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"Janine", "lastName": "Heutschi" }, { "creatorType": "author", "firstName": "Quentin", "lastName": "Barraud" }, { "creatorType": "author", "firstName": "Jack", "lastName": "DiGiovanna" }, { "creatorType": "author", "firstName": "Kay", "lastName": "Bartholdi" }, { "creatorType": "author", "firstName": "Michèle", "lastName": "Huerlimann" }, { "creatorType": "author", "firstName": "Lucia", "lastName": "Friedli" }, { "creatorType": "author", "firstName": "Isabel", "lastName": "Vollenweider" }, { "creatorType": "author", "firstName": "Eduardo Martin", "lastName": "Moraud" }, { "creatorType": "author", "firstName": "Simone", "lastName": "Duis" }, { "creatorType": "author", "firstName": "Nadia", "lastName": "Dominici" }, { "creatorType": "author", "firstName": "Silvestro", "lastName": "Micera" }, { "creatorType": "author", "firstName": "Pavel", "lastName": "Musienko" }, { "creatorType": "author", "firstName": "Grégoire", "lastName": "Courtine" } ], "abstractNote": "Half of human spinal cord 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Here, we introduce an electrochemical neuroprosthesis and a robotic postural interface designed to encourage supraspinally mediated movements in rats with paralyzing lesions. Despite the interruption of direct supraspinal pathways, the cortex regained the capacity to transform contextual information into task-specific commands to execute refined locomotion. This recovery relied on the extensive remodeling of cortical projections, including the formation of brainstem and intraspinal relays that restored qualitative control over electrochemically enabled lumbosacral circuitries. Automated treadmill-restricted training, which did not engage cortical neurons, failed to promote translesional plasticity and recovery. 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Each year, traumatic brain injuries contribute to a substantial number of deaths and cases of permanent disability. Recent data shows that, on average, approximately 1.7 million people sustain a traumatic brain injury annually.", "websiteTitle": "", "websiteType": "", "date": "", "publisher": "", "place": "", "DOI": "", "citationKey": "", "url": "http://www.cdc.gov/traumaticbraininjury/scifacts.html", "accessDate": "2012-12-04T20:19:23Z", "shortTitle": "CDC - Spinal Cord Injury (SCI)", "language": "eng", "rights": "", "extra": "", "tags": [ { "tag": "CDC", "type": 1 }, { "tag": "Injury Center", "type": 1 }, { "tag": "National Center for Injury Prevention and Control", "type": 1 }, { "tag": "TBI", "type": 1 }, { "tag": "brain injury", "type": 1 }, { "tag": "concussion", "type": 1 }, { "tag": "head injury", "type": 1 }, { "tag": "injury", "type": 1 }, { "tag": "traumatic brain injury", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2012-12-05T04:29:52Z", "dateModified": "2012-12-05T04:29:52Z" } } ]