[ { "key": "DTDNIF9H", "version": 443, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/DTDNIF9H", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/DTDNIF9H", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/P6I4SSKD", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "DTDNIF9H", "version": 443, "parentItem": "P6I4SSKD", "itemType": "attachment", "linkMode": "linked_url", "title": "On the Facebook page of Terry Wahls MD", "accessDate": "2014-11-21T21:49:39Z", "url": "https://www.facebook.com/TerryWahls/posts/780830891974964", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-11-21T21:49:39Z", "dateModified": "2014-11-21T21:50:07Z" } }, { "key": "P6I4SSKD", "version": 443, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/P6I4SSKD", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/P6I4SSKD", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "emainfo", "parsedDate": "2013-11-04", "numChildren": 1 }, "data": { "key": "P6I4SSKD", "version": 443, "itemType": "videoRecording", "title": "Critical review of outcomes used in MS clinical trials", "creators": [ { "creatorType": "contributor", "name": "emainfo" } ], "abstractNote": "Speaker: George Ebers, John Radcliffe Hospital\n\nSession 1: New outcome measures in multiple sclerosis\n\nWorkshop on the clinical investigation of new medicines for the treatment of multiple sclerosis", "videoRecordingFormat": "", "seriesTitle": "", "volume": "", "numberOfVolumes": "", "studio": "", "place": "", "date": "2013-11-04", "runningTime": "977 seconds", "ISBN": "", "DOI": "", "citationKey": "", "url": "https://www.youtube.com/watch?v=OqY-_K1fYJY&feature=youtube_gdata_player", "accessDate": "2014-11-21T21:49:08Z", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "YouTube", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-11-21T21:49:08Z", "dateModified": "2014-11-21T21:49:08Z" } }, { "key": "7BZ42S27", "version": 442, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/7BZ42S27", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/7BZ42S27", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/FDCERXTP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "7BZ42S27", "version": 442, "parentItem": "FDCERXTP", "itemType": "attachment", "linkMode": "linked_url", "title": "News article in Science Daily", "accessDate": "2014-10-29T02:49:49Z", "url": "http://www.sciencedaily.com/releases/2014/10/141028082508.htm", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-29T02:49:49Z", "dateModified": "2014-10-29T02:50:04Z" } }, { "key": "FDCERXTP", "version": 442, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/FDCERXTP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/FDCERXTP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Benedict et al.", "numChildren": 2 }, "data": { "key": "FDCERXTP", "version": 442, "itemType": "journalArticle", "title": "Self-reported sleep disturbance is associated with Alzheimer's disease risk in men", "creators": [ { "creatorType": "author", "firstName": "Christian", "lastName": "Benedict" }, { "creatorType": "author", "firstName": "Liisa", "lastName": "Byberg" }, { "creatorType": "author", "firstName": "Jonathan", "lastName": "Cedernaes" }, { "creatorType": "author", "firstName": "Pleunie S.", "lastName": "Hogenkamp" }, { "creatorType": "author", "firstName": "Vilmantas", "lastName": "Giedratis" }, { "creatorType": "author", "firstName": "Lena", "lastName": "Kilander" }, { "creatorType": "author", "firstName": "Lars", "lastName": "Lind" }, { "creatorType": "author", "firstName": "Lars", "lastName": "Lannfelt" }, { "creatorType": "author", "firstName": "Helgi B.", "lastName": "Schiöth" } ], "abstractNote": "Objective\nTo study the association between self-reported sleep disturbances and dementia risk.\nMethods\nSelf-reported sleep disturbances and established risk factors for dementia were measured in men at ages 50 (n = 1574) and 70 (n = 1029) years. Dementia incidence was determined by reviewing their patient history between ages 50 and 90 years. In addition, plasma levels of β-amyloid (Aβ) peptides 1–40 and 1–42 were measured at ages 70, 77, and 82 years.\nResults\nCox regression demonstrated that men with self-reported sleep disturbances had a higher risk of developing dementia (+33%) and Alzheimer's disease (AD, +51%) than men without self-reported sleep disturbances (both P < .05). Binary logistic regression showed the increased risk for both dementia (+114%) and AD (+192%) were highest when sleep disturbance was reported at age 70 years (both P < .001). No group differences were found in Aβ levels.