[ { "key": "2FFKSAGU", "version": 180, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/2FFKSAGU", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/2FFKSAGU", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Anantasit et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "2FFKSAGU", "version": 180, "itemType": "journalArticle", "title": "Balanced salt solution versus normal saline solution as initial fluid re- suscitation in pediatric septic shock: A randomized, double-blind con- trolled trial", "creators": [ { "creatorType": "author", "firstName": "Nattachai", "lastName": "Anantasit" }, { "creatorType": "author", "firstName": "Sriwanna", "lastName": "Thansanthiah" }, { "creatorType": "author", "firstName": "Rojjanee", "lastName": "Lerbunrian" } ], "abstractNote": "", "publicationTitle": "Critical Care and Shock", "volume": "23", "issue": "", "pages": "158-168", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Crit Care Shock", "language": "", "DOI": "", "ISSN": "", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "Q6XBYW6J", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/Q6XBYW6J", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/Q6XBYW6J", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Gummalla et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "Q6XBYW6J", "version": 179, "itemType": "journalArticle", "title": "Intravenous methylprednisolone versus intravenous methylprednisolone combined with inhaled budesonide in acute severe pediatric asthma", "creators": [ { "creatorType": "author", "firstName": "Prabhavathi", "lastName": "Gummalla" }, { "creatorType": "author", "firstName": "Diana", "lastName": "Weaver" }, { "creatorType": "author", "firstName": "Youssef", "lastName": "Ahmed" }, { "creatorType": "author", "firstName": "Vikas", "lastName": "Shah" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Keenaghan" }, { "creatorType": "author", "firstName": "Sule", "lastName": "Doymaz" } ], "abstractNote": "Introduction Corticosteroids are important part of acute severe asthma (ASA) management in pediatric intensive care units. Few studies look at the efficacy of inhaled corticosteroids (ICS) in critical care settings. We aimed to investigate the potential beneficial effects of ICS when added to intravenous corticosteroids in pediatric patients with ASA admitted to the pediatric intensive care unit (PICU) Methods This was a randomized controlled trial involving pediatric patients aged 1–21 years admitted to PICU with ASA. Patients were randomized into 2 groups using block randomization. Patients in Group A received intravenous methylprednisolone (2 mg/kg/day) alone and patients in Group B received intravenous methylprednisolone (2 mg/kg/day) plus budesonide nebulization (0.5 mg every 12 h). Main outcomes were duration of continuous albuterol treatment, PICU and hospital length of stay (LOS), and need and duration of respiratory support. Kruskal-Wallis and Chi-square tests were used for statistical analysis, in which a p-value < 0.05 was considered statistically significant. Results Duration of continuous albuterol treatment was not different between the 2 groups median/(QR), 30/(18–51) vs. 25/(14–49). (p = 0.38) PICU and hospital LOS between the 2 groups was similar, median/(QR), 44/(30–64) vs. 46/(30–62), (p = 0.75) and 78/(65–95) vs.72/(58–92), (p = 0.19). Number of patients requiring respiratory support was 22(58%) in Group A and 25(64%) in Group B (p = 0.19). Conclusions In critically ill children with ASA, intravenous methylprednisolone combined with inhaled budesonide did not shorten the duration of continuous albuterol inhalation treatment, the PICU and hospital LOS, and the need for respiratory support.", "publicationTitle": "Journal of Asthma", "volume": "", "issue": "", "pages": "1-6", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Asthma", "language": "", "DOI": "10.1080/02770903.2020.1808988", "ISSN": "0277-0903", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "89RQSDDS", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/89RQSDDS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/89RQSDDS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Chorney et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "89RQSDDS", "version": 179, "itemType": "journalArticle", "title": "Timing the First Pediatric Tracheostomy Tube Change: A Randomized Controlled Trial", "creators": [ { "creatorType": "author", "firstName": "Stephen R", "lastName": "Chorney" }, { "creatorType": "author", "firstName": "Rosemary C", "lastName": "Patel" }, { "creatorType": "author", "firstName": "Allison E", "lastName": "Boyd" }, { "creatorType": "author", "firstName": "Joanne", "lastName": "Stow" }, { "creatorType": "author", "firstName": "Mary M", "lastName": "Schmitt" }, { "creatorType": "author", "firstName": "Deborah", "lastName": "Lipman" }, { "creatorType": "author", "firstName": "Julia F", "lastName": "Dailey" }, { "creatorType": "author", "firstName": "Carol", "lastName": "Nhan" }, { "creatorType": "author", "firstName": "Terri", "lastName": "Giordano" }, { "creatorType": "author", "firstName": "Steven E", "lastName": "Sobol" } ], "abstractNote": "Objective The first pediatric tracheostomy tube change often occurs within 7 days after placement; however, the optimal timing is not known. The primary objective was to determine the rate of adverse events of an early tube change. Secondary objectives compared rates of significant peristomal wounds, sedation requirements, and expedited intensive care discharges. Study Design Prospective randomized controlled trial. Setting Tertiary children’s hospital between October 2018 and April 2020. Methods A randomized controlled trial enrolled children under 24 months to early (day 4) or late (day 7) first tracheostomy tube changes. Results Sixteen children were enrolled with 10 randomized to an early change. Median age was 5.9 months (interquartile range, 5.4-8.3), and 86.7% required tracheostomy for respiratory failure. All tracheostomy tube changes were performed without adverse events. There were no accidental decannulations. Significant wounds developed in 10% of children with early tracheostomy tube changes and 83.3% of children with late tracheostomy tube changes (odds ratio [OR], 45.0; 95% CI, 2.3-885.6; P = .01). This significant reduction in wound complications justified concluding trial enrollment. Hours of dexmedetomidine sedation ( P = .11) and boluses of midazolam during the first 7 days ( P = .08) were no different between groups. After the first change, 90% of the early group were discharged from intensive care within 5 weeks compared to 33.3% of patients in the late group (OR, 18.0; 95% CI, 1.2-260.9; P = .03). Conclusion The first tracheostomy tube change