôpital Tenon (AP-HP), 4 rue de la Chine, 75020 Paris.\n[3]  Service de Chirurgie thoracique, Hôtel Dieu (AP-HP).\n\nTirés à part : D. Grahek [1]\n\t\nRésumé\n\nL'examen au [18F]-FDG, pratiqué grâce à une machine dédiée TEP ou « hybride » TEDC a vu son utilité clinique reconnue en France, en novembre 1998, dans trois circonstances cliniques majeures du cancer bronchique non à petites cellules : le diagnostic différentiel, la stadification et la recherche de récidives. Après un bref rappel de la technique scintigraphique TEP, les auteurs font la synthèse des résultats publiés pour ces indications et rapportent l'expérience de l'équipe de médecine nucléaire de l'hôpital Tenon. En ce qui concerne le diagnostic différentiel, c'est-à-dire la caractérisation d'un nodule solitaire en tant que cancer, une méta-analyse récente retrouve une sensibilité de 96 %, une spécificité de 73 %, une VPP de 91 % et une VPN de 90 %, les résultats étant meilleurs pour les lésions de plus de 10 mm. Pour la stadification, on constate, en TEDC comme en TEP, une amélioration de plus de 15 % à la fois de la sensibilité et de la spécificité en TEP par rapport à la TDM pour la détermination du stade N et une bien meilleure détection des métastases à distance. L'amélioration est comparable dans notre expérience voire supérieure pour certains auteurs dans la détection des récidives. Une meilleure localisation anatomique des lésions détectées par le FDG est possible grâce à la fusion des images TEP et TDM qui devrait se développer en routine. Enfin, l'examen au FDG aboutit à une modification de l'attitude thérapeutique et de la prise en charge du patient dans 37 % des cas selon la même méta-analyse contre 53 % dans notre étude rétrospective réalisée dès la première année d'installation d'une machine TEP dédiée. Ce taux était similaire en TEP et en TEDC (58 %). Dans 46 % des cas, il s'agissait d'un changement majeur ou d'inter-modalités (d'une modalité thérapeutique à une autre) et dans 7 % d'un changement intra-modalité correspondant le plus souvent à une adaptation du geste chirurgical. Lorsque l'examen au FDG est disponible, son impact clinique dans la pratique médicale française se situe rapidement dans les valeurs hautes de l'expérience mondiale.",
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            "title": "The size of metastatic foci and lymph nodes yielding false-negative and false-positive lymph node staging with positron emission tomography in patients with lung cancer",
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                    "creatorType": "author",
                    "firstName": "Hiroaki",
                    "lastName": "Nomori"
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                {
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                    "firstName": "Kenichi",
                    "lastName": "Watanabe"
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                    "firstName": "Takashi",
                    "lastName": "Ohtsuka"
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                    "lastName": "Naruke"
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                    "firstName": "Kimiichi",
                    "lastName": "Uno"
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            "abstractNote": "BACKGROUND\n\nWe examined the sizes of lymph nodes and metastatic foci within the lymph nodes that affect false-positive and false-negative lymph node staging by positron emission tomography in lung cancer.\n\n\nMETHODS\n\nPreoperative positron emission tomography and computed tomography scans were performed for 564 lymph node stations in 80 patients with peripheral-type lung cancer. The sizes of both the lymph nodes and the metastatic foci within the lymph nodes were measured, and these measurements were compared with those obtained with positron emission tomography scanning. To establish general sizes of metastatic foci within the lymph nodes, 277 metastatic lymph nodes in operative specimens previously resected from another 111 patients with lung cancer were examined as a control.\n\n\nRESULTS\n\nThe sensitivity was significantly higher for positron emission tomography than for computed tomographic scanning (P =.026). The sizes of metastatic foci within lymph nodes that showed false-negative (n = 8) and true-positive (n = 28) with positron emission tomography ranged from 0.5 to 9 mm (3 +/- 1 mm) and from 4 to 18 mm (10 +/- 3 mm), respectively (P <.001). None of the metastatic foci smaller than 4 mm could be detected with positron emission tomography scanning. The review of the 277 previously resected metastatic lymph nodes showed that 89 (32%) had metastatic foci smaller than 4 mm. The sizes of true-positive (n = 28) and false-positive (n = 10) lymph nodes ranged from 6 to 15 mm (10 +/- 2 mm) and from 9 to 16 mm (12 +/- 2 mm), respectively (P <.01). None of the false-positive lymph nodes was smaller than 9 mm.