\nConclusion\nImproving sleep quality may help reduce the neurodegenerative risk in older men.", "publicationTitle": "Alzheimer's & Dementia: The Journal of the Alzheimer's Association", "publisher": "", "place": "", "date": "", "volume": "0", "issue": "0", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.jalz.2014.08.104", "citationKey": "", "url": "http://www.alzheimersanddementia.com/article/S1552526014028192/abstract", "accessDate": "2014-10-29T02:47:23Z", "PMID": "", "PMCID": "", "ISSN": "1552-5260", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "English", "libraryCatalog": "www.alzheimersanddementia.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "All-cause dementia", "type": 1 }, { "tag": "Alzheimer's disease", "type": 1 }, { "tag": "Longitudinal study", "type": 1 }, { "tag": "Sleep", "type": 1 } ], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-10-29T02:47:23Z", "dateModified": "2014-10-29T02:47:23Z" } }, { "key": "RDVD4UVU", "version": 441, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/RDVD4UVU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/RDVD4UVU", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/4FT23HQC", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "RDVD4UVU", "version": 441, "parentItem": "4FT23HQC", "itemType": "attachment", "linkMode": "linked_url", "title": "News article in Scientific American", "accessDate": "2014-10-29T00:49:05Z", "url": "http://www.scientificamerican.com/podcast/episode/fecal-transplanters-fish-out-key-ingredient/", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-29T00:49:05Z", "dateModified": "2014-10-29T00:49:25Z" } }, { "key": "4FT23HQC", "version": 441, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/4FT23HQC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/4FT23HQC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Buffie et al.", "parsedDate": "2014-10-22", "numChildren": 1 }, "data": { "key": "4FT23HQC", "version": 441, "itemType": "journalArticle", "title": "Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile", "creators": [ { "creatorType": "author", "firstName": "Charlie G.", "lastName": "Buffie" }, { "creatorType": "author", "firstName": "Vanni", "lastName": "Bucci" }, { "creatorType": "author", "firstName": "Richard R.", "lastName": "Stein" }, { "creatorType": "author", "firstName": "Peter T.", "lastName": "McKenney" }, { "creatorType": "author", "firstName": "Lilan", "lastName": "Ling" }, { "creatorType": "author", "firstName": "Asia", "lastName": "Gobourne" }, { "creatorType": "author", "firstName": "Daniel", "lastName": "No" }, { "creatorType": "author", "firstName": "Hui", "lastName": "Liu" }, { "creatorType": "author", "firstName": "Melissa", "lastName": "Kinnebrew" }, { "creatorType": "author", "firstName": "Agnes", "lastName": "Viale" }, { "creatorType": "author", "firstName": "Eric", "lastName": "Littmann" }, { "creatorType": "author", "firstName": "Marcel R. M.", "lastName": "van den Brink" }, { "creatorType": "author", "firstName": "Robert R.", "lastName": "Jenq" }, { "creatorType": "author", "firstName": "Ying", "lastName": "Taur" }, { "creatorType": "author", "firstName": "Chris", "lastName": "Sander" }, { "creatorType": "author", "firstName": "Justin", "lastName": "Cross" }, { "creatorType": "author", "firstName": "Nora C.", "lastName": "Toussaint" }, { "creatorType": "author", "firstName": "Joao B.", "lastName": "Xavier" }, { "creatorType": "author", "firstName": "Eric G.", "lastName": "Pamer" } ], "abstractNote": "The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that contribute to health, including colonization resistance against intestinal pathogens. Many antibiotics destroy intestinal microbial communities and increase susceptibility to intestinal pathogens. Among these, Clostridium difficile, a major cause of antibiotic-induced diarrhoea, greatly increases morbidity and mortality in hospitalized patients. Which intestinal bacteria provide resistance to C. difficile infection and their in vivo inhibitory mechanisms remain unclear. Here we correlate loss of specific bacterial taxa with development of infection, by treating mice with different antibiotics that result in distinct microbiota changes and lead to varied susceptibility to C. difficile. Mathematical modelling augmented by analyses of the microbiota of hospitalized patients identifies resistance-associated bacteria common to mice and humans. Using these platforms, we determine that Clostridium scindens, a bile acid 7α-dehydroxylating intestinal bacterium, is associated with resistance to C. difficile infection and, upon administration, enhances resistance to infection in a secondary bile acid dependent fashion. Using a workflow involving mouse models, clinical studies, metagenomic analyses, and mathematical modelling, we identify a probiotic candidate that corrects a