in children can occur without adverse events on day 4, resulting in fewer significant peristomal wounds and earlier intensive care discharge.", "publicationTitle": "Otolaryngology–Head and Neck Surgery", "volume": "", "issue": "", "pages": "019459982095413", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Otolaryngology Head Neck Surg", "language": "", "DOI": "10.1177/0194599820954137", "ISSN": "0194-5998", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "RP2IVUJY", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/RP2IVUJY", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/RP2IVUJY", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Tiacharoen et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "RP2IVUJY", "version": 179, "itemType": "journalArticle", "title": "Protocolized Sedative Weaning vs Usual Care in Pediatric Critically Ill Patients: A Pilot Randomized Controlled Trial", "creators": [ { "creatorType": "author", "firstName": "Duangtip", "lastName": "Tiacharoen" }, { "creatorType": "author", "firstName": "Rojjanee", "lastName": "Lertbunrian" }, { "creatorType": "author", "firstName": "Jarin", "lastName": "Veawpanich" }, { "creatorType": "author", "firstName": "Nattanicha", "lastName": "Suppalarkbunlue" }, { "creatorType": "author", "firstName": "Nattachai", "lastName": "Anantasit" } ], "abstractNote": "The prolonged use of benzodiazepines and opioids can lead to an increase in the incidence of withdrawal syndrome. One of the known risk factors is the lack of a sedative-weaning protocol. This study established a sedative-weaning protocol and compared this protocol with the usual care of weaning in high-risk critically ill children.", "publicationTitle": "Indian Journal of Critical Care Medicine", "volume": "24", "issue": "6", "pages": "451-458", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Indian J Critical Care Medicine", "language": "", "DOI": "10.5005/jp-journals-10071-23465", "ISSN": "0972-5229", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "ZBLXAX6Y", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/ZBLXAX6Y", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/ZBLXAX6Y", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Rameshkumar et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "ZBLXAX6Y", "version": 179, "itemType": "journalArticle", "title": "Randomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections", "creators": [ { "creatorType": "author", "firstName": "Ramachandran", "lastName": "Rameshkumar" }, { "creatorType": "author", "firstName": "Arun", "lastName": "Bansal" }, { "creatorType": "author", "firstName": "Sunit", "lastName": "Singhi" }, { "creatorType": "author", "firstName": "Pratibha", "lastName": "Singhi" }, { "creatorType": "author", "firstName": "Muralidharan", "lastName": "Jayashree" } ], "abstractNote": "Mannitol is a commonly used osmotherapy agent in raised intracranial pressure. However, the side effects of mannitol are significant. In traumatic brain injury (adult and pediatric), hypertonic saline (3%) shows varied results in comparison with 20% mannitol. We compared the effect of 3% hypertonic saline versus 20% mannitol (using common dosing strategies) on raised intracranial pressure in pediatric acute CNS infections.", "publicationTitle": "Pediatric Critical Care Medicine", "volume": "Publish Ahead of Print", "issue": "", "pages": "", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pediatr Crit Care Me", "language": "", "DOI": "10.1097/pcc.0000000000002557", "ISSN": "1529-7535", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "9HLFVI4F", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/9HLFVI4F", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/9HLFVI4F", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Roudi et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "9HLFVI4F", "version": 179, "itemType": "journalArticle", "title": "Effects of High-Dose Selenium Supplementation on Oxidative Stress and Inflammatory Markers in Critically Ill Children After Gastrointestinal Surgery: A Randomized Clinical Trial", "creators": [ { "creatorType": "author", "firstName": "Fatemeh", "lastName": "Roudi" }, { "creatorType": "author", "firstName": "Gholamreza", "lastName": "Khademi" }, { "creatorType": "author", "firstName": "Golnaz", "lastName": "Ranjbar" }, { "creatorType": "author", "firstName": "Houshang", "lastName": "Rafatpanah" }, { "creatorType": "author", "firstName": "Habibollah", "lastName": "Esmaily" }, { "creatorType": "author", "firstName": "Mohsen", "lastName": "Nematy" } ], "abstractNote": "Background: Pediatric observational studies have indicated that most critically ill children have low serum selenium level, which is associated with the increased incidence of multiple organ failure and deteriorated clinical outcomes. Selenium plays a key role in the endogenous antioxidant defense mechanism and inflammatory pathways. Objectives: The present study aimed to assess the effects of high-dose selenium supplementation on the improvement of inflammatory and oxidative stress indices, as well as clinical outcomes, in pediatric patients with severe oxidative stress and inflammation following major gastrointestinal surgeries. Methods: This prospective, single-blind, randomized, parallel group superiority trial was conducted at the pediatric intensive care unit (PICU) of Akbar Pediatric Hospital in Mashhad, Iran in 2019. Patients were assigned to the supplementation (high-dose selenium: 20 µg/kg/d) and control groups (placebo with the recommended dietary allowance doses of selenium) using stratified blocks. Among 72 eligible critically ill children after gastrointestinal surgery, 66 patients completed the study. Inflammatory markers were measured and compared between the groups, including high-sensitivity C-reactive protein (hsCRP), interleukin 1 beta (IL-1β), prooxidant-antioxidant balance (PAB) assay, and clinical outcomes. Data analysis was performed in SPSS version 20 using the intention-to-treat approach. Results: Only 14 patients had optimal serum selenium concentrations before the surgery and PICU admission. At the end of the study, 90.6% of the patients (n = 29) in the intervention group and 100% (n = 34) of those in the placebo group had suboptimal serum selenium levels (< 50 ng/mL). Although supplementation with high-dose selenium decreased the inflammatory markers in the post-surgical critically ill children (-18 mg/mL and -37.5 pg/mL for hsCRP and IL-1β, respectively), the administered dose could not improve the serum glutathione peroxidase (GPx) concentrations as the selenium functional marker, as well as the PAB assay as the single test to assess the balance/imbalance of the oxidants and antioxidants simultaneously. Additionally, clinical