[ { "key": "23IBE7P6", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/23IBE7P6", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/23IBE7P6", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Witten et al.", "parsedDate": "2011-12-08", "numChildren": 1 }, "data": { "key": "23IBE7P6", "version": 7149, "itemType": "journalArticle", "title": "Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement", "creators": [ { "creatorType": "author", "firstName": "Ilana B.", "lastName": "Witten" }, { "creatorType": "author", "firstName": "Elizabeth E.", "lastName": "Steinberg" }, { "creatorType": "author", "firstName": "Soo Yeun", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Thomas J.", "lastName": "Davidson" }, { "creatorType": "author", "firstName": "Kelly A.", "lastName": "Zalocusky" }, { "creatorType": "author", "firstName": "Matthew", "lastName": "Brodsky" }, { "creatorType": "author", "firstName": "Ofer", "lastName": "Yizhar" }, { "creatorType": "author", "firstName": "Saemi L.", "lastName": "Cho" }, { "creatorType": "author", "firstName": "Shiaoching", "lastName": "Gong" }, { "creatorType": "author", "firstName": "Charu", "lastName": "Ramakrishnan" }, { "creatorType": "author", "firstName": "Garret D.", "lastName": "Stuber" }, { "creatorType": "author", "firstName": "Kay M.", "lastName": "Tye" }, { "creatorType": "author", "firstName": "Patricia H.", "lastName": "Janak" }, { "creatorType": "author", "firstName": "Karl", "lastName": "Deisseroth" } ], "abstractNote": "Currently there is no general approach for achieving specific optogenetic control of genetically defined cell types in rats, which provide a powerful experimental system for numerous established neurophysiological and behavioral paradigms. To overcome this challenge we have generated genetically restricted recombinase-driver rat lines suitable for driving gene expression in specific cell types, expressing Cre recombinase under the control of large genomic regulatory regions (200-300 kb). Multiple tyrosine hydroxylase (Th)::Cre and choline acetyltransferase (Chat)::Cre lines were produced that exhibited specific opsin expression in targeted cell types. We additionally developed methods for utilizing optogenetic tools in freely moving rats and leveraged these technologies to clarify the causal relationship between dopamine (DA) neuron firing and positive reinforcement, observing that optical stimulation of DA neurons in the ventral tegmental area (VTA) of Th::Cre rats is sufficient to support vigorous intracranial self-stimulation (ICSS). These studies complement existing targeting approaches by extending the generalizability of optogenetics to traditionally non-genetically-tractable but vital animal models.", "publicationTitle": "Neuron", "publisher": "", "place": "", "date": "Dec 8, 2011", "volume": "72", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "721-733", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Neuron", "DOI": "10.1016/j.neuron.2011.10.028", "citationKey": "", "url": "", "accessDate": "", "PMID": "22153370", "PMCID": "PMC3282061", "ISSN": "1097-4199", "archive": "", "archiveLocation": "", "shortTitle": "Recombinase-driver rat lines", "language": "eng", "libraryCatalog": "NCBI PubMed", "callNumber": "", "rights": "", "extra": "00180", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Choline O-Acetyltransferase", "type": 1 }, { "tag": "Conditioning, Operant", "type": 1 }, { "tag": "Dopamine", "type": 1 }, { "tag": "Gene Expression Regulation", "type": 1 }, { "tag": "In Vitro Techniques", "type": 1 }, { "tag": "Integrases", "type": 1 }, { "tag": "Male", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Opsins", "type": 1 }, { "tag": "Optics and Photonics", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Rats, Transgenic", "type": 1 }, { "tag": "Reinforcement (Psychology)", "type": 1 }, { "tag": "Reinforcement Schedule", "type": 1 }, { "tag": "Self Stimulation", "type": 1 }, { "tag": "Transduction, Genetic", "type": 1 }, { "tag": "Tyrosine 3-Monooxygenase", "type": 1 }, { "tag": "Ventral Tegmental Area", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2015-01-29T03:11:22Z", "dateModified": "2015-09-13T14:36:53Z" } }, { "key": "MCA3PR83", "version": 7132, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/MCA3PR83", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/MCA3PR83", "type": "text/html" }, "up": { "href": "https://api.zotero.org/groups/10943/items/23IBE7P6", "type": "application/json" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } } }, "data": { "key": "MCA3PR83", "version": 7132, "parentItem": "23IBE7P6", "itemType": "attachment", "linkMode": "linked_url", "title": "PubMed entry", "accessDate": "2015-01-29T03:11:22Z", "url": "http://www.ncbi.nlm.nih.gov/pubmed/22153370", "note": "", "contentType": "text/html", "charset": "", "tags": [], "relations": {}, "dateAdded": "2015-01-29T03:11:22Z", "dateModified": "2015-01-29T03:11:22Z" } }, { "key": "ZNWGZ2W8", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/ZNWGZ2W8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/ZNWGZ2W8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Gunaydin et al.", "parsedDate": "2010-01-17", "numChildren": 0 }, "data": { "key": "ZNWGZ2W8", "version": 7149, "itemType": "journalArticle", "title": "Ultrafast optogenetic control", "creators": [ { "creatorType": "author", "firstName": "Lisa A", "lastName": "Gunaydin" }, { "creatorType": "author", "firstName": "Ofer", "lastName": "Yizhar" }, { "creatorType": "author", "firstName": "André", "lastName": "Berndt" }, { "creatorType": "author", "firstName": "Vikaas S", "lastName": "Sohal" }, { "creatorType": "author", "firstName": "Karl", "lastName": "Deisseroth" }, { "creatorType": "author", "firstName": "Peter", "lastName": "Hegemann" } ], "abstractNote": "Channelrhodopsins such as channelrhodopsin-2 (ChR2) can drive spiking with millisecond precision in a wide variety of cells, tissues and animal species. However, several properties of this protein have limited the precision of optogenetic control. First, when ChR2 is expressed at high levels, extra spikes (for example, doublets) can occur in response to a single light pulse, with potential implications as doublets may be important for neural coding. Second, many cells cannot follow ChR2-driven spiking above the gamma ( approximately 40 Hz) range in sustained trains, preventing temporally stationary optogenetic access to a broad and important neural signaling band. Finally, rapid optically driven spike trains can result in plateau potentials of 10 mV or more, causing incidental upstates with information-processing implications. We designed and validated an engineered opsin gene (ChETA) that addresses all of these limitations (profoundly reducing extra spikes, eliminating plateau potentials and allowing temporally stationary, sustained spike trains up to at least 200 Hz).", "publicationTitle": "Nature Neuroscience", "publisher": "", "place": "", "date": "Jan 17, 