clinically relevant microbiome deficiency. These findings have implications for the rational design of targeted antimicrobials as well as microbiome-based diagnostics and therapeutics for individuals at risk of C. difficile infection.", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "October 22, 2014", "volume": "advance online publication", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature13828", "citationKey": "", "url": "http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13828.html", "accessDate": "2014-10-29T00:46:12Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "en", "libraryCatalog": "www.nature.com", "callNumber": "", "rights": "© 2014 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.", "extra": "", "tags": [], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-10-29T00:46:12Z", "dateModified": "2014-10-29T00:46:12Z" } }, { "key": "UN2XSHJ7", "version": 440, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/UN2XSHJ7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/UN2XSHJ7", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/AZUHV3UP", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "UN2XSHJ7", "version": 440, "parentItem": "AZUHV3UP", "itemType": "attachment", "linkMode": "imported_url", "title": "Huffington Post", "accessDate": "2014-10-26T17:02:29Z", "url": "http://www.huffingtonpost.com/2014/10/25/nurse-criticizes-ebola-quarantine_n_6047308.html?view=print&comm_ref=false", "note": "", "contentType": "text/html", "charset": "utf-8", "filename": "nurse-criticizes-ebola-quarantine_n_6047308.html", "md5": null, "mtime": null, "tags": [], "relations": {}, "dateAdded": "2014-10-26T17:02:29Z", "dateModified": "2014-10-26T17:02:29Z" } }, { "key": "CV2AR8WN", "version": 439, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/CV2AR8WN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/CV2AR8WN", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/X34R43QF", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "CV2AR8WN", "version": 439, "parentItem": "X34R43QF", "itemType": "attachment", "linkMode": "linked_url", "title": "In Facebook group Psykologer (Swedish, closed)", "accessDate": "2014-10-26T14:38:30Z", "url": "https://www.facebook.com/groups/psykologer/permalink/747253665310110/", "note": "", "contentType": "", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-26T14:38:30Z", "dateModified": "2014-10-26T14:38:40Z" } }, { "key": "BG44MMW9", "version": 439, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/BG44MMW9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/BG44MMW9", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/X34R43QF", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "BG44MMW9", "version": 439, "parentItem": "X34R43QF", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-10-26T14:18:43Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25161917", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-26T14:18:43Z", "dateModified": "2014-10-26T14:18:43Z" } }, { "key": "X34R43QF", "version": 439, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/X34R43QF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/X34R43QF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Hamidpour et al.", "parsedDate": "2014-07", "numChildren": 2 }, "data": { "key": "X34R43QF", "version": 439, "itemType": "journalArticle", "title": "Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer's Disease, and Cancer", "creators": [ { "creatorType": "author", "firstName": "Rafie", "lastName": "Hamidpour" }, { "creatorType": "author", "firstName": "Soheila", "lastName": "Hamidpour" }, { "creatorType": "author", "firstName": "Mohsen", "lastName": "Hamidpour" }, { "creatorType": "author", "firstName": "Mina", "lastName": "Shahlari" }, { "creatorType": "author", "firstName": "Mahnaz", "lastName": "Sohraby" } ], "abstractNote": "Savory (Satureja L.) plant species have been used for centuries as culinary herbs and spices, as well as traditional remedies for the treatment or relief of various common health symptoms in many parts of the world. Recent studies suggest that the use of some Satureja species is effective in protecting the body against oxidative stress, free radical damage, inflammation, microbial infections, etc., A review of many studies suggests that savory species, in addition to treating minor ordinary ailments, can potentially provide a novel natural prevention or treatment for some chronic and serious illnesses such as diabetes, cardiovascular diseases, cancer, and Alzheimer's.", "publicationTitle": "Journal of Traditional and Complementary Medicine", "publisher": "", "place": "", "date": "Jul 