outcomes such as infections, length of ICU stay, and 28-day mortality did not improve after the intervention. Conclusions: According to the results, high-dose selenium supplementation (20 µg/kg/d) in the post-surgical critically ill children could improve the serum inflammatory markers. However, the changes were suboptimal with no significant effects of the serum GPx concentrations, antioxidant defense system, and clinical outcomes.", "publicationTitle": "Iranian Journal of Pediatrics", "volume": "30", "issue": "4", "pages": "", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Iran J Pediatr", "language": "", "DOI": "10.5812/ijp.102118", "ISSN": "2008-2142", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "94GWNJEE", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/94GWNJEE", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/94GWNJEE", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "India et al.", "parsedDate": "2018", "numChildren": 0 }, "data": { "key": "94GWNJEE", "version": 179, "itemType": "journalArticle", "title": "High flow nasal cannula vs non-invasive ventilation in pediatric ARDS: an RCT", "creators": [ { "creatorType": "author", "firstName": "Department of Pediatrics, SRMS Institute of Medical Sciences, Bareilly, UP,", "lastName": "India" }, { "creatorType": "author", "firstName": "Dr Surabhi", "lastName": "Chandra" }, { "creatorType": "author", "firstName": "Dr Vijayshri", "lastName": "Vijayshri" }, { "creatorType": "author", "firstName": "Dr Aditi", "lastName": "Gupta" }, { "creatorType": "author", "firstName": "Dr Pratishtha", "lastName": "Goyal" }, { "creatorType": "author", "firstName": "Dr P L", "lastName": "Prasad" } ], "abstractNote": "", "publicationTitle": "Pediatric Review: International Journal of Pediatric Research", "volume": "5", "issue": "11", "pages": "592-595", "date": "2018", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pediatric Rev Int J Pediatric Res", "language": "", "DOI": "10.17511/ijpr.2018.i11.07", "ISSN": "2349-5499", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "EXIRDXKH", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/EXIRDXKH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/EXIRDXKH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Cesar et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "EXIRDXKH", "version": 179, "itemType": "journalArticle", "title": "High-Flow Nasal Cannula versus Continuous Positive Airway Pressure in Critical Bronchiolitis: A Randomized Controlled Pilot", "creators": [ { "creatorType": "author", "firstName": "Regina", "lastName": "Cesar" }, { "creatorType": "author", "firstName": "Bibiane", "lastName": "Bispo" }, { "creatorType": "author", "firstName": "Priscilla", "lastName": "Felix" }, { "creatorType": "author", "firstName": "Maria", "lastName": "Modolo" }, { "creatorType": "author", "firstName": "Andreia", "lastName": "Souza" }, { "creatorType": "author", "firstName": "Nelson", "lastName": "Horigoshi" }, { "creatorType": "author", "firstName": "Alexandre", "lastName": "Rotta" } ], "abstractNote": "We conducted a randomized controlled pilot study in infants with critical bronchiolitis ( n = 63) comparing high-flow nasal cannula (HFNC, n = 35) to continuous positive airway pressure (CPAP, n = 28). The primary outcome was treatment failure, defined as the need for bilevel positive pressure ventilation or endotracheal intubation. Treatment failure occurred in 10 patients (35.7%) in the CPAP group and 13 patients (37.1%) in the HFNC group ( p = 0.88). Pediatric intensive care unit length of stay was similar between the CPAP and HFNC groups (5 [4–7] days and 5 [4–8] days, p = 0.46, respectively). In this pilot study, treatment with HFNC resulted in a rate of treatment failure similar to CPAP.", "publicationTitle": "Journal of Pediatric Intensive Care", "volume": "09", "issue": "04", "pages": "248-255", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Pediatric Intensive Care", "language": "", "DOI": "10.1055/s-0040-1709656", "ISSN": "2146-4618", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:07Z", "dateModified": "2020-11-06T19:13:07Z" } }, { "key": "NRGL96ZZ", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/NRGL96ZZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/NRGL96ZZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Chen et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "NRGL96ZZ", "version": 179, "itemType": "journalArticle", "title": "Investigating the Efficacy of Hydrocolloid Dressing for Preventing Nasotracheal Tube-Related Pressure Injury in the PICU", "creators": [ { "creatorType": "author", "firstName": "Jie", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Jinlu", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Jine", "lastName": "Yang" }, { "creatorType": "author", "firstName": "Yanxuan", "lastName": "Chen" }, { "creatorType": "author", "firstName": "Yufeng", "lastName": "Liang" }, { "creatorType": "author", "firstName": "Yan", "lastName": "Lin" } ], "abstractNote": "To investigate the efficacy of hydrocolloid dressing in reducing the occurrence rate and severity of nasotracheal tube-related pressure injury.", "publicationTitle": "Pediatric Critical Care Medicine", "volume": "21", "issue": "9", "pages": "e752-e758", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pediatr Crit Care Me", "language": "", "DOI": "10.1097/pcc.0000000000002494", "ISSN": "1529-7535", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:06Z", "dateModified": "2020-11-06T19:13:06Z" } }, { "key": "HCAEKC4B", "version": 179, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/HCAEKC4B", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/HCAEKC4B", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Erickson et al.", "parsedDate": "2020", "numChildren": 0 }, "data": { "key": "HCAEKC4B", "version": 179, "itemType": "journalArticle", "title": "Dexmedetomidine Sedation in Mechanically Ventilated Critically Ill Children: A Pilot Randomized Controlled Trial", "creators": [ { "creatorType": "author", "firstName": "Simon J", "lastName": "Erickson" }, { "creatorType": "author", "firstName": "Johnny", "lastName": "Millar" }, { "creatorType": "author", "firstName": "Brian J", "lastName": "Anderson" }, { "creatorType": "author", "firstName": "Marino S", "lastName": "Festa" }, { "creatorType": "author", "firstName": "Lahn", "lastName": "Straney" }, { "creatorType": "author", "firstName": "Yahya", "lastName": "Shehabi" }, { "creatorType": "author", "firstName": "Debbie A", "lastName": "Long" }, { "creatorType": "author", "firstName": "Baby SPICE Investigators and the Australian and New Zealand Intensive Care Society Paediatric Study Group", "lastName": "(ANZICS-PSG)" } ], "abstractNote": "To assess the