2010", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Neurosci", "DOI": "10.1038/nn.2495", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20081849", "accessDate": "", "PMID": "20081849", "PMCID": "", "ISSN": "1546-1726", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00278", "tags": [], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T19:28:10Z", "dateModified": "2015-01-03T15:19:35Z" } }, { "key": "ZMGI4EKC", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/ZMGI4EKC", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/ZMGI4EKC", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Huang et al.", "parsedDate": "1998-03", "numChildren": 2 }, "data": { "key": "ZMGI4EKC", "version": 7130, "itemType": "journalArticle", "title": "The empirical mode decomposition and the Hilbert spectrum for nonlinear and non-stationary time series analysis", "creators": [ { "creatorType": "author", "firstName": "NE", "lastName": "Huang" }, { "creatorType": "author", "firstName": "Z", "lastName": "Shen" }, { "creatorType": "author", "firstName": "SR", "lastName": "Long" }, { "creatorType": "author", "firstName": "MC", "lastName": "Wu" }, { "creatorType": "author", "firstName": "HH", "lastName": "Shih" }, { "creatorType": "author", "firstName": "Q", "lastName": "Zheng" }, { "creatorType": "author", "firstName": "NC", "lastName": "Yen" }, { "creatorType": "author", "firstName": "CC", "lastName": "Tung" }, { "creatorType": "author", "firstName": "HH", "lastName": "Liu" } ], "abstractNote": "A new method for analysing nonlinear and non-stationary data has been developed. The key part of the method is the `empirical mode decomposition' method with which any complicated data set can be decomposed into a finite and often small number of `intrinsic mode functions' that admit well-behaved Hilbert transforms. This decomposition method is adaptive, and, therefore, highly efficient. Since the decomposition is based on the local characteristic time scale of the data, it is applicable to nonlinear and non-stationary processes. With the Hilbert transform, the `instrinic mode functions' yield instantaneous frequencies as functions of time that give sharp identifications of imbedded structures. The final presentation of the results is an energy-frequency-time distribution, designated as the Hilbert spectrum. In this method, the main conceptual innovations are the introduction of `intrinsic mode functions' based on local properties of the signal, which make the instantaneous frequency meaningful; and the introduction of the instantaneous frequencies for complicated data sets, which eliminate the need for spurious harmonics to represent nonlinear and non-stationary signals. Examples from the numerical results of the classical nonlinear equation systems and data representing natural phenomena are given to demonstrate the power of this new method. Classical nonlinear system data are especially interesting, for they serve to illustrate the roles played by the nonlinear and non-stationary effects in the energy-frequency-time distribution.", "publicationTitle": "Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences", "publisher": "", "place": "", "date": "March 1998", "volume": "454", "issue": "1971", "section": "", "partNumber": "", "partTitle": "", "pages": "995, 903", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://dx.doi.org/10.1098/rspa.1998.0193", "accessDate": "2009-12-21T19:49:55Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CiteULike", "callNumber": "0000", "rights": "", "extra": "00248", "tags": [], "collections": [ "ERXSA5RT" ], "relations": { "owl:sameAs": "http://zotero.org/groups/6130/items/V6R3Q46J" }, "dateAdded": "2010-03-01T20:18:41Z", "dateModified": "2015-01-03T15:19:34Z" } }, { "key": "XTFETJW8", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/XTFETJW8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/XTFETJW8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 123987, "username": "BurgessCorp", "name": "Chris Burgess", "links": { "alternate": { "href": "https://www.zotero.org/burgesscorp", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Remme et al.", "parsedDate": "2009-09", "numChildren": 1 }, "data": { "key": "XTFETJW8", "version": 7149, "itemType": "journalArticle", "title": "The role of ongoing dendritic oscillations in single-neuron dynamics", "creators": [ { "creatorType": "author", "firstName": "Michiel W H", "lastName": "Remme" }, { "creatorType": "author", "firstName": "Máté", "lastName": "Lengyel" }, { "creatorType": "author", "firstName": "Boris S", "lastName": "Gutkin" } ], "abstractNote": "The dendritic tree contributes significantly to the elementary computations a neuron performs while converting its synaptic inputs into action potential output. Traditionally, these computations have been characterized as both temporally and spatially localized. Under this localist account, neurons compute near-instantaneous mappings from their current input to their current output, brought about by somatic summation of dendritic contributions that are generated in functionally segregated compartments. However, recent evidence about the presence of oscillations in dendrites suggests a qualitatively different mode of operation: the instantaneous phase of such oscillations can depend on a long history of inputs, and under appropriate conditions, even dendritic oscillators that are remote may interact through synchronization. Here, we develop a mathematical framework to analyze the interactions of local dendritic oscillations and the way these interactions influence single cell computations. Combining weakly coupled oscillator methods with cable theoretic arguments, we derive phase-locking states for multiple oscillating dendritic compartments. We characterize how the phase-locking properties depend on key parameters of the oscillating dendrite: the electrotonic properties of the (active) dendritic segment, and the intrinsic properties of the dendritic oscillators. As a direct consequence, we show how input to the dendrites can modulate phase-locking behavior and hence global dendritic coherence. In turn, dendritic coherence is able to gate the integration and propagation of synaptic signals to the soma, ultimately leading to an effective control of somatic spike generation. Our results suggest that dendritic oscillations enable the dendritic tree to operate on more global temporal and spatial scales than previously thought; notably that local dendritic activity may be a mechanism for generating on-going whole-cell voltage oscillations.", "publicationTitle": "PLoS Computational Biology", "publisher": "", "place": "", "date": "Sep 2009", "volume": "5", "issue": "9", "section": "", "partNumber": "", "partTitle": "", "pages": "e1000493", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "PLoS Comput. Biol", "DOI": "10.1371/journal.pcbi.1000493", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19730677", "accessDate": "2010-02-12T14:45:48Z", "PMID": "19730677", "PMCID": "", "ISSN": "1553-7358", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "0000", "rights": "", "extra": "00036", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Algorithms", "type": 1 }, { "tag": "Dendrites", "type": 1 }, { "tag": "Models, Neurological", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Synapses", "type": 1 }, { "tag": "Systems Biology", "type": 1 } ], "collections": [], "relations": {}, "dateAdded": "2010-02-12T15:26:50Z", "dateModified": "2015-01-03T15:19:33Z" } }, { "key": "XR5GHW3Q", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/XR5GHW3Q", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/XR5GHW3Q", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Grubb and Burrone", "parsedDate": "2010-06-24", "numChildren": 2 }, "data": { "key": "XR5GHW3Q", "version": 7130, "itemType": "journalArticle", "title": "Activity-dependent relocation of the axon initial segment fine-tunes neuronal excitability", "creators": [ { "creatorType": "author", "firstName": "Matthew S.", "lastName": "Grubb" }, { "creatorType": "author", "firstName": "Juan", "lastName": "Burrone" } ], "abstractNote": "", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "June 24, 2010", "volume": "465", "issue": "7301", "section": "", "partNumber": "", "partTitle": "", "pages": "1070-1074", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature09160", "citationKey": "", "url": "http://dx.doi.org/10.1038/nature09160", "accessDate": "2010-07-13T23:32:42Z", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "Nature", "callNumber": "", "rights": "", "extra": "00153", "tags": [], "collections": [ "5U2VQBF7" ], "relations": { "owl:sameAs": "http://zotero.org/groups/6130/items/PR8HGTZP" }, "dateAdded": "2010-07-19T10:49:41Z", "dateModified": "2015-01-03T15:19:32Z" } }, { "key": "XM7MCGTH", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/XM7MCGTH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/XM7MCGTH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Chelaru and Jog", "parsedDate": "2005", "numChildren": 0 }, "data": { "key": "XM7MCGTH", "version": 7130, "itemType": "journalArticle", "title": "Spike source localization with tetrodes", "creators": [ { "creatorType": "author", "firstName": "M", "lastName": "Chelaru" }, { "creatorType": "author", "firstName": "M", "lastName": "Jog" } ], "abstractNote": "", "publicationTitle": "Journal of Neuroscience Methods", "publisher": "", "place": "", "date": "03/2005", "volume": "142", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "305-315", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Neuroscience Methods", "DOI": "10.1016/j.jneumeth.2004.09.004", "citationKey": "", "url": "http://linkinghub.elsevier.com/retrieve/pii/S0165027004003280", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "01650270", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00023", "tags": [], "collections": [ "PDAMKGC4" ], "relations": {}, "dateAdded": "2010-03-15T14:09:18Z", "dateModified": "2015-01-03T15:19:31Z" } }, { "key": "XHWDD9AJ", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/XHWDD9AJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/XHWDD9AJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Wilms and Häusser", "parsedDate": "2009-12", "numChildren": 1 }, "data": { "key": "XHWDD9AJ", "version": 7149, "itemType": "journalArticle", "title": "Lighting up neural networks using a new generation of genetically encoded calcium sensors", "creators": [ { "creatorType": "author", "firstName": "Christian D", "lastName": "Wilms" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Häusser" } ], "abstractNote": "Two improved genetically encoded calcium indicators-based on structure-guided sensor design or on precise subcellular targeting to presynaptic boutons-allow single spikes to be detected in genetically defined populations of neurons and synapses in vivo.", "publicationTitle": "Nature Methods", "publisher": "", "place": "", "date": "Dec 2009", "volume": "6", "issue": "12", "section": "", "partNumber": "", "partTitle": "", "pages": "871-872", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat. Methods", "DOI": "10.1038/nmeth1209-871", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19935839", "accessDate": "", "PMID": "19935839", "PMCID": "", "ISSN": "1548-7105", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00007", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Calcium", "type": 1 }, { "tag": "Mice", "type": 1 }, { "tag": "Nerve Net", "type": 1 }, { "tag": "Subcellular Fractions", "type": 1 } ], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T19:21:20Z", "dateModified": "2015-01-03T15:19:30Z" } }, { "key": "W6UT8THT", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/W6UT8THT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/W6UT8THT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Du et al.", "parsedDate": "2008", "numChildren": 1 }, "data": { "key": "W6UT8THT", "version": 7130, "itemType": "journalArticle", "title": "High-Resolution Three-Dimensional Extracellular Recording of Neuronal Activity With Microfabricated Electrode Arrays", "creators": [ { "creatorType": "author", "firstName": "J.", "lastName": "Du" }, { "creatorType": "author", "firstName": "I. H.", "lastName": "Riedel-Kruse" }, { "creatorType": "author", "firstName": "J. C.", "lastName": "Nawroth" }, { "creatorType": "author", "firstName": "M. L.", "lastName": "Roukes" }, { "creatorType": "author", "firstName": "G.", "lastName": "Laurent" }, { "creatorType": "author", "firstName": "S. C.", "lastName": "Masmanidis" } ], "abstractNote": "", "publicationTitle": "Journal of Neurophysiology", "publisher": "", "place": "", "date": "12/2008", "volume": "101", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "1671-1678", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Neurophysiology", "DOI": "10.1152/jn.90992.2008", "citationKey": "", "url": "http://jn.physiology.org/cgi/doi/10.1152/jn.90992.2008", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-3077", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00000", "tags": [], "collections": [ "PDAMKGC4" ], "relations": {}, "dateAdded": "2010-03-15T13:57:20Z", "dateModified": "2015-01-03T15:19:29Z" } }, { "key": "V7B5AJBX", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/V7B5AJBX", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/V7B5AJBX", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Walker et al.", "parsedDate": "2010", "numChildren": 1 }, "data": { "key": "V7B5AJBX", "version": 7130, "itemType": "journalArticle", "title": "A 'sustain pedal' in the hippocampus?", "creators": [ { "creatorType": "author", "firstName": "Matthew C", "lastName": "Walker" }, { "creatorType": "author", "firstName": "Ivan", "lastName": "Pavlov" }, { "creatorType": "author", "firstName": "Dimitri M", "lastName": "Kullmann" } ], "abstractNote": "", "publicationTitle": "Nature Neuroscience", "publisher": "", "place": "", "date": "2/2010", "volume": "13", "issue": "2", "section": "", "partNumber": "", "partTitle": "", "pages": "146-148", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nat Neurosci", "DOI": "10.1038/nn0210-146", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/nn0210-146", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "1097-6256", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00002", "tags": [], "collections": [ "MVVKJDZN" ], "relations": { "dc:relation": "http://zotero.org/groups/10943/items/98P5M6CQ" }, "dateAdded": "2010-02-01T19:26:37Z", "dateModified": "2015-01-03T15:19:28Z" } }, { "key": "V3M2DKPA", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/V3M2DKPA", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/V3M2DKPA", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Tort et al.", "parsedDate": "2008-12-23", "numChildren": 3 }, "data": { "key": "V3M2DKPA", "version": 7149, "itemType": "journalArticle", "title": "Dynamic cross-frequency couplings of local field potential oscillations in rat striatum and hippocampus during performance of a T-maze task", "creators": [ { "creatorType": "author", "firstName": "Adriano B L", "lastName": "Tort" }, { "creatorType": "author", "firstName": "Mark A", "lastName": "Kramer" }, { "creatorType": "author", "firstName": "Catherine", "lastName": "Thorn" }, { "creatorType": "author", "firstName": "Daniel J", "lastName": "Gibson" }, { "creatorType": "author", "firstName": "Yasuo", "lastName": "Kubota" }, { "creatorType": "author", "firstName": "Ann M", "lastName": "Graybiel" }, { "creatorType": "author", "firstName": "Nancy J", "lastName": "Kopell" } ], "abstractNote": "Oscillatory rhythms in different frequency ranges mark different behavioral states and are thought to provide distinct temporal windows that coherently bind cooperating neuronal assemblies. However, the rhythms in different bands can also interact with each other, suggesting the possibility of higher-order representations of brain states by such rhythmic activity. To explore this possibility, we analyzed local field potential oscillations recorded simultaneously from the striatum and the hippocampus. As rats performed a task requiring active navigation and decision making, the amplitudes of multiple high-frequency oscillations were dynamically modulated in task-dependent patterns by the phase of cooccurring theta-band oscillations both within and across these structures, particularly during decision-making behavioral epochs. Moreover, the modulation patterns uncovered distinctions among both high- and low-frequency subbands. Cross-frequency coupling of multiple neuronal rhythms could be a general mechanism used by the brain to perform network-level dynamical computations underlying voluntary behavior.", "publicationTitle": "Proceedings of the National Academy of Sciences of the United States of America", "publisher": "", "place": "", "date": "Dec 23, 2008", "volume": "105", "issue": "51", "section": "", "partNumber": "", "partTitle": "", "pages": "20517-20522", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Proc. Natl. Acad. Sci. U.S.A", "DOI": "10.1073/pnas.0810524105", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19074268", "accessDate": "2010-01-15T14:23:06Z", "PMID": "19074268", "PMCID": "", "ISSN": "1091-6490", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "NCBI PubMed", "callNumber": "0000", "rights": "", "extra": "00183", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Behavior, Animal", "type": 1 }, { "tag": "Biological Clocks", "type": 1 }, { "tag": "Corpus Striatum", "type": 1 }, { "tag": "Decision Making", "type": 1 }, { "tag": "Electroencephalography", "type": 1 }, { "tag": "Hippocampus", "type": 1 }, { "tag": "Maze Learning", "type": 1 }, { "tag": "Mental Processes", "type": 1 }, { "tag": "Neural Pathways", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "dylan" } ], "collections": [ "A4PUMEID", "ERXSA5RT", "QM4CW3Z6", "T5PUDEVW" ], "relations": { "owl:sameAs": "http://zotero.org/groups/6130/items/25QEKAAE" }, "dateAdded": "2010-02-09T16:59:41Z", "dateModified": "2015-01-03T15:19:27Z" } }, { "key": "UQTR76KP", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/UQTR76KP", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/UQTR76KP", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Doeller et al.", "parsedDate": "2010", "numChildren": 0 }, "data": { "key": "UQTR76KP", "version": 7130, "itemType": "journalArticle", "title": "Evidence for grid cells in a human memory network", "creators": [ { "creatorType": "author", "firstName": "Christian F.", "lastName": "Doeller" }, { "creatorType": "author", "firstName": "Caswell", "lastName": "Barry" }, { "creatorType": "author", "firstName": "Neil", "lastName": "Burgess" } ], "abstractNote": "", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "1/2010", "volume": "", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature08704", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/nature08704", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00156", "tags": [], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T19:25:24Z", "dateModified": "2015-01-03T15:19:26Z" } }, { "key": "U58P2RIJ", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/U58P2RIJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/U58P2RIJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Grill et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "U58P2RIJ", "version": 7149, "itemType": "journalArticle", "title": "Implanted neural interfaces: biochallenges and engineered solutions", "creators": [ { "creatorType": "author", "firstName": "Warren M", "lastName": "Grill" }, { "creatorType": "author", "firstName": "Sharon E", "lastName": "Norman" }, { "creatorType": "author", "firstName": "Ravi V", "lastName": "Bellamkonda" } ], "abstractNote": "Neural interfaces are connections that enable two-way exchange of information with the nervous system. These connections can occur at multiple levels, including with peripheral nerves, with the spinal cord, or with the brain; in many instances, fundamental biophysical and biological challenges are shared across these levels. We review these challenges, including selectivity, stability, resolution versus invasiveness, implant-induced injury, and the host-interface response. Subsequently, we review the engineered solutions to these challenges, including electrode designs and geometry, stimulation waveforms, materials, and surface modifications. Finally, we consider emerging opportunities to improve neural interfaces, including cellular-level silicon to neuron connections, optical stimulation, and approaches to control inflammation. Overcoming the biophysical and biological challenges will enable effective high-density neural interfaces for stimulation and recording.", "publicationTitle": "Annual Review of Biomedical Engineering", "publisher": "", "place": "", "date": "2009", "volume": "11", "issue": "", "section": "", "partNumber": "", "partTitle": "", "pages": "1-24", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Annu Rev Biomed Eng", "DOI": "10.1146/annurev-bioeng-061008-124927", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19400710", "accessDate": "", "PMID": "19400710", "PMCID": "", "ISSN": "1545-4274", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00112", "tags": [ { "tag": "Animals", "type": 1 }, { "tag": "Biophysics", "type": 1 }, { "tag": "Electric Stimulation", "type": 1 }, { "tag": "Electrodes, Implanted", "type": 