2014", "volume": "4", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "140-144", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Tradit Complement Med", "DOI": "10.4103/2225-4110.136540", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "2225-4110", "archive": "", "archiveLocation": "", "shortTitle": "Summer Savory", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25161917 \nPMCID: PMC4142450", "tags": [], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-10-26T14:18:43Z", "dateModified": "2014-10-26T14:18:43Z" } }, { "key": "CGES8GNV", "version": 438, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/CGES8GNV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/CGES8GNV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Grady", "parsedDate": "2013-01-16", "numChildren": 0 }, "data": { "key": "CGES8GNV", "version": 438, "itemType": "newspaperArticle", "title": "Fecal Treatment Gains Favor for Some Illnesses", "creators": [ { "creatorType": "author", "firstName": "Denise", "lastName": "Grady" } ], "abstractNote": "Transplanting feces from a healthy person into the gut of one who is sick can cure some severe intestinal infections.\n\nA new study finds that such transplants cured 15 of 16 people who had recurring infections with Clostridium difficile bacteria, whereas antibiotics cured only 3 of 13 and 4 of 13 patients in two comparison groups. The treatment appears to work by restoring the gut’s normal balance of bacteria, which fight off C. difficile.\n\nThe study is the first to compare the transplants with standard antibiotic therapy. The research, conducted in the Netherlands, was published Wednesday in The New England Journal of Medicine.", "publicationTitle": "The New York Times", "publisher": "", "place": "", "date": "2013-01-16", "volume": "", "issue": "", "edition": "", "section": "Health", "pages": "", "ISSN": "0362-4331", "DOI": "", "citationKey": "", "url": "http://www.nytimes.com/2013/01/17/health/disgusting-maybe-but-treatment-works-study-finds.html", "accessDate": "2014-10-13T23:57:45Z", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NYTimes.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Antibiotics", "type": 1 }, { "tag": "Clostridium Difficile (Bacterium)", "type": 1 }, { "tag": "Digestive Tract", "type": 1 }, { "tag": "Feces", "type": 1 }, { "tag": "Intestinal Tract", "type": 1 }, { "tag": "Keller, Josbert J", "type": 1 }, { "tag": "Medicine and Health", "type": 1 }, { "tag": "New England Journal of Medicine", "type": 1 }, { "tag": "Transplants", "type": 1 } ], "collections": [ "VJ4J8TPH" ], "relations": { "dc:relation": "http://zotero.org/groups/136570/items/Q4JT5DMB" }, "dateAdded": "2014-10-13T23:57:45Z", "dateModified": "2014-10-14T00:07:12Z" } }, { "key": "Q4JT5DMB", "version": 438, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/Q4JT5DMB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/Q4JT5DMB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "van Nood et al.", "parsedDate": "2013-01-31", "numChildren": 1 }, "data": { "key": "Q4JT5DMB", "version": 438, "itemType": "journalArticle", "title": "Duodenal infusion of donor feces for recurrent Clostridium difficile", "creators": [ { "creatorType": "author", "firstName": "Els", "lastName": "van Nood" }, { "creatorType": "author", "firstName": "Anne", "lastName": "Vrieze" }, { "creatorType": "author", "firstName": "Max", "lastName": "Nieuwdorp" }, { "creatorType": "author", "firstName": "Susana", "lastName": "Fuentes" }, { "creatorType": "author", "firstName": "Erwin G.", "lastName": "Zoetendal" }, { "creatorType": "author", "firstName": "Willem M.", "lastName": "de Vos" }, { "creatorType": "author", "firstName": "Caroline E.", "lastName": "Visser" }, { "creatorType": "author", "firstName": "Ed J.", "lastName": "Kuijper" }, { "creatorType": "author", "firstName": "Joep F. W. M.", "lastName": "Bartelsman" }, { "creatorType": "author", "firstName": "Jan G. P.", "lastName": "Tijssen" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Speelman" }, { "creatorType": "author", "firstName": "Marcel G. W.", "lastName": "Dijkgraaf" }, { "creatorType": "author", "firstName": "Josbert J.", "lastName": "Keller" } ], "abstractNote": "BACKGROUND: Recurrent Clostridium difficile infection is difficult to treat, and failure rates for antibiotic therapy are high. We studied the effect of duodenal infusion of donor feces in patients with recurrent C. difficile infection.\nMETHODS: We randomly assigned patients to receive one of three therapies: an initial vancomycin regimen (500 mg orally four times per day for 4 days), followed by bowel lavage and subsequent infusion of a solution of donor feces through a nasoduodenal tube; a standard vancomycin regimen (500 mg orally four times per day for 14 days); or a standard vancomycin regimen with bowel lavage. The primary end point was the resolution of diarrhea associated with C. difficile infection without relapse after 10 weeks.