feasibility, safety, and efficacy of a sedation protocol using dexmedetomidine as the primary sedative in mechanically ventilated critically ill children.", "publicationTitle": "Pediatric Critical Care Medicine", "volume": "21", "issue": "9", "pages": "e731-e739", "date": "2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Pediatr Crit Care Me", "language": "", "DOI": "10.1097/pcc.0000000000002483", "ISSN": "1529-7535", "shortTitle": "", "url": "", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-11-06T19:13:06Z", "dateModified": "2020-11-06T19:13:06Z" } }, { "key": "I6FDQLNQ", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/I6FDQLNQ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/I6FDQLNQ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Adineh et al.", "parsedDate": "2016-01-01", "numChildren": 1 }, "data": { "key": "I6FDQLNQ", "version": 175, "itemType": "journalArticle", "title": "The effect of family presence during pediatric intensive care unit bedside on family general health: A clinical trial study", "creators": [ { "creatorType": "author", "firstName": "Mohammad", "lastName": "Adineh" }, { "creatorType": "author", "firstName": "Tahereh", "lastName": "Toulabi" }, { "creatorType": "author", "firstName": "Yadollah", "lastName": "Pournia" }, { "creatorType": "author", "firstName": "Shahram", "lastName": "Baraz" } ], "abstractNote": "Background A child's hospitalization in intensive care units causes stress and worry in other family members. This study aimed to determine the effect of family presence during pediatric ICU bedside on family general health. Materials and Methods In this clinical trial study, 46 family members of the pediatrics hospitalized in the ICU in Teaching hospital affiliated with the Lorestan University of Medical Sciences in Khorramabad in April to November 2014 were divided into two groups using the stratified block randomization. Family members of the intervention group were present at the bedside of their patients two hours a day for six days, but family members of the control group did not visit their patients during six day. The general health status of the family members in the two groups was evaluated immediately before and after the visit on the first, sixth and twelfth visit, by using the General Health Questionnaire (GHQ). The data was analyzed using the repeated measure tests and independent t-tests. Results Results showed there was a significant difference between the groups in terms of the means of the GHQ scores of the family members before and after the intervention (P", "publicationTitle": "International Journal of Pediatrics", "volume": "4", "issue": "5", "pages": "1809-1817", "date": "January 1, 2016", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "language": "", "DOI": "10.22038/ijp.2016.6776", "ISSN": "", "shortTitle": "", "url": "http://ijp.mums.ac.ir/article_6776.html", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "Publisher: Mashhad University of Medical Sciences", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "UQDCKSY2", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/UQDCKSY2", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/UQDCKSY2", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Fayazi et al.", "parsedDate": "2016-01-01", "numChildren": 1 }, "data": { "key": "UQDCKSY2", "version": 175, "itemType": "journalArticle", "title": "Comparing two methods of enteral nutrition in terms of their complications and the time needed to reach goal calorie in children hospitalized in ICU", "creators": [ { "creatorType": "author", "firstName": "Sedigheh", "lastName": "Fayazi" }, { "creatorType": "author", "firstName": "Mohammad", "lastName": "Adineh" }, { "creatorType": "author", "firstName": "Somayeh Zahraei", "lastName": "Fard" }, { "creatorType": "author", "firstName": "Hoda Farokh", "lastName": "Payam" }, { "creatorType": "author", "firstName": "Zahra Ahmadie", "lastName": "Batvandy" } ], "abstractNote": "Background Nutrition support and noticing the required goal calories in patients having critical conditions are essential aspects of medical care in preventing malnutrition in these patients. Materials and Methods This research is a clinical trial which was done on 60 children aging between 5 to 17 years old hospitalized in Intensive Care Unit (ICU) of Shiraz's Namazee hospital, South West of Iran, during April to September 2015. Patients were separated randomly into two groups. Enteral nutrition was done with infusion pump for one of the groups and intermittently for the other one. The data was collected for 7 days by a check list regarding enteral nutrition method, complications and the time needed to reach goal calories. Data analysis was done using SPSS-18 software through Chi-square and t-student test. Results The results of this study showed that there was a significant difference of the mean time needed to reach target goal calorie between the continuous and intermittent nutrition methods (P 0.05). Conclusion This study showed that continuous enteral nutrition method has better outcomes in children hospitalized in ICU than intermittent method.", "publicationTitle": "International Journal of Pediatrics", "volume": "4", "issue": "7", "pages": "2119-2130", "date": "January 1, 2016", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "language": "", "DOI": "10.22038/ijp.2016.7042", "ISSN": "", "shortTitle": "", "url": "https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85006966736&origin=inward", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "QLD6FGBL", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/QLD6FGBL", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/QLD6FGBL", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Abdollahi et al.", "parsedDate": "2016-01-01", "numChildren": 1 }, "data": { "key": "QLD6FGBL", "version": 175, "itemType": "journalArticle", "title": "Effect of gastric acid suppressant prophylaxis on incidence of gastrointestinal bleeding in pediatric intensive care unit", "creators": [ { "creatorType": "author", "firstName": "Tahoora", "lastName": "Abdollahi" }, { "creatorType": "author", "firstName": "Alireza", "lastName": "Sabzevari" }, { "creatorType": "author", "firstName": "Ali", "lastName": "Khakshour" }, { "creatorType": "author", "firstName": "Alireza Ataiee", "lastName": "Nakhaie" }, { "creatorType": "author", "firstName": "Majid", "lastName": "Sezavar" }, { "creatorType": "author", "firstName": "Toktam", "lastName": "Etezadie" }, { "creatorType": "author", "firstName": "hamidreza", "lastName": "kianifar" }, { "creatorType": "author", "firstName": "Seyed Ali", "lastName": "Jafari" }, { "creatorType": "author", "firstName": "Mohammad Ali", "lastName": "Kiani" } ], "abstractNote": "Background: Critically ill children admitted to pediatric intensive care unit (PICU) are at increased risk of gastrointestinal bleeding due to stress related mucosal injury. Reducing gastric acid by acid suppressant medication is the accepted prophylaxis treatment, but there is not any definitive guideline for using prophylaxis in PICU patients. The present study aimed to assess the effect of Proton Pump Inhibitor (PPI) and H2 Blocker (H2B) prophylaxis on gastrointestinal bleeding in admitted patients of PICU, Mashhad- Iran. Materials and Methods: In this study, 100 patients admitted in PICU divided into two equal groups on the first day of admission. They received ranitidine or pantoprazole as prophylaxis of stress ulcer. Those patients who had history of gastrointestinal bleeding or coagulation disorder were excluded. 