1 }, { "tag": "Ganglia, Spinal", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Inflammation", "type": 1 }, { "tag": "Models, Biological", "type": 1 }, { "tag": "Models, Neurological", "type": 1 }, { "tag": "Nerve Net", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Optics and Photonics", "type": 1 }, { "tag": "Peripheral Nervous System", "type": 1 } ], "collections": [ "8UTZCTTX" ], "relations": {}, "dateAdded": "2010-02-01T19:33:49Z", "dateModified": "2015-01-03T15:19:25Z" } }, { "key": "TTBKDUZT", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/TTBKDUZT", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/TTBKDUZT", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Gold", "parsedDate": "2006", "numChildren": 1 }, "data": { "key": "TTBKDUZT", "version": 7130, "itemType": "journalArticle", "title": "On the Origin of the Extracellular Action Potential Waveform: A Modeling Study", "creators": [ { "creatorType": "author", "firstName": "C.", "lastName": "Gold" } ], "abstractNote": "", "publicationTitle": "Journal of Neurophysiology", "publisher": "", "place": "", "date": "01/2006", "volume": "95", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "3113-3128", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Neurophysiology", "DOI": "10.1152/jn.00979.2005", "citationKey": "", "url": "http://jn.physiology.org/cgi/doi/10.1152/jn.00979.2005", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0022-3077", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00232", "tags": [ { "tag": "mic" } ], "collections": [ "A4PUMEID", "PDAMKGC4" ], "relations": {}, "dateAdded": "2010-03-15T14:14:56Z", "dateModified": "2015-01-03T15:19:24Z" } }, { "key": "T6HCGMJ9", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/T6HCGMJ9", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/T6HCGMJ9", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Paralikar et al.", "parsedDate": "2009-06-30", "numChildren": 0 }, "data": { "key": "T6HCGMJ9", "version": 7149, "itemType": "journalArticle", "title": "New approaches to eliminating common-noise artifacts in recordings from intracortical microelectrode arrays: inter-electrode correlation and virtual referencing", "creators": [ { "creatorType": "author", "firstName": "Kunal J", "lastName": "Paralikar" }, { "creatorType": "author", "firstName": "Chinmay R", "lastName": "Rao" }, { "creatorType": "author", "firstName": "Ryan S", "lastName": "Clement" } ], "abstractNote": "Intracortical microelectrode arrays record multi-unit extracellular activity for neurophysiology studies and for brain-machine interface applications. The common first step is neural spike-detection; a process complicated by common-noise signals from motion artifacts, electromyographic activity, and electric field pickup, especially in awake/behaving subjects. Often common-noise spikes are very similar to neural spikes in their magnitude, spectral, and temporal features. Provided sufficient spacing exists between electrodes of the array, a local neural spike is rarely recorded on multiple electrodes simultaneously. This is not true for distant common-noise sources. Two new techniques compatible with standard spike-detection schemes are introduced and evaluated. The first method, virtual referencing (VR), takes the average recording from all functional electrodes in the array (represents the signal from a virtual-electrode at the array's center) and subtracts it from the test electrode signal. The second method, inter-electrode correlation (IEC), computes a correlation coefficient between threshold exceeding candidate spike segments on the test electrode and concurrent segments from remaining electrodes. When sufficient correlation is detected, the candidate spike is rejected as originating from a distant common-noise source. The performance of these algorithms was compared with standard thresholding and differential referencing approaches using neural recordings from un-anaesthetized rats. By evaluating characteristics of mean-spike waveforms generated by each method under different levels of common-noise, it was found that IEC consistently offered the most robust means of neural spike-detection. Furthermore, IEC's rejection of supra-threshold events not likely originating from local neurons significantly reduces data handling for downstream spike sorting and processing operations.", "publicationTitle": "Journal of Neuroscience Methods", "publisher": "", "place": "", "date": "Jun 30, 2009", "volume": "181", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "27-35", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurosci. Methods", "DOI": "10.1016/j.jneumeth.2009.04.014", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19394363", "accessDate": "", "PMID": "19394363", "PMCID": "", "ISSN": "1872-678X", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00006", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Artifacts", "type": 1 }, { "tag": "Cerebral Cortex", "type": 1 }, { "tag": "Microelectrodes", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Rats", "type": 1 }, { "tag": "Reference Values", "type": 1 }, { "tag": "Reproducibility of Results", "type": 1 }, { "tag": "Signal Processing, Computer-Assisted", "type": 1 }, { "tag": "Statistics as Topic", "type": 1 }, { "tag": "User-Computer Interface", "type": 1 } ], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T18:32:53Z", "dateModified": "2015-01-03T15:19:23Z" } }, { "key": "SUIGT7XM", "version": 7130, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/SUIGT7XM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/SUIGT7XM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Atencio et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "SUIGT7XM", "version": 7130, "itemType": "journalArticle", "title": "From the Cover: Hierarchical computation in the canonical auditory cortical circuit", "creators": [ { "creatorType": "author", "firstName": "C. A.", "lastName": "Atencio" }, { "creatorType": "author", "firstName": "T. O.", "lastName": "Sharpee" }, { "creatorType": "author", "firstName": "C. E.", "lastName": "Schreiner" } ], "abstractNote": "", "publicationTitle": "Proceedings of the National Academy of Sciences", "publisher": "", "place": "", "date": "11/2009", "volume": "106", "issue": "51", "section": "", "partNumber": "", "partTitle": "", "pages": "21894-21899", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Proceedings of the National Academy of Sciences", "DOI": "10.1073/pnas.0908383106", "citationKey": "", "url": "http://www.pnas.org/cgi/doi/10.1073/pnas.0908383106", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0027-8424", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00000", "tags": [], "collections": [ "9FPGBTTJ", "CP4XNPTS" ], "relations": {}, "dateAdded": "2010-04-15T18:37:15Z", "dateModified": "2015-01-03T15:19:22Z" } }, { "key": "SEB2PRAS", "version": 7129, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/SEB2PRAS", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/SEB2PRAS", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Fröhlich and