\nRESULTS: The study was stopped after an interim analysis. Of 16 patients in the infusion group, 13 (81%) had resolution of C. difficile-associated diarrhea after the first infusion. The 3 remaining patients received a second infusion with feces from a different donor, with resolution in 2 patients. Resolution of C. difficile infection occurred in 4 of 13 patients (31%) receiving vancomycin alone and in 3 of 13 patients (23%) receiving vancomycin with bowel lavage (P<0.001 for both comparisons with the infusion group). No significant differences in adverse events among the three study groups were observed except for mild diarrhea and abdominal cramping in the infusion group on the infusion day. After donor-feces infusion, patients showed increased fecal bacterial diversity, similar to that in healthy donors, with an increase in Bacteroidetes species and clostridium clusters IV and XIVa and a decrease in Proteobacteria species.\nCONCLUSIONS: The infusion of donor feces was significantly more effective for the treatment of recurrent C. difficile infection than the use of vancomycin. (Funded by the Netherlands Organization for Health Research and Development and the Netherlands Organization for Scientific Research; Netherlands Trial Register number, NTR1177.).", "publicationTitle": "The New England Journal of Medicine", "publisher": "", "place": "", "date": "Jan 31, 2013", "volume": "368", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "407-415", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "N. Engl. J. Med.", "DOI": "10.1056/NEJMoa1205037", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1533-4406", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 23323867", "tags": [ { "tag": "Administration, Oral", "type": 1 }, { "tag": "Aged", "type": 1 }, { "tag": "Anti-Bacterial Agents", "type": 1 }, { "tag": "Clostridium difficile", "type": 1 }, { "tag": "Combined Modality Therapy", "type": 1 }, { "tag": "Diarrhea", "type": 1 }, { "tag": "Duodenum", "type": 1 }, { "tag": "Feces", "type": 1 }, { "tag": "Female", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Intubation, Gastrointestinal", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Metagenome", "type": 1 }, { "tag": "Middle Aged", "type": 1 }, { "tag": "Recurrence", "type": 1 }, { "tag": "Therapeutic Irrigation", "type": 1 }, { "tag": "Vancomycin", "type": 1 } ], "collections": [ "VJ4J8TPH" ], "relations": { "dc:relation": "http://zotero.org/groups/136570/items/CGES8GNV" }, "dateAdded": "2014-10-14T00:06:56Z", "dateModified": "2014-10-14T00:06:56Z" } }, { "key": "EQJVZNQI", "version": 438, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/EQJVZNQI", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/EQJVZNQI", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/Q4JT5DMB", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "EQJVZNQI", "version": 438, "parentItem": "Q4JT5DMB", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-10-14T00:06:56Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/23323867", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-14T00:06:56Z", "dateModified": "2014-10-14T00:06:56Z" } }, { "key": "DX89F72X", "version": 437, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/DX89F72X", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/DX89F72X", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Velasquez-manoff", "parsedDate": "2014-10-11", "numChildren": 0 }, "data": { "key": "DX89F72X", "version": 437, "itemType": "newspaperArticle", "title": "Can Celiac Disease Affect the Brain?", "creators": [ { "creatorType": "author", "firstName": "Moises", "lastName": "Velasquez-manoff" } ], "abstractNote": "Some scientists have linked gluten with neurological symptoms.\n\nI began encountering case descriptions like this some years ago as I researched autoimmune disease. The first few seemed like random noise in an already nebulous field. But as I amassed more — describing seizures, hallucinations, psychotic breaks and even, in one published case, what looked like regressive autism, all ultimately associated with celiac disease — they began to seem less like anomalies, and more like a frontier in celiac research.\n\nThey tended to follow a similar plot. What looked like neurological or psychiatric symptoms appeared suddenly. The physician ran through a diagnostic checklist without success. Drugs directed at the brain failed. Some clue suggestive of celiac disease was observed. The diagnosis was made. And the patient recovered on a gluten-free diet.