100 PICU patients who had not received prophylaxis during last 6 months retrospectively evaluated as control of the study. Data were collected as demographic characteristics, admission reason, definitive diagnosis, receiving corticosteroid and mechanical ventilation in each patient. Gastrointestinal bleeding (hematemesis, coffee ground aspirate, and melena) and clinically significant gastrointestinal bleeding were daily monitored. Data analyzed through descriptive statistical tests, Chi-square, logistic regression, t-test and using SPSS-16 software. Results: Among 204 patients (control group=105 and case group=99), incidence of gastrointestinal bleeding (GB) was 13.2% in which 6.9% of cases presented with clinically significant gastrointestinal bleeding (CSGB). Loss of consciousness and respiratory distress were the main reason of admission. There was no significant differences between the incidence of (GB) and (CSGB) in experimental and control groups (P > 0.05) as well as ranitidine and pantoprazole prophylaxis (P > 0.05). Significant risk factors of (GB) were mechanical ventilation and loss of consciousness and corticosteroid therapy. Conclusion: There is ambiguity about probable benefits of gastrointestinal bleeding prophylaxis in critically ill children. We proposed that prophylaxis should prescribe in patients with two or more risk factors of gastrointestinal bleeding.", "publicationTitle": "International Journal of Pediatrics", "volume": "4", "issue": "11", "pages": "3917-3924", "date": "January 1, 2016", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "language": "", "DOI": "10.22038/ijp.2016.7315", "ISSN": "", "shortTitle": "", "url": "http://ijp.mums.ac.ir/article_7315.html", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "Publisher: Mashhad University of Medical Sciences", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "W4I8VA3Q", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/W4I8VA3Q", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/W4I8VA3Q", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Bilan and Ganji", "parsedDate": "2014-01-01", "numChildren": 1 }, "data": { "key": "W4I8VA3Q", "version": 175, "itemType": "journalArticle", "title": "Weaning from ventilator and effect of Blender-Humidifier on outcome of it", "creators": [ { "creatorType": "author", "firstName": "Nemat", "lastName": "Bilan" }, { "creatorType": "author", "firstName": "Shalaleh", "lastName": "Ganji" } ], "abstractNote": "Background and objectives: the weaning procedure of mechanical ventilation in many patients is a difficult and long process and increases the time of mechanical ventilation. There are numerous ways to achieve this goal. One common way is using CPAP-ventilator. Considering the lower price of Blender-Humidifier compared to CPAPof ventilator and the limited number of studies in this field, this study was aimed to compare these two procedures.Methods: 102 patients in pediatric Intensive Care Unit (PICU) were allocated randomly in one group: CPAP-ventilator and Blender-Humidifier. Duration of hospital and PICU stay, the number of days of mechanichal ventilation, the frequency of re-intubation, and the mortality of the patients were recorded. Results: the study was conducted on 66 male and 36 female patients (64.7% and 35.3% respectively). The average age was 22.5 ± 4.5 months. The most frequent complaint of the patients at the time of visit was coughing (35%), hyperventilation and respiratory distress (21.6%). Hospital stay was 23±14 and 20±12days in humidifier and cpap groups respectively (p=0/52).PICU stay was 15± 11and 20±11 days in humidifier and cpap groups respectively (p=0/18).Re- intubation rate was 16/2% and 33/5% in humidifier and cpap groups respectively (p=0/15).Mortality rate 8/4% and 21.5% in humidifier and cpap groups respectively (p=0/06). Conclusion: Although there was no statistically significant difference between two groups, considering the differences in mortality rate, the need for re-intubation, rate of hospital and PICU stay, and at the same time, with easy availability and low prices, using Blender- Humidifier is recommended.", "publicationTitle": "International Journal of Pediatrics", "volume": "2", "issue": "4.2", "pages": "39-45", "date": "January 1, 2014", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "language": "", "DOI": "", "ISSN": "", "shortTitle": "", "url": "http://ijp.mums.ac.ir/article_3395_64e49f6ea4f9ea876aeb9b2dc0e23b79.pdf", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "WYLB6YW5", "version": 172, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/WYLB6YW5", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/WYLB6YW5", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/1345589/items/UQDCKSY2", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "WYLB6YW5", "version": 172, "parentItem": "UQDCKSY2", "itemType": "note", "note": "
446_
", "tags": [], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "25MHA7WX", "version": 172, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/25MHA7WX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/25MHA7WX", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/1345589/items/QLD6FGBL", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "25MHA7WX", "version": 172, "parentItem": "QLD6FGBL", "itemType": "note", "note": "447_
", "tags": [], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "QBQINLDW", "version": 172, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/QBQINLDW", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/QBQINLDW", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/1345589/items/I6FDQLNQ", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "QBQINLDW", "version": 172, "parentItem": "I6FDQLNQ", "itemType": "note", "note": "448_