McCormick", "parsedDate": "2010-07-15", "numChildren": 2 }, "data": { "key": "SEB2PRAS", "version": 7129, "itemType": "journalArticle", "title": "Endogenous Electric Fields May Guide Neocortical Network Activity", "creators": [ { "creatorType": "author", "firstName": "Flavio", "lastName": "Fröhlich" }, { "creatorType": "author", "firstName": "David", "lastName": "McCormick" } ], "abstractNote": "Local field potentials and the underlying endogenous electric fields (EFs) are traditionally considered to be epiphenomena of structured neuronal network activity. Recently, however, externally applied EFs have been shown to modulate pharmacologically evoked network activity in rodent hippocampus. In contrast, very little is known about the role of endogenous EFs during physiological activity states in neocortex. Here, we used the neocortical slow oscillation in vitro as a model system to show that weak sinusoidal and naturalistic EFs enhance and entrain physiological neocortical network activity with an amplitude threshold within the range of in vivo endogenous field strengths. Modulation of network activity by positive and negative feedback fields based on the network activity in real-time provide direct evidence for a feedback loop between neuronal activity and endogenous EF. This significant susceptibility of active networks to EFs that only cause small changes in membrane potential in individual neurons suggests that endogenous EFs could guide neocortical network activity. º Endogenous electric field reaches 2⬚4 mV/mm during physiological network activity º Neocortical slow oscillation is entrained by weak electric field º Neocortical network activity may be enhanced by its own endogenous electric field º Modulation by weak electric fields demonstrate power of weak but global perturbations", "publicationTitle": "", "publisher": "", "place": "", "date": "July 15, 2010", "volume": "67", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "143, 129", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "", "citationKey": "", "url": "http://www.cell.com/neuron/abstract/S0896-6273(10)00463-0", "accessDate": "2010-07-19T21:07:57Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "CiteULike", "callNumber": "", "rights": "", "extra": "00177", "tags": [], "collections": [ "5U2VQBF7" ], "relations": { "owl:sameAs": "http://zotero.org/groups/6130/items/TX4NNSSC" }, "dateAdded": "2010-07-19T21:44:38Z", "dateModified": "2015-01-03T15:19:20Z" } }, { "key": "RHW8KSJV", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/RHW8KSJV", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/RHW8KSJV", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Du et al.", "parsedDate": "2009-03", "numChildren": 0 }, "data": { "key": "RHW8KSJV", "version": 7149, "itemType": "journalArticle", "title": "High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays", "creators": [ { "creatorType": "author", "firstName": "Jiangang", "lastName": "Du" }, { "creatorType": "author", "firstName": "Ingmar H", "lastName": "Riedel-Kruse" }, { "creatorType": "author", "firstName": "Janna C", "lastName": "Nawroth" }, { "creatorType": "author", "firstName": "Michael L", "lastName": "Roukes" }, { "creatorType": "author", "firstName": "Gilles", "lastName": "Laurent" }, { "creatorType": "author", "firstName": "Sotiris C", "lastName": "Masmanidis" } ], "abstractNote": "Microelectrode array recordings of neuronal activity present significant opportunities for studying the brain with single-cell and spike-time precision. However, challenges in device manufacturing constrain dense multisite recordings to two spatial dimensions, whereas access to the three-dimensional (3D) structure of many brain regions appears to remain a challenge. To overcome this limitation, we present two novel recording modalities of silicon-based devices aimed at establishing 3D functionality. First, we fabricated a dual-side electrode array by patterning recording sites on both the front and back of an implantable microstructure. We found that the majority of single-unit spikes could not be simultaneously detected from both sides, suggesting that in addition to providing higher spatial resolution measurements than that of single-side devices, dual-side arrays also lead to increased recording yield. Second, we obtained recordings along three principal directions with a multilayer array and demonstrated 3D spike source localization within the enclosed measurement space. The large-scale integration of such dual-side and multilayer arrays is expected to provide massively parallel recording capabilities in the brain.", "publicationTitle": "Journal of Neurophysiology", "publisher": "", "place": "", "date": "Mar 2009", "volume": "101", "issue": "3", "section": "", "partNumber": "", "partTitle": "", "pages": "1671-1678", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurophysiol", "DOI": "10.1152/jn.90992.2008", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19091921", "accessDate": "", "PMID": "19091921", "PMCID": "", "ISSN": "0022-3077", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00047", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Brain", "type": 1 }, { "tag": "Electric Stimulation", "type": 1 }, { "tag": "Imaging, Three-Dimensional", "type": 1 }, { "tag": "Microelectrodes", "type": 1 }, { "tag": "Models, Neurological", "type": 1 }, { "tag": "Nerve Net", "type": 1 }, { "tag": "Neurons", "type": 1 }, { "tag": "Robinia", "type": 1 } ], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T18:32:53Z", "dateModified": "2015-01-03T15:19:19Z" } }, { "key": "Q3W4H5N7", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/Q3W4H5N7", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/Q3W4H5N7", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Gold et al.", "parsedDate": "2006-05", "numChildren": 0 }, "data": { "key": "Q3W4H5N7", "version": 7149, "itemType": "journalArticle", "title": "On the origin of the extracellular action potential waveform: A modeling study", "creators": [ { "creatorType": "author", "firstName": "Carl", "lastName": "Gold" }, { "creatorType": "author", "firstName": "Darrell A", "lastName": "Henze" }, { "creatorType": "author", "firstName": "Christof", "lastName": "Koch" }, { "creatorType": "author", "firstName": "György", "lastName": "Buzsáki" } ], "abstractNote": "Although extracellular unit recording is typically used for the detection of spike occurrences, it also has the theoretical ability to report about what are typically considered intracellular features of the action potential. We address this theoretical ability by developing a model system that captures features of experimentally recorded simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons. We use the line source approximation method of Holt and Koch to model the extracellular action potential (EAP) voltage resulting from the spiking activity of individual neurons. We compare the simultaneous intracellular and extracellular recordings of CA1 pyramidal neurons recorded in vivo with model predictions for the same cells reconstructed and simulated with compartmental models. The