\n\nThe cases highlighted, in an unusually concrete fashion, the so-called gut-brain axis. The supposed link between the intestinal tract and the central nervous system is much discussed in science journals, often in the context of the microbial community inhabiting the gut. But it’s unclear how, really, we can leverage the link to improve health.", "publicationTitle": "The New York Times", "publisher": "", "place": "", "date": "2014-10-11", "volume": "", "issue": "", "edition": "", "section": "", "pages": "", "ISSN": "0362-4331", "DOI": "", "citationKey": "", "url": "http://www.nytimes.com/2014/10/12/opinion/sunday/can-celiac-disease-affect-the-brain.html", "accessDate": "2014-10-13T23:52:35Z", "archive": "", "archiveLocation": "", "shortTitle": "Can Celiac Disease Affect the Brain?", "language": "", "libraryCatalog": "NYTimes.com", "callNumber": "", "rights": "", "extra": "", "tags": [ { "tag": "Autism", "type": 1 }, { "tag": "Autoimmune Diseases", "type": 1 }, { "tag": "Brain", "type": 1 }, { "tag": "Celiac Disease", "type": 1 }, { "tag": "Gluten", "type": 1 }, { "tag": "Immune System", "type": 1 }, { "tag": "Mental Health and Disorders", "type": 1 }, { "tag": "Nerves and Nervous System", "type": 1 }, { "tag": "Research", "type": 1 }, { "tag": "Schizophrenia", "type": 1 } ], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-10-13T23:52:35Z", "dateModified": "2014-10-13T23:54:40Z" } }, { "key": "TE9GNBDN", "version": 436, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/TE9GNBDN", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/TE9GNBDN", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Belcheva et al.", "parsedDate": "2014-07-17", "numChildren": 1 }, "data": { "key": "TE9GNBDN", "version": 436, "itemType": "journalArticle", "title": "Gut microbial metabolism drives transformation of MSH2-deficient colon epithelial cells", "creators": [ { "creatorType": "author", "firstName": "Antoaneta", "lastName": "Belcheva" }, { "creatorType": "author", "firstName": "Thergiory", "lastName": "Irrazabal" }, { "creatorType": "author", "firstName": "Susan J.", "lastName": "Robertson" }, { "creatorType": "author", "firstName": "Catherine", "lastName": "Streutker" }, { "creatorType": "author", "firstName": "Heather", "lastName": "Maughan" }, { "creatorType": "author", "firstName": "Stephen", "lastName": "Rubino" }, { "creatorType": "author", "firstName": "Eduardo H.", "lastName": "Moriyama" }, { "creatorType": "author", "firstName": "Julia K.", "lastName": "Copeland" }, { "creatorType": "author", "firstName": "Sachin", "lastName": "Kumar" }, { "creatorType": "author", "firstName": "Blerta", "lastName": "Green" }, { "creatorType": "author", "firstName": "Kaoru", "lastName": "Geddes" }, { "creatorType": "author", "firstName": "Rossanna C.", "lastName": "Pezo" }, { "creatorType": "author", "firstName": "William W.", "lastName": "Navarre" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Milosevic" }, { "creatorType": "author", "firstName": "Brian C.", "lastName": "Wilson" }, { "creatorType": "author", "firstName": "Stephen E.", "lastName": "Girardin" }, { "creatorType": "author", "firstName": "Thomas M. S.", "lastName": "Wolever" }, { "creatorType": "author", "firstName": "Winfried", "lastName": "Edelmann" }, { "creatorType": "author", "firstName": "David S.", "lastName": "Guttman" }, { "creatorType": "author", "firstName": "Dana J.", "lastName": "Philpott" }, { "creatorType": "author", "firstName": "Alberto", "lastName": "Martin" } ], "abstractNote": "The etiology of colorectal cancer (CRC) has been linked to deficiencies in mismatch repair and adenomatous polyposis coli (APC) proteins, diet, inflammatory processes, and gut microbiota. However, the mechanism through which the microbiota synergizes with these etiologic factors to promote CRC is not clear. We report that altering the microbiota composition reduces CRC in APC(Min/+)MSH2(-/-) mice, and that a diet reduced in carbohydrates phenocopies this effect. Gut microbes did not induce CRC in these mice through an inflammatory response or the production of DNA mutagens but rather by providing carbohydrate-derived metabolites such as butyrate that fuel hyperproliferation of MSH2(-/-) colon epithelial cells. Further, we provide evidence that the mismatch repair pathway has a role in regulating β-catenin activity and modulating the differentiation of transit-amplifying cells in the colon. These data thereby provide an explanation for the interaction between microbiota, diet, and mismatch repair deficiency in CRC induction. PAPERCLIP:", "publicationTitle": "Cell", "publisher": "", "place": "", "date": "Jul 17, 