", "tags": [], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "9SWK5VL6", "version": 172, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/9SWK5VL6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/9SWK5VL6", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/1345589/items/W4I8VA3Q", "type": "application/json" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "numChildren": 0 }, "data": { "key": "9SWK5VL6", "version": 172, "parentItem": "W4I8VA3Q", "itemType": "note", "note": "449_
", "tags": [], "relations": {}, "dateAdded": "2020-08-14T18:45:40Z", "dateModified": "2020-08-14T18:45:40Z" } }, { "key": "SKYFLSJR", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/SKYFLSJR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/SKYFLSJR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Salarian et al.", "parsedDate": "2018-01-01", "numChildren": 1 }, "data": { "key": "SKYFLSJR", "version": 175, "itemType": "journalArticle", "title": "Rate of Self-Extubation in Pediatric Intensive Care Unit Following Administration of Fentanyl, Midazolam and Midazolam-Fentanyl Combination: A Comparative Study", "creators": [ { "creatorType": "author", "firstName": "Sara", "lastName": "Salarian" }, { "creatorType": "author", "firstName": "Bahador", "lastName": "Mirrahimi" }, { "creatorType": "author", "firstName": "Bahador", "lastName": "Bagheri" } ], "abstractNote": "Background Self-extubation is a problem in pediatric intensive care unit (PICU) and can be harmful for children. Level of sedation is a determining factor for self-extubation. The aim of this study was to compare thr rate of self-extubation and duration of ventilation following different sedative modalities. Materials and Methods This prospective and randomized study was done in Mofid Children Hospital, Tehran, Iran from October 2015 to September 2016. One hundred and fifty seven children from 1 month to 15 years of age with normal consciousness level requiring mechanical ventilation were included.The rate of self-extubation, and duration of ventilation were compared among 3 groups; Midazolam group (n= 50) 0.1 mg/kg/hr, Fentanyl group (n= 50) 2 mcg/kg/hr., and Midazolam-Fentanyl group (n= 57); midazolam 0.05 mg/kg/hr and fentanyl 1 mcg/kg/hr. All administrations were IV. Optimal level of sedation was 2-3 using Ramsay score. Results: One hundred and fifty seven children were studied. The mean age of patients was 4.5 ± 1.5 years with an excess of boys (57.9% vs. 42.1%). Rate of self-extubation was lower in Midazolam-Fentanyl group; the difference was significant among 3 groups (p < 0.01). There was a significant difference in duration of ventilation in Midazolam- Fentanyl group compared the other groups (Midazolam group and Fentanyl group) (p < 0.001). Conclusion This study showed that combination therapy with Fentanyl + Midazolam was associated with lower rate of self-extubation and shorter duration of ventilation. In addition, this combination therapy seems safe.", "publicationTitle": "International Journal of Pediatrics", "volume": "6", "issue": "1", "pages": "6971-6976", "date": "January 1, 2018", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "language": "", "DOI": "", "ISSN": "", "shortTitle": "", "url": "http://ijp.mums.ac.ir/article_9553_83c30355c458d6a06d239862c8098f23.pdf", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "PFG9J2JJ", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/PFG9J2JJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/PFG9J2JJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Salarian et al.", "parsedDate": "2019-01-01", "numChildren": 1 }, "data": { "key": "PFG9J2JJ", "version": 175, "itemType": "journalArticle", "title": "Impact of Oral Clonidine on Duration of Opioid and Benzodiazepine Use in Mechanically Ventilated Children: A Randomized, Double-Blind, Placebo-Controlled Study.", "creators": [ { "creatorType": "author", "firstName": "Sara", "lastName": "Salarian" }, { "creatorType": "author", "firstName": "Raha", "lastName": "Khosravi" }, { "creatorType": "author", "firstName": "Ghamartaj", "lastName": "Khanbabaei" }, { "creatorType": "author", "firstName": "Bahador", "lastName": "Bagheri" } ], "abstractNote": "Long term use of opioids and benzodiazepines are associated with important untoward effects. The α2 adrenergic agonist clonidine has sedative effects. Our goal was to study clonidine addition to total doses of fentanyl and midazolam and duration of ventilation in pediatric ICU (PICU). This randomized, double-blind, and placebo-controlled trial was conducted in PICU of Mofid Children Hospital. Hundred children aged from 2 to 15 years were randomized in 1:1 ratio to receive 5 μg/kg oral clonidine every 6 h or placebo plus 1-5 µg/kg/hr IV fentanyl and 0.05- 0.1 mg/kg/hr IV midazolam. Daily use of fentanyl and midazolam were measured. Ramsay sedation score was used for evaluation of sedation. A total of 96 patients were studied. The patients in placebo group received more midazolam and fentanyl compared with the patients in intervention group. Mean total dose of midazolam was 4.3 ± 2.2 mg in the placebo group and 2.7 ± 2.9 mg in the intervention group (P<0.05). Mean total dose of fentanyl was 34.4 ± 23.1 µg in the placebo group and 18.9 ± 10 µg in the intervention group (P<0.01). No significant differences were observed in duration of ventilation and length of PICU stay. No case of severe adverse effects was seen. This trial showed a reduction in total doses of midazolam and fentanyl given in ventilated children who were administered clonidine as add-on therapy. Clonidine addition had no effect on duration of mechanical ventilation.", "publicationTitle": "Iranian journal of pharmaceutical research : IJPR", "volume": "18", "issue": "4", "pages": "2157-2162", "date": "January 1, 2019", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Iran J Pharm Res", "language": "", "DOI": "10.22037/ijpr.2019.14862.12705", "ISSN": "", "shortTitle": "", "url": "http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=32184880&retmode=ref&cmd=prlinks", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "PULTU79J", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/PULTU79J", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/PULTU79J", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Fatehi et al.", "parsedDate": "2019-10-01", "numChildren": 1 }, "data": { "key": "PULTU79J", "version": 175, "itemType": "journalArticle", "title": "A Randomized Clinical Trial Evaluating the Efficacy of Colistin Loading Dose in Critically Ill Children.", "creators": [ { "creatorType": "author", "firstName": "Shiva", "lastName": "Fatehi" }, { "creatorType": "author", "firstName": "Hamid", "lastName": "Eshaghi" }, { "creatorType": "author", "firstName": "Meisam", "lastName": "Sharifzadeh" }, { "creatorType": "author", "firstName": "Bahador", "lastName": "Mirrahimi" }, { "creatorType": "author", "firstName": "Mostafa", "lastName": "Qorbani" }, { "creatorType": "author", "firstName": "Parin", "lastName": "Tanzifi" }, { "creatorType": "author", "firstName": "Kheirollah", "lastName": "Gholami" }, { "creatorType": "author", "firstName": "Toktam", "lastName": "Faghihi" } ], "abstractNote": "Objective:Pharmacokinetic and clinical studies recommend applying loading dose of colistin for the treatment of severe infections in the critically ill adults. Pharmacokinetic studies of colistin in children also highlight the need for a loading dose. However, there are no clinical studies evaluating the effectiveness of colistin loading dose in children.