model accurately reproduces both the waveform and the amplitude of the EAPs, although it was difficult to achieve simultaneous good matches on both the intracellular and extracellular waveforms. This suggests that accounting for the EAP waveform provides a considerable constraint on the overall model. The developed model explains how and why the waveform varies with electrode position relative to the recorded cell. Interestingly, each cell's dendritic morphology had very little impact on the EAP waveform. The model also demonstrates that the varied composition of ionic currents in different cells is reflected in the features of the EAP.", "publicationTitle": "Journal of Neurophysiology", "publisher": "", "place": "", "date": "May 2006", "volume": "95", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "3113-3128", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurophysiol", "DOI": "10.1152/jn.00979.2005", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/16467426", "accessDate": "", "PMID": "16467426", "PMCID": "", "ISSN": "0022-3077", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00232", "tags": [ { "tag": "Action Potentials", "type": 1 }, { "tag": "Animals", "type": 1 }, { "tag": "Computer Simulation", "type": 1 }, { "tag": "Dendrites", "type": 1 }, { "tag": "Extracellular Space", "type": 1 }, { "tag": "Hippocampus", "type": 1 }, { "tag": "Intracellular Space", "type": 1 }, { "tag": "Models, Neurological", "type": 1 }, { "tag": "Pyramidal Cells", "type": 1 } ], "collections": [ "QMKA8ESQ" ], "relations": {}, "dateAdded": "2010-06-01T16:57:27Z", "dateModified": "2015-01-03T15:19:18Z" } }, { "key": "PM3MAJQ8", "version": 7129, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/PM3MAJQ8", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/PM3MAJQ8", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Rasch et al.", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "PM3MAJQ8", "version": 7129, "itemType": "journalArticle", "title": "From Neurons to Circuits: Linear Estimation of Local Field Potentials", "creators": [ { "creatorType": "author", "firstName": "M.", "lastName": "Rasch" }, { "creatorType": "author", "firstName": "N. K.", "lastName": "Logothetis" }, { "creatorType": "author", "firstName": "G.", "lastName": "Kreiman" } ], "abstractNote": "", "publicationTitle": "Journal of Neuroscience", "publisher": "", "place": "", "date": "11/2009", "volume": "29", "issue": "44", "section": "", "partNumber": "", "partTitle": "", "pages": "13785-13796", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Journal of Neuroscience", "DOI": "10.1523/JNEUROSCI.2390-09.2009", "citationKey": "", "url": "http://www.jneurosci.org/cgi/doi/10.1523/JNEUROSCI.2390-09.2009", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0270-6474", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00047", "tags": [], "collections": [ "PDAMKGC4" ], "relations": {}, "dateAdded": "2010-03-15T14:08:26Z", "dateModified": "2015-01-03T15:19:17Z" } }, { "key": "PGWT7QUJ", "version": 7129, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/PGWT7QUJ", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/PGWT7QUJ", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Scanziani and Häusser", "parsedDate": "2009", "numChildren": 0 }, "data": { "key": "PGWT7QUJ", "version": 7129, "itemType": "journalArticle", "title": "Electrophysiology in the age of light", "creators": [ { "creatorType": "author", "firstName": "Massimo", "lastName": "Scanziani" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Häusser" } ], "abstractNote": "", "publicationTitle": "Nature", "publisher": "", "place": "", "date": "10/2009", "volume": "461", "issue": "7266", "section": "", "partNumber": "", "partTitle": "", "pages": "930-939", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Nature", "DOI": "10.1038/nature08540", "citationKey": "", "url": "http://www.nature.com/doifinder/10.1038/nature08540", "accessDate": "", "PMID": "", "PMCID": "", "ISSN": "0028-0836", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00151", "tags": [], "collections": [ "8UTZCTTX" ], "relations": {}, "dateAdded": "2010-02-01T19:33:37Z", "dateModified": "2015-01-03T15:19:16Z" } }, { "key": "MDR3PN64", "version": 7129, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/MDR3PN64", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/MDR3PN64", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Mann and Paulsen", "parsedDate": "2010-07-15", "numChildren": 2 }, "data": { "key": "MDR3PN64", "version": 7129, "itemType": "journalArticle", "title": "Local Field Potential Oscillations as a Cortical Soliloquy", "creators": [ { "creatorType": "author", "firstName": "Edward O.", "lastName": "Mann" }, { "creatorType": "author", "firstName": "Ole", "lastName": "Paulsen" } ], "abstractNote": "Synchronized network activity can be recorded as fluctuations in the local field potential (LFP). In this issue of Neuron, Fröhlich and McCormick suggest that cortical LFPs themselves contribute to synchronization of the very network that generates them. Thus, in monitoring these brain waves, we may be listening to the cortex talking to itself.", "publicationTitle": "Neuron", "publisher": "", "place": "", "date": "July 15, 2010", "volume": "67", "issue": "1", "section": "", "partNumber": "", "partTitle": "", "pages": "3-5", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1016/j.neuron.2010.06.036", "citationKey": "", "url": "http://www.sciencedirect.com/science/article/B6WSS-50HX69T-2/2/2a7257986692126059cc619f6ccb4a1f", "accessDate": "2010-07-19T21:16:14Z", "PMID": "", "PMCID": "", "ISSN": "0896-6273", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "ScienceDirect", "callNumber": "", "rights": "", "extra": "00010", "tags": [], "collections": [ "5U2VQBF7" ], "relations": { "owl:sameAs": "http://zotero.org/groups/6130/items/5CG4UE2T" }, "dateAdded": "2010-07-19T21:44:38Z", "dateModified": "2015-01-03T15:19:15Z" } }, { "key": "M9Q43KFH", "version": 7129, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/M9Q43KFH", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/M9Q43KFH", "type": "text/html" } }, "meta": { "createdByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "lastModifiedByUser": { "id": 23645, "username": "gedili", "name": "Adrien Brilhault", "links": { "alternate": { "href": "https://www.zotero.org/gedili", "type": "text/html" } } }, "creatorSummary": "Epsztein et al.", "parsedDate": "2010-01-22", "numChildren": 2 }, "data": { "key": "M9Q43KFH", "version": 7129, "itemType": "journalArticle", "title": "Impact of Spikelets on Hippocampal CA1 Pyramidal Cell Activity During Spatial Exploration", "creators": [ { "creatorType": "author", "firstName": "Jerome", "lastName": "Epsztein" }, { "creatorType": "author", "firstName": "Albert K.", "lastName": "Lee" }, { "creatorType": "author", "firstName": "Edith", "lastName": "Chorev" }, { "creatorType": "author", "firstName": "Michael", "lastName": "Brecht" } ], "abstractNote": "In vivo intracellular recordings of hippocampal neurons reveal the occurrence of fast events of small amplitude called spikelets