2014", "volume": "158", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "288-299", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Cell", "DOI": "10.1016/j.cell.2014.04.051", "citationKey": "", "url": "", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1097-4172", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "PMID: 25036629", "tags": [], "collections": [ "VJ4J8TPH" ], "relations": { "dc:relation": "http://zotero.org/groups/136570/items/SMCVAHMX" }, "dateAdded": "2014-10-11T15:36:03Z", "dateModified": "2014-10-11T15:36:18Z" } }, { "key": "EBJ3RQI6", "version": 436, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/EBJ3RQI6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/EBJ3RQI6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/136570/items/TE9GNBDN", "type": "application/json" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } } }, "data": { "key": "EBJ3RQI6", "version": 436, "parentItem": "TE9GNBDN", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2014-10-11T15:36:03Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/25036629", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2014-10-11T15:36:03Z", "dateModified": "2014-10-11T15:36:03Z" } }, { "key": "SMCVAHMX", "version": 435, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/SMCVAHMX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/SMCVAHMX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "SMCVAHMX", "version": 435, "itemType": "blogPost", "title": "The Link Between Carbs, Gut Microbes, and Colon Cancer", "creators": [], "abstractNote": "Reduced carb intake among mice protected them from colon cancer.\n\nAnd new research, which was published last week in Cell, has provided insights into the dangerous link between colorectal cancers and modern diets heavy in wheat, rice, and other complex carbohydrates—diets that became possible with the advent of agriculture.\nUniversity of Toronto scientists led research that suggests a common type of gut-dwelling bacteria breaks down carbs into certain metabolites that can lead to cancer. These metabolites appear to cause cells that line the colon to divide and proliferate rapidly, forming polyps. These polyps, which can grow into a cancer, are the abnormal growths that your doctor is probing for when they subject you to a colonoscopy.", "blogTitle": "Pacific Standard", "websiteType": "", "date": "", "DOI": "", "citationKey": "", "url": "http://www.psmag.com/navigation/health-and-behavior/links-carbs-gut-microbes-colon-cancer-86437/", "accessDate": "2014-10-11T15:34:20Z", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [], "collections": [ "VJ4J8TPH" ], "relations": { "dc:relation": "http://zotero.org/groups/136570/items/TE9GNBDN" }, "dateAdded": "2014-10-11T15:34:20Z", "dateModified": "2014-10-11T15:35:12Z" } }, { "key": "ANUEFMAB", "version": 434, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/ANUEFMAB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/ANUEFMAB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "creatorSummary": "Newman", "numChildren": 0 }, "data": { "key": "ANUEFMAB", "version": 434, "itemType": "blogPost", "title": "Whole-Foods Diet May Protect Against Leaky Gut and Multiple Sclerosis Progression", "creators": [ { "creatorType": "author", "firstName": "+Maureen", "lastName": "Newman" } ], "abstractNote": "Read more about how a whole-foods diet may protect against leaky gut syndrome and multiple sclerosis progression.", "blogTitle": "IBD News Today", "websiteType": "", "date": "", "DOI": "", "citationKey": "", "url": "http://ibdnewstoday.com/2014/10/07/whole-foods-diet-may-protect-against-leaky-gut-and-multiple-sclerosis-progression/", "accessDate": "2014-10-08T01:22:13Z", "ISSN": "", "shortTitle": "", "language": "", "rights": "", "extra": "", "tags": [ { "tag": "leaky gut syndrome", "type": 1 } ], "collections": [ "VJ4J8TPH" ], "relations": {}, "dateAdded": "2014-10-08T01:22:13Z", "dateModified": "2014-10-08T01:22:13Z" } }, { "key": "RWVINXZB", "version": 433, "library": { "type": "group", "id": 136570, "name": "Minding My Mitochondria, Terry Wahls", "links": { "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/136570/items/RWVINXZB", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/minding_my_mitochondria_terry_wahls/items/RWVINXZB", "type": "text/html" } }, "meta": { "createdByUser": { "id": 5982, "username": "beogl", "name": "Lennart Borgman", "links": { "alternate": { "href": "https://www.zotero.org/beogl", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "RWVINXZB", "version": 433, "itemType": "webpage", "title": "Why No Grains and Legumes? Part 1: Lectins", "creators": [], "abstractNote": "A reminder to Paleo eaters why they don't want to eat delicious grains and legumes. 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