\n\nMethods:In a randomized trial, children with ventilator-associated pneumonia or central line-associated bloodstream infection (CLABSI) for whom colistin was initiated, were enrolled. Patients were randomized into two groups; loading dose and conventional dose treatment arms. In the conventional treatment arm, colistimethate sodium was initiated with maintenance dose. In the loading dose group, colistimethate sodium was commenced with a loading dose of 150,000 international unit/kg, then on the maintenance dose. Both treatment arms also received meropenem as combination therapy. Primary outcomes were overall efficacy, clinical improvement and microbiological cure. Secondary outcomes were colistin-induced nephrotoxicity and development of resistance.\n\nFindings:Thirty children completed this study. There was a significantly higher overall efficacy in the group received loading dose (42.9 vs. 6.3%, P = 0.031). There weren't any significant differences in the clinical and microbiological endpoints. In the subgroup of children with CLABSI, results illustrated a trend toward (though statistically nonsignificant) better clinical cure for patients receiving loading dose.\n\nConclusion:This preliminary study suggests that colistin loading dose might have some benefits in critically ill children, specifically in children with CLABSI. Further trials are required to elucidate colistin best dosing strategy in critically ill children with severe infections.", "publicationTitle": "Journal of research in pharmacy practice", "volume": "8", "issue": "4", "pages": "196-201", "date": "October 1, 2019", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J Res Pharm Pract", "language": "", "DOI": "10.4103/jrpp.JRPP_19_68", "ISSN": "", "shortTitle": "", "url": "http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31956632&retmode=ref&cmd=prlinks", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "WB6R3SC7", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/WB6R3SC7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/WB6R3SC7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Bigelow et al.", "parsedDate": "2019-12-01", "numChildren": 1 }, "data": { "key": "WB6R3SC7", "version": 175, "itemType": "journalArticle", "title": "Safety and Efficacy of Vasopressin After Fontan Completion: A Randomized Pilot Study", "creators": [ { "creatorType": "author", "firstName": "Amee M", "lastName": "Bigelow" }, { "creatorType": "author", "firstName": "Nancy S", "lastName": "Ghanayem" }, { "creatorType": "author", "firstName": "Nathan E", "lastName": "Thompson" }, { "creatorType": "author", "firstName": "John P", "lastName": "Scott" }, { "creatorType": "author", "firstName": "Laura D", "lastName": "Cassidy" }, { "creatorType": "author", "firstName": "Katherine J", "lastName": "Woods" }, { "creatorType": "author", "firstName": "Ronald K", "lastName": "Woods" }, { "creatorType": "author", "firstName": "Michael E", "lastName": "Mitchell" }, { "creatorType": "author", "firstName": "Viktor", "lastName": "Hraŝka" }, { "creatorType": "author", "firstName": "George M", "lastName": "Hoffman" } ], "abstractNote": "© 2019 The Society of Thoracic Surgeons Background: Arginine vasopressin is a nonapeptide hormone with effects on intracellular water transport and arterial tone that is used in distributive shock and following cardiopulmonary bypass. We sought to evaluate the safety and efficacy of vasopressin infusion on hemodynamics and fluid balance in the early postoperative period after Fontan completion. Methods: We conducted a randomized, double-blinded, placebo-controlled study of vasopressin infusion for 24 hours after cardiopulmonary bypass for Fontan completion. Patient characteristics, hospital outcomes, and measures of hemodynamic parameters, urine output, chest tube drainage, fluid balance, laboratory data, and plasma arginine vasopressin concentrations were collected at baseline and for 48 postoperative hours. Data were analyzed using mixed-effect regressions. Results: Twenty patients were randomized, 10 to vasopressin and 10 to placebo. Transpulmonary gradient (6.4 ± 0.5 vs 8.3 ± 0.5 mm Hg, P = .011) and chest tube drainage (23 ± 20 vs 40 ± 20 mL/kg, P = .028) for 48 hours after surgery were significantly lower in the vasopressin arm compared to placebo. Arginine vasopressin concentrations were elevated above baseline after surgery until 4 hours post cardiac intensive care unit admission in both arms, and higher in the vasopressin arm during postoperative infusion. No differences in sodium concentration, liver function, or renal function were noted between groups. Conclusions: Vasopressin infusion after Fontan completion appears safe and was associated with reduced transpulmonary gradient and chest tube drainage in the early postoperative period. A larger multiinstitutional study may show further outcome benefit.", "publicationTitle": "Annals of Thoracic Surgery", "volume": "108", "issue": "6", "pages": "1865-1874", "date": "December 1, 2019", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Ann. Thorac. Surg.", "language": "", "DOI": "10.1016/j.athoracsur.2019.06.053", "ISSN": "", "shortTitle": "", "url": "http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31400337&retmode=ref&cmd=prlinks", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "W79MQVRR", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/W79MQVRR", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/W79MQVRR", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Pietroboni et al.", "parsedDate": "2020-03-01", "numChildren": 1 }, "data": { "key": "W79MQVRR", "version": 175, "itemType": "journalArticle", "title": "Landmark versus ultrasound-guided insertion of femoral venous catheters in the pediatric intensive care unit: An efficacy and safety comparison study", "creators": [ { "creatorType": "author", "firstName": "P F", "lastName": "Pietroboni" }, { "creatorType": "author", "firstName": "C M", "lastName": "Carvajal" }, { "creatorType": "author", "firstName": "Y I", "lastName": "Zuleta" }, { "creatorType": "author", "firstName": "P