or fast prepotentials. Because intracellular recordings have been restricted to anesthetized or head-fixed animals, it is not known how spikelet activity contributes to hippocampal spatial representations. We addressed this question in CA1 pyramidal cells by using in vivo whole-cell recording in freely moving rats. We observed a high incidence of spikelets that occurred either in isolation or in bursts and could drive spiking as fast prepotentials of action potentials. Spikelets strongly contributed to spiking activity, driving ~30% of all action potentials. CA1 pyramidal cell firing and spikelet activity were comodulated as a function of the animal's location in the environment. We conclude that spikelets have a major impact on hippocampal activity during spatial exploration.", "publicationTitle": "Science", "publisher": "", "place": "", "date": "January 22, 2010", "volume": "327", "issue": "5964", "section": "", "partNumber": "", "partTitle": "", "pages": "474-477", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "", "DOI": "10.1126/science.1182773", "citationKey": "", "url": "http://www.sciencemag.org/cgi/content/abstract/327/5964/474", "accessDate": "2010-02-09T18:18:43Z", "PMID": "", "PMCID": "", "ISSN": "", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "HighWire", "callNumber": "0000", "rights": "", "extra": "00056", "tags": [], "collections": [ "QM4CW3Z6", "T5PUDEVW" ], "relations": {}, "dateAdded": "2010-02-09T18:18:43Z", "dateModified": "2015-01-03T15:19:14Z" } }, { "key": "KV6EHMEM", "version": 7149, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/KV6EHMEM", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/KV6EHMEM", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Anastassiou et al.", "parsedDate": "2010-02-03", "numChildren": 0 }, "data": { "key": "KV6EHMEM", "version": 7149, "itemType": "journalArticle", "title": "The effect of spatially inhomogeneous extracellular electric fields on neurons", "creators": [ { "creatorType": "author", "firstName": "Costas A", "lastName": "Anastassiou" }, { "creatorType": "author", "firstName": "Sean M", "lastName": "Montgomery" }, { "creatorType": "author", "firstName": "Mauricio", "lastName": "Barahona" }, { "creatorType": "author", "firstName": "György", "lastName": "Buzsáki" }, { "creatorType": "author", "firstName": "Christof", "lastName": "Koch" } ], "abstractNote": "The cooperative action of neurons and glia generates electrical fields, but their effect on individual neurons via ephaptic interactions is mostly unknown. Here, we analyze the impact of spatially inhomogeneous electric fields on the membrane potential, the induced membrane field, and the induced current source density of one-dimensional cables as well as morphologically realistic neurons and discuss how the features of the extracellular field affect these quantities. We show through simulations that endogenous fields, associated with hippocampal theta and sharp waves, can greatly affect spike timing. These findings imply that local electric fields, generated by the cooperative action of brain cells, can influence the timing of neural activity.", "publicationTitle": "The Journal of Neuroscience: The Official Journal of the Society for Neuroscience", "publisher": "", "place": "", "date": "Feb 3, 2010", "volume": "30", "issue": "5", "section": "", "partNumber": "", "partTitle": "", "pages": "1925-1936", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "J. Neurosci", "DOI": "10.1523/JNEUROSCI.3635-09.2010", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/20130201", "accessDate": "", "PMID": "20130201", "PMCID": "", "ISSN": "1529-2401", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00072", "tags": [], "collections": [ "QMKA8ESQ" ], "relations": {}, "dateAdded": "2010-06-01T16:57:27Z", "dateModified": "2015-01-03T15:19:13Z" } }, { "key": "KUWQGPKF", "version": 7150, "library": { "type": "group", "id": 10943, "name": "multidisciplinary neuroscience journal club", "links": { "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club", "type": "text/html" } } }, "links": { "self": { "href": "https://api.zotero.org/groups/10943/items/KUWQGPKF", "type": "application/json" }, "alternate": { "href": "https://www.zotero.org/groups/multidisciplinary_neuroscience_journal_club/items/KUWQGPKF", "type": "text/html" } }, "meta": { "createdByUser": { "id": 108891, "username": "micalith", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/micalith", "type": "text/html" } } }, "lastModifiedByUser": { "id": 58144, "username": "dylanrich", "name": "", "links": { "alternate": { "href": "https://www.zotero.org/dylanrich", "type": "text/html" } } }, "creatorSummary": "Rickgauer and Tank", "parsedDate": "2009-09-01", "numChildren": 0 }, "data": { "key": "KUWQGPKF", "version": 7150, "itemType": "journalArticle", "title": "Two-photon excitation of channelrhodopsin-2 at saturation", "creators": [ { "creatorType": "author", "firstName": "John Peter", "lastName": "Rickgauer" }, { "creatorType": "author", "firstName": "David W", "lastName": "Tank" } ], "abstractNote": "We demonstrate that channelrhodopsin-2 (CR), a light-gated ion channel that is conventionally activated by using visible-light excitation, can also be activated by using IR two-photon excitation (TPE). An empirical estimate of CR's two-photon absorption cross-section at lambda = 920 nm is presented, with a value (260 +/- 20 GM) indicating that TPE stimulation of CR photocurrents is not typically limited by intrinsic molecular excitability [1 GM = 10(-50)(cm4 s)/photon]. By using direct physiological measurements of CR photocurrents and a model of ground-state depletion, we evaluate how saturation of CR's current-conducting state influences the spatial resolution of focused TPE photostimulation, and how photocurrents stimulated by using low-power scanning TPE temporally summate. We show that TPE, like visible-light excitation, can be used to stimulate action potentials in cultured CR-expressing neurons.", "publicationTitle": "Proceedings of the National Academy of Sciences of the United States of America", "publisher": "", "place": "", "date": "Sep 1, 2009", "volume": "106", "issue": "35", "section": "", "partNumber": "", "partTitle": "", "pages": "15025-15030", "series": "", "seriesTitle": "", "seriesText": "", "journalAbbreviation": "Proc. Natl. Acad. Sci. U.S.A", "DOI": "10.1073/pnas.0907084106", "citationKey": "", "url": "http://www.ncbi.nlm.nih.gov/pubmed/19706471", "accessDate": "", "PMID": "19706471", "PMCID": "", "ISSN": "1091-6490", "archive": "", "archiveLocation": "", "shortTitle": "", "language": "", "libraryCatalog": "", "callNumber": "0000", "rights": "", "extra": "00098", "tags": [ { "tag": "Cell Line", "type": 1 }, { "tag": "Electrophysiological Phenomena", "type": 1 }, { "tag": "Humans", "type": 1 }, { "tag": "Ion Channels", "type": 1 }, { "tag": "Patch-Clamp Techniques", "type": 1 }, { "tag": "Photons", "type": 1 }, { "tag": "Rhodopsin", "type": 1 } ], "collections": [ "MVVKJDZN" ], "relations": {}, "dateAdded": "2010-02-01T19:25:00Z", "dateModified": "2015-01-03T15:19:12Z" } } ]