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            "title": "Event-Related Functional Magnetic Resonance Imaging Measures of Neural Activity to Positive Social Stimuli in Pre- and Post-Treatment Depression.",
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                    "creatorType": "author",
                    "firstName": "Hillary S.",
                    "lastName": "Schaefer"
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                {
                    "creatorType": "author",
                    "firstName": "Katherine M.",
                    "lastName": "Putnam"
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                {
                    "creatorType": "author",
                    "firstName": "Ruth M.",
                    "lastName": "Benca"
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                {
                    "creatorType": "author",
                    "firstName": "Richard J.",
                    "lastName": "Davidson"
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            "abstractNote": "Background: Relationships between aberrant social functioning and depression have been explored via behavioral, clinical, and survey methodologies, highlighting their importance in the etiology of depression. The neural underpinnings of these relationships, however, have not been explored. Methods: Nine depressed participants and 14 never-depressed control subjects viewed emotional and neutral pictures at two functional magnetic resonance imaging (fMRI) scanning sessions approximately 22 weeks apart. In the interim, depressed patients received the antidepressant Venlafaxine. Positively rated images were parsed into three separate comparisons: social interaction, human faces, and sexual images; across scanning session, activation to these images was compared with other positively rated images. Results: For each of the three social stimulus types (social interaction, faces, sexual images), a distinguishable circuitry was activated equally in non-depressed control subjects and post-treatment depressed subjects but showed a hypo-response in the depressed group pre-treatment. These structures include regions of prefrontal, temporal, and parietal cortices, insula, basal ganglia, and the hippocampus. Conclusions: The neural hypo-response to positively valenced social stimuli that is observed in depression remits as response to antidepressant medication occurs, suggesting a state-dependent deficiency in response to positive social incentives. These findings underscore the importance of addressing social dysfunction in research and treatment of depression. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract)",
            "publicationTitle": "Biological Psychiatry",
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            "pages": "974-986",
            "series": "The Clinical and Neural Phenotype of Mood Disturbance in Children and Adults",
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                    "lastName": "Ellenbogen"
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                    "firstName": "Alex E.",
                    "lastName": "Schwartzman"
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                    "firstName": "Jane",
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            "abstractNote": "Examined the effects of a stressful challenge on the processing of emotional words in 135 18-36 yr olds. Stress induction was achieved using a competitive computer task, where the individual either repeatedly lost or won against a confederate. Mood, attention, and cortisol were recorded during the study. There were 4 findings: (1) participants in the negative stressor condition were faster to shift attention away from negative words than positive or neutral words; (2) attentional shifts away from negative words were associated with stress-induced mood lowering; (3) participants in the negative stress condition with elevated scores on the Beck Depression Inventory were slow to disengage attention from all stimuli; and (4) elevated depression scores were associated with lower cortisol change from baseline during the experimental phase, and with higher cortisol levels during the recovery phase. It is concluded that these findings point to information processing strategies as a means to regulate emotion, and to atypical features of cognitive and adrenocortical function that may serve as putative risk markers of depression. The words used in the spatial cueing task are appended. (PsycINFO Database Record (c) 2010 APA, all rights reserved)",
            "publicationTitle": "Psychophysiology",
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            "date": "November 2002",
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                    "lastName": "Brummett"
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            "title": "Glucocorticoid regulation of diverse cognitive functions in normal and pathological emotional states.",
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                    "creatorType": "author",
                    "firstName": "Kristine",
                    "lastName": "Erickson"
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                    "creatorType": "author",
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                    "firstName": "Jay",
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            "abstractNote": "The glucocorticoid hormone cortisol is essential for many forms of regulatory physiology and for cognitive appraisal. Cortisol, while associated with fear and stress response, is also the hormone of energy metabolism and it coordinates behavioral adaptation to the environmental and internal conditions through the regulation of many neurotransmitters and neural circuits. Cortisol has diverse effects on many neuropeptide and neurotransmitter systems thus affecting functional brain systems. As a result, cortisol affects numerous cognitive domains including attention, perception, memory, and emotional processing. When certain pathological emotional states are present, cortisol may have a role in differential activation of brain regions, particularly suppression of hippocampal activation, enhancement of amygdala activity, and dendritic reshaping in these regions as well as in the ventral prefrontal cortex. The coordinated actions of glucocorticoid regulation on various brain systems such as those implicated in emotional processing can lead to perceptual and cognitive adaptations and distortions of events that may be relevant for understanding mood disorders. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract)",
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                    "firstName": "William",
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                    "firstName": "Nancy C.",
                    "lastName": "Andreasen"
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            "abstractNote": "Objective: A variety of findings have implicated the portion of the anterior cingulate cortex ventral to the corpus callosum in the pathophysiology of familial depressive disorder. There are, as yet, few data to address the specificity of these abnormalities to depressive disorders or to characterize their stability over time. Method: The authors studied 10 subjects who were judged to have had major depressive disorder with psychotic features, who underwent magnetic resonance imaging (MRI) protocols, and who participated in a longitudinal study of recent-onset psychosis. These were group-matched to 10 subjects with schizophrenia and to 10 well comparison subjects. Volumetric measures were made of the posterior and anterior portions of the subgenual prefrontal cortex for these 30 subjects. Followup scans done an average of 4 years after intake were available for seven subjects with major depressive disorder, nine subjects with schizophrenia, and five well comparison subjects. Results: Volumes of the left side of the posterior subgenual prefrontal cortex differed significantly by group and were smallest for the group with psychotic major depressive disorder. Volumes of the anterior subgenual prefrontal cortex did not differ significantly by group. Patients with major depressive disorder were more likely to show increases in posterior subgenual prefrontal cortex volume on follow-up than were comparison subjects or patients with schizophrenia. Conclusions: These findings add to the evidence that abnormalities in the subgenual region of the anterior cingulate play a role in at least some types of mood disorder. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract)",
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                    "firstName": "Cédric",
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            "abstractNote": "Major depression is associated with an excessive self-focus, a tendency to engage oneself in self-referential processing. The medial frontal gyrus (MFG) is central to self-referential processing. This study aimed to explore the neural bases of this excessive self-focus and to disambiguate the role of the MFG in the pathophysiology of major depression. We presented 15 depressed patients and 15 healthy subjects with personality traits during functional magnetic resonance imaging and asked them to judge whether each trait described them (‘self’ condition) or a generally desirable trait (‘general’ condition). Both patients and healthy subjects activated the MFG in ‘self’ vs ‘general’ condition. However, the activation of the dorsal part of the MFG and of the dorsolateral prefrontal cortex (DLPFC) in ‘self’ vs ‘general’ condition was unique to patients. Additionally, patients displayed an increased functional connectivity between the MFG, the dorsal anterior cingulate cortex and the DLPFC. These results provide evidence for an extended medial prefrontal network during self-referential processing in major depression, suggesting the involvement of a greater cognitive control. (PsycINFO Database Record (c) 2010 APA, all rights reserved) (journal abstract)",
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