L", "lastName": "Ortiz" }, { "creatorType": "author", "firstName": "Y C", "lastName": "Lucero" }, { "creatorType": "author", "firstName": "M", "lastName": "Drago" }, { "creatorType": "author", "firstName": "B", "lastName": "vonDessauer" } ], "abstractNote": "", "publicationTitle": "Medicina Intensiva", "volume": "44", "issue": "2", "pages": "96-100", "date": "March 1, 2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Medicina Intensiva", "language": "", "DOI": "10.1016/j.medin.2019.07.014", "ISSN": "", "shortTitle": "", "url": "https://linkinghub.elsevier.com/retrieve/pii/S0210569119301986", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "GXRAC9SZ", "version": 175, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/GXRAC9SZ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/GXRAC9SZ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Sankar et al.", "parsedDate": "2020-01-01", "numChildren": 1 }, "data": { "key": "GXRAC9SZ", "version": 175, "itemType": "journalArticle", "title": "‘Intermittent’ versus ‘continuous’ ScvO2 monitoring in children with septic shock: a randomised, non-inferiority trial", "creators": [ { "creatorType": "author", "firstName": "Jhuma", "lastName": "Sankar" }, { "creatorType": "author", "firstName": "Man", "lastName": "Singh" }, { "creatorType": "author", "firstName": "Kiran", "lastName": "Kumar" }, { "creatorType": "author", "firstName": "M Jeeva", "lastName": "Sankar" }, { "creatorType": "author", "firstName": "Sushil Kumar", "lastName": "Kabra" }, { "creatorType": "author", "firstName": "Rakesh", "lastName": "Lodha" } ], "abstractNote": "© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Purpose: To compare the effect of ‘intermittent’ central venous oxygen saturation (ScvO2) monitoring with ‘continuous’ ScvO2 monitoring on shock resolution and mortality in children with septic shock. Methods: Primary outcome was the achievement of therapeutic goals or shock resolution in the first 6 h. We randomly assigned children", "publicationTitle": "Intensive Care Medicine", "volume": "46", "issue": "1", "pages": "82-92", "date": "January 1, 2020", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Intensive Care Med", "language": "", "DOI": "10.1007/s00134-019-05858-w", "ISSN": "", "shortTitle": "", "url": "http://link.springer.com/10.1007/s00134-019-05858-w", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "Publisher: Springer-Verlag", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } }, { "key": "68QNBEDT", "version": 174, "library": { "type": "group", "id": 1345589, "name": "PICUtrials", "links": { "alternate": { "href": "https://www.zotero.org/groups/picutrials", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/1345589/items/68QNBEDT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/picutrials/items/68QNBEDT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 4014192, "username": "Mark Duffett", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/mark_duffett", "type": "text/html" } } }, "creatorSummary": "Ingelse et al.", "parsedDate": "2019-01-01", "numChildren": 1 }, "data": { "key": "68QNBEDT", "version": 174, "itemType": "journalArticle", "title": "Less Is More?-A Feasibility Study of Fluid Strategy in Critically Ill Children With Acute Respiratory Tract Infection.", "creators": [ { "creatorType": "author", "firstName": "Sarah A", "lastName": "Ingelse" }, { "creatorType": "author", "firstName": "Vincent G", "lastName": "Geukers" }, { "creatorType": "author", "firstName": "Monique E", "lastName": "Dijsselhof" }, { "creatorType": "author", "firstName": "Joris", "lastName": "Lemson" }, { "creatorType": "author", "firstName": "Reinout A", "lastName": "Bem" }, { "creatorType": "author", "firstName": "Job B", "lastName": "van Woensel" } ], "abstractNote": "Background: Fluid overload is common in critically ill children and is associated with adverse outcome. Therefore, restricting fluid intake may be beneficial. This study aims to study the feasibility of a randomized controlled trial (RCT) comparing a conservative to a standard, more liberal, strategy of fluid management in mechanically ventilated pediatric patients with acute respiratory tract infection (ARTI). Methods: This is a feasibility study in a single, tertiary referral pediatric intensive care unit (PICU). Twenty-three children receiving mechanical ventilation for ARTI, without ongoing hemodynamic support, admitted to the PICU of the Emma Children's Hospital/Amsterdam UMC between 2016 and 2018 were included. Patients were randomized to a conservative (<70% of normal intake) or standard (>85% of normal intake) fluid strategy, which was kept throughout the period of mechanical ventilation. Results: Primary endpoints were adherence to fluid strategy and safety parameters such as calorie and protein intake. Secondary outcomes were cumulative fluid intake (CFI) and cumulative fluid balance (CFB) on day 3. In the conservative group, in 75% of the mechanical ventilation days patients achieved their target fluid intake. Median [25th-75th percentiles] calorie intake over all mechanical ventilation days was 67.9 [51.5-74.0] kcal/kg/day in the conservative vs. 67.2 [58.0-75.2] kcal/kg/day in the standard group (p = 0.878). Protein intake was 1.6 [1.3-1.8] gr protein/kg in the conservative and 1.5 [1.2-1.7] gr protein/kg in the standard group (p = 0.598). No adverse effects on hemodynamics or electrolyte imbalances were noted. Mean (±SD) CFI on day 3 was 262.3 (±58.9) ml/kg in the conservative group vs. 360.5 (±52.6) ml/kg in the standard fluid group (p < 0.001), which did not result in a lower CFB. Conclusions: A conservative fluid strategy in mechanically ventilated children with ARTI seems feasible, without limiting metabolic needs. However, in our study a conservative fluid strategy surprisingly did not reduce the degree of fluid overload. This study aids the design and sample size calculation of a future larger multicenter RCT, in which we need to redefine the target fluid strategy, possibly by even further fluid restriction and early initiation of active diuresis. Clinical Trial Registration: ClinicalTrials.gov, identifier: NCT02989051.", "publicationTitle": "Frontiers in pediatrics", "volume": "7", "issue": "", "pages": "496", "date": "January 1, 2019", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Front Pediatr", "language": "", "DOI": "10.3389/fped.2019.00496", "ISSN": "", "shortTitle": "", "url": "http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=31921715&retmode=ref&cmd=prlinks", "accessDate": "", "archive": "", "archiveLocation": "", "libraryCatalog": "", "callNumber": "", "rights": "", "extra": "", "tags": [], "collections": [ "RV77PV9V" ], "relations": {}, "dateAdded": "2020-08-14T18:45:39Z", "dateModified": "2020-08-14T18:45:39Z" } } ]