\n\n\nCONCLUSIONS\n\nAlthough positron emission tomography was superior to computed tomography scanning in lymph node staging in lung cancer, positron emission tomography was unable to distinguish metastatic foci smaller than 4 mm, which were not unusual sizes for lymph node metastases in lung cancer. Positive lymph nodes with positron emission tomography smaller than 9 mm are likely to be true-positive rather than false-positive.",
            "publicationTitle": "The Journal of thoracic and cardiovascular surgery",
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            "place": "",
            "date": "Apr 2004",
            "volume": "127",
            "issue": "4",
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            "partNumber": "",
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            "pages": "1087-1092",
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            "journalAbbreviation": "J. Thorac. Cardiovasc. Surg.",
            "DOI": "10.1016/j.jtcvs.2003.08.010",
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                    "tag": "Adenocarcinoma",
                    "type": 1
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            "itemType": "journalArticle",
            "title": "Oncological diagnosis using (11)C-choline-positron emission tomography in comparison with 2-deoxy-2-[(18)F] fluoro-D-glucose-positron emission tomography",
            "creators": [
                {
                    "creatorType": "author",
                    "firstName": "Mei",
                    "lastName": "Tian"
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                {
                    "creatorType": "author",
                    "firstName": "Hong",
                    "lastName": "Zhang"
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                {
                    "creatorType": "author",
                    "firstName": "Tetsuya",
                    "lastName": "Higuchi"
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                {
                    "creatorType": "author",
                    "firstName": "Noboru",
                    "lastName": "Oriuchi"
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                {
                    "creatorType": "author",
                    "firstName": "Keigo",
                    "lastName": "Endo"
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            "abstractNote": "PURPOSE\n\nTo assess and compare the usefulness of (11)C-Choline-positron emission tomography (PET) with that of 2-deoxy-2-[(18)F]fluoro-D-glucose (FDG)-PET for the differentiation between benign and malignant in various tumors.\n\n\nMATERIALS AND METHODS\n\nWe examined 38 consecutive patients with various tumors, including seven patients with brain tumors, two with oral cavity tumor, two with esophageal cancer, six with lung cancer, 11 with bone tumor, nine with soft tissue tumors, and one with myeloma. (11)C-Choline-PET and FDG-PET were performed from five minutes and 40 minutes, respectively, after injection of 275-455 MBq tracer. Tracer uptakes were evaluated by the standardized uptake value (SUV) and were analyzed in according to the pathologic data.\n\n\nRESULTS\n\n(11)C-Choline uptake in malignancies (3.9 +/- 1.7, n=24) was significantly higher than that in benign lesions (1.7 +/- 1.2, n=14) (P < 0.0001). On the other hand, the FDG uptake in malignancies was 4.9 +/- 2.0 (n=24) and was also significantly larger than that in benign lesions 1.6 +/- 1.3 (n=14) (P < 0.0001). The (11)C-Choline uptake in all the lesions correlated with FDG uptake (r=0.658, P < 0.02, n=38). According to the receiver operating characteristic (ROC) analysis, the area under the ROC curve for (11)C-Choline-PET was 0.871, and with no significant difference compared to FDG-PET with the area of 0.929.\n\n\nCONCLUSIONS\n\nThis study demonstrated that (11)C-Choline-PET is similar to FDG-PET in differentiation between malignant and benign lesion in various tumors.",
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            "volume